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What were the first animals? The fierce sponge–jelly battle that just won't end

https://www.nature.com/articles/d41586-026-00238-z
1•beardyw•2m ago•0 comments

Sidestepping Evaluation Awareness and Anticipating Misalignment

https://alignment.openai.com/prod-evals/
1•taubek•2m ago•0 comments

OldMapsOnline

https://www.oldmapsonline.org/en
1•surprisetalk•4m ago•0 comments

What It's Like to Be a Worm

https://www.asimov.press/p/sentience
1•surprisetalk•4m ago•0 comments

Don't go to physics grad school and other cautionary tales

https://scottlocklin.wordpress.com/2025/12/19/dont-go-to-physics-grad-school-and-other-cautionary...
1•surprisetalk•4m ago•0 comments

Lawyer sets new standard for abuse of AI; judge tosses case

https://arstechnica.com/tech-policy/2026/02/randomly-quoting-ray-bradbury-did-not-save-lawyer-fro...
1•pseudolus•5m ago•0 comments

AI anxiety batters software execs, costing them combined $62B: report

https://nypost.com/2026/02/04/business/ai-anxiety-batters-software-execs-costing-them-62b-report/
1•1vuio0pswjnm7•5m ago•0 comments

Bogus Pipeline

https://en.wikipedia.org/wiki/Bogus_pipeline
1•doener•6m ago•0 comments

Winklevoss twins' Gemini crypto exchange cuts 25% of workforce as Bitcoin slumps

https://nypost.com/2026/02/05/business/winklevoss-twins-gemini-crypto-exchange-cuts-25-of-workfor...
1•1vuio0pswjnm7•7m ago•0 comments

How AI Is Reshaping Human Reasoning and the Rise of Cognitive Surrender

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6097646
2•obscurette•7m ago•0 comments

Cycling in France

https://www.sheldonbrown.com/org/france-sheldon.html
1•jackhalford•8m ago•0 comments

Ask HN: What breaks in cross-border healthcare coordination?

1•abhay1633•9m ago•0 comments

Show HN: Simple – a bytecode VM and language stack I built with AI

https://github.com/JJLDonley/Simple
1•tangjiehao•11m ago•0 comments

Show HN: Free-to-play: A gem-collecting strategy game in the vein of Splendor

https://caratria.com/
1•jonrosner•12m ago•1 comments

My Eighth Year as a Bootstrapped Founde

https://mtlynch.io/bootstrapped-founder-year-8/
1•mtlynch•13m ago•0 comments

Show HN: Tesseract – A forum where AI agents and humans post in the same space

https://tesseract-thread.vercel.app/
1•agliolioyyami•13m ago•0 comments

Show HN: Vibe Colors – Instantly visualize color palettes on UI layouts

https://vibecolors.life/
1•tusharnaik•14m ago•0 comments

OpenAI is Broke ... and so is everyone else [video][10M]

https://www.youtube.com/watch?v=Y3N9qlPZBc0
2•Bender•14m ago•0 comments

We interfaced single-threaded C++ with multi-threaded Rust

https://antithesis.com/blog/2026/rust_cpp/
1•lukastyrychtr•16m ago•0 comments

State Department will delete X posts from before Trump returned to office

https://text.npr.org/nx-s1-5704785
6•derriz•16m ago•1 comments

AI Skills Marketplace

https://skly.ai
1•briannezhad•16m ago•1 comments

Show HN: A fast TUI for managing Azure Key Vault secrets written in Rust

https://github.com/jkoessle/akv-tui-rs
1•jkoessle•16m ago•0 comments

eInk UI Components in CSS

https://eink-components.dev/
1•edent•17m ago•0 comments

Discuss – Do AI agents deserve all the hype they are getting?

