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IgE disruptor for food allergy with Claude-enabled antibody design [pdf]

https://divergencelabs.com/publications/ige-preprint.pdf
12•matco11•55m ago

Comments

JumpCrisscross•41m ago
Entire classes of allergies are basically caused by IgE, our worm-targeting depth charges, getting bored by the lack of worms in our bodies for possibly the first time in millennia.

If we could tweak our bodies we wouldn’t want to eliminate IgE. But we’d want to have it produced only when a recognizer complex finds thar be worms.

manmal•18m ago
How can IgE get bored? That doesn’t sound right. Why would the body, a master of efficiency, produce IgE just for fun?
changoplatanero•13m ago
they are saying that the body produced to to fight parasites like worms. these were a big problem for most of evolutionary history. With modern living standards, our immune systems don't encounter many parasites so they get "bored" and over react to harmless things like food. Evolution hasn't had time to adjust to the new living standards since its only been a few generations.
adam791•8m ago
Hygiene hypothesis
altairprime•6m ago
[delayed]

Show HN: Type and+ in Claude Code and a second Claude rewrites your prompt first

https://github.com/marciob/prompt-refiner
1•marciob•17s ago•0 comments

A Tale of Two Markets: A Dickensian Take on the Coming Years in Defense Tech

https://warontherocks.com/cogs-of-war/a-tale-of-two-markets-a-dickensian-take-on-the-coming-years...
1•crescit_eundo•1m ago•0 comments

How to Scale Your Model – Google DeepMind

https://jax-ml.github.io/scaling-book/
1•auraham•1m ago•0 comments

AI Made Me Homeless

https://medium.com/effortless-programming/ai-made-me-homeless-a7266d716e59
1•thelifeline•2m ago•0 comments

As search traffic dries up, Reddit announces shift to a logged-in experience

https://techcrunch.com/2026/10/29/as-search-traffic-dries-up-reddit-announces-its-shifting-to-a-l...
1•csnover•2m ago•0 comments

Show HN: Decode.bg Simple Image to Text Extractor

https://decode.bg
1•ds•2m ago•0 comments

The Endless Chip War

https://warontherocks.com/cogs-of-war/the-endless-chip-war/
1•crescit_eundo•2m ago•0 comments

Sustainable Software Development Goals

https://numpde.github.io/best-practices/
1•_codah_•2m ago•0 comments

Running coding agents like engineering orgs

https://twitter.com/MiguelriosEN/status/2115891556251234339
1•ajmalasver•5m ago•1 comments

Full of contempt, she refused to talk to the engineers

https://respectfulleadership.substack.com/p/full-of-contempt-she-refused-to-talk
1•crescit_eundo•5m ago•1 comments

Show HN: Sunlight – the camera-based infinite canvas window manager for Mac

https://sunlight.software/
2•darindd•5m ago•0 comments

How to Raise a Martian

https://bryancurtis.substack.com/p/how-to-raise-a-martian
1•ero5004•6m ago•0 comments

Robots are coming for your housecleaner's job

https://twitter.com/alexkoch_ai/status/2115871971393331663
1•bigwheels•7m ago•0 comments

Canada buy stake in Cohere via $7B Series E at $36B valuation

https://betakit.com/canada-to-invest-up-to-1-6-billion-in-ai-firm-cohere/
1•ziptron•8m ago•0 comments

Proton CEO Andy Yen: "This will be the last year that we hire engineers."

https://twitter.com/LayoffAI/status/2115871654366642624
5•101008•9m ago•1 comments

Patrick Stewart Dies at 86

https://www.yahoo.com/entertainment/celebrity/article/patrick-stewart-star-of-x-men-and-star-trek...
3•emrah•9m ago•0 comments

Intel Reports Third-Quarter 2026 Financial Results

https://www.intc.com/news-events/press-releases/detail/1786/intel-reports-third-quarter-2026-fina...
2•tekdude•9m ago•1 comments

Constraint as Language: The Aesthetics of New Media and the Fate of the Image

https://medium.com/@smoking2man/constraint-as-language-the-aesthetics-of-new-media-and-the-fate-o...
1•Aldus551•10m ago•0 comments

$20 silent speech interface

https://asashepard.com/silent-speech
1•asashepard•11m ago•0 comments

Patrick Stewart Dead: Star Trek and X-Men Actor Was 86

https://variety.com/2026/tv/news/patrick-stewart-dead-star-trek-picardx-men-xavier-1236934412/
2•thm•11m ago•0 comments

Show HN: CatalogKite – Product catalogs and line sheets buyers can order from

https://catalogkite.com/
1•xalgord•12m ago•0 comments

Show HN: Concordia, a 21 km rotating space city you can walk in the browser

https://concordia.davidveksler.com/
1•HeroicLife•13m ago•0 comments

Polymarket Halts Trading as Users Report $1.4M Drained

https://finance.yahoo.com/markets/crypto/articles/polymarket-halts-trading-users-report-183518883...
1•ck2•13m ago•0 comments

The Surprising Popularity of AI

https://www.economist.com/international/2026/10/22/the-surprising-popularity-of-ai
1•Gander5739•13m ago•1 comments

Does Sabrina Pasterski's holographic theory make her the next Einstein?

https://www.newscientist.com/article/2594010-does-sabrina-pasterskis-holographic-theory-make-her-...
2•alchemist1e9•14m ago•0 comments

Different Gemini model setups for agentic video analysis: Deep vs. Lite

https://jorgecolonconsulting.com/deep-vs-lite-different-model-reasoning-level-different-benefits/
1•2upmedia•14m ago•1 comments

We interrupt our usual programming to inform you that I was never hired

https://statmodeling.stat.columbia.edu/2026/10/27/we-interrupt-our-usual-programming-to-inform-yo...
2•jruohonen•14m ago•0 comments

Amazon.com Announces Q3 2026 Results [pdf]

https://ir.aboutamazon.com/files/doc_earnings/2026/q3/earnings-result/AMZN-Q3-2026-Earnings-Relea...
5•mfiguiere•16m ago•0 comments

Covenant-72B

https://huggingface.co/1Covenant/Covenant-72B
1•cobbzilla•17m ago•0 comments

Don't Tell Your Customers You Don't Trust Them

https://spicermatthews.com/blog/dont-tell-your-customers-you-dont-trust-them/
1•cloudmanic•19m ago•0 comments