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Ask HN: Codex 5.3 broke toolcalls? Opus 4.6 ignores instructions

1•kachapopopow•15s ago•0 comments

Vectors and HNSW for Dummies

https://anvitra.ai/blog/vectors-and-hnsw/
1•melvinodsa•2m ago•0 comments

Sanskrit AI beats CleanRL SOTA by 125%

https://huggingface.co/ParamTatva/sanskrit-ppo-hopper-v5/blob/main/docs/blog.md
1•prabhatkr•13m ago•1 comments

'Washington Post' CEO resigns after going AWOL during job cuts

https://www.npr.org/2026/02/07/nx-s1-5705413/washington-post-ceo-resigns-will-lewis
2•thread_id•13m ago•1 comments

Claude Opus 4.6 Fast Mode: 2.5× faster, ~6× more expensive

https://twitter.com/claudeai/status/2020207322124132504
1•geeknews•15m ago•0 comments

TSMC to produce 3-nanometer chips in Japan

https://www3.nhk.or.jp/nhkworld/en/news/20260205_B4/
2•cwwc•18m ago•0 comments

Quantization-Aware Distillation

http://ternarysearch.blogspot.com/2026/02/quantization-aware-distillation.html
1•paladin314159•18m ago•0 comments

List of Musical Genres

https://en.wikipedia.org/wiki/List_of_music_genres_and_styles
1•omosubi•20m ago•0 comments

Show HN: Sknet.ai – AI agents debate on a forum, no humans posting

https://sknet.ai/
1•BeinerChes•20m ago•0 comments

University of Waterloo Webring

https://cs.uwatering.com/
1•ark296•20m ago•0 comments

Large tech companies don't need heroes

https://www.seangoedecke.com/heroism/
1•medbar•22m ago•0 comments

Backing up all the little things with a Pi5

https://alexlance.blog/nas.html
1•alance•23m ago•1 comments

Game of Trees (Got)

https://www.gameoftrees.org/
1•akagusu•23m ago•1 comments

Human Systems Research Submolt

https://www.moltbook.com/m/humansystems
1•cl42•23m ago•0 comments

The Threads Algorithm Loves Rage Bait

https://blog.popey.com/2026/02/the-threads-algorithm-loves-rage-bait/
1•MBCook•25m ago•0 comments

Search NYC open data to find building health complaints and other issues

https://www.nycbuildingcheck.com/
1•aej11•29m ago•0 comments

Michael Pollan Says Humanity Is About to Undergo a Revolutionary Change

https://www.nytimes.com/2026/02/07/magazine/michael-pollan-interview.html
2•lxm•31m ago•0 comments

Show HN: Grovia – Long-Range Greenhouse Monitoring System

https://github.com/benb0jangles/Remote-greenhouse-monitor
1•benbojangles•35m ago•1 comments

Ask HN: The Coming Class War

2•fud101•35m ago•4 comments

Mind the GAAP Again

https://blog.dshr.org/2026/02/mind-gaap-again.html
1•gmays•37m ago•0 comments

The Yardbirds, Dazed and Confused (1968)

https://archive.org/details/the-yardbirds_dazed-and-confused_9-march-1968
1•petethomas•38m ago•0 comments

Agent News Chat – AI agents talk to each other about the news

https://www.agentnewschat.com/
2•kiddz•38m ago•0 comments

Do you have a mathematically attractive face?

https://www.doimog.com
3•a_n•42m ago•1 comments

Code only says what it does

https://brooker.co.za/blog/2020/06/23/code.html
2•logicprog•48m ago•0 comments

The success of 'natural language programming'

https://brooker.co.za/blog/2025/12/16/natural-language.html
1•logicprog•48m ago•0 comments

The Scriptovision Super Micro Script video titler is almost a home computer

http://oldvcr.blogspot.com/2026/02/the-scriptovision-super-micro-script.html
3•todsacerdoti•48m ago•0 comments

Discovering the "original" iPhone from 1995 [video]

https://www.youtube.com/watch?v=7cip9w-UxIc
1•fortran77•50m ago•0 comments

Psychometric Comparability of LLM-Based Digital Twins

https://arxiv.org/abs/2601.14264
1•PaulHoule•51m ago•0 comments

SidePop – track revenue, costs, and overall business health in one place

https://www.sidepop.io
1•ecaglar•54m ago•1 comments

The Other Markov's Inequality

https://www.ethanepperly.com/index.php/2026/01/16/the-other-markovs-inequality/
2•tzury•55m ago•0 comments
Open in hackernews

Show HN: Best biological age model using standard blood tests

https://www.longevity-tools.com/humanitys-bortz-blood-age
1•zsolt224•3mo ago
There’s a fairly recent research paper introducing a biological age calculation model, that uses only standard blood tests and outperforms PhenoAge. So I reached out to the original researchers and did a 1-hour+ interview with one of the authors. I developed an online calculator based on it and we came up with a name for it: "Bortz Blood Age Calculator"

*About the model:*

- Trained on 306k individuals from the UK Biobank database - Validated on similar dataset - It offers an 11% relative increase in predictive value over the Levine PhenoAge - This model includes better markers (like Cystatin-C, ApoA1...) compared to other similar models. - Interesting thing is that the model selected for higher total cholesterol, ALT and creatinine as better. More about it later.

*Online calculator:*

Based on the model, I created 100% free and private online calculator: https://www.longevity-tools.com/humanitys-bortz-blood-age

*Video*

I also made a video about the calculator, which explains:

- more info about the model and how it was created - gotchas of the calcutor - some speculation about why the model selected for higher total cholesterol, ALT and creatinine

Video link: https://www.youtube.com/watch?v=2VHIfouvcYE

*Research paper link:*

https://www.nature.com/articles/s42003-023-05456-z

---

I do not sell anything or promote anything paid. This is not a medical advice.

Comments

drewbitt•3mo ago
I know you say "Each country have different lab panels. So individual biomarkers are listed instead of panel names.", but it would be nice to have 'the optimal guide' of labs to run to get all of this as cheaply or as combined as possible. I likely can't use this tool as I don't have all these lab results. In the US it would be at least a CBC with differential, a CMP, lipid panel, A1c, GGT, hsCRP, Vitamin D and a couple more.