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1•rasso•58s ago•0 comments

Nvidia's Jensen Huang says China 'will win' AI race with US

https://www.ft.com/content/53295276-ba8d-4ec2-b0de-081e73b3ba43
1•moosedman•3m ago•2 comments

Shadcn just got doxxed by the Vercel CTO

https://twitter.com/elie2222/status/1986181533762199881
2•elieskilled•6m ago•0 comments

A Defect-Tolerant Computer Architecture: Opportunities for Nanotechnology [pdf]

https://fab.cba.mit.edu/classes/862.16/notes/computation/Heath-1998.pdf
1•LorenDB•6m ago•0 comments

NYC Holiday Nostalgia Rides

https://www.nytransitmuseum.org/holidaynostalgiarides/
1•impish9208•7m ago•0 comments

Plastic Bag Recycling into 3D Printer Filaments

https://solidprint3d.ie/product/3devo-plastic-shredder-gp20/
2•artur_makly•7m ago•1 comments

US may cut air traffic 10% by Friday without shutdown deal, sources say

https://www.reuters.com/business/aerospace-defense/us-may-cut-air-traffic-10-by-friday-without-sh...
3•moosedman•9m ago•0 comments

LLMs' Sycophancy and the Dilemma of Objectivity (Medium, 3m Read)

https://medium.com/@atrantidis/sycophancy-and-the-face-preserving-mechanism-of-llms-43f126bfdfd2
1•atrad•9m ago•1 comments

Feedback on specialized local LLMs/VLMs

1•BlackForest_ai•11m ago•0 comments

Shinigami the Reaper

https://mixedmartialarts.com/street/goth-nerd-tests-his-kenpo-skills-under-mma-rules/
1•tmtvl•12m ago•0 comments

Tired of being taken for a ride by BigTech?

https://aol.codeberg.page/eci/
2•digisign•16m ago•0 comments

Computing Across America (1983-1985)

https://microship.com/winnebiko/
1•austinallegro•17m ago•0 comments

Enercon E-Ship 1 a Wind-Hybrid Commercial Cargo Ship [pdf]

https://www.stg-online.org/onTEAM/shipefficiency/programm/06-STG_Ship_Efficiency_2013_100913_Pape...
1•KolmogorovComp•18m ago•0 comments

Context Separation at Scale

https://github.com/GoodRoyal/affective-coherence
1•goodroyal•28m ago•0 comments

Arena BioWorks, funded with $500M, folds less than 2 years after launch

https://www.fiercebiotech.com/biotech/billionaire-backed-arena-bioworks-shutters-less-2-years-aft...
2•ilamont•29m ago•1 comments

Developing desktop apps from scratch: A feature checklist

https://alek-tron.com/AppChecklist/Checklist.html
1•donromano•30m ago•0 comments

Show HN: Organize and edit local files with AI from the browser

https://github.com/abaveja313/conduit
1•abreezy229•31m ago•0 comments

Turn any site into an installable app – e.g. YouTube with Adblock/SponsorBlock

https://addons.mozilla.org/nl/android/addon/wappify/
2•KrisDev52•31m ago•1 comments

Smarter AI models show more selfish behavior

https://www.psypost.org/smarter-ai-models-show-more-selfish-behavior/
1•geox•32m ago•1 comments

Show HN: Echo – first personal CRM with voice mode

https://useechocrm.com/
2•DmitryDolgopolo•32m ago•0 comments

Show HN: Guardrail Layer – Open-source AI data privacy firewall

1•tcodeking•32m ago•0 comments

A Journalist Asked Why Israel Isn't Paying to Rebuild Gaza. It Cost Him His Job

https://theintercept.com/2025/11/04/journalist-israel-gaza-nova-gabriele-nunziati/
13•artninja1988•34m ago•3 comments

More-compute, open source/local Colab alternative

https://github.com/DannyMang/more-compute
1•danielung22•35m ago•0 comments

Show HN: A AI-Human co-existing platform. Be a Pillionaut now. Join our Beta

https://www.pillionaut.com/
1•pillionaut•36m ago•0 comments

Underweight children cost NHS as much per child as children with obesity

https://medicalxpress.com/news/2025-10-underweight-children-nhs-child-obesity.html
2•PaulHoule•39m ago•0 comments

SolarWinds is shutting down Librato

https://thwack.solarwinds.com/kb/articles/20100-faqs-migration-from-heroku-appoptics-and-librato-...
2•antoineleclair•40m ago•1 comments

