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New Brain Maps Show How Chemical Tags Change and Link to Disease

https://www.nature.com/articles/s41593-025-02112-z
1•stevenjgarner•1h ago

Comments

stevenjgarner•1h ago
Since this study reveals that certain RNA tags change in brain regions and genes connected to disorders, can scientists develop new medicines that target these specific chemical tags to halt or reverse neurological diseases?

Agentica TypeScript SDK

https://github.com/symbolica-ai/agentica-typescript-sdk
1•handfuloflight•27s ago•0 comments

Zig asserts are not C asserts

https://cryptocode.github.io/blog/docs/assert/
1•birdculture•2m ago•0 comments

GitHub UI Unresponsive

1•polyrand•6m ago•0 comments

Manchester United's seat licence plan threatened by ticket tout clampdown

https://www.theguardian.com/football/2025/nov/19/manchester-united-seat-licence-plan-threatened-b...
1•PaulHoule•7m ago•0 comments

The (re)-prioritization of open-source AI – Pinterest

https://medium.com/pinterest-engineering/on-the-re-prioritization-of-open-source-ai-86f7279481e3
1•yellow_postit•7m ago•0 comments

Adopters of 'zone zero' fared better in L.A. County fires, investigation finds

https://www.latimes.com/environment/story/2025-12-10/zone-zero-early-adopters-fared-better-in-la-...
1•dangle1•10m ago•0 comments

Show HN: A cloud hardware workspace for open-source CAD/EDA tools

https://foundry.siameseai.com/
1•mister_jmm•10m ago•1 comments

A Fentanyl Vaccine Is About to Get Its First Major Test

https://www.wired.com/story/a-fentanyl-vaccine-is-about-to-get-its-first-major-test/
1•bookofjoe•11m ago•1 comments

A new test for if your LLM is subtly manipulating you

https://rosmine.ai/2025/12/10/a-new-test-for-if-your-llm-is-subtly-manipulating-you/
1•rosmine•12m ago•0 comments

Rubio orders return to Times New Roman font over 'wasteful' Calibri

https://www.bbc.com/news/articles/cgkez3367xmo
14•jnord•12m ago•2 comments

US taking 25% cut of Nvidia chip sales "makes no sense," experts say

https://arstechnica.com/tech-policy/2025/12/us-taking-25-cut-of-nvidia-chip-sales-makes-no-sense-...
4•gametorch•13m ago•0 comments

Omniclip – universal clipboard free from the Apple ecosystem

https://github.com/quantbagel/omniclip
1•quantbagel•13m ago•1 comments

Systemization of Knowledge: Security and Safety Challenges in MCP

https://arxiv.org/abs/2512.08290
2•sambhu•13m ago•0 comments

Green Spaces Tied to Fewer Mental Health Hospitalizations

https://www.medscape.com/viewarticle/green-spaces-tied-fewer-mental-health-hospitalizations-2025a...
1•wjb3•13m ago•1 comments

Echomine – Search and export your ChatGPT and Claude conversations

https://github.com/aucontraire/echomine
1•ohcontraire•14m ago•1 comments

Best Japanese Learning Tools: 2025 Award Show

https://skerritt.blog/best-japanese-learning-tools-2025-award-show/
1•wahnfrieden•15m ago•0 comments

Rails Updates: Schema-Enforced JSON Access, Postgres Type Decoding and More

https://rubyonrails.org/2025/12/5/this-week-in-rails
3•andrewstetsenko•16m ago•0 comments

Nonlinear Quantum Mechanics and Artificial Intelligence

https://arxiv.org/abs/2512.07809
1•measurablefunc•16m ago•0 comments

What is eBPF?

https://oneuptime.com/blog/post/2025-12-10-what-is-ebpf-and-how-does-it-work/view
2•ndhandala•18m ago•0 comments

Libretro

https://www.libretro.com/
2•apitman•20m ago•0 comments

Ask HN: Anyone Else Noticed This?

2•piratesAndSons•22m ago•0 comments

What's needed for AI agents to work

https://substack.com/home/post/p-181262619
1•thejash•23m ago•0 comments

Show HN: See what your Reddit history reveals about you

https://think-pol.com/
1•r00m101•23m ago•0 comments

AI mania to swell datacenter capex to $1.6T by 2030 – if bubble doesnt pop first

https://www.theregister.com/2025/12/09/omdia_datacenter_capex/
1•Bender•24m ago•0 comments

Intel, AMD Processors Affected by PCIe Vulnerabilities

https://www.securityweek.com/intel-amd-processors-affected-by-pcie-vulnerabilities/
3•Bender•25m ago•0 comments

Glibc Now Enabling 2MB THP On AArch64 By Default For Better Performance

https://www.phoronix.com/news/Glibc-malloc-2MB-THP-AArch64
1•Bender•26m ago•0 comments

NVAP Reference Guide: Animal Identification

https://www.aphis.usda.gov/nvap/reference-guide/animal-identification
1•hyperific•26m ago•0 comments

Windows 3.1 'Hot Dog Stand' color scheme, original UI designer explains why

https://www.pcgamer.com/software/windows/windows-3-1-included-a-red-and-yellow-hot-dog-stand-colo...
1•rmason•27m ago•1 comments

Genome-wide analyses identify distinct genetic architectures for depression

https://www.nature.com/articles/s41588-025-02396-8
1•wjb3•27m ago•0 comments

AI browsing in Brave now available for early testing

https://brave.com/blog/ai-browsing/
2•grepex•29m ago•0 comments