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Origami on Another Level with 3D Printing

https://hackaday.com/2025/12/21/origami-on-another-level-with-3d-printing/
1•fangpenlin•37s ago•0 comments

Britons are less well off than they were in 2019 – and these figures show it

https://news.sky.com/story/britons-poorer-than-they-were-in-2019-as-living-standards-continue-to-...
2•ivewonyoung•1m ago•0 comments

The Duodecimal Bulletin, Vol. 55, No. 1, Year 1209 [pdf]

https://dozenal.org/drupal/sites_bck/default/files/DuodecimalBulletinIssue551.pdf
2•susam•3m ago•0 comments

NYC Spends $200 Million on Cell Service for School Chromebooks

https://nysfocus.com/2025/12/22/eric-adams-school-chromebooks-contract
4•h2si•5m ago•0 comments

I Stopped Reading and Embraced Audiobooks

https://www.nytimes.com/2025/12/21/books/review/audiobooks-reading-listening-habits.html
3•lxm•6m ago•0 comments

Administration suspends 5 wind projects off East Coast, cites security concerns

https://apnews.com/article/trump-offshore-wind-energy-climate-c0ac1e447c93126327f1922327921aa0
3•JKCalhoun•8m ago•1 comments

I Died on DMT

https://rebeccadai.substack.com/p/i-died-on-dmt
3•randomparticlez•11m ago•0 comments

Running Claude Code from my phone via SSH with Tailscale and tmux

https://www.qu8n.com/posts/running-claude-code-from-my-phone
3•quanwinn•12m ago•0 comments

In stock on Framework Desktop and updates on the industry-wide silicon crunch

https://community.frame.work/t/in-stock-on-framework-desktop-and-updates-on-the-industry-wide-sil...
2•nateb2022•17m ago•0 comments

Data 2025: The year in review with Mike Stonebraker and Andy Pavlo

https://www.dbos.dev/webcast-2025-in-review-with-mike-stonebraker-and-andy-pavlo
2•teleforce•18m ago•0 comments

Antimeme Antichrist

https://www.johnnychang.com/antimeme/
3•zcase•21m ago•1 comments

FDA Approves Pill Version of Wegovy

https://www.wired.com/story/fda-approves-pill-version-of-wegovy/
3•stein1946•21m ago•1 comments

Release Trains Aren't About Releases

https://cameronwestland.com/release-trains-arent-about-releases/
2•camwest•21m ago•1 comments

Wozmonc64.bas

https://github.com/gabrielsroka/gabrielsroka.github.io/blob/master/wozmon/wozmonc64.bas
2•gabrielsroka•23m ago•1 comments

State of the Geomagnetic Field, December 2025 (PDF 19 pages)

https://www.ncei.noaa.gov/sites/default/files/2025-12/WMM%20SoGF%20Dec2025%20508.pdf
2•defrost•27m ago•0 comments

A House Ahead of Its Time (2024)

https://www.nist.gov/feature-stories/house-ahead-its-time
2•1659447091•29m ago•0 comments

Exposing a $10B Fraudulent Debt Relief Industry [video]

https://www.youtube.com/watch?v=hBNWInRS6hM
3•fortran77•32m ago•0 comments

President Trump Announces New Trump Class Battleship

https://www.navy.mil/Press-Office/Press-Releases/display-pressreleases/Article/4366856/president-...
4•duxup•33m ago•2 comments

Show HN: StringTune-3D – Control Three.js scenes via CSS variables

https://github.com/penev-palemiya/StringTune-3D
2•penev_tech•42m ago•0 comments

We removed 80% of our agent's tools

https://vercel.com/blog/we-removed-80-percent-of-our-agents-tools
2•forks•44m ago•0 comments

Jim Beam halts production at main distillery for a year

https://www.bbc.com/news/articles/cy5gv5z24n2o
4•geox•49m ago•0 comments

Snitch – a friendly netstat alternative for humans

https://github.com/karol-broda/snitch
2•karol-broda•49m ago•0 comments

Grok Collections API

https://x.ai/news/grok-collections-api
2•lmariscal•51m ago•1 comments

San Francisco power won't be fully restored until Tuesday, PG&E says

https://www.sfgate.com/bayarea/article/san-francisco-power-pge-outage-21255221.php
2•bryan0•55m ago•0 comments

Colorado Windstorm Causes 4.8 Microsecond Glitch in Official US Time

https://gizmodo.com/colorado-windstorm-causes-4-8-microsecond-glitch-in-official-u-s-time-2000702524
2•Stratoscope•55m ago•1 comments

Salisbury Steak is super weird

https://www.youtube.com/watch?v=d9z8DK_VWKs
2•bane•55m ago•0 comments

Document search using Claude and Inverted Index

https://annanay.dev/claude-inverted-index-search/
2•annanay•57m ago•0 comments

Aspartame study suggests that current guidelines should be re-examined

https://www.sciencedirect.com/science/article/pii/S0753332225010856
2•shaggie76•58m ago•0 comments

Trump Administration Declares Foreign-Made Drones a Security Threat

https://www.nytimes.com/2025/12/22/us/dji-drones-china-barred-us.html
3•Sherveen•1h ago•2 comments

Regenerative Software

https://aicoding.leaflet.pub/3majnyfydzs2y
3•andsoitis•1h ago•0 comments
Open in hackernews

FDA approves Novo Nordisk's Wegovy pill, the first and only oral GLP-1

https://www.prnewswire.com/news-releases/fda-approves-novo-nordisks-wegovy-pill-the-first-and-only-oral-glp-1-for-weight-loss-in-adults-302648344.html
12•andsoitis•2h ago

Comments

ggm•2h ago
Longterm, are pills both cheaper to manufacture and distribute than injectable? It's tempting to assume so because of not needing a mechanism and production line processes towards pill encapsulation. About the only possible advantage a liquid would have is flow state manufacturing and avoidance of drying cycles somewhere in production. I can't see that outweighing the cost of the injector.

Cost, and price are of course fully disconnected here. I look forward to Indian and Canadian generics in due course.

toomuchtodo•1h ago
Yes, the cost and distribution stories are better for oral vs injectable. This pill is a peptide, which means you still have to be mindful when you take it versus food and beverage. Eli Lilly’s version is a small molecule versus a peptide, which means you can take it at any time. Long story short, for most obesity situations, this is going to be a broad system improvement.

Lilly is building a large manufacturing facility north of Indianapolis in Lebanon, and these drugs will be part of their manufacturing.

devilbunny•36m ago
> are pills both cheaper to manufacture and distribute than injectable

Vastly. Dehydrating purified compounds is cheap and easy, and pills don't have to be truly sterile. Sterile injectables are not cheap lines to set up even aside from packaging in the injector.