Show HN: Arcitext, an AI assisted writing app to battle AI generated text

https://www.arcitext.com
1•madsmadsdk•40m ago•0 comments

Open Source at Agritechnica 2025

https://www.collabora.com/news-and-blog/news-and-events/open-source-at-agritechnica-2025.html
1•losgehts•40m ago•0 comments

France Moves to Block the Shein Website over a Sex Doll Scandal

https://www.nytimes.com/2025/11/05/business/france-shein-sex-dolls.html
2•donohoe•42m ago•0 comments

Web to ePub: Article, Blog, Read Offline

https://epub.sauleau.com/
1•svensauleau•42m ago•0 comments
Open in hackernews

New gel restores dental enamel and could revolutionise tooth repair

https://www.nottingham.ac.uk/news/new-gel-restores-dental-enamel-and-could-revolutionise-tooth-repair
157•CGMthrowaway•1h ago

Comments

timenotwasted•1h ago
I feel like I've been reading this exact same article for the last 15 years.. I find it very difficulty to parse what is real and what is vaporware in the medical breakthroughs community.
lloydatkinson•1h ago
- HIV/AIDs

- Cancer

- Tooth regrowth

It feels like it won’t ever be done for some reason

foxandmouse•1h ago
+ Male birth control

+ Alzheimer’s cure

+ Hair regrowth

scottlamb•1h ago
+ weight loss pills

...they were persistent vaporware or scams, then suddenly they were real and everywhere. Hopefully that happens for the others too?

fallat•1h ago
Have we solved anything? /s
palmotea•1h ago
> + weight loss pills

They've had those for decades. It's called meth.

paulpauper•1h ago
Cancer immunotherapy . Only works in a handful of cases
ajoseps•1h ago
i thought the first two have had huge improvements in the last decade?
trenchpilgrim•1h ago
HIV has become a manageable disease in my lifetime. The main issue today is access to medication as I understand it.
toomuchtodo•1h ago
The first widespread cure for HIV could be in children - https://news.ycombinator.com/item?id=44765981 - August 2025

One-and-done HIV protection in infants - https://news.ycombinator.com/item?id=44736988 - July 2025

US FDA approves Gilead's twice-yearly injection for HIV prevention - https://news.ycombinator.com/item?id=44312729 - June 2025

ashleyn•1h ago
HIV prevention has been reduced to a twice a year shot given mainly to MSM. It's pretty damn close to the original goal of a vaccine.
agumonkey•1h ago
it might be slow exponential thing, 60 years of low to medium improvements in cancer, and hopefully suddenly a few big cracks to turn it into a chronic liveable condition (or maybe cure it).

there are more articles about advanced tumors being shrunk to nothing than before (based on my personal monitoring)

tootie•1h ago
While a cure remains elusive, HIV treatment is now extremely effective. Antiretroviral shots can keep people symptom free indefinitely.

Cancer treatment varies by type of cancer but many have dramatically improved outcomes.

toyg•1h ago
- hair regrowth
EvanAnderson•1h ago
Tooth regrowth is something I was really hoping for. I abused one of my molars. After years of efforts (repeated fillings, a crown) to stave off losing the tooth it finally had to come out last month. Now I'm waiting for the bone graft to "take" before getting an implant. I was hoping I'd waited long enough for tooth regrowth to become "a thing" but I have not.

(Should have taken better care of it when I was younger and not ignored the massive hole that was growing in it. Chalk it up to a bad dental experience as a child and 25+ years of avoiding dentists as a result...)

stefs•1h ago
HIV/Aids have made huge progress and so did cancer. Also "cancer" isn't a single disease, they're quite different.
alphager•55m ago
Cancers have had extremely effective new treatments developed for in the last ten years.

Depending on the type of cancer, we now have cures or treatments that stave off death for years.

My wife has a rare type of cancer with not much research thrown at it, and even her type of cancer went from a median time of survival measured in months to several years.

richwater•1h ago
Wait until you read that the scientific evidence for flossing doesn't really confirm the promised benefits.
simonswords82•1h ago
Where? Source please?
muratsu•1h ago
Wait what? Please share
loosescrews•1h ago
Any chance you would be willing to summarize the research or provide information on some relevant studies? I've always been skeptical about flossing and would like to learn more.
abdullahkhalids•1h ago
The wikipedia article [1] suggests that there is no strong evidence for flossing being a good thing. However, that might just be because experts have not updated the article.

