Instead of having a single cluttered desktop, make many desktops each with their own layout of file/folder icons, wallpaper and widget visibility. Have a desktop for Work, one for interesting Hacker News links, a fully empty desktop etc.
Version 3 of the app (just released) now supports hotkeys to switch desktops in a blink, and also onscreen HUD notifications.
Inspired by the Unix Common Desktop Environment of the 1990s, InfiniDesk is the only app that brings multiple desktops (workspaces/identities) to your Mac.