There are still ISA slots in new systems with fairly modern processors and plenty of RAM, if you don’t mind buying specific models of industrial PCs for way too much money.

For $1100 or so you, too, could have a 4th generation Core i3 machine. https://www.rampcsystems.com/product/2-isa-slot

Or maybe you need 4 PCI and 9 ISA for some reason. DuroPC’s got you, if you can drop $1800 on a system with the same generation of processor. https://duropc.com/product/r810-4p9i-4

Most things.

Plastics and rubbers tend to not survive well a lot of the time just because of the chemistry. There's really no way around plastic embrittlement and rubber decomposing. You can prolong it with the right storage conditions, but those molecules are gonna break down sooner or later.

But that code would have to be selected in menuconfig, compiled, and the module loaded. I assume that nobody does that for bus mice, and even if someone, by mistake, selects one of the drivers, that's 1 machine in a billion. Who would target that?

Same argument for any retro-tech. What hacker would spend hours/days to hack my bare-metal DOS box running Arachne + a packet driver just to mine bitcoins on a K6-2 for a couple of hours until I turn it off from the AT power switch (not button).