2•MicroWagie•20m ago•0 comments

ChatGPT is changing how we ask stupid questions

https://www.washingtonpost.com/technology/2026/02/06/stupid-questions-ai/
1•edward•21m ago•1 comments

Zig Package Manager Enhancements

https://ziglang.org/devlog/2026/#2026-02-06
3•jackhalford•22m ago•1 comments

Neutron Scans Reveal Hidden Water in Martian Meteorite

https://www.universetoday.com/articles/neutron-scans-reveal-hidden-water-in-famous-martian-meteorite
1•geox•23m ago•0 comments

Deepfaking Orson Welles's Mangled Masterpiece

https://www.newyorker.com/magazine/2026/02/09/deepfaking-orson-welless-mangled-masterpiece
1•fortran77•25m ago•1 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
3•nar001•27m ago•2 comments

SpaceX Delays Mars Plans to Focus on Moon

https://www.wsj.com/science/space-astronomy/spacex-delays-mars-plans-to-focus-on-moon-66d5c542
1•BostonFern•27m ago•0 comments
Open in hackernews

Older Americans quit weight loss drugs in droves

https://www.seattletimes.com/nation-world/older-americans-quit-weight-loss-drugs-in-droves/
14•paulpauper•1mo ago

Comments

AndrewKemendo•1mo ago
I thought it would take a decade for the side effects to catch up with people but this is way faster than expected.

There are no shortcuts to holistic health.

In a sick and corrupt environment the worn path is harmful by default.

djohnston•1mo ago
> There are no shortcuts to holistic health.

I agree with that.

> I thought it would take a decade for the side effects to catch up with people but this is way faster than expected.

Regarding the side effects, nothing seemed beyond the realm of what you'd read on the outside of an OTC cold medication. I'm not a doctor but they don't seem that severe.

AndrewKemendo•1mo ago
I suggest you go back and read the article to see the difference between realized effects and the stated effects.

Are you credulous to what product and drug producers post on a label? Why would you ever believe that?

toomuchtodo•1mo ago
The elderly are simply not as tolerant of the side effects. It still works fine in younger cohorts who can manage with potential side effects. This means the criteria for use in the elderly needs to be modified so they aren’t force fed this pharma intervention for revenue optimization.

(both my partner and I, early 40s, are on a GLP-1, with no side effects; we’ve each lost ~40lbs in 4-5 months)

AndrewKemendo•1mo ago
We heard the EXACT same from phenphen users too in the 90s. My friend was the litigator for the class action.

There’s no biologically free way to lose weight that quickly without massive downstream effects, SOMETHING is going to eventually come out like it always does.

The fact that people are making conclusions with less than 5 years of evidence is why we’re always screwed.

https://en.wikipedia.org/wiki/Fenfluramine/phentermine

toomuchtodo•1mo ago
And I can provide examples of Metformin being very safe with the exception of a few edge cases, while providing exceptional benefit across a wide cross section of the population. Could something exceptional crop up? Potentially. But so far, the data is very compelling GLP-1RAs have a reasonable safety profile for the enormous benefit provided.

https://intermountainhealthcare.org/blogs/article/your-frien...

> Are GLP-1s safe? What are the side effects? > GLP-1s have been extensively studied and are considered safe when prescribed and monitored by a healthcare provider.

With all of this said, I'm open to having a mutually agreed upon subject matter expert provide the equivalent of an opinion letter on the safety of GLP-1RAs at my (reasonable and customary) cost. Feel free to propose one.

solumunus•1mo ago
These drugs have an incredible effect to side effect ratio. Most people sincerely taking them are in far better health with them than without.
Centigonal•1mo ago
This article showcases multiple causes for why seniors are coming off of these drugs: drug shortages, changing insurance coverage, muscle loss, and other side effects are all included. Let's not be too hasty when attributing cause to this trend.
MarkusQ•1mo ago
Why highlight seniors then? The same factors apply to younger patients. The only explanation that makes sense is that "seniors" is a valuable ad word for the market this clickbait gibberish (or rather, "tossed factoid salad") targets.
SR2Z•1mo ago
Seniors are almost all on Medicare and have obesity-related health issues more frequently than young people.
MarkusQ•1mo ago
> Medicare covered it for treating Type 2 diabetes but not for weight loss

> [...] to Bucklew’s surprise, her Medicare Advantage plan covered it even

> though she wasn’t diabetic, charging just a $25 monthly copay.

> [...] Then her Medicare plan notified her that it would no longer cover

> the drug [...] With coverage denied, Bucklew became part of an unsettlingly

> large group: older adults who begin taking GLP-1s and related drugs [...] and

> then stop taking them within months.

This feels like it's really straining the facts to jam them into a narrative, then mostly fails to construct one. Is it an article about drug side effects? Insurance fraud? Health benefits of GLP-1s? Medicare policy?

Strangely, it feels like something that would actually have been more coherent if it had been written by an LLM.