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In China, the Dream of Outrunning Time

https://www.nytimes.com/2025/11/08/world/asia/china-aging-longevity-science.html
1•bookofjoe•6m ago•2 comments

Downgrading Debian from testing to stable (trixie)

https://neilzone.co.uk/2025/11/downgrading-debian-from-testing-to-stable-trixie/
1•ColinWright•9m ago•0 comments

Germany considers the 'Nordic model' to curb sex work

https://www.dw.com/en/germany-considers-the-nordic-model-to-curb-sex-work/a-74673114
2•toomanyrichies•10m ago•1 comments

Ask HN: How do you get over the fear of sharing code?

2•sodokuwizard•10m ago•2 comments

Value classes are the new data classes

https://curiouslab.dev/0002-value-classes-are-new-data-casses.html
2•todsacerdoti•14m ago•0 comments

Large Language Models Struggle with Reading Clocks

https://spectrum.ieee.org/large-language-models-reading-clocks
1•Anon84•16m ago•0 comments

Lisbon Airport is turning away private jets inbound for the Web Summit

https://www.engadget.com/big-tech/the-lisbon-airport-is-turning-away-private-jets-inbound-for-the...
3•rock_artist•17m ago•0 comments

UK full fibre availability rises to cover 81% of UK premises

https://www.thinkbroadband.com/news/uk-full-fibre-availability-rises-to-cover-81-of-uk-premises
3•ksec•19m ago•0 comments

Managing Your Manager

https://yusufaytas.com/managing-your-manager/
8•yusufaytas•27m ago•0 comments

Comparing GPT-4o vs. GPT-4o-Mini: How Different AI Models Rank the Same Content

https://lightcapai.medium.com/i-used-ai-to-rank-your-articles-b8cc86f691da
3•hadiai•29m ago•1 comments

Trinity Desktop Environment R14.1.5 Released

https://trinitydesktop.org/newsentry.php?entry=2025.11.09
2•calvinmorrison•31m ago•0 comments

Math Books

https://github.com/valeman/Awesome_Math_Books
1•tzury•35m ago•0 comments

Why Wise and Airwallex aren't worried about stablecoins

https://text-incubation.com/why-wise-and-airwallex-arent-worried-about-stablecoins
1•krrishd•35m ago•0 comments

Jelly Slider

https://docs.swmansion.com/TypeGPU/examples/#example=rendering--jelly-slider
1•birdculture•37m ago•0 comments

Show HN: Fast Semantic Tool-filtering for MCP servers

https://github.com/Portkey-AI/mcp-tool-filter
1•roh26it•38m ago•0 comments

Basecamp's Shape Up is a Michelin restaurant brigade system for software

https://itwasjacob.com/posts/michelin-software-teams/
2•Bocajmai•39m ago•3 comments

A Powerful Tool to Override Constitutional Rights Goes to Court

https://www.nytimes.com/2025/11/08/world/canada/a-powerful-tool-to-override-constitutional-rights...
2•Teever•43m ago•1 comments

Show HN: Automate recurring GitHub project items from YAML config

https://github.com/Rindrics/recurring-backlog-item-creator
1•Rindrics•44m ago•0 comments

How this 31-year-old made $250M in 30 months

https://www.ft.com/content/ec749b06-651b-431d-bf0b-5b61c7b5fba0
1•mmarian•45m ago•2 comments

16-Bit Data Pointers on RV32

https://wren.wtf/shower-thoughts/16-bit-data-pointers-on-rv32/
2•todsacerdoti•47m ago•1 comments

Arti, a complete rewrite of the C Tor codebase in Rust

https://tpo.pages.torproject.net/core/arti/about/
3•sibellavia•49m ago•0 comments

Algorithms for Decision Making

https://algorithmsbook.com/decisionmaking/
3•__grob•50m ago•0 comments

Why unions are becoming a problem for self-driving cars

https://www.axios.com/2025/11/05/waymo-unions-boston-self-driving-cars
4•josephcsible•52m ago•3 comments

