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Time Is No Different

https://czep.net/26/this-time.html
1•czep•54s ago•0 comments

How I sequenced my genome at home

https://twitter.com/sethshowes/status/2045782975380406623
1•Finbarr•1m ago•0 comments

EU LOTL trust anchors are rotating on April 28: what breaks and how to patch

https://guust.ysebie.be/blog/new-eu-trusted-certificates-updated
2•whizzx•2m ago•0 comments

The Trouble with Transformers

https://roblh.substack.com/p/the-trouble-with-transformers
2•rob_lh•4m ago•1 comments

Time-Variation of Fundamental Constants

https://en.wikipedia.org/wiki/Time-variation_of_fundamental_constants
1•tcp_handshaker•7m ago•0 comments

Why I de-Googled

https://kevinboone.me/why_i_degoogled.html
3•ingve•7m ago•0 comments

Show HN: A chess playground that lets you share board configurations

https://www.chesster.eu
1•MirceaOprea•15m ago•0 comments

Put away your phone and play Pokémon on your Nintendo DS instead

https://alexwennerberg.com/blog/2026-04-15-ds.html
1•abnercoimbre•16m ago•0 comments

We scored 10k Polymarket wallets. Calibration barely predicts profit

https://www.convexly.app/blog/polymarket-10k-wallet-study
2•convexly•17m ago•0 comments

Show HN: Design Graph – a canvas for reviewing parallel HTML variants

https://github.com/noemica-io/design-graph
1•SebastianSosa•18m ago•0 comments

BreachLab Phantom – 32-level post-exploitation wargame on a real Linux box

https://breachlab.org/tracks/phantom
2•atobones•18m ago•0 comments

AgentID – Shared identity. Shared memory. Shared tasks. Lower token costs

https://agentid.live/
1•colapsis•18m ago•0 comments

Koide Formula

https://en.wikipedia.org/wiki/Koide_formula
1•tcp_handshaker•20m ago•0 comments

In a first, Blue Origin uses a recycled rocket to send a satellite into space

https://www.geekwire.com/2026/blue-origin-uses-a-recycled-rocket-to-launch-satellite-for-ast-spac...
1•SilverElfin•21m ago•1 comments

Making Illegal State Unrepresentable

https://blog.frankel.ch/illegal-state-unrepresentable/
2•Tomte•22m ago•0 comments

We Need a New Product Hunt

https://molodtsov.me/2026/04/we-need-a-new-product-hunt/
4•twapi•22m ago•1 comments

You're Invisible on the Internet. Here's the Why

https://medium.com/@simbamudonzvo/youre-invisible-on-the-internet-here-s-the-why-fbe086d99d62
1•TechOnionKing•22m ago•0 comments

The Best Photos of the Artemis II Mission

https://nautil.us/the-best-photos-of-the-artemis-ii-mission-1279789
2•Bender•24m ago•1 comments

Embedded Rust discovery guide for the official Rust ESP32-C3 board

https://github.com/melastmohican/esp-rust-board-discovery
2•melastmohican•25m ago•0 comments

Passmark: Open-source Playwright library for AI regression testing

https://passmark.dev
4•hliyan•26m ago•1 comments

Sandboxed AI agent orchestration platform

https://github.com/superhq-ai/superhq
4•purusa0x6c•26m ago•0 comments

The Secret Life of Circuits

https://lcamtuf.coredump.cx/electronics/
2•signa11•28m ago•0 comments

Turtle WoW classic server announces shutdown after Blizzard wins injunction

https://www.pcgamer.com/games/world-of-warcraft/turtle-wow-classic-server-announces-shutdown-afte...
6•Brajeshwar•28m ago•2 comments

Claude Brain

https://github.com/memvid/claude-brain
3•DeathArrow•29m ago•0 comments

Per-Screen Virtual Desktops Is Finally on KDE Plasma

https://www.neowin.net/news/after-21-years-of-waiting-kde-plasma-is-finally-adding-this-long-requ...
1•bundie•31m ago•0 comments

Against an Endless Present

https://thedispatch.com/article/short-video-memory-culture-books/
1•XzetaU8•31m ago•0 comments

What Category Is Prune?

https://contemplativegames.com/prune
1•justinneuman•32m ago•0 comments

Have your agent post Markdown/HTML/JSX to internet

https://www.saved.md/
1•anboias•35m ago•0 comments

Show HN: Find jobs and know your fit before you apply

https://karriero.net/
2•alenn_m•35m ago•2 comments

Who Voted You King?

