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NASA now allowing astronauts to bring their smartphones on space missions

https://twitter.com/NASAAdmin/status/2019259382962307393
2•gbugniot•3m ago•0 comments

Claude Code Is the Inflection Point

https://newsletter.semianalysis.com/p/claude-code-is-the-inflection-point
1•throwaw12•5m ago•0 comments

MicroClaw – Agentic AI Assistant for Telegram, Built in Rust

https://github.com/microclaw/microclaw
1•everettjf•5m ago•2 comments

Show HN: Omni-BLAS – 4x faster matrix multiplication via Monte Carlo sampling

https://github.com/AleatorAI/OMNI-BLAS
1•LowSpecEng•6m ago•1 comments

The AI-Ready Software Developer: Conclusion – Same Game, Different Dice

https://codemanship.wordpress.com/2026/01/05/the-ai-ready-software-developer-conclusion-same-game...
1•lifeisstillgood•8m ago•0 comments

AI Agent Automates Google Stock Analysis from Financial Reports

https://pardusai.org/view/54c6646b9e273bbe103b76256a91a7f30da624062a8a6eeb16febfe403efd078
1•JasonHEIN•11m ago•0 comments

Voxtral Realtime 4B Pure C Implementation

https://github.com/antirez/voxtral.c
1•andreabat•13m ago•0 comments

I Was Trapped in Chinese Mafia Crypto Slavery [video]

https://www.youtube.com/watch?v=zOcNaWmmn0A
1•mgh2•19m ago•0 comments

U.S. CBP Reported Employee Arrests (FY2020 – FYTD)

https://www.cbp.gov/newsroom/stats/reported-employee-arrests
1•ludicrousdispla•21m ago•0 comments

Show HN: I built a free UCP checker – see if AI agents can find your store

https://ucphub.ai/ucp-store-check/
2•vladeta•26m ago•1 comments

Show HN: SVGV – A Real-Time Vector Video Format for Budget Hardware

https://github.com/thealidev/VectorVision-SVGV
1•thealidev•28m ago•0 comments

Study of 150 developers shows AI generated code no harder to maintain long term

https://www.youtube.com/watch?v=b9EbCb5A408
1•lifeisstillgood•28m ago•0 comments

Spotify now requires premium accounts for developer mode API access

https://www.neowin.net/news/spotify-now-requires-premium-accounts-for-developer-mode-api-access/
1•bundie•31m ago•0 comments

When Albert Einstein Moved to Princeton

https://twitter.com/Math_files/status/2020017485815456224
1•keepamovin•32m ago•0 comments

Agents.md as a Dark Signal

https://joshmock.com/post/2026-agents-md-as-a-dark-signal/
2•birdculture•34m ago•0 comments

System time, clocks, and their syncing in macOS

https://eclecticlight.co/2025/05/21/system-time-clocks-and-their-syncing-in-macos/
1•fanf2•36m ago•0 comments

McCLIM and 7GUIs – Part 1: The Counter

https://turtleware.eu/posts/McCLIM-and-7GUIs---Part-1-The-Counter.html
2•ramenbytes•38m ago•0 comments

So whats the next word, then? Almost-no-math intro to transformer models

https://matthias-kainer.de/blog/posts/so-whats-the-next-word-then-/
1•oesimania•40m ago•0 comments

Ed Zitron: The Hater's Guide to Microsoft

https://bsky.app/profile/edzitron.com/post/3me7ibeym2c2n
2•vintagedave•43m ago•1 comments

UK infants ill after drinking contaminated baby formula of Nestle and Danone

https://www.bbc.com/news/articles/c931rxnwn3lo
1•__natty__•43m ago•0 comments

Show HN: Android-based audio player for seniors – Homer Audio Player

https://homeraudioplayer.app
3•cinusek•44m ago•1 comments

Starter Template for Ory Kratos

https://github.com/Samuelk0nrad/docker-ory
1•samuel_0xK•45m ago•0 comments

LLMs are powerful, but enterprises are deterministic by nature

2•prateekdalal•49m ago•0 comments

Make your iPad 3 a touchscreen for your computer

https://github.com/lemonjesus/ipad-touch-screen
2•0y•54m ago•1 comments

Internationalization and Localization in the Age of Agents

https://myblog.ru/internationalization-and-localization-in-the-age-of-agents
1•xenator•54m ago•0 comments