Bumble Berry Pi – A Cheap DIY Raspberry Pi Handheld Cyberdeck

https://github.com/samcervantes/bumble-berry-pi
5•MakerSam•52m ago•0 comments

Automating image resizing and format conversion with ImageMagick

https://transloadit.com/devtips/automating-image-resizing-and-format-conversion-with-imagemagick/
1•speckx•58m ago•0 comments

Long-Context Attention from Kernel Efficiency to Distributed Context Parallelism

https://arxiv.org/abs/2510.17896
1•PaulHoule•59m ago•0 comments

Marble Fountain

https://willmorrison.net/posts/marble-fountain/
2•chris_overseas•1h ago•0 comments

Bull markets make you feel smarter than you are

https://awealthofcommonsense.com/2025/11/ben-graham-bull-market-brains/
7•raw_anon_1111•1h ago•0 comments

Digital Woes: Why We Should Not Depend on Software (1994)

https://archive.org/details/digitalwoeswhywe0000wien
2•turtleyacht•1h ago•0 comments

AI Isn't Alchemy: Not Mystical, Just Messy

https://www.craftedlogiclab.com/devblog/devblog11092025
1•IanTepoot•1h ago•0 comments
Open in hackernews

Genetically Engineered Babies Are Banned. Tech Titans Are Trying to Make One

https://www.wsj.com/tech/biotech/genetically-engineered-babies-tech-billionaires-6779efc8
23•nradov•2h ago

Comments

bookofjoe•1h ago
no paywall: https://www.wsj.com/tech/biotech/genetically-engineered-babi...
im3w1l•1h ago
One intermediate step between labrats and humans that seems sensible is pets. Maybe dogs in particular. Many popular breeds seem to be prone to genetic issues. I think once owning your own fuzzy little gmo is popular it would seem less dramatic to use it on people.
Ziomislaw•1h ago
Domestic rats are very fragile genetically, it would be nice to try to "fix" them. Also science knows a lot about rat genome so it would be even easier than dogs.
estimator7292•59m ago
Pet rat owners will fall over themselves to throw money at anyone offering a longer-lived and healthier breed. I would pay more money than I care to admit for a rat that lived just a few years longer.

There's actually a huge problem with pet rats in that they're all remarkably inbred. If you don't get your rats from a dedicated professional breeder who's been at it for decades, your pet is likely going to get really sick at the end of their life. Females tend to get catastrophic tumors, and all have extremely delicate respiratory systems. Out of the dozens of rats I've kept, only one died quietly in her sleep of old age. The rest were horrific and gruesome.

Yeah, there'd be a good amount of money in it for whoever can fix rats' genetics.

more_corn•45m ago
Great, super rats. There no way that could go badly at all ever.
embedding-shape•41m ago
Put them on a planet and leave them there, at least then it couldn't go badly for us. And no, I'm fairly sure there are no books about this already.
toast0•38m ago
We need super rats (or at least one) to train the super turtles.
expedition32•31m ago
Are you aware of Star Trek lore? Tech billionaires will make their Khan.

Funny thing is that this kind of stuff is considered haram by the CCP who are fanatically dedicated to social order.

Metacelsus•27m ago
I know someone working on this! That's about all I can say for now though :)
xvector•24m ago
They shouldn't be banned, but regulators would regulate their own shadow if they could.

People are allowed to mutilate their babies, raise them in whatever destructive fashion they please, avoid vaccinating them in an environment where they will be exposed to deadly viruses.

But god forbid someone try to make their baby immune to AIDS, some other genetic disease, or reduce the likelihood of psychosis given family history.

There is no world in which regulators will let this happen. There is no way to test this in a manner that will satisfy them, because babies can't consent to a trial. If it was up to regulators, human evolution ends here. No group should have that power over our species.

