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Near-Instantly Aborting the Worst Pain Imaginable with Psychedelics

https://psychotechnology.substack.com/p/near-instantly-aborting-the-worst
1•eatitraw•4m ago•0 comments

Show HN: Nginx-defender – realtime abuse blocking for Nginx

https://github.com/Anipaleja/nginx-defender
2•anipaleja•4m ago•0 comments

The Super Sharp Blade

https://netzhansa.com/the-super-sharp-blade/
1•robin_reala•5m ago•0 comments

Smart Homes Are Terrible

https://www.theatlantic.com/ideas/2026/02/smart-homes-technology/685867/
1•tusslewake•7m ago•0 comments

What I haven't figured out

https://macwright.com/2026/01/29/what-i-havent-figured-out
1•stevekrouse•8m ago•0 comments

KPMG pressed its auditor to pass on AI cost savings

https://www.irishtimes.com/business/2026/02/06/kpmg-pressed-its-auditor-to-pass-on-ai-cost-savings/
1•cainxinth•8m ago•0 comments

Open-source Claude skill that optimizes Hinge profiles. Pretty well.

https://twitter.com/b1rdmania/status/2020155122181869666
2•birdmania•8m ago•1 comments

First Proof

https://arxiv.org/abs/2602.05192
2•samasblack•10m ago•1 comments

I squeezed a BERT sentiment analyzer into 1GB RAM on a $5 VPS

https://mohammedeabdelaziz.github.io/articles/trendscope-market-scanner
1•mohammede•11m ago•0 comments

Kagi Translate

https://translate.kagi.com
2•microflash•12m ago•0 comments

Building Interactive C/C++ workflows in Jupyter through Clang-REPL [video]

https://fosdem.org/2026/schedule/event/QX3RPH-building_interactive_cc_workflows_in_jupyter_throug...
1•stabbles•13m ago•0 comments

Tactical tornado is the new default

https://olano.dev/blog/tactical-tornado/
2•facundo_olano•15m ago•0 comments

Full-Circle Test-Driven Firmware Development with OpenClaw

https://blog.adafruit.com/2026/02/07/full-circle-test-driven-firmware-development-with-openclaw/
1•ptorrone•15m ago•0 comments

Automating Myself Out of My Job – Part 2

https://blog.dsa.club/automation-series/automating-myself-out-of-my-job-part-2/
1•funnyfoobar•15m ago•0 comments

Google staff call for firm to cut ties with ICE

https://www.bbc.com/news/articles/cvgjg98vmzjo
39•tartoran•16m ago•5 comments

Dependency Resolution Methods

https://nesbitt.io/2026/02/06/dependency-resolution-methods.html
1•zdw•16m ago•0 comments

Crypto firm apologises for sending Bitcoin users $40B by mistake

https://www.msn.com/en-ie/money/other/crypto-firm-apologises-for-sending-bitcoin-users-40-billion...
1•Someone•17m ago•0 comments

Show HN: iPlotCSV: CSV Data, Visualized Beautifully for Free

https://www.iplotcsv.com/demo
2•maxmoq•18m ago•0 comments

There's no such thing as "tech" (Ten years later)

https://www.anildash.com/2026/02/06/no-such-thing-as-tech/
1•headalgorithm•18m ago•0 comments

List of unproven and disproven cancer treatments

https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments
1•brightbeige•18m ago•0 comments

Me/CFS: The blind spot in proactive medicine (Open Letter)

https://github.com/debugmeplease/debug-ME
1•debugmeplease•19m ago•1 comments

Ask HN: What are the word games do you play everyday?

1•gogo61•22m ago•1 comments

Show HN: Paper Arena – A social trading feed where only AI agents can post

https://paperinvest.io/arena
1•andrenorman•23m ago•0 comments

TOSTracker – The AI Training Asymmetry

https://tostracker.app/analysis/ai-training
1•tldrthelaw•27m ago•0 comments

The Devil Inside GitHub

https://blog.melashri.net/micro/github-devil/
2•elashri•27m ago•0 comments

Show HN: Distill – Migrate LLM agents from expensive to cheap models

https://github.com/ricardomoratomateos/distill
1•ricardomorato•28m ago•0 comments

Show HN: Sigma Runtime – Maintaining 100% Fact Integrity over 120 LLM Cycles

https://github.com/sigmastratum/documentation/tree/main/sigma-runtime/SR-053
1•teugent•28m ago•0 comments

