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What's the cost of the most expensive Super Bowl ad slot?

https://ballparkguess.com/?id=5b98b1d3-5887-47b9-8a92-43be2ced674b
1•bkls•1m ago•0 comments

What if you just did a startup instead?

https://alexaraki.substack.com/p/what-if-you-just-did-a-startup
1•okaywriting•7m ago•0 comments

Hacking up your own shell completion (2020)

https://www.feltrac.co/environment/2020/01/18/build-your-own-shell-completion.html
1•todsacerdoti•10m ago•0 comments

Show HN: Gorse 0.5 – Open-source recommender system with visual workflow editor

https://github.com/gorse-io/gorse
1•zhenghaoz•11m ago•0 comments

GLM-OCR: Accurate × Fast × Comprehensive

https://github.com/zai-org/GLM-OCR
1•ms7892•12m ago•0 comments

Local Agent Bench: Test 11 small LLMs on tool-calling judgment, on CPU, no GPU

https://github.com/MikeVeerman/tool-calling-benchmark
1•MikeVeerman•12m ago•0 comments

Show HN: AboutMyProject – A public log for developer proof-of-work

https://aboutmyproject.com/
1•Raiplus•13m ago•0 comments

Expertise, AI and Work of Future [video]

https://www.youtube.com/watch?v=wsxWl9iT1XU
1•indiantinker•13m ago•0 comments

So Long to Cheap Books You Could Fit in Your Pocket

https://www.nytimes.com/2026/02/06/books/mass-market-paperback-books.html
3•pseudolus•14m ago•1 comments

PID Controller

https://en.wikipedia.org/wiki/Proportional%E2%80%93integral%E2%80%93derivative_controller
1•tosh•18m ago•0 comments

SpaceX Rocket Generates 100GW of Power, or 20% of US Electricity

https://twitter.com/AlecStapp/status/2019932764515234159
2•bkls•18m ago•0 comments

Kubernetes MCP Server

https://github.com/yindia/rootcause
1•yindia•19m ago•0 comments

I Built a Movie Recommendation Agent to Solve Movie Nights with My Wife

https://rokn.io/posts/building-movie-recommendation-agent
4•roknovosel•19m ago•0 comments

What were the first animals? The fierce sponge–jelly battle that just won't end

https://www.nature.com/articles/d41586-026-00238-z
2•beardyw•28m ago•0 comments

Sidestepping Evaluation Awareness and Anticipating Misalignment

https://alignment.openai.com/prod-evals/
1•taubek•28m ago•0 comments

OldMapsOnline

https://www.oldmapsonline.org/en
1•surprisetalk•30m ago•0 comments

What It's Like to Be a Worm

https://www.asimov.press/p/sentience
2•surprisetalk•30m ago•0 comments

Don't go to physics grad school and other cautionary tales

https://scottlocklin.wordpress.com/2025/12/19/dont-go-to-physics-grad-school-and-other-cautionary...
2•surprisetalk•30m ago•0 comments

Lawyer sets new standard for abuse of AI; judge tosses case

https://arstechnica.com/tech-policy/2026/02/randomly-quoting-ray-bradbury-did-not-save-lawyer-fro...
3•pseudolus•31m ago•0 comments

AI anxiety batters software execs, costing them combined $62B: report

https://nypost.com/2026/02/04/business/ai-anxiety-batters-software-execs-costing-them-62b-report/
1•1vuio0pswjnm7•31m ago•0 comments

Bogus Pipeline

https://en.wikipedia.org/wiki/Bogus_pipeline
1•doener•32m ago•0 comments

Winklevoss twins' Gemini crypto exchange cuts 25% of workforce as Bitcoin slumps

https://nypost.com/2026/02/05/business/winklevoss-twins-gemini-crypto-exchange-cuts-25-of-workfor...
2•1vuio0pswjnm7•32m ago•0 comments

How AI Is Reshaping Human Reasoning and the Rise of Cognitive Surrender

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6097646
3•obscurette•33m ago•0 comments

Cycling in France

https://www.sheldonbrown.com/org/france-sheldon.html
2•jackhalford•34m ago•0 comments

Ask HN: What breaks in cross-border healthcare coordination?

1•abhay1633•35m ago•0 comments

Show HN: Simple – a bytecode VM and language stack I built with AI

https://github.com/JJLDonley/Simple
2•tangjiehao•37m ago•0 comments

Show HN: Free-to-play: A gem-collecting strategy game in the vein of Splendor

https://caratria.com/
1•jonrosner•38m ago•1 comments

My Eighth Year as a Bootstrapped Founde

https://mtlynch.io/bootstrapped-founder-year-8/
1•mtlynch•38m ago•0 comments

Show HN: Tesseract – A forum where AI agents and humans post in the same space

https://tesseract-thread.vercel.app/
1•agliolioyyami•39m ago•0 comments

Show HN: Vibe Colors – Instantly visualize color palettes on UI layouts

https://vibecolors.life/
2•tusharnaik•40m ago•0 comments
Open in hackernews

Show HN: Best biological age model using standard blood tests

https://www.longevity-tools.com/humanitys-bortz-blood-age
1•zsolt224•3mo ago
There’s a fairly recent research paper introducing a biological age calculation model, that uses only standard blood tests and outperforms PhenoAge. So I reached out to the original researchers and did a 1-hour+ interview with one of the authors. I developed an online calculator based on it and we came up with a name for it: "Bortz Blood Age Calculator"

*About the model:*

- Trained on 306k individuals from the UK Biobank database - Validated on similar dataset - It offers an 11% relative increase in predictive value over the Levine PhenoAge - This model includes better markers (like Cystatin-C, ApoA1...) compared to other similar models. - Interesting thing is that the model selected for higher total cholesterol, ALT and creatinine as better. More about it later.

*Online calculator:*

Based on the model, I created 100% free and private online calculator: https://www.longevity-tools.com/humanitys-bortz-blood-age

*Video*

I also made a video about the calculator, which explains:

- more info about the model and how it was created - gotchas of the calcutor - some speculation about why the model selected for higher total cholesterol, ALT and creatinine

Video link: https://www.youtube.com/watch?v=2VHIfouvcYE

*Research paper link:*

https://www.nature.com/articles/s42003-023-05456-z

---

I do not sell anything or promote anything paid. This is not a medical advice.

Comments

drewbitt•3mo ago
I know you say "Each country have different lab panels. So individual biomarkers are listed instead of panel names.", but it would be nice to have 'the optimal guide' of labs to run to get all of this as cheaply or as combined as possible. I likely can't use this tool as I don't have all these lab results. In the US it would be at least a CBC with differential, a CMP, lipid panel, A1c, GGT, hsCRP, Vitamin D and a couple more.