https://chrisabraham.substack.com/p/who-voted-you-king
1•chrisabraham•36m ago•0 comments
Open in hackernews

Notes from the SF Peptide Scene

https://12gramsofcarbon.com/p/notes-from-the-sf-peptide-scene
35•theahura•1h ago

Comments

Analemma_•51m ago
Note that this post isn't just about peptides, it's more an overview of the SF social scene in general and what has changed in just the last year. So it includes things like "Tesla FSD actually works now" and "the right is uncool again and nobody talks about e.g. Curtis Yarvin anymore" (both true, IME).
ambicapter•47m ago
I think this author has a very different conception of what “sincerity” is than I do, but I guess that’s the difference between the east coast and the west coast.
perching_aix•11m ago
Yeah lol, it reminded me to this Onion post:

> Claim: My uncle says Mamdani will abolish the entire NYPD.

> Fact: Your uncle does say that.

halper•42m ago
Sometimes I have been in situations in life where I think I must be insane, because everyone else sees something I do not. I got a bit of that feeling reading this article.
Aurornis•41m ago
This article is an anecdote extrapolated to something bigger: A type of lazy journalism where the writer has a single social experience with a group of weird people and then writes about it like it’s the common experience in a place.

The writer went to SF for a few days and went to one party where a group of friends were into peptides. From the article, they were also particularly terrible people. Just read this quote:

> “They change your personality, it’s literally made me less shallow knowing that we can just looksmax you.” “Ugliness is just a choice now.” “I shot up a twink with ozempic who did not need to lose any weight.”

I can’t believe I have to say this, but if someone is bragging to you about injecting weight loss drugs into another person who shouldn’t be taking weight loss drugs, your response shouldn’t be “lol how quirky”. You should recognize that they are a bad person. In my experience the drug enthusiasts who brag about getting other people started on their drugs are bad news, but the ones who brag about introducing to their drugs to people who clearly should not be taking those drugs are the worst variety.

These people always exist. Go back a few years and they might be talking about nootropics or “research chemical” drugs that are analogs of methamphetamine or MDMA. Go back further and they might be bragging about doing steroids and importing testosterone from gray market sources. Go back before that and they’d be bragging about all the Modafinil they’re taking.

The thing about drug user bubbles like this is that when you’re talking to them you’d be convinced that everyone is doing what they’re doing: Taking the latest on-trend drugs in large amounts and one-upping each other on dose, stories, or drug-fueled adventures.

What’s not talked about is the long-term consequences of falling into these groups where excessive drug self-experimentation is normalized. The party doesn’t last forever and the mindset of being able to endlessly adjust your body and/or your mood with drugs starts to turn dark after the early years where hubris makes users feel like they’ve found the secret to better living through chemistry.

If you’ve encountered groups like this you’ve also seen how the “everyone is doing it” mentality becomes embedded in their minds. That doesn’t mean everyone is importing various Chinese peptides and injecting them for “looksmaxxing” and whatever these people were on about about the “peptide party”. These are just garden variety young drug users riding the latest trend

tptacek•18m ago
This is a blog post, not journalism as such. It's someone humorously recounting their own personal experience. They have no responsibility to contextualize anything for you.
Aurornis•17m ago
Okay? Points still stand: It’s written as an authoritative exploration of a social scene extrapolated from a few days visiting a place and attending one party.

If someone’s writing in journalistic style I think it’s fair to criticize it as journalism, even if it’s on Substack

keiferski•13m ago
I read the entire post and it isn't, at all. It's a personal story with his own reflections on a scene as he experienced it. It's no different than literally any other blog post or journal entry, and at no point does it claim to be a neutral sociological study.
stickfigure•10m ago
It is not presented as authoritative anything, except perhaps one person's experience. And we should assume it is embellished.

You are taking this far too seriously. It is a vignette which captures the flavor of a place at a particular time. And it is delightfully written.

Aurornis•7m ago
> It is a vignette which captures the flavor of a place at a particular time.

That’s my point: It captured a specific party with a small group of friends, but the blog goes on to wax philosophically about how it’s indicative of society and tech as a whole

It’s a perfect motte-and-bailey setup where you’re supposed to read it as a big trend indicative of a place and a scene, but the second anyone criticizes the writing it becomes a retreat to arguments that we shouldn’t take it seriously, that’s it’s just a blog, that we should selectively believe it’s embellished however convenient to defuse any criticism.

tptacek•3m ago
I think you're on tilt with this argument now. This is a personal essay. You disagree with some of its implications. That's fine. People disagree with each other. You should just write "I disagree with this", rather than try to critique it as formally bad journalism.
cjbgkagh•18m ago
They did point out, with numbers, that the SF scene is a lot smaller than would ordinarily be expected. Additionally this is the party scene which is a subset of the general tech scene. These people have more time and money to spare than those who are busy working but they do form a bit of a nexus that channels information. The blog post seems to go to great lengths not to pretend that it is something that it isn’t.

