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Beating AlphaFold3

https://genesis.ml/news/introducing-pearl-the-next-generation-foundation-model-for-drug-discovery/
1•slashdave•2h ago

Comments

slashdave•2h ago
First model to clearly surpass AlphaFold 3 on protein-ligand structure prediction

KDE Linux deep dive: package mgmt is amazing, which is why we don't include it

https://pointieststick.com/2025/10/25/kde-linux-deep-dive-package-management-is-amazing-which-is-...
1•MaximilianEmel•57s ago•0 comments

MCP Gateway and Registry: Enterprise-Grade Tool Governance for AI Agents

https://github.com/agentic-community/mcp-gateway-registry
1•aarora79•1m ago•1 comments

Aisuru Botnet Shifts from DDoS to Residential Proxies

https://krebsonsecurity.com/2025/10/aisuru-botnet-shifts-from-ddos-to-residential-proxies/
1•feross•3m ago•0 comments

Show HN: PDF to Text Without OCR

https://www.signmypdf.com/tools/extract-text-from-pdf/
1•aqrashik•3m ago•0 comments

The fleet is the data center

https://twitter.com/niccruzpatane/status/1983227043887058974
1•delichon•4m ago•0 comments

OpenAI completes restructure as for-profit company

https://www.semafor.com/article/10/28/2025/openai-completes-restructure-as-for-profit-company
1•smithcoin•7m ago•0 comments

The Smallest Pixel in the World

https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/hecht-science-advances/
1•layer8•9m ago•1 comments

Death by Scrolling

https://store.steampowered.com/app/3773590/Death_by_Scrolling/
1•doener•10m ago•0 comments

HoloDoom [video]

https://www.youtube.com/watch?v=Ozzpirkhi5c
1•garaetjjte•11m ago•0 comments

Univ of Miami scientists launch accessible global climate modeling framework

https://news.miami.edu/rosenstiel/stories/2025/09/university-of-miami-scientists-launch-accessibl...
1•susiecambria•12m ago•0 comments

AI's labor market squeeze tightens

https://www.axios.com/2025/10/28/ai-jobs-amazon-layoffs
2•moneycantbuy•18m ago•1 comments

FCC Changes Course on the Price of Prisoners' Phone Calls

https://www.nytimes.com/2025/10/28/upshot/prisoners-phone-calls-prices.html
2•coloneltcb•21m ago•0 comments

Semantic Compression with Large Language Models

https://arxiv.org/abs/2304.12512
1•manikandaraj•25m ago•1 comments

ChatGPT Atlas

https://openai.com/index/introducing-chatgpt-atlas/
1•manikandaraj•27m ago•1 comments

Galactic Empires May Live at the Center of Our Galaxy, Hence Why We Don't Hear

https://www.universetoday.com/articles/galactic-empires-may-live-at-the-center-of-our-galaxy-henc...
2•atilimcetin•31m ago•1 comments

Saint Pierre and Miquelon

https://en.wikipedia.org/wiki/Saint_Pierre_and_Miquelon
1•derbOac•32m ago•0 comments

Opportunistic Mutation in Roc

https://www.roc-lang.org/functional#opportunistic-mutation
2•coffeeaddict1•34m ago•0 comments

Online outages: Q3 2025 Internet disruption summary

https://blog.cloudflare.com/q3-2025-internet-disruption-summary/
1•corvad•36m ago•0 comments

Show HN: Monitor on Your Chess Addiction

https://chess-stats.alexboden.ca/
2•alexboden•37m ago•0 comments

Red Hat to Distribute Nvidia CUDA Across RHEL, Red Hat AI and OpenShift

https://www.phoronix.com/news/Red-Hat-Distribute-CUDA-RHEL
2•ashvardanian•37m ago•0 comments

Ask HN: Are the tech levels now diluted post-pandemic (Google/Meta)

2•alpb•40m ago•0 comments

Show HN: Sonura Studio: AI music production built for collaboration

https://sonurastudio.com/
1•kindred•42m ago•0 comments

Discovering state-of-the-art reinforcement learning algorithms

https://www.nature.com/articles/s41586-025-09761-x
4•lawrenceyan•44m ago•0 comments

X-59 Soars: A New Era in Supersonic Flight Begins – Oct 28, 2025

https://news.lockheedmartin.com/2025-10-28-X-59-Soars-A-New-Era-in-Supersonic-Flight-Begins
2•bpierre•49m ago•0 comments

Database backups, dump files and restic

https://strugglers.net/posts/2025/database-backups-dump-files-and-restic/
3•todsacerdoti•51m ago•0 comments

Pearl: A Foundation Model for Placing Every Atom in the Right Location [pdf]

https://genesis.ml/wp-content/uploads/2025/10/pearl_technical_report.pdf
4•daedalus2718•51m ago•0 comments

Show HN: OXH AI – Open-Source AI Crypto Signal Platform with Real-Time Analysis

https://www.oxher.com
1•oxhai•59m ago•0 comments

Show HN: Created a Live Anime Channel, no server necessary

https://animaxreboot.pages.dev/
2•LandOfMightDev•1h ago•3 comments

Westinghouse is claiming a nuclear deal would see $80B of new reactors

https://arstechnica.com/science/2025/10/westinghouse-is-claiming-a-nuclear-deal-would-see-80b-of-...
5•atilimcetin•1h ago•2 comments

AMZN Layoffs show what AI is coming for our jobs, whether its good enough or not

https://www.amazonclimatejustice.org/open-letter
2•todchavez•1h ago•2 comments