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BTDUex Safe? The Back End Withdrawal Anomalies

1•aoijfoqfw•32s ago•0 comments

Show HN: Compile-Time Vibe Coding

https://github.com/Michael-JB/vibecode
1•michaelchicory•3m ago•0 comments

Show HN: Ensemble – macOS App to Manage Claude Code Skills, MCPs, and Claude.md

https://github.com/O0000-code/Ensemble
1•IO0oI•6m ago•1 comments

PR to support XMPP channels in OpenClaw

https://github.com/openclaw/openclaw/pull/9741
1•mickael•6m ago•0 comments

Twenty: A Modern Alternative to Salesforce

https://github.com/twentyhq/twenty
1•tosh•8m ago•0 comments

Raspberry Pi: More memory-driven price rises

https://www.raspberrypi.com/news/more-memory-driven-price-rises/
1•calcifer•14m ago•0 comments

Level Up Your Gaming

https://d4.h5go.life/
1•LinkLens•18m ago•1 comments

Di.day is a movement to encourage people to ditch Big Tech

https://itsfoss.com/news/di-day-celebration/
2•MilnerRoute•19m ago•0 comments

Show HN: AI generated personal affirmations playing when your phone is locked

https://MyAffirmations.Guru
4•alaserm•20m ago•3 comments

Show HN: GTM MCP Server- Let AI Manage Your Google Tag Manager Containers

https://github.com/paolobietolini/gtm-mcp-server
1•paolobietolini•21m ago•0 comments

Launch of X (Twitter) API Pay-per-Use Pricing

https://devcommunity.x.com/t/announcing-the-launch-of-x-api-pay-per-use-pricing/256476
1•thinkingemote•21m ago•0 comments

Facebook seemingly randomly bans tons of users

https://old.reddit.com/r/facebookdisabledme/
1•dirteater_•22m ago•1 comments

Global Bird Count

https://www.birdcount.org/
1•downboots•23m ago•0 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
2•soheilpro•25m ago•0 comments

Jon Stewart – One of My Favorite People – What Now? with Trevor Noah Podcast [video]

https://www.youtube.com/watch?v=44uC12g9ZVk
2•consumer451•27m ago•0 comments

P2P crypto exchange development company

1•sonniya•41m ago•0 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
2•jesperordrup•45m ago•0 comments

Write for Your Readers Even If They Are Agents

https://commonsware.com/blog/2026/02/06/write-for-your-readers-even-if-they-are-agents.html
1•ingve•46m ago•0 comments

Knowledge-Creating LLMs

https://tecunningham.github.io/posts/2026-01-29-knowledge-creating-llms.html
1•salkahfi•46m ago•0 comments

Maple Mono: Smooth your coding flow

https://font.subf.dev/en/
1•signa11•53m ago•0 comments

Sid Meier's System for Real-Time Music Composition and Synthesis

https://patents.google.com/patent/US5496962A/en
1•GaryBluto•1h ago•1 comments

Show HN: Slop News – HN front page now, but it's all slop

https://dosaygo-studio.github.io/hn-front-page-2035/slop-news
6•keepamovin•1h ago•1 comments

Show HN: Empusa – Visual debugger to catch and resume AI agent retry loops

https://github.com/justin55afdfdsf5ds45f4ds5f45ds4/EmpusaAI
1•justinlord•1h ago•0 comments

Show HN: Bitcoin wallet on NXP SE050 secure element, Tor-only open source

https://github.com/0xdeadbeefnetwork/sigil-web
2•sickthecat•1h ago•1 comments

White House Explores Opening Antitrust Probe on Homebuilders

https://www.bloomberg.com/news/articles/2026-02-06/white-house-explores-opening-antitrust-probe-i...
1•petethomas•1h ago•0 comments

Show HN: MindDraft – AI task app with smart actions and auto expense tracking

https://minddraft.ai
2•imthepk•1h ago•0 comments

How do you estimate AI app development costs accurately?

