frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Open in hackernews

Dynamics of genetic and somatic trade-offs in ageing and mortality

https://www.nature.com/articles/s41586-026-10407-9
2•robwwilliams•1h ago

Comments

robwwilliams•1h ago
Senior author here (with Danny Arends, co-lead). We mapped 59 genetic loci (large chunks of chromosomes) that shape mortality across the full mouse lifespan, with strong and often antagonistic sex effects. Happy to answer questions about the actuarial lifespan and mortality mapping approach, the UM-HET3 mouse population, the Vita vs Soma locus distinction, and the sex differences in mortality rates. Or anything else. Paper is CC BY 4.0. All data and code are open — GeneNetwork.org and github.com/DannyArends/UM-HET3.

Stop publishing conference videos (2022)

https://www.notcheckmark.com/2022/11/stop-publishing-conference-videos/
1•Tomte•31s ago•0 comments

Show HN: SkillGuard – scan agent skills for prompt injection payloads

https://github.com/obielin/skillguard
1•arabking•54s ago•0 comments

Itron Project

https://en.wikipedia.org/wiki/ITRON_project
1•doener•57s ago•0 comments

Hey, it's Earth Day today

2•burnt-resistor•1m ago•0 comments

We Are All Playing Politics at Work

https://idiallo.com/blog/we-are-playing-politics
2•firefoxd•2m ago•0 comments

Dryos

https://en.wikipedia.org/wiki/DRYOS
1•doener•2m ago•0 comments

SpaceX developing Golden Dome software

https://www.bloomberg.com/news/articles/2026-04-22/spacex-tapped-for-industry-group-developing-go...
2•infinitewars•3m ago•0 comments

OpenAI demos cyber-focused GPT to governments, who secures the model itself?

https://www.axios.com/2026/04/22/openai-gpt-cyber-government-meeting
1•Almured•3m ago•1 comments

Agents with Taste – How to transfer taste into an AI

https://emilkowal.ski/ui/agents-with-taste
2•emilkowalski•4m ago•0 comments

They will force you, open source maintainers, to drink the gasoline

https://www.notcheckmark.com/2026/04/you-will-drink-the-gasoline/
1•withzombies•6m ago•0 comments

Don't Use RLS in Supabase

https://www.paralect.com/stack/dont-use-rls-in-supabase
1•igorkrasnik•8m ago•0 comments

Ok, What actually uses Rust?

https://blog.goose.love
2•mellosouls•12m ago•0 comments

Let's enable MFA for all Ruby gems

https://thoughtbot.com/blog/lets-enable-mfa-for-all-ruby-gems
1•thunderbong•14m ago•0 comments

Open-Source contributions do not help

1•PerchunPak•15m ago•2 comments

New study compares growing corn for energy to solar production. It's no contest

https://www.anthropocenemagazine.org/2025/04/new-study-compares-growing-corn-for-energy-to-solar-...
2•dotcoma•15m ago•1 comments

Show HN: macOS VMs to let you agents run wild

https://ghostvm.org/
1•CarolineWang•16m ago•0 comments

You Need MLOps: When CI/CD for Machine Learning Becomes Mandatory

https://blog.ateljevagabond.se/posts/why-you-need-mlops/
1•dr_linux•17m ago•0 comments

Show HN: Ghost Pepper Meet local meeting transcription and diarization

https://matthartman.github.io/ghost-pepper/
1•MattHart88•17m ago•0 comments

Freelancers Not Delivering

2•sushrut1058•18m ago•1 comments

500 AI prompts scored across 8 quality dimensions. None passed

https://promptqualityscore.com/blog/500-ai-prompts
1•onchainintel•18m ago•0 comments

Twenty: The open alternative to Salesforce, designed for AI

https://github.com/twentyhq/twenty
3•thunderbong•19m ago•0 comments

Brick Farm Simplifies X API

https://buy.stripe.com/dRm5kD4y4eIo3skfSKb7y02
1•Quantumfields•19m ago•0 comments

The invisible engineering behind Lambda's network

https://www.allthingsdistributed.com/2026/04/the-invisible-engineering-behind-lambdas-network.html
2•mjb•22m ago•0 comments

It's None of Your Business

https://docs.eventsourcingdb.io/blog/2026/04/23/its-none-of-your-business/
3•goloroden•23m ago•0 comments

Who Gets to Stay Human – The AI hype, stripped of the hype

https://www.gailweiner.com/post/who-gets-to-stay-human-the-ai-hype-stripped-of-the-hype
2•speckx•24m ago•0 comments

Hindsight Reaches 10k GitHub Stars: The Community's Choice for Agent Memory

https://hindsight.vectorize.io/blog/2026/04/22/hindsight-10k-stars
2•benbbenb•24m ago•0 comments

Crypto Billionaire Justin Sun Accuses World Liberty of 'Criminal Extortion'

https://www.wsj.com/finance/currencies/crypto-billionaire-accuses-trump-familys-world-liberty-of-...
4•fortran77•25m ago•3 comments

Web Stalker – an artist-made browser that ignored images and formatting (1998)

https://anthology.rhizome.org/the-web-stalker
2•rfarley04•26m ago•0 comments

Show HN: Legal Action Boundary Eval for agentic legal workflows

https://github.com/bigkan8/legal-action-boundary-eval
1•kankouadio_vx•28m ago•1 comments

The Macroeconomic Effects of Tariffs: Insights from 180 Years of Trade Policy

https://www.nber.org/papers/w35102
1•paulpauper•28m ago•0 comments