1. The Autogenous vaccine, where a veterinarian submits swabs of offending organisms to a lab that cultures and produces a vaccine specific to that strain to sell back to the clinic. Genomics play a role in determining if the currently circulating strains match the culture that the vaccine is based on.
2. The prescription platform vaccine, where genomic sequences are used to create a custom antigen that is produced in a microbial factory.
The efficacy of these types of vaccines is hotly debated because they do not have to go through clinical trial before distribution. The development of "commercial" (i.e. clinical trial-burdened) vaccines appears to have slowed based on my observations. While I think some of these new vaccines show promise, many autogenous and prescription platform vaccines are just more expensive versions of vaccines already available, or they package organisms that are suspected commensals and market it as something that no one else has done.
It's hard for me to call today a "golden age of vaccine development" in that light. I hope that the article is only taking human vaccines into account and that there is appropriate efficacy data for every vaccine shown in the last chart.
reify•1mo ago
a self-amplifying mRNA vaccine construct consists of the replicase of Venezuela equine encephalitis virus.
tooo cool! just a moment, let me get my 1mm syringe, spoon, lighter, tourniquet and inject some directly into my femoral artery and let it course around my body. Then let it multiply until im dead.
yep you read correctly
Venezuelan equine encephalitis virus is a mosquito-borne viral pathogen that causes Venezuelan equine encephalitis or encephalomyelitis (VEE).
VEE can affect all equine species, such as horses, donkeys, and zebras. After infection, equines may suddenly die or show progressive central nervous system disorders.
vampire race on the horizon