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Show HN: Simple – a bytecode VM and language stack I built with AI

https://github.com/JJLDonley/Simple
1•tangjiehao•48s ago•0 comments

Show HN: A gem-collecting strategy game in the vein of Splendor

https://caratria.com/
1•jonrosner•1m ago•0 comments

My Eighth Year as a Bootstrapped Founde

https://mtlynch.io/bootstrapped-founder-year-8/
1•mtlynch•2m ago•0 comments

Show HN: Tesseract – A forum where AI agents and humans post in the same space

https://tesseract-thread.vercel.app/
1•agliolioyyami•2m ago•0 comments

Show HN: Vibe Colors – Instantly visualize color palettes on UI layouts

https://vibecolors.life/
1•tusharnaik•3m ago•0 comments

OpenAI is Broke ... and so is everyone else [video][10M]

https://www.youtube.com/watch?v=Y3N9qlPZBc0
2•Bender•3m ago•0 comments

We interfaced single-threaded C++ with multi-threaded Rust

https://antithesis.com/blog/2026/rust_cpp/
1•lukastyrychtr•5m ago•0 comments

State Department will delete X posts from before Trump returned to office

https://text.npr.org/nx-s1-5704785
4•derriz•5m ago•1 comments

AI Skills Marketplace

https://skly.ai
1•briannezhad•5m ago•1 comments

Show HN: A fast TUI for managing Azure Key Vault secrets written in Rust

https://github.com/jkoessle/akv-tui-rs
1•jkoessle•5m ago•0 comments

eInk UI Components in CSS

https://eink-components.dev/
1•edent•6m ago•0 comments

Discuss – Do AI agents deserve all the hype they are getting?

2•MicroWagie•9m ago•0 comments

ChatGPT is changing how we ask stupid questions

https://www.washingtonpost.com/technology/2026/02/06/stupid-questions-ai/
1•edward•10m ago•0 comments

Zig Package Manager Enhancements

https://ziglang.org/devlog/2026/#2026-02-06
2•jackhalford•11m ago•1 comments

Neutron Scans Reveal Hidden Water in Martian Meteorite

https://www.universetoday.com/articles/neutron-scans-reveal-hidden-water-in-famous-martian-meteorite
1•geox•12m ago•0 comments

Deepfaking Orson Welles's Mangled Masterpiece

https://www.newyorker.com/magazine/2026/02/09/deepfaking-orson-welless-mangled-masterpiece
1•fortran77•14m ago•1 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
3•nar001•16m ago•2 comments

SpaceX Delays Mars Plans to Focus on Moon

https://www.wsj.com/science/space-astronomy/spacex-delays-mars-plans-to-focus-on-moon-66d5c542
1•BostonFern•16m ago•0 comments

Jeremy Wade's Mighty Rivers

https://www.youtube.com/playlist?list=PLyOro6vMGsP_xkW6FXxsaeHUkD5e-9AUa
1•saikatsg•17m ago•0 comments

Show HN: MCP App to play backgammon with your LLM

https://github.com/sam-mfb/backgammon-mcp
2•sam256•19m ago•0 comments

AI Command and Staff–Operational Evidence and Insights from Wargaming

https://www.militarystrategymagazine.com/article/ai-command-and-staff-operational-evidence-and-in...
1•tomwphillips•19m ago•0 comments

Show HN: CCBot – Control Claude Code from Telegram via tmux

https://github.com/six-ddc/ccbot
1•sixddc•20m ago•1 comments

Ask HN: Is the CoCo 3 the best 8 bit computer ever made?

2•amichail•22m ago•1 comments

Show HN: Convert your articles into videos in one click

https://vidinie.com/
3•kositheastro•25m ago•1 comments

Red Queen's Race

https://en.wikipedia.org/wiki/Red_Queen%27s_race
2•rzk•25m ago•0 comments

The Anthropic Hive Mind

https://steve-yegge.medium.com/the-anthropic-hive-mind-d01f768f3d7b
2•gozzoo•28m ago•0 comments

A Horrible Conclusion

https://addisoncrump.info/research/a-horrible-conclusion/
1•todsacerdoti•28m ago•0 comments

I spent $10k to automate my research at OpenAI with Codex

https://twitter.com/KarelDoostrlnck/status/2019477361557926281
2•tosh•29m ago•1 comments

From Zero to Hero: A Spring Boot Deep Dive

https://jcob-sikorski.github.io/me/
1•jjcob_sikorski•29m ago•0 comments

Show HN: Solving NP-Complete Structures via Information Noise Subtraction (P=NP)

https://zenodo.org/records/18395618
1•alemonti06•34m ago•1 comments
Open in hackernews

FDA described as a "clown show" amid latest scandal; top drug regulator is out

https://arstechnica.com/health/2025/11/fda-described-as-a-clown-show-amid-latest-scandal-top-drug-regulator-is-out/
165•duxup•3mo ago

Comments

duxup•3mo ago
>In early August, soon after joining the FDA, Tidmarsh announced actions that would effectively remove from the market a drug ingredient made by a company associated with Tang. Tidmarsh’s lawyer then sent a letter to Tang proposing that he extend a “service agreement” for “another 10 years,” which would see Tang making payments to a Tidmarsh-associated entity until 2044. The email was seen as attempted extortion, with such payments being in exchange for Tidmarsh rolling back the FDA’s regulatory change.

