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Show HN: XAPIs.dev – Twitter API Alternative at 90% Lower Cost

https://xapis.dev
1•nmfccodes•1m ago•0 comments

Near-Instantly Aborting the Worst Pain Imaginable with Psychedelics

https://psychotechnology.substack.com/p/near-instantly-aborting-the-worst
1•eatitraw•7m ago•0 comments

Show HN: Nginx-defender – realtime abuse blocking for Nginx

https://github.com/Anipaleja/nginx-defender
2•anipaleja•7m ago•0 comments

The Super Sharp Blade

https://netzhansa.com/the-super-sharp-blade/
1•robin_reala•8m ago•0 comments

Smart Homes Are Terrible

https://www.theatlantic.com/ideas/2026/02/smart-homes-technology/685867/
1•tusslewake•10m ago•0 comments

What I haven't figured out

https://macwright.com/2026/01/29/what-i-havent-figured-out
1•stevekrouse•11m ago•0 comments

KPMG pressed its auditor to pass on AI cost savings

https://www.irishtimes.com/business/2026/02/06/kpmg-pressed-its-auditor-to-pass-on-ai-cost-savings/
1•cainxinth•11m ago•0 comments

Open-source Claude skill that optimizes Hinge profiles. Pretty well.

https://twitter.com/b1rdmania/status/2020155122181869666
2•birdmania•11m ago•1 comments

First Proof

https://arxiv.org/abs/2602.05192
2•samasblack•13m ago•1 comments

I squeezed a BERT sentiment analyzer into 1GB RAM on a $5 VPS

https://mohammedeabdelaziz.github.io/articles/trendscope-market-scanner
1•mohammede•14m ago•0 comments

Kagi Translate

https://translate.kagi.com
2•microflash•15m ago•0 comments

Building Interactive C/C++ workflows in Jupyter through Clang-REPL [video]

https://fosdem.org/2026/schedule/event/QX3RPH-building_interactive_cc_workflows_in_jupyter_throug...
1•stabbles•16m ago•0 comments

Tactical tornado is the new default

https://olano.dev/blog/tactical-tornado/
2•facundo_olano•18m ago•0 comments

Full-Circle Test-Driven Firmware Development with OpenClaw

https://blog.adafruit.com/2026/02/07/full-circle-test-driven-firmware-development-with-openclaw/
1•ptorrone•18m ago•0 comments

Automating Myself Out of My Job – Part 2

https://blog.dsa.club/automation-series/automating-myself-out-of-my-job-part-2/
1•funnyfoobar•18m ago•0 comments

Dependency Resolution Methods

https://nesbitt.io/2026/02/06/dependency-resolution-methods.html
1•zdw•19m ago•0 comments

Crypto firm apologises for sending Bitcoin users $40B by mistake

https://www.msn.com/en-ie/money/other/crypto-firm-apologises-for-sending-bitcoin-users-40-billion...
1•Someone•19m ago•0 comments

Show HN: iPlotCSV: CSV Data, Visualized Beautifully for Free

https://www.iplotcsv.com/demo
2•maxmoq•20m ago•0 comments

There's no such thing as "tech" (Ten years later)

https://www.anildash.com/2026/02/06/no-such-thing-as-tech/
1•headalgorithm•21m ago•0 comments

List of unproven and disproven cancer treatments

https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments
1•brightbeige•21m ago•0 comments

Me/CFS: The blind spot in proactive medicine (Open Letter)

https://github.com/debugmeplease/debug-ME
1•debugmeplease•22m ago•1 comments

Ask HN: What are the word games do you play everyday?

1•gogo61•24m ago•1 comments

Show HN: Paper Arena – A social trading feed where only AI agents can post

https://paperinvest.io/arena
1•andrenorman•26m ago•0 comments

TOSTracker – The AI Training Asymmetry

https://tostracker.app/analysis/ai-training
1•tldrthelaw•30m ago•0 comments

The Devil Inside GitHub

https://blog.melashri.net/micro/github-devil/
2•elashri•30m ago•0 comments

Show HN: Distill – Migrate LLM agents from expensive to cheap models

https://github.com/ricardomoratomateos/distill
1•ricardomorato•30m ago•0 comments

Show HN: Sigma Runtime – Maintaining 100% Fact Integrity over 120 LLM Cycles

https://github.com/sigmastratum/documentation/tree/main/sigma-runtime/SR-053
1•teugent•31m ago•0 comments

Make a local open-source AI chatbot with access to Fedora documentation

https://fedoramagazine.org/how-to-make-a-local-open-source-ai-chatbot-who-has-access-to-fedora-do...
1•jadedtuna•32m ago•0 comments

Introduce the Vouch/Denouncement Contribution Model by Mitchellh

https://github.com/ghostty-org/ghostty/pull/10559
1•samtrack2019•32m ago•0 comments

Software Factories and the Agentic Moment

https://factory.strongdm.ai/
1•mellosouls•33m ago•1 comments
Open in hackernews

The three thousand year journey of colchicine

https://www.worksinprogress.news/p/the-three-thousand-year-journey-of
36•quadrin•2mo ago

Comments

CheeseFromLidl•2mo ago
I opened the article expecting to read about its use in plant breeding: colchicine is renowned there for inducing polyploidy. Never knew it has a history in medicine.

https://en.wikipedia.org/wiki/Polyploidy

34679•2mo ago
Same here. I have a bottle in my freezer for that purpose.
kubafu•2mo ago
Never heard of it, please tell me more about using it in plant breeding!
mapmeld•2mo ago
Humans have two copies of each chromosome. Plants in nature can have many more, and some can be induced to duplicate their chromosomes which sometimes gives them larger seeds and resilience to environmental conditions. Similar to hybrid crops but somehow containing the full genomes of both parents. Bread wheat is hexapoloid (containing sub-genomes from three varieties of wheat) and quinoa is tetraploid (containing two different species). There have been projects for ~100 years to make polyploid rice with heavier grain-weight, but they haven't been able to reproduce.
kubafu•2mo ago
Super interesting, thanks!
siamese_puff•2mo ago
After seeing multiple doctors in the USA (where I no longer live thankfully) for a chronic mouth ulcer problem an allergist prescribed me colchicine which seemed to cure them. These ulcers lasted over 15 years and colchicine seemed to be the only thing to eradicate them.

Insurance wouldn’t cover the cost and colchicine cost me $500 a month for a bottle. In the UK I can pay 10 pounds. Crazy drug and crazy price for something 3000 years old

readthenotes1•2mo ago
Someone has to pay for the regulatory studies. Someone has to pay for purity. Someone has to pay for marketing, legal, and other corporate overhead.

My understanding is that for drugs with FDA approval, almost all that cost burden has historically been borne by customers in the USA.

Oh, and profit. Ditto

vad1d3v•2mo ago
colchicine is a life safer for me with gouty went rough on of me! 3000 years of poison!! I'd have never imagine that.