frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Open in hackernews

How fast does a protein fold? Real-time technique captures the moment

https://www.nature.com/articles/d41586-026-00755-x
2•lc0_stein•2h ago

Comments

lc0_stein•2h ago
Link to original paper: https://journals.aps.org/prl/abstract/10.1103/2q9m-4scc
dekhn•1h ago
I can't speak to the scientific conclusions in the article, but the smallest/simplest proteins go from completely unfolded to fully folded in a few microseconds. Other proteins will never reach their fully folded state without assistance (usually this correlates with the size of the protein, but many other factors, such as hydrophobic surface, play a big role). Understand that process at a molecular level using experimental methods has been an active area of research and we have definitely come to appreciate that proteins are FAST and that it seems like folding speed is often one of the most important aspects of their evolution.

So improvements to experimental technology in this area are very valuable.

Loom vs. Linear: A tale of two AI-cities

https://jamespember.substack.com/p/loom-vs-linear-a-tale-of-two-ai-cities
1•jep888•39s ago•0 comments

Reese's changed its chocolate because of climate change

https://www.fooddive.com/news/hershey-reeses-ingredients-chocolate-climate-change-oped/813903/
1•del82•44s ago•1 comments

Financial group probed by congressional committee over Chinese stock scams

https://www.ft.com/content/49f541f8-c73d-4268-9621-f8604f1a8141
1•petethomas•1m ago•0 comments

Boredom Is the Price We Pay for Meaning

https://www.theatlantic.com/ideas/2026/02/boredom-parenthood-father/686158/
1•myth_drannon•2m ago•0 comments

Something feels weird about this economy

https://www.noahpinion.blog/p/something-feels-weird-about-this
1•paulpauper•2m ago•0 comments

Phonyhuman

https://github.com/manav03panchal/phonyhuman
1•manavpanchal•4m ago•0 comments

Ask HN: What game engine would you recommend for vibe coding?

1•general_reveal•5m ago•0 comments

American Prairie Grows Again with 2k+ Acres of Critical Wetland Habitat

https://americanprairie.org/the-latest/american-prairie-grow-again-with-2k-acres-of-critical-wetl...
1•gametorch•7m ago•0 comments

Emergent Quantization from a Dynamic Vacuum

https://journals.aps.org/prresearch/abstract/10.1103/l8y7-r3rm
1•Rover222•17m ago•2 comments

High-throughput phenomics of global ant biodiversity

https://www.nature.com/articles/s41592-026-03005-0
1•bookofjoe•18m ago•0 comments

The Deadliest Animals

https://ourworldindata.org/deadliest-animals
1•gmays•19m ago•0 comments

Fast and Powerful Code Editor

https://lap.dev/lapce/
2•arthurz•21m ago•1 comments

The greatest unsolved problem in computer science

https://www.youtube.com/watch?v=x36UmiSiEzc
1•ArturoNereu•24m ago•0 comments

China Deploys 30k-Ton Liaowang-1 "Floating Supercomputer" to Gulf of Oman

https://defencesecurityasia.com/en/china-liaowang-1-spy-ship-gulf-of-oman-us-israel-iran-war-surv...
3•swed420•24m ago•1 comments

Family of Tumbler Ridge shooting victim suing OpenAI

https://www.cbc.ca/news/canada/british-columbia/openai-sued-tumbler-ridge-victim-9.7121635
2•stygiansonic•26m ago•0 comments

Show HN: Open-source, model-agnostic alternative to Claude Code Review

https://github.com/kodustech/kodus-ai
3•edvaldodfreitas•29m ago•0 comments

Trump cancels sanctions against countries buying Russian oil

https://unn.ua/en/news/trump-cancels-sanctions-against-countries-buying-russian-oil
2•testing22321•30m ago•0 comments

Show HN: CLI for Atlassian

https://github.com/chinmaymk/acli
3•_chinmaymk•31m ago•0 comments

The Custodian Shift

https://igorschwarzmann.com/strategyasprotocol/custodian-shift/
2•doener•31m ago•0 comments

How to Get Free Email for Your Custom Domain

https://timleland.com/how-to-get-free-email-for-your-custom-domain/
2•TimLeland•32m ago•0 comments

Corporateapology.com – Accountability at Scale

https://corporateapology.com
1•drawbars•35m ago•1 comments

Karpathy: Autoresearch

https://github.com/karpathy/autoresearch/blob/master/README.md
3•champagnepapi•37m ago•1 comments

The CIA's attempt to make Havana Syndrome disappear

https://theins.press/en/inv/290088
2•FergusArgyll•37m ago•0 comments

Against the Orthogonality Thesis Part 2 – Alignment

https://jonasmoman.substack.com/p/against-the-orthogonality-thesis-f99
3•paulpauper•41m ago•0 comments

Finding Remote Work as a Drone Operator

https://nathankyoung.substack.com/p/finding-remote-work-as-a-drone-operator
2•paulpauper•42m ago•0 comments

Cybertruck in Autopilot mode tried to drive off Houston bridge, suit says

https://www.chron.com/culture/article/cybertruck-houston-lawsuit-21965298.php
2•zzzeek•43m ago•0 comments

LLM Integrity During Inference in Llama.cpp

https://bednarskiwsieci.pl/en/blog/integrity-llm-inference-tampering/
1•piotrbednarsalt•45m ago•1 comments

The iPhone 17e

https://daringfireball.net/2026/03/the_iphone_17e
1•chmaynard•47m ago•0 comments

The Requirements Layer Your AI System Is Missing

https://kiln.tech/blog/requirements_layer_your_ai_system_is_missing
1•samfierro•48m ago•1 comments

Simulating Catalog and Table Conflicts in Iceberg

https://cdouglas.github.io/posts/2026/03/catalog
1•eatonphil•52m ago•0 comments