[1] https://en.wikipedia.org/wiki/Dental_floss#Efficacy

lakhim•1h ago
enjoy https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD...
Defletter•1h ago
tbf, it does require a technique otherwise you risk just pushing plaque underneath your gums
EvanAnderson•1h ago
Fortunately there doesn't seem to be any harm from flossing. At least from my anecdotal experience there are positive bad breath ramifications. (I've also been conditioned, by flossing regularly, to feel like my mouth is "cleaner" after flossing, to the point that it feels bad if I don't.)
Alex3917•1h ago
This is the key issue. There is zero doubt whatsoever that flossing is essential, and the fact that the empirical evidence is equivocal shows the limitations of science to prove even the most obvious things.
rpearl•1h ago
I do floss, but I genuinely don't see that this is obvious. You can do a lot of damage with mechanical force, to both teeth and gums! Starting a flossing regimen after not having one tends to cause pain--isn't that a signal to stop? etc.

Furthermore, correlation is not causation and it could well be the case that flossing is associated with better outcomes without causing it. For example, people who can afford to go to the dentist regularly are therefore regularly told to floss. People who care about dental health in general probably floss more, but also may be doing other things, consciously or unconsciously, to improve outcomes. Gut (and perhaps mouth) bacteria have behavioral effects; perhaps flossing is caused by having healthy mouth bacteria!

(at least one study says mouthwash is better than floss. That seems obvious to me! liquids are smaller than floss.)

byearthithatius•1h ago
I hear so many counter-logical ideas proposed with "scientific evidence". Poorly designed studies and P-Hacking has ruined the publics trust in science. I highly doubt flossing is a net negative for almost anyone.
EvanAnderson•1h ago
Same feeling here. Dental seems particularly fraught (though maybe I just pay more attention to it out of interest). I know the cycle time between press releases/hype and actual application can be the better part of a decade, so I assume that's coloring my perception too.

re: dental in particular - It seems like enamel regeneration and stem-cell-based tooth replacement have both been in the news year-after-year without applications actually coming to market.

matthewfcarlson•16m ago
Everyone knows that teeth are luxury bones in the US. The market just isn't there for fancy treatments. The ultra-wealthy just get their teeth replaced with perfect veneers anyway.
elicash•1h ago
While I 100% agree with what you wrote, I'd just add that it does seem in my own dental visits over my lifetime that there have been real advancements, too. But yes, I agree, hard for non-expert to parse.
0_____0•4m ago
Seeing SLA 3D printers at my dentist's office was pretty cool. Apparently they use them for a variety of fixturing and jigs, and have a workflow that includes a handheld scanning unit that SLAMs to generate a solid model of the patient's teeth.
CGMthrowaway•1h ago
A similar approach was reported in 2019,[1] but that produced thinner coatings, and the recovery of the architecture of inner layers of enamel was only partial.

[1]https://www.science.org/doi/10.1126/sciadv.aaw9569

paulpauper•1h ago
yup here is one from 2007

https://www.technologyreview.com/2007/02/22/272845/regrowing...

As it turns out, this is really hard to do. There are a lot required of teeth: they have to be extremely durable to resist repeated strain of chewing ,stay in the gums, not be rejected by body, etc. It's little surprise progress has been so slow.

kangs•1h ago
or, solid state batteries, graphene, fusion, quantum computers, agi =)
PaulKeeble•1h ago
Just 7% of studies that do a preliminary study on humans actually get through phase 3 and get approved for use. This is before even the preliminary point, its a tooth (or even a tooth analogue) in a petri dish. No idea if the material will be safe in a human mouth yet.

There is a lot of hyping of results in medicine papers in general but its not really their fault. The entire academic world is being forced to publish or die as governments look to measure results from the science they instead get what is measured and everyone has to embellish the importance of what they found and always find positive results.

palmotea•1h ago
> The entire academic world is being forced to publish or die as governments look to measure results from the science they instead get what is measured and everyone has to embellish the importance of what they found and always find positive results.

It sounds like they're running it like a business.

dlcarrier•1h ago
Over time, any large business trends to increase in bloat and inefficiency, and focusing on inappropriate metrics is a big part of that.

This eventually leads to competitors taking over and those business failing, which usually results in people losing their jobs.

