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The Genus Amanita

https://www.mushroomexpert.com/amanita.html
1•rolph•4m ago•0 comments

We have broken SHA-1 in practice

https://shattered.io/
1•mooreds•5m ago•1 comments

Ask HN: Was my first management job bad, or is this what management is like?

1•Buttons840•6m ago•0 comments

Ask HN: How to Reduce Time Spent Crimping?

1•pinkmuffinere•7m ago•0 comments

KV Cache Transform Coding for Compact Storage in LLM Inference

https://arxiv.org/abs/2511.01815
1•walterbell•12m ago•0 comments

A quantitative, multimodal wearable bioelectronic device for stress assessment

https://www.nature.com/articles/s41467-025-67747-9
1•PaulHoule•14m ago•0 comments

Why Big Tech Is Throwing Cash into India in Quest for AI Supremacy

https://www.wsj.com/world/india/why-big-tech-is-throwing-cash-into-india-in-quest-for-ai-supremac...
1•saikatsg•14m ago•0 comments

How to shoot yourself in the foot – 2026 edition

https://github.com/aweussom/HowToShootYourselfInTheFoot
1•aweussom•14m ago•0 comments

Eight More Months of Agents

https://crawshaw.io/blog/eight-more-months-of-agents
3•archb•16m ago•0 comments

From Human Thought to Machine Coordination

https://www.psychologytoday.com/us/blog/the-digital-self/202602/from-human-thought-to-machine-coo...
1•walterbell•17m ago•0 comments

The new X API pricing must be a joke

https://developer.x.com/
1•danver0•18m ago•0 comments

Show HN: RMA Dashboard fast SAST results for monorepos (SARIF and triage)

https://rma-dashboard.bukhari-kibuka7.workers.dev/
1•bumahkib7•18m ago•0 comments

Show HN: Source code graphRAG for Java/Kotlin development based on jQAssistant

https://github.com/2015xli/jqassistant-graph-rag
1•artigent•23m ago•0 comments

Python Only Has One Real Competitor

https://mccue.dev/pages/2-6-26-python-competitor
3•dragandj•24m ago•0 comments

Tmux to Zellij (and Back)

https://www.mauriciopoppe.com/notes/tmux-to-zellij/
1•maurizzzio•25m ago•1 comments

Ask HN: How are you using specialized agents to accelerate your work?

1•otterley•27m ago•0 comments

Passing user_id through 6 services? OTel Baggage fixes this

https://signoz.io/blog/otel-baggage/
1•pranay01•27m ago•0 comments

DavMail Pop/IMAP/SMTP/Caldav/Carddav/LDAP Exchange Gateway

https://davmail.sourceforge.net/
1•todsacerdoti•28m ago•0 comments

Visual data modelling in the browser (open source)

https://github.com/sqlmodel/sqlmodel
1•Sean766•30m ago•0 comments

Show HN: Tharos – CLI to find and autofix security bugs using local LLMs

https://github.com/chinonsochikelue/tharos
1•fluantix•31m ago•0 comments

Oddly Simple GUI Programs

https://simonsafar.com/2024/win32_lights/
1•MaximilianEmel•31m ago•0 comments

The New Playbook for Leaders [pdf]

https://www.ibli.com/IBLI%20OnePagers%20The%20Plays%20Summarized.pdf
1•mooreds•31m ago•1 comments

Interactive Unboxing of J Dilla's Donuts

https://donuts20.vercel.app
1•sngahane•33m ago•0 comments

OneCourt helps blind and low-vision fans to track Super Bowl live

https://www.dezeen.com/2026/02/06/onecourt-tactile-device-super-bowl-blind-low-vision-fans/
1•gaws•34m ago•0 comments

Rudolf Vrba

https://en.wikipedia.org/wiki/Rudolf_Vrba
1•mooreds•35m ago•0 comments

Autism Incidence in Girls and Boys May Be Nearly Equal, Study Suggests

https://www.medpagetoday.com/neurology/autism/119747
1•paulpauper•36m ago•0 comments

Wellness Hotels Discovery Application

https://aurio.place/
1•cherrylinedev•37m ago•1 comments

NASA delays moon rocket launch by a month after fuel leaks during test

https://www.theguardian.com/science/2026/feb/03/nasa-delays-moon-rocket-launch-month-fuel-leaks-a...
1•mooreds•37m ago•0 comments

Sebastian Galiani on the Marginal Revolution

https://marginalrevolution.com/marginalrevolution/2026/02/sebastian-galiani-on-the-marginal-revol...
2•paulpauper•40m ago•0 comments

Ask HN: Are we at the point where software can improve itself?

