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AI Slop Is Ruining Reddit for Everyone

https://www.wired.com/story/ai-slop-is-ruining-reddit-for-everyone/
1•toomuchtodo•1m ago•0 comments

Could MrBeast IPO? CEO wants fans to have 'a chance to be owners of the company'

https://techcrunch.com/2025/12/03/could-mrbeast-ipo-his-ceo-wants-fans-to-have-a-chance-to-be-own...
1•gfortaine•3m ago•0 comments

Cancer rates in Australians under 50 are rising at an alarming pace

https://www.abc.net.au/news/2025-07-07/cancer-diagnosis-rates-under-50s-rising-causes-four-corner...
1•breve•3m ago•0 comments

Rant: I Don't Need an Office. Let Me Work Remotely

https://0xff.nu/remote-work/
1•hxii•4m ago•1 comments

The Polyglot Neuroscientist Resolving How the Brain Parses Language

https://www.quantamagazine.org/the-polyglot-neuroscientist-resolving-how-the-brain-parses-languag...
1•ibobev•5m ago•0 comments

Final Judgement in United States of America et al., vs. Google LLC [pdf]

https://storage.courtlistener.com/recap/gov.uscourts.dcd.223205/gov.uscourts.dcd.223205.1462.0.pdf
1•decentrality•6m ago•0 comments

Gmail Same-Tab Switcher: keep account switches in one tab

https://twitter.com/BourAbdelhadi/status/1997067403381850129
2•bscript•6m ago•1 comments

AOC: 'World will end in 12 years' if climate change not addressed (2019)

https://thehill.com/policy/energy-environment/426353-ocasio-cortez-the-world-will-end-in-12-years...
1•RickJWagner•7m ago•0 comments

The (Knife) Sharpener's Credo

https://www.thesharpist.com/sharpener-s-credo
1•mooreds•7m ago•0 comments

How I keep up with AI-generated PRs

https://www.raf.xyz/blog/03-how-i-keep-up-with-ai-generated-prs
2•rgarcia•9m ago•0 comments

Meta buys AI pendant startup Limitless to expand hardware push

https://www.ft.com/content/a1a7adab-506e-4623-8f7a-0b7c94c8d6b4
1•toephu2•9m ago•1 comments

OSS Friday Update – The Shape of Ruby I/O to Come

https://noteflakes.com/articles/2025-12-05-friday-update
2•todsacerdoti•10m ago•0 comments

Mr. Roberts Goes to Hollywood, Part 2: The Producer

https://www.filfre.net/2025/12/mr-roberts-goes-to-hollywood-part-2-the-producer/
2•doppp•12m ago•0 comments

Adenosine on the common path of rapid antidepressant action: The coffee paradox

https://genomicpress.kglmeridian.com/view/journals/brainmed/aop/article-10.61373-bm025c.0134/arti...
1•PaulHoule•13m ago•0 comments

Trump awarded FIFA peace prize

https://apnews.com/article/trump-world-cup-fifa-peace-prize-e14f95b8adaa197c869cad407b6ef604
1•mungoman2•16m ago•1 comments

KeePassXC Integration with Rclone and Secret Service API

https://www.lshnk.me/2025/12/02/arch-linux-bulletproof-keepassxc-integration-with-rclone-and-secr...
1•vldmr•16m ago•1 comments

Show HN: The Doorstep – Voice RPG

https://qforge.studio/the-doorstep
3•michalwarda•16m ago•0 comments

AI Doesn't Kill Expertise – It Kills Mediocrity

https://medium.com/@jasonkennedysr/ai-doesnt-kill-expertise-it-kills-mediocrity-95c513f5622b
1•minotaursr•22m ago•1 comments

Google AI Pro and Ultra subscribers now have higher rate limits for Antigravity

https://antigravity.google/docs/plans
1•jnd0•27m ago•0 comments

Git worktree management for parallel AI agent workflows

https://worktrunk.dev/
1•maximilianroos•27m ago•0 comments

Arc Prize 2025 Results and Analysis: Year of the Refinement Loop

https://arcprize.org/blog/arc-prize-2025-results-analysis
2•frozenseven•31m ago•0 comments

Agent Harnesses Are Just Shells

https://pavpanchekha.com/blog/agents-are-shells.html
2•yurivish•32m ago•0 comments

Wall Street Races to Cut Its Risk from AI's Borrowing Binge

https://www.bloomberg.com/news/articles/2025-12-05/wall-street-races-to-cut-its-risk-from-ai-s-bo...
2•zerosizedweasle•32m ago•0 comments

I got Claude and ChatGPT to stop being sycophantic cheerleaders

https://medium.com/@scott_waddell/how-i-got-claude-and-chatgpt-to-stop-being-sycophantic-cheerlea...
3•scott_waddell•36m ago•0 comments