1•insights123•1h ago•0 comments

Going Through Snowden Documents, Part 5

https://libroot.org/posts/going-through-snowden-documents-part-5/
1•goto1•1h ago•0 comments

Show HN: MCP Server for TradeStation

https://github.com/theelderwand/tradestation-mcp
1•theelderwand•1h ago•0 comments

Canada unveils auto industry plan in latest pivot away from US

https://www.bbc.com/news/articles/cvgd2j80klmo
3•breve•1h ago•1 comments
Open in hackernews

FDA approves Novo Nordisk's Wegovy pill, the first and only oral GLP-1

https://www.prnewswire.com/news-releases/fda-approves-novo-nordisks-wegovy-pill-the-first-and-only-oral-glp-1-for-weight-loss-in-adults-302648344.html
30•andsoitis•1mo ago

Comments

ggm•1mo ago
Longterm, are pills both cheaper to manufacture and distribute than injectable? It's tempting to assume so because of not needing a mechanism and production line processes towards pill encapsulation. About the only possible advantage a liquid would have is flow state manufacturing and avoidance of drying cycles somewhere in production. I can't see that outweighing the cost of the injector.

Cost, and price are of course fully disconnected here. I look forward to Indian and Canadian generics in due course.

toomuchtodo•1mo ago
Yes, the cost and distribution stories are better for oral vs injectable. This pill is a peptide, which means you still have to be mindful when you take it versus food and beverage. Eli Lilly’s version is a small molecule versus a peptide, which means you can take it at any time. Long story short, for most obesity situations, this is going to be a broad system improvement.

Lilly is building a large manufacturing facility north of Indianapolis in Lebanon, and these drugs will be part of their manufacturing.

devilbunny•1mo ago
> are pills both cheaper to manufacture and distribute than injectable

Vastly. Dehydrating purified compounds is cheap and easy, and pills don't have to be truly sterile. Sterile injectables are not cheap lines to set up even aside from packaging in the injector.

iancmceachern•1mo ago
Exactly, and this is because a huge part of our immune system lies in our gut. You can eat things all day that would kill you if injected.
hyghjiyhu•1mo ago
I think it's also the physical barrier. Like how getting bacteria on your skin is no big deal.
cheald•1mo ago
This is, specifically, why oral GLP-1s haven't been a thing until now; peptides are too fragile to survive the digestive system and make it into the bloodstream.
gedy•1mo ago
GLP-1 meds are so effective, and likely will be cheap enough for most that I worry that there will be a "RTO" type push from companies to ban or discourage them due to the financial impact on food, snack, booze companies.
john01dav•1mo ago
That would be a horrifying violation of bodily autonomy.

This doesn't mean that it won't happen, but it does make it especially vile if it does.

resoluteteeth•1mo ago
The thing is, even people who are obese and gaining weight over time are usually just eating a tiny calorie surplus each day.

If people take GLP-1 meds and get down into the normal range, at that point even if they stay on the drugs, they're going to have to adjust the dose so they stop losing weight again (without gaining weight).

This means that even if everyone who's overweight or obese started taking GLP-1 drugs and started losing weight right now, the reduction in food consumption would still be limited and short term.

So I think this concern is somewhat overblown.

gedy•1mo ago
They really don't seem to work that way, it's not a calorie minusing weight loss pill.
resoluteteeth•1mo ago
They don't work by reducing appetite, causing people to eat less? What mechanism do you think they work by then?
aussieguy1234•1mo ago
Most return to office mandates benefit downtown real estate and businesses, despite remote work being equally as effective as in office for most office jobs.

So its not out of the question that processed food and alcohol companies might lobby to restrict or ban these medications to protect their profits, despite them being proven to be medically effective.

It wouldn't be the first time corporate profit interests override the interests of ordinary people.

moioci•1mo ago
Headline is incorrect; Rybelsus, an oral semaglutide, was approved in 2019. Maybe oral Wegovy is the first oral GLP-1 approved for obesity rather than diabetes.