Building a Custom Clawdbot Workflow to Automate Website Creation

https://seedance2api.org/
1•pekingzcc•57m ago•1 comments

Why the "Taiwan Dome" won't survive a Chinese attack

https://www.lowyinstitute.org/the-interpreter/why-taiwan-dome-won-t-survive-chinese-attack
2•ryan_j_naughton•57m ago•0 comments

Xkcd: Game AIs

https://xkcd.com/1002/
2•ravenical•59m ago•0 comments

Windows 11 is finally killing off legacy printer drivers in 2026

https://www.windowscentral.com/microsoft/windows-11/windows-11-finally-pulls-the-plug-on-legacy-p...
2•ValdikSS•59m ago•0 comments

From Offloading to Engagement (Study on Generative AI)

https://www.mdpi.com/2306-5729/10/11/172
1•boshomi•1h ago•1 comments
Open in hackernews

FDA approves Novo Nordisk's Wegovy pill, the first and only oral GLP-1

https://www.prnewswire.com/news-releases/fda-approves-novo-nordisks-wegovy-pill-the-first-and-only-oral-glp-1-for-weight-loss-in-adults-302648344.html
30•andsoitis•1mo ago

Comments

ggm•1mo ago
Longterm, are pills both cheaper to manufacture and distribute than injectable? It's tempting to assume so because of not needing a mechanism and production line processes towards pill encapsulation. About the only possible advantage a liquid would have is flow state manufacturing and avoidance of drying cycles somewhere in production. I can't see that outweighing the cost of the injector.

Cost, and price are of course fully disconnected here. I look forward to Indian and Canadian generics in due course.

toomuchtodo•1mo ago
Yes, the cost and distribution stories are better for oral vs injectable. This pill is a peptide, which means you still have to be mindful when you take it versus food and beverage. Eli Lilly’s version is a small molecule versus a peptide, which means you can take it at any time. Long story short, for most obesity situations, this is going to be a broad system improvement.

Lilly is building a large manufacturing facility north of Indianapolis in Lebanon, and these drugs will be part of their manufacturing.

devilbunny•1mo ago
> are pills both cheaper to manufacture and distribute than injectable

Vastly. Dehydrating purified compounds is cheap and easy, and pills don't have to be truly sterile. Sterile injectables are not cheap lines to set up even aside from packaging in the injector.

iancmceachern•1mo ago
Exactly, and this is because a huge part of our immune system lies in our gut. You can eat things all day that would kill you if injected.
hyghjiyhu•1mo ago
I think it's also the physical barrier. Like how getting bacteria on your skin is no big deal.
cheald•1mo ago
This is, specifically, why oral GLP-1s haven't been a thing until now; peptides are too fragile to survive the digestive system and make it into the bloodstream.
gedy•1mo ago
GLP-1 meds are so effective, and likely will be cheap enough for most that I worry that there will be a "RTO" type push from companies to ban or discourage them due to the financial impact on food, snack, booze companies.
john01dav•1mo ago
That would be a horrifying violation of bodily autonomy.

This doesn't mean that it won't happen, but it does make it especially vile if it does.

resoluteteeth•1mo ago
The thing is, even people who are obese and gaining weight over time are usually just eating a tiny calorie surplus each day.

If people take GLP-1 meds and get down into the normal range, at that point even if they stay on the drugs, they're going to have to adjust the dose so they stop losing weight again (without gaining weight).

This means that even if everyone who's overweight or obese started taking GLP-1 drugs and started losing weight right now, the reduction in food consumption would still be limited and short term.

So I think this concern is somewhat overblown.

gedy•1mo ago
They really don't seem to work that way, it's not a calorie minusing weight loss pill.
resoluteteeth•1mo ago
They don't work by reducing appetite, causing people to eat less? What mechanism do you think they work by then?
aussieguy1234•1mo ago
Most return to office mandates benefit downtown real estate and businesses, despite remote work being equally as effective as in office for most office jobs.

So its not out of the question that processed food and alcohol companies might lobby to restrict or ban these medications to protect their profits, despite them being proven to be medically effective.

It wouldn't be the first time corporate profit interests override the interests of ordinary people.

moioci•1mo ago
Headline is incorrect; Rybelsus, an oral semaglutide, was approved in 2019. Maybe oral Wegovy is the first oral GLP-1 approved for obesity rather than diabetes.