I think it’s important to understand that AI, even at its current level, is revolutionary as are cheap Chinese peptides. This isn’t a crypto bubble, both of these will be world changing. I’ve been doing AI for decades and peptides for 5 years (treating an actual medical condition) so I was in this space before it was cool, happy SF finally caught up.

weego•12m ago
It's not journalism though is it, it's just someone's blog where they can tell any story they want, as has been the entire history of story telling. With that out of the way the rest of your post is just flanneling.
Aurornis•8m ago
If the title was “I went to a single party while visiting SF and say some weird things” I might agree, but the article from beginning to end is written as if the party was a lens into society as a whole and indicative of larger trends.

There’s a motte and bailey thing going on with this type of rationalist writing where someone writes authoritatively on broad subjects and then when anyone starts responding to it they immediately repeats to “it’s just a blog” to forgive all of the problems with it.

nipponese•4m ago
this is likely to be the most interesting argument I will read today: is substack legit editorial journalism?

certainly there is no organized journalistic outfit behind it, but also, a lot of legit journalists want their substacks to be taken as facts of record.

sonofhans•11m ago
Well said. This is better written and more sensible than the article itself.
lanyard-textile•8m ago
I'm inclined to agree.

But...

I'm also inclined to believe we are not the cool people being invited to these circles :)

Looking at what has happened with wegovy etc, it doesn't seem impossible.

dkarl•4m ago
I don't think that's the way you're supposed to read it? I think you're supposed to read it as, the trendy extremes tell you something about a place, even if the details are silly and ephemeral. People with no filter, no shame, no interest in correctness or consequences, and no pole star except trends are like a cartoon guide to the trends and the mentality driving them.

I think the author would agree with most of what you wrote.

uxp100•40m ago
20% work in tech? I think that’s gone up quite a bit since I last spent a lot of time there in 2015. I would see these articles from time to time and think, people are getting the wrong idea if they haven’t been there, when I think of SF I think of middle aged Chinese people and alleycat bike races and music venues and book stores and drug dealing and gays, though tech bros are also present (and overlapping). But damn, 20%, that’s a lot bigger than finance bros, maybe tech really is ruining the city. Shoot.
blululu•30m ago
I think that’s 20% of the workforce not the population overall. That’s still a large number but its not the whole city. Also nobody is ruining the city, SF is doing just fine these days.
righthand•38m ago
The citrus party fervor just sounds like dead internet theory and social media ad targeting doing it’s job. If everything is peptides and ai then a citrus party sticks out. Wow it must be really ego-fulfilling to be rich and just party all the time in SF. And your momentum is that you experiment with drugs.
balamatom•27m ago
One word: Omelas.
richard___•27m ago
My issue with this article is the author writes about them in a frame that says “they are so quirky and this makes them cool / good” when really they are a bunch of degenerates.
keiferski•20m ago
I really didn't get that vibe at all. If anything, he seems pretty balanced in his appraisal of SF.
xrd•25m ago
Can I claim I invented the term "partydes" for these events? Is there anyone else out there that can make that claim?
roxolotl•22m ago
> Someone once said that SF is a town of extremely high sincerity, and all of its modern and historical weirdness

Not directly related to the piece but this explains so much. I’ve always seen it as high credulity. That is to say all lots of people are lying but lots of other people trust them. The missing part has been why would you take some of these people at face value. If there’s also a lot of sincere people it would then make sense that many would end up overly credulous.

keiferski•21m ago
This pairs well with this recent article by NY Magazine: The AI Kids Take San Francisco: Brilliant, workaholic teenagers are flooding the city — and reshaping our future in their image

https://nymag.com/intelligencer/article/san-francisco-ai-boo...

adregan•13m ago
I’m not really understanding the notion that these people are so sincere. Perhaps we have different definitions of sincerity.

To my eye, the entire fascination of unsafely injecting peptides in a desire to change your being is largely the opposite of sincerity.

Invictus0•9m ago
https://x.com/Kaz_Khadem/status/2045600370617995600?s=20