It is the same problem as modern medicine being so prohibitively expensive to test, that most ideas go to the bin. We need a deregulated zone to allow for progress to actually happen.

portaouflop•16m ago
People aren’t allowed to mutilate babies what the hell are you going on about?

Genetic tampering can lead to all kinds of unknowable nightmares.

maleldil•13m ago
> People aren’t allowed to mutilate babies

Circumcision?

xvector•11m ago
Circumcision is absolutely mutilation.

There are plenty of unknowable things about life. You could die in a car crash. You certainly will die eventually.

I guess this means we should avoid taking risks entirely because they might result in bad outcomes! We will never evolve when paralyzed by our own fear.

stalfie•2m ago
I think OP might be referring to circumcision.

And just as a small aside, not really related to OPs points, I'd just like to point out that nature pretty consistently tampers with everyones kids DNA, which quite regularly leads to absolute nightmare fuel. Whatever those unknowable nightmares may be, they have to be pretty gruesome in order to compete.

darth_avocado•13m ago
Genetic engineering is banned because people will almost certainly use it for something else more nefarious than cure AIDS the first chance they get.
xvector•10m ago
The same can be said of things like mRNA vaccines, but they have done good for society.

You're also just wrong - the first scientist to genetically edit human embryos edited in immunity to AIDS

_trampeltier•15m ago
In sport, are such super-humans allowd to play with normal people.

In society, i guess, if such super-humans are designed to have a 500 year life, they have automatic adusted there pension age to something like 450 years.

In law, because such super smart super-humans allways know things better, the fines are 100 times higher.

On the other side, of course, who would not choose the best for the best for the own child. Why should a person wear glasses the whole life, if it is possible to switch a few genoms.

So many difficult questions ..

doodlebugging•6m ago
>In sport, are such super-humans allowd to play with normal people.

There are already prohibitions on allowing transgender people to participate in some sports. It seems unlikely that the children of ordinary people will be allowed to participate in sports with children who are known to be genetically enhanced so that they are more powerful, etc. It is an interesting question though.

arjie•14m ago
My wife and I have a whole-genome sequenced embryo that we selected based on Orchid’s results. In our case, we were trying to avoid (and succeeded) a specific kind of hearing loss caused by a mutation in GJB2.

People often try to bill these technologies as “trying to control everything” or “trying to make the perfect child” or all this business about “tech people think they deserve what they have due to their genetics” (paraphrasing Sasha Gusev) etc. but I don’t think that’s the driving impulse for most parents.

The reality is so much more complex than the headlines people chase. One couple who I spoke to who were considering this were afraid of the opposite. The mother was concerned that she’d pass on her Asperger’s Syndrome. Another friend of mine doesn’t want to have kids because her brothers (and other male relatives) have schizophrenia.

In my family’s case, we will not have boys (coincidence: all our female embryos are the ones unaffected) but that’s fine. Our baby girl is a beautiful happy child and even if she weren’t, she’d be mine and I’d love her as much. But being able to ensure she has the full sensory experience available to mankind brings me a bit of content.

I hope all of these people I have met who fear genetic disease will be able to mitigate the risks as well as we have. Ours is monogenic, but as polygenic prediction improves their chances will improve too.

People on the happy path don’t often realize what it’s like for those not on that path. In our family, a cousin had her child via her last embryo. That also happened to a friend. Imagine if the last one had a debilitating condition that could be edited out. Most parents would choose not to have that child and then they would simply be childless.

In some future world, those people could have the condition edited and they could have the child.

Finally, here are the notes I made throughout the process:

https://wiki.roshangeorge.dev/w/IVF

And a view into my genome

https://viz.roshangeorge.dev/roshan-genvue/

And a link to my comment on an HN article on something similar: the potential for removing trisomy-21 (Down’s) from an embryo https://news.ycombinator.com/item?id=44677834

bicepjai•6m ago
Side note: You folks should watch the movie “the substance”