Straight up extortion.

Kapura•3mo ago
it's crazy how much of the current regime's position is "crime is legal if it's my guys doing it."
watwut•3mo ago
To be fair, that was always conservative position.

Edit: I do not mean it cynically or as a joke. I think that is exactly what conservative position was for years. The only difference now is that it is not possible to euphemism away or plausible deniality away out of it.

smithoc•3mo ago
It's not, and the current administration isn't conservative.

The MAGA movement has completely purged all the conservatives from the Republican party.

They've increased the deficit by a trillion dollars, built an army of ICE agents and deployed them to terrorize people in cities around the country, added billions of dollars in import taxes, taken state ownership stakes in multiple companies.

They're closer to Stalin or Mao than to any conservative ideology of a small government that stays out of people's business.

tastyface•3mo ago
And yet the non-MAGA Republicans in Congress are (almost) fully complicit. After all, just a handful of their votes would be sufficient to shutter the whole operation.
teddy-smith•3mo ago
This makes me wonder how much of the Tariffs are extortion of other countries.

How randomly they seem to be applied to makes me wonder if theres back room deals going on.

yongjik•3mo ago
Trump tariffs are extortion. It's orthogonal to whether it's a good policy for the US, but nobody outside the US has any doubt about it being extortion. It's not even a back room deal kind of stuff; "Give America your money or I'll raise tariffs" is how Trump is openly talking to every country.
tastyface•3mo ago
Backroom? The Korean government publicly gifted Trump a golden crown just last week!
yongjik•3mo ago
Well as a Korean I can't say I'm proud of what happened, but if the choice is between "get robbed by someone who fancies himself a king" and "get robbed by someone who fancies himself a king, but also get a nuclear submarine deal" ...
vibrio•3mo ago
“He had the temerity to reject a drug that had lousy data…”

Was that data really “lousy”? (Referencing the REPL data?) Was it a trial design issue? (which he has very strong and unconventional opinions on) Is it the role of his position to overrule his specialist review teams ? (in the absence of any clear safety risks or malfeasance)

ubiquitysc•3mo ago
At least clowns can be fun to watch
_carbyau_•3mo ago
From another country, it is mildly amusing in one sense of schadenfreude.

It is also incredibly saddening to see great institutions of expertise be treated as playthings by the ignorant.

vibrio•3mo ago
It’s much less fun if you have a loved one, say an aggressive autoimmune disease. Do not recommend.
pstuart•3mo ago
My ex works in QA for a biotech company and FDA audits are a regular thing and are taken very seriously.

There's plenty to criticize of the org (as with almost all others) but the rank and file are doing good work to help try to keep us safe.

wswope•3mo ago
I work in biotech and the FDA is openly reviewing our submissions with LLMs now. The shark has been jumped.

https://www.fda.gov/news-events/press-announcements/fda-anno...

teddy-smith•3mo ago
I don't know. If this speeds up their work and helps them do more with the same staff I can see this as being a good thing. a.i. is really good at combing through data to answer questions.
Balgair•3mo ago
It will not.

One (of many) issue is that this has no bearing on other regulatory regimes. So, sure, the FDA approves of the drug/device/thingy because the AI got lost and no one is checking what it's saying. But Canada's CFIA doesn't because they are still using real people or centaurs ( people + AI, but I'm not 100% sure so don't quote me on that ).

That makes it so that you can only sell the drug/device/thingy in the US and some other countries that blindly follow US FDA (mostly poorer nations with very small markets and a lack of legal recourse, they'll just turn to the EFSA/EMA).

Which fine, but that is not the bet that these large companies made about a decade ago when it came to whether or not this drug/device/thingy would be worth it to pursue. These big drugs need to pay off all the failed research with international sales. Same is somewhat true with devices (mostly internal these days). These big drug makers want stability. Profits are fine, but revenue is just as important as these pipelines are sooooo long and soooo fraught. The human body is just too variable.

The tariffs and all the monkey business with this admin is very much not good for the US when it comes to these large drug/device/thingy makers. Chaos is not good for business. They have all learned that Donny and his ilk (per the article here) do not keep their words when it comes to corruption. They do not stay bought, they are not stable.

We're already shedding jobs here in favor of moving to the EU. Yes, not India or China, but the Baltics mostly (inside Schengen zone). We lost 10 people with jobs opening up there (same day) just this last week. The EU is stable in the eyes of my very own bosses.

KuhlMensch•3mo ago
> not India or China, but the Baltics mostly

Interesting.

So you're seeing "scientific development" pipelines (research/development/trials) moving wholesale to EU?

Balgair•3mo ago
In parts for now, not wholesale yet. And more than just RnD, it's other sectors of the corpo too.
cameldrv•3mo ago
Waiting to see the job posts popping up for a prompt engineer for FDA submissions.
vibrio•3mo ago
This. They don’t get paid much, or much glory if any, but overall they are smart and hard working and are eager to have rational and data driven discussions about the programs they oversee. Current status is heartbreaking.
cosmicgadget•3mo ago
And they are slowly being attrited by layoffs, being led by corrupt shitbirds, and the Russell Vought ethos of making career public servants miserable.