A Golden Land? Questioning Frontiers, Fantasies, Fulfillment in the Northwest

https://lithub.com/a-golden-land-questioning-frontiers-fantasies-and-fulfillment-in-the-pacific-n...
1•felixbraun•38m ago•0 comments

Show HN: FlowCoder – Flowcharts for "Programming" Claude Code and Codex

https://github.com/px-pride/flowcoder
1•px_pride•39m ago•0 comments

Evaluating TCP BBRv2 on the Dropbox edge network

https://arxiv.org/abs/2008.07699
1•fanf2•42m ago•0 comments

New 'physics shortcut' lets laptops tackle quantum problems

https://www.livescience.com/technology/computing/new-physics-shortcut-lets-laptops-tackle-quantum...
1•jhncls•42m ago•0 comments

National Security Strategy of the United States of America [pdf]

https://www.whitehouse.gov/wp-content/uploads/2025/12/2025-National-Security-Strategy.pdf
3•TechTechTech•44m ago•3 comments

Ask HN: "Freelancer? Seeking freelancer?" threads gone?

2•AlexITC•44m ago•1 comments
Open in hackernews

A $20 drug in Europe requires a prescription and $800 in the U.S.

https://www.statnews.com/2025/10/31/why-miebo-costs-40-times-more-than-its-european-version/
48•geox•57m ago

Comments

rational_human•33m ago
because f. you, pay me
jaggederest•30m ago
It's a very interesting drug. There are a lot of concerns right now around PFAS in water supplies, for example, and Miebo/Evotears are pure PFAS (perfluorohexyloctane) that's instilled directly in the eye, giving you a dose somewhere around a million times higher than levels of concern in drinking water.

But it is absolutely revolutionary if you have dry eyes. Quotes include "I feel like my eye is actually too wet now"

wagwang•1m ago
What the fuck... what's stopping this from poisoning our water supply?
kotaKat•28m ago
Why is it eye medication seems to be the market with the slimier moves? Sudden memories to when Allegran sold the patents for Restasis to the Awkwesasne-Mohawks to try to protect it with soverign immunity.

https://en.wikipedia.org/wiki/The_St._Regis_Mohawk_Tribe_and...

ghostDancer•26m ago
Nothing says capitalism and free market like good extortion on health products and services. That's the way to go USA.
Aurornis•22m ago
There is no free market at play here. This is the result of FDA regulations not allowing anyone to sell it unless they did a New Drug Application first, which could cost a billion or more. Therefore nobody in the free market was allowed to sell it without putting up the capital first, which they have to collect back now.

You could actually order this from amazon.de up until recently and have it shipped to you. That seems to have disappeared, though.

yieldcrv•26m ago
out of curiosity, how much would this drug cost in Europe if they had required prescriptions as well

the article does a good job of showing the self serving double speak and the lack of pursuing an OTC option in the US, but I want to compare costs directly, since the article also acknowledges that OTC would have been much cheaper than $800 in the US too

Insanity•22m ago
Not a meaningful difference. I can't recall a time when I got prescription drugs in EU and had to pay a lot.
Aurornis•24m ago
FYI for anyone who isn't familiar with the wacky US insurance situation: Nobody in the US actually pays $800 for the drug. That's the "list price" for insurance companies to pay. Even insurance companies don't pay that price because they negotiate their own rates with the drug companies, which are lower.

Then the drug companies come in and offer a "savings card" which you apply at the pharmacy like another layer of insurance. I searched and Miebo has one too: https://miebo.blsavingscard.com/ You'd have to read all the fine print, but it reveals that the actual cash-pay price is $225 (still high, obviously) and they have a co-pay assistance program that reduces your copay to $0 to incentivize you to get your insurance billed for this drug. So a lot of people who take this drug in the US actually pay $0 because they sign up for this card.

The FDA is partially to blame for this situation: They required a complete New Drug Application before they would let anyone bring it to market, even though it's over the counter in other countries.

The cost of performing a New Drug Application starts in the mid hundreds of millions of dollars range and can extend into the billions for some drugs.

So nobody could feasibly introduce it to the market here without investing $500 million or more up front. At that price, your only viable option is to stick a big price tag on it and try to milk that money back from insurers.

Insanity•22m ago
I think that might be worse than just having the high price. Such a kafka-esque systems just to get medicine.
averageRoyalty•2m ago
Absolutely. I'd prefer to go to the pharmacy and just pay my $20 and go.
ThePowerOfFuet•20m ago
All that handwaving and apology but yet

>the actual cash-pay price is $225

So still 11x the price, plus whatever the prescription costs.

Unforgiveable.

yread•1m ago
Well but that $225 feeds and clothes a lot of the people who spend all day designing these cards and systems around that
brianherbert•18m ago
These "savings cards" have a maximum annual benefit applied to them so for those on insurance that do not cover those expensive medications or who are self-paying use up the benefits before year end and do in fact eventually pay full sticker price.
Ancapistani•14m ago
Then you switch to a difference card.