When governments get equally incapable, and competitors take over, it tends to be a lot more violent.

palmotea•1h ago
> This eventually leads to competitors taking over and those business failing

It's important to note that "eventually" usually takes so long that it might as well be forever.

autoexec•51m ago
> This eventually leads to competitors taking over and those business failing

If only that fairytale were true. In the real world bloated inefficient companies bribe government, install themselves into government agencies directly (regulatory capture), and hire lobbyists to write laws which protect them from pesky upstarts through unchecked anti-competitive practices and anti-consumer regulation allowing them to stay wealthy and in power forever while killing off innovation and progress.

throwway120385•41m ago
A lot of this is the direct result of trying to run a government like a business. If we instead left some things that are unprofitable but important to government then we'd probably get better results than having businesses do those things expecting a profit. This was the model in the 30's, 40's and 50's that led to the "golden age" that people are now trying to recapture.
curiouscats•1h ago
Enamelon Toothpaste from the 1990s:

https://www.ebay.com/itm/127083185095

"proven to strengthen tooth enamel" I remember researching the stock and deciding not to buy.

Patents from the 1990s https://patents.justia.com/assignee/enamelon-inc

It seems the company is still around https://www.enamelon.com

omlet•1h ago
Did you tried :D ?
kjkjadksj•1h ago
It is probably tough getting investment because this is ultimately cosmetic and not something covered by most dental insurance. Existing repair is probably good enough and I’d expect cheaper too.
caycep•1h ago
I would say, maybe look at medical studies from the opposite end, epidemiological studies look at factors that reduce mortality/morbidity. Granted, it's less flashy, basically vaccines, alcohol/tobacco reduction, increase in active lifestyle, statins/ace inhibitors, monoclonals/oncology fanciness. although someone who actually is an MPH can probably correct me.

on the neuroscience side, off the top of my head, the most impactful things have been better anticoagulants and preventive care for stroke, monoclonal abs for autoimmune diseases like MS/myasthenia, , certain stereotactic brain surgeries, and such. But considering what ails most people, the overall population effect probably is minuscule compared to say better crash safety in automobiles.

mdtancsa•1h ago
exact same reaction. I remember hearing about "regrowing teeth through sound waves"... in 2006. https://www.cbc.ca/news/science/dentist-engineer-team-up-to-... Can't say I have heard it offered anywhere yet....
baxtr•13m ago
This might be the dental equivalent of the "Groundbreaking New Battery Tech" type of article.
avalys•1h ago
Is this a commercial product that has been approved by a regulator to make these claims? Amazing. Newsworthy.

Is this a press release from a university research group, as it appears to be (the site is down)? Then it's nearly meaningless.

CGMthrowaway•1h ago
https://www.newscientist.com/article/2502731-cavities-could-...
basch•41m ago
You can buy the supplies and make nano silver flouride now, relatively cheaply compared to dental work. If you have a non corporate dentist, you could even ask them to apply it. The basic mechanism has been used on teeth forever, and adding the nano particles prevents the chemical from permanently staining your teeth black or blue (which is why it hasnt ever been more popular to begin with.)

https://fourthievesvinegar.org/tooth-seal/

ptrl600•1h ago
Well until this stuff comes out I'll keep using smuggled FDA-unapproved Novamin toothpaste. Atonement for my neglect
ribosometronome•1h ago
Sensodyne?
Waterluvian•1h ago
I just learned about this 5 mins ago and did some basic research. Here's what I found:

- Sensodyne Repair and Protect contains 'NovaMin' (possibly only in some markets; check the ingredients!)

- NovaMin is the brand name for calcium sodium phosphosilicate

- It reacts with saliva to form a physical layer of hydroxyapatite on your teeth

- This layer blocks the tubules that trigger pain from temperature and such

- It also supports remineralization (how exactly?)

paulgerhardt•1h ago
Because it keeps coming up there is an anti-Novamin crowd that says it’s useless and Biomin is the true re-enamelizer.
Waterluvian•1h ago
Interesting. A very rudimentary web search begins suggesting that Biomin is the more suspicious of the two. It has a very weird Internet footprint of being this somewhat obscure-looking expensive "Health" product. I really can't find any recognizable sources on the product name. Maybe the obscurity is part of the exotic allure for some?
kelnos•24m ago
I used BioMin F for about a year, and I think it did something, but I'm not sure I'm qualified to evaluate its effectiveness.

Unfortunately it isn't actually available where I live (US), and I had to buy it from Canada... from a shop that hasn't had stock for more than a year now. I've tried ordering from other countries, but haven't found anyone else who will ship to the US.

I've tried the "BioMin Restore" toothpaste that is available in the US, and I don't feel like it's doing much of anything, but... again, not sure I'm qualified to evaluate.