1•ManuelKiessling•41m ago•2 comments
Open in hackernews

FDA approves Novo Nordisk's Wegovy pill, the first and only oral GLP-1

https://www.prnewswire.com/news-releases/fda-approves-novo-nordisks-wegovy-pill-the-first-and-only-oral-glp-1-for-weight-loss-in-adults-302648344.html
30•andsoitis•1mo ago

Comments

ggm•1mo ago
Longterm, are pills both cheaper to manufacture and distribute than injectable? It's tempting to assume so because of not needing a mechanism and production line processes towards pill encapsulation. About the only possible advantage a liquid would have is flow state manufacturing and avoidance of drying cycles somewhere in production. I can't see that outweighing the cost of the injector.

Cost, and price are of course fully disconnected here. I look forward to Indian and Canadian generics in due course.

toomuchtodo•1mo ago
Yes, the cost and distribution stories are better for oral vs injectable. This pill is a peptide, which means you still have to be mindful when you take it versus food and beverage. Eli Lilly’s version is a small molecule versus a peptide, which means you can take it at any time. Long story short, for most obesity situations, this is going to be a broad system improvement.

Lilly is building a large manufacturing facility north of Indianapolis in Lebanon, and these drugs will be part of their manufacturing.

devilbunny•1mo ago
> are pills both cheaper to manufacture and distribute than injectable

Vastly. Dehydrating purified compounds is cheap and easy, and pills don't have to be truly sterile. Sterile injectables are not cheap lines to set up even aside from packaging in the injector.

iancmceachern•1mo ago
Exactly, and this is because a huge part of our immune system lies in our gut. You can eat things all day that would kill you if injected.
hyghjiyhu•1mo ago
I think it's also the physical barrier. Like how getting bacteria on your skin is no big deal.
cheald•1mo ago
This is, specifically, why oral GLP-1s haven't been a thing until now; peptides are too fragile to survive the digestive system and make it into the bloodstream.
gedy•1mo ago
GLP-1 meds are so effective, and likely will be cheap enough for most that I worry that there will be a "RTO" type push from companies to ban or discourage them due to the financial impact on food, snack, booze companies.
john01dav•1mo ago
That would be a horrifying violation of bodily autonomy.

This doesn't mean that it won't happen, but it does make it especially vile if it does.

resoluteteeth•1mo ago
The thing is, even people who are obese and gaining weight over time are usually just eating a tiny calorie surplus each day.

If people take GLP-1 meds and get down into the normal range, at that point even if they stay on the drugs, they're going to have to adjust the dose so they stop losing weight again (without gaining weight).

This means that even if everyone who's overweight or obese started taking GLP-1 drugs and started losing weight right now, the reduction in food consumption would still be limited and short term.

So I think this concern is somewhat overblown.

gedy•1mo ago
They really don't seem to work that way, it's not a calorie minusing weight loss pill.
resoluteteeth•1mo ago
They don't work by reducing appetite, causing people to eat less? What mechanism do you think they work by then?
aussieguy1234•1mo ago
Most return to office mandates benefit downtown real estate and businesses, despite remote work being equally as effective as in office for most office jobs.

So its not out of the question that processed food and alcohol companies might lobby to restrict or ban these medications to protect their profits, despite them being proven to be medically effective.

It wouldn't be the first time corporate profit interests override the interests of ordinary people.

moioci•1mo ago
Headline is incorrect; Rybelsus, an oral semaglutide, was approved in 2019. Maybe oral Wegovy is the first oral GLP-1 approved for obesity rather than diabetes.