And the amyloid situation is a word of warning to anybody thinking they could really speed up drug discovery. The researchers had a model. They created various compounds that were effective vs this model. These compounds were active in vivo vs the model target and safe to deliver. Problem was, they didn’t actually do anything vs dementia.
The human body isn’t really well understood. There are unknown mechanisms and interactions that appear at unexpected often undesirable times. There’s things that only show up in human testing, after models and animal testing shows no problems. And as in this case, the disease reveals it’s not really understood. Companies have burned through billions chasing this as the upside is damn well infinite.
My mum died two years ago aged 86.
She was diagnosed 10 years previously with, early onset dementia, then Alzheimer's, then dementia. I thought she was just my annoying mum.
My mum was just getting old and getting ready to die. She had spent 86 years living on this planet and her time was slowly coming to an end.
Its not difficult to understand that our bodies and our minds deteriorate as we get older, and then we die.
Its not rocket science
Its been happening for millennia
_wire_•2h ago
midwesterndoctor is legit!