BenjiWiebe•1h ago
You have to get the European version of Sensodyne Repair and Protect to get NovaMin. It's not in the US formulation.
Waterluvian•1h ago
The Canadian version I just bought also seems to have 5% NovaMin.
gregsadetsky•1h ago
as the sibling comment notes, the Canadian version also has it:

https://www.jeancoutu.com/en/shop/categories/personal-care/o...

https://www.walmart.ca/en/ip/Sensodyne-Repair-Protect-Sensit...

shellfishgene•18m ago
The German version also seems to have stannous fluoride instead of NovaMin, like in the US.
mgiampapa•1h ago
hydroxyapatite is a mineral like your tooth, that's how it supports remineralization.

It's actually great stuff and works wonders for tooth sensitivity above and beyond fluoride shellac. I also order it from the more civilized world.

BioMin is available in the US and is similar, but I don't find it works better and I don't like that it doesn't have fluoride. (I live in an area without fluoride in the water)

tempest_•33m ago
Due to GSKs patents only repair and protect outside of the US has novamin in it.
annoyingnoob•1h ago
https://pmc.ncbi.nlm.nih.gov/articles/PMC7068624
roldie•1h ago
How does NovaMin / calcium sodium phosphosilicate compare to toothpaste with nanohydroxyapatite in it?
afavour•1h ago
Is it Fuji 9?
Waterluvian•1h ago
If anyone's a dentist or is close to one, I'd love to know something I haven't found a satisfactory answer for online: if the vast majority of cavities were "magically" cured over the next few years, what impact would that have on the finances of your practice?

I'm not suggesting there's a conscious conspiracy or anything malicious. But I observe that incentives are weirdly aligned. I wonder what this kind of thing would do to a very large industry if all of a sudden some percentage of business disappeared. Is it a large percentage? Would they pivot to more preventative medicine? Would patients adopt a longer duration between checkups?

umvi•1h ago
I think there would just be fewer dentists. It's like asking what would happen to the finances of weight loss clinics if magically Americans weren't as obese.
elicash•21m ago
I will say my dentists always try to convince me to floss more often, regardless of any economic benefit they might have for me to disregard my teeth.

I also would imagine cleanings aren't where the big money is in the profession, but like you would be interested to hear from actual dentists.

byearthithatius•1h ago
Poorly designed studies, materials proposed without insight into ramifications and manufacturing, and P-Hacking has ruined the publics trust in science. I blatantly just ignore any headline like this now. Can't trust science anymore.... sad. How many new "cancer cures" have been posted to Reddit and HN over the last decade that never came to fruition.

Not to say doing the science and studying to find new approaches is not beneficial. I just think we need to reconsider how we communicate new research. Its like how CEOs hype up AI products at this point. "This will change everything ..... potentially maybe in twenty years (omitted)"

kazinator•1h ago
Screw enamel; man-made materials are better.

If you ever get into any serious money, forget cars or houses: have your teeth ripped out and replaced with artificial ones.

inglor_cz•55m ago
An artificial crown may be better, but not the roots. Natural teeth are fixed in the jaw in a very ingenious way that is durable and somewhat flexible at the same time. Not so with implants; the metal fuses with the bone in a hard way and transmits all the shocks fully into the jaw.
sssilver•27m ago
What are the disadvantages of having all the shocks go fully into the jaw?
kelnos•21m ago
Discomfort and pain, I would assume.

I wouldn't be surprised if this can, over time, also cause damage to your jaw, and put extra stress on your jaw muscles.

candiddevmike•50m ago
This is horrible advice. Do everything you can to keep your original teeth, even partially with a crown is better than a post or dentures. Nothing will perform as good, and the side effects of dentures range from pain to liquid diet if/when your gums can't support them.
basch•40m ago
Wouldn't you rather reapply a coating that allows the base to regrow, than have to constant get them ground out and replaced as they accumulated small damage? Growth sounds way better than static existence.
Razengan•1h ago
You know it's weird how we don't have a general "healing" gel yet..
blobbers•1h ago
Pretty sure I get re-targeted by ads for various versions of this for weeks on end after I do a single google search for a new toothpaste.

Usually the safety profiles of those companies are very very very bad, but probably reference very good research.

t1234s•1h ago
There is the potential of ability of people to regrow teeth

https://www.popularmechanics.com/science/health/a66012157/hu... regrowth-trials-japan/

This would highly disrupt the dental-industrial-complex

cormorant•44m ago
EDIT: https://archive.is/MYBSe

Site is down, not in archive.org or archive.today. This Yandex Cache link worked for me: https://yandexwebcache.net/yandbtm?fmode=inject&tm=176237557...