Make a local open-source AI chatbot with access to Fedora documentation

https://fedoramagazine.org/how-to-make-a-local-open-source-ai-chatbot-who-has-access-to-fedora-do...
1•jadedtuna•29m ago•0 comments

Introduce the Vouch/Denouncement Contribution Model by Mitchellh

https://github.com/ghostty-org/ghostty/pull/10559
1•samtrack2019•30m ago•0 comments

Software Factories and the Agentic Moment

https://factory.strongdm.ai/
1•mellosouls•30m ago•1 comments
Open in hackernews

Older Americans quit weight loss drugs in droves

https://www.seattletimes.com/nation-world/older-americans-quit-weight-loss-drugs-in-droves/
14•paulpauper•1mo ago

Comments

AndrewKemendo•1mo ago
I thought it would take a decade for the side effects to catch up with people but this is way faster than expected.

There are no shortcuts to holistic health.

In a sick and corrupt environment the worn path is harmful by default.

djohnston•1mo ago
> There are no shortcuts to holistic health.

I agree with that.

> I thought it would take a decade for the side effects to catch up with people but this is way faster than expected.

Regarding the side effects, nothing seemed beyond the realm of what you'd read on the outside of an OTC cold medication. I'm not a doctor but they don't seem that severe.

AndrewKemendo•1mo ago
I suggest you go back and read the article to see the difference between realized effects and the stated effects.

Are you credulous to what product and drug producers post on a label? Why would you ever believe that?

toomuchtodo•1mo ago
The elderly are simply not as tolerant of the side effects. It still works fine in younger cohorts who can manage with potential side effects. This means the criteria for use in the elderly needs to be modified so they aren’t force fed this pharma intervention for revenue optimization.

(both my partner and I, early 40s, are on a GLP-1, with no side effects; we’ve each lost ~40lbs in 4-5 months)

AndrewKemendo•1mo ago
We heard the EXACT same from phenphen users too in the 90s. My friend was the litigator for the class action.

There’s no biologically free way to lose weight that quickly without massive downstream effects, SOMETHING is going to eventually come out like it always does.

The fact that people are making conclusions with less than 5 years of evidence is why we’re always screwed.

https://en.wikipedia.org/wiki/Fenfluramine/phentermine

toomuchtodo•1mo ago
And I can provide examples of Metformin being very safe with the exception of a few edge cases, while providing exceptional benefit across a wide cross section of the population. Could something exceptional crop up? Potentially. But so far, the data is very compelling GLP-1RAs have a reasonable safety profile for the enormous benefit provided.

https://intermountainhealthcare.org/blogs/article/your-frien...

> Are GLP-1s safe? What are the side effects? > GLP-1s have been extensively studied and are considered safe when prescribed and monitored by a healthcare provider.

With all of this said, I'm open to having a mutually agreed upon subject matter expert provide the equivalent of an opinion letter on the safety of GLP-1RAs at my (reasonable and customary) cost. Feel free to propose one.

solumunus•1mo ago
These drugs have an incredible effect to side effect ratio. Most people sincerely taking them are in far better health with them than without.
Centigonal•1mo ago
This article showcases multiple causes for why seniors are coming off of these drugs: drug shortages, changing insurance coverage, muscle loss, and other side effects are all included. Let's not be too hasty when attributing cause to this trend.
MarkusQ•1mo ago
Why highlight seniors then? The same factors apply to younger patients. The only explanation that makes sense is that "seniors" is a valuable ad word for the market this clickbait gibberish (or rather, "tossed factoid salad") targets.
SR2Z•1mo ago
Seniors are almost all on Medicare and have obesity-related health issues more frequently than young people.
MarkusQ•1mo ago
> Medicare covered it for treating Type 2 diabetes but not for weight loss

> [...] to Bucklew’s surprise, her Medicare Advantage plan covered it even

> though she wasn’t diabetic, charging just a $25 monthly copay.

> [...] Then her Medicare plan notified her that it would no longer cover

> the drug [...] With coverage denied, Bucklew became part of an unsettlingly

> large group: older adults who begin taking GLP-1s and related drugs [...] and

> then stop taking them within months.

This feels like it's really straining the facts to jam them into a narrative, then mostly fails to construct one. Is it an article about drug side effects? Insurance fraud? Health benefits of GLP-1s? Medicare policy?

Strangely, it feels like something that would actually have been more coherent if it had been written by an LLM.