That's pretty much the entire business model of GoodRx.

khannn•9m ago
I was on a blood thinner and the medication was very pricey. Didn't have insurance and the "savings card" covered fuck all unless you had insurance. There are three blood thinners on the US market and they all cost a lot.
aucisson_masque•23m ago
in some part of europe, we have national healthcare so basically people don't think they are paying their medications, like there was some magic money.

in that case, you don't care if you drug cost 10€ or 2000€ because you aren't spending a single € from your own wallet, at least if you don't factor in taxes.

Contrary to the USA where it's a much more responsible market, people do pay for the medications or they get it paid by their own insurance but it cost them directly a lot of money.

I would think that americans would be much more vigilant about what medication they take, the price it cost, and so would have much lower pricing. That's just how free market work, and technically there are many medication manufacturer and many customer.

Is it the proof that a true unregulated free market doesn't work ? if left unsupervised, big companies are going to buy smaller companies until they are monopoly or make secret, behind the door, deal to keep price up.

It's what the USA is made on, the idea of freedom and free market. i believe the idea of unregulated market is more recent, think the 70's, but surely in the 50 years since then american would have pushed back against it and not elected people like Trump who are all in.

xp84•16m ago
> I would think that americans would be much more vigilant about what medication they take, the price it cost, and so would have much lower pricing.

> Is it the proof that a true unregulated free market doesn't work ?

The market is heavily regulated (frequently crazily) by the FDA, and the actual amount anything costs is heavily obscured from the eyes of any consumers by the fog of bureaucracy and insurance.

Many people have 3-4 tiers of fixed copays that the insurance company makes up - some pharmacies won't even tell you when there is a cash price or a "coupon" that would be cheaper than your insurance copay! And pharmacies don't publish a plain list of what the cash prices are, and it would be hard for most people to even produce the tier formulary, it's buried as a PDF in some obscure page of a horrible website. So we just go to the pharmacy and see what it'll cost us.

Also, one major insurer owns a major pharmacy benefits manager and one of the big 2 pharmacy chains, so they use that to put their thumb on the scale however they can, while the other insurers and PBMs play games to lock consumers into restrictive exclusive deals that are to their detriment.

Anyway we don't have a market at all when it comes to healthcare, because the majority of price information is withheld from consumers until the opportunity to make any choice, if it even existed, is well past.

thrwwXZTYE•14m ago
The funny thing is that when you have one big customer (a country) - you get good prices.

When you have 30 insurance companies, 10000 companies buying insurance policies and millions of individuals - you get shit prices.

That's why the drug in question is 200 USD in US (after deductions) and 20 in Europe (including taxes).

DangitBobby•13m ago
Part of the problem is that the way our healthcare system is setup, it's not even a remotely free market. It's pretty much a worst of all worlds situation.
Ancapistani•11m ago
> Contrary to the USA where it's a much more responsible market, people do pay for the medications or they get it paid by their own insurance but it cost them directly a lot of money.

That's the idea, but in practice there are so many layers of indirect government incentives, disincentives, and direct interventions that market is no longer effective for this purpose.

It's virtually impossible to find out how much a medical procedure actually costs. Most hospitals and clinics refuse to even estimate as a policy, which has led to the creation of things like pre-paid services for labor and delivery. Those are quite rare.

I'm 100% in favor of allowing the market to work - but at this point, we have the worst of both worlds and the best of neither. Either extreme would be better than what we have.

amiga386•11m ago
> in some part of europe, we have national healthcare so basically people don't think they are paying their medications, like there was some magic money.

Europe is a big place, buddy. Which particular part are "we" from today?

NHS England has NICE (National Institute for Health and Care Excellence), which does the cost-benefit analysis for all medicines prescribed, nationally. It frequently decides medicines aren't worth the money. If you, as a private citizen, want that particular medicine, you can waste your own money on it. NHS England does not have a moral hazard problem.

The NHS also spends money trying to convince people to exercise, eat well, lose weight, not smoke, look for early signs of cancer, etc., because they find that relatively tiny amounts of money on these campaigns results in massive, massive savings from not having to treat so much preventable disease later in life.

heathrow83829•1m ago
i think healthcare is one market where capitalism just doesn't work well at all. for those areas, it actually makes sense to introduce hard or soft price ceilings.
picafrost•3m ago
The US is a GDP ponzi scheme disguised as an economy. The silly prices exist to shuffle money between pharmaceutical companies, PBMs, insurers, pharmacies, hospitals, and who knows what other intermediaries. Everyone takes a cut and can put large revenues on their balance sheet.

The US today is structurally dependent on this sort of cash migration. If all Americans suddenly began to save 10%+ of their income every month (also structurally impossible for most), GDP would dramatically contract.

These things aren't broken. They are by design.