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Tiny C Compiler

https://bellard.org/tcc/
60•guerrilla•1h ago•22 comments

SectorC: A C Compiler in 512 bytes

https://xorvoid.com/sectorc.html
151•valyala•5h ago•25 comments

The F Word

http://muratbuffalo.blogspot.com/2026/02/friction.html
81•zdw•3d ago•33 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
86•surprisetalk•5h ago•91 comments

GitBlack: Tracing America's Foundation

https://gitblack.vercel.app/
19•martialg•59m ago•3 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
120•mellosouls•8h ago•239 comments

FDA intends to take action against non-FDA-approved GLP-1 drugs

https://www.fda.gov/news-events/press-announcements/fda-intends-take-action-against-non-fda-appro...
36•randycupertino•1h ago•33 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
160•AlexeyBrin•11h ago•28 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
866•klaussilveira•1d ago•266 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
116•vinhnx•8h ago•14 comments

First Proof

https://arxiv.org/abs/2602.05192
78•samasblack•8h ago•57 comments

Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
73•thelok•7h ago•13 comments

Show HN: A luma dependent chroma compression algorithm (image compression)

https://www.bitsnbites.eu/a-spatial-domain-variable-block-size-luma-dependent-chroma-compression-...
22•mbitsnbites•3d ago•1 comments

I write games in C (yes, C) (2016)

https://jonathanwhiting.com/writing/blog/games_in_c/
157•valyala•5h ago•136 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
253•jesperordrup•15h ago•82 comments

Brookhaven Lab's RHIC concludes 25-year run with final collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
36•gnufx•4h ago•41 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
535•theblazehen•3d ago•197 comments

LLMs as the new high level language

https://federicopereiro.com/llm-high/
27•swah•4d ago•19 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
100•onurkanbkrc•10h ago•5 comments

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

https://github.com/Momciloo/fun-with-clip-path
39•momciloo•5h ago•5 comments

Selection rather than prediction

https://voratiq.com/blog/selection-rather-than-prediction/
19•languid-photic•4d ago•5 comments

Microsoft account bugs locked me out of Notepad – Are thin clients ruining PCs?

https://www.windowscentral.com/microsoft/windows-11/windows-locked-me-out-of-notepad-is-the-thin-...
55•josephcsible•3h ago•67 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
213•1vuio0pswjnm7•12h ago•326 comments

72M Points of Interest

https://tech.marksblogg.com/overture-places-pois.html
43•marklit•5d ago•6 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
278•alainrk•10h ago•454 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
129•videotopia•4d ago•41 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
53•rbanffy•4d ago•14 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
651•nar001•9h ago•285 comments

Show HN: Kappal – CLI to Run Docker Compose YML on Kubernetes for Local Dev

https://github.com/sandys/kappal
41•sandGorgon•2d ago•17 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
109•speckx•4d ago•149 comments
Open in hackernews

New nanoparticle therapies target two major killers

https://www.science.org/content/article/new-nanoparticle-therapies-target-two-major-killers
87•rbanffy•10mo ago

Comments

pwdiscflatmajor•10mo ago
Science and AAAS are killers?
throwawa14223•10mo ago
That's how I read the headline at first.
ceejayoz•10mo ago
I suppose we'll have to hope researchers overseas complete the work.

https://arstechnica.com/health/2025/03/federal-funding-for-m...

> Federal support for mRNA vaccine research appears in jeopardy after KFF Health News reported Sunday that officials at the National Institutes of Health have directed scientists to remove all references to the lifesaving technology from their grant applications. All such research is now under direct scrutiny from health secretary and long-time anti-vaccine advocate Robert F. Kennedy Jr.

nimbius•10mo ago
Chinese scientists under the steadfast leadership of the communist party of China will gladly undertake this important scientific research.
rbanffy•10mo ago
There is a point to be made in favor of political stability.

One of the great things in Ireland is the list-based voting that punishes extreme viewpoints and policies. OTOH, sometimes we need politicians willing to make unpopular choices, and our system makes that more difficult.

China, IIRC, has a different concept, one where a person can't be a candidate to a position more than one level higher than the highest one they were previously elected for. This prevents anomalies like Trump, and seems to be a very sensible approach (if coupled with a couple extra freedoms and multiple parties).

wkat4242•10mo ago
Xi Jinping has removed many of those protections though like the maximum term count so he could stay in power.

And Ireland politics got me pretty sad. It just seems to pingpong between two equally inept parties (fianna fail and fine gael) and nothing new ever happens. They just keep piling problem on problem without ever solving anything. I remember there being a lot of fuss about patients in hallways during mary harney's reign in the mid '00s and I don't think that was ever solved. Last time I ended up in hospital there I ended up in exactly that situation. The post-2007 housing crisis is another one. Does anyone actually expect that to be ever solved? And the strange thing is, this country has no shortage of land whatsoever.

What happens is that one party blames their predecessor and wins the election and then next term things switch back again through exactly the same mechanism.

I think something more left like sinn fein would be good for the country but they have too much image baggage due to their past. And labour seems to really just sit at the sidelines forever.

TechDebtDevin•10mo ago
>What happens is that one party blames their predecessor and wins the election and then next term things switch back again through exactly the same mechanism.

This is literally the United States for the last half century.

colechristensen•10mo ago
The unpopular choices that need to be made in America are the centrist ones.

One of them being "whether it's left- or right-aligned, let's not engage in your social agenda on the federal level for a while"

>where a person can't be a candidate to a position more than one level higher than the highest one they were previously elected for

For much of the time in the Roman Republic they also had this

https://en.wikipedia.org/wiki/Cursus_honorum

jimbob45•10mo ago
So you have to work your way up from the bottom? Surely there’s a mathematical impossibility to get to the presidency here unless you’re making astronomical progress year over year?
ceejayoz•10mo ago
There aren't that many (11) levels.

https://en.wikipedia.org/wiki/Civil_service_of_the_People%27...

Functionally, the US mostly works the same way - people start in small local roles and move to county, state, and national levels over time. It's just not enforced as a hard rule, just a practical thing.

jimbob45•10mo ago
That makes more sense then. The US probably has around that number too and you’re right that we do mostly work up from the bottom. The most common method of avoiding the ladder is through military service but that’s basically a parallel ladder requiring very similar work.
ceejayoz•10mo ago
Yeah. If you're a somewhat senior officer in the military, you know how to do things like budget, manage, lead, etc. that all come in handy running an organization like a campaign or Congressional office.
ajuc•10mo ago
The only 2 countries on Earth - USA and China.

You don't have to choose between oligarchy and communism. There's normal countries out there.

slowmovintarget•10mo ago
Some more words from Aristotle to aid the discussion: https://www.worldatlas.com/articles/the-different-forms-of-g...

I'd probably go with plutocracy for the U.S., but we're in the process of trying to disrupt that. (Trying...)

TechDebtDevin•10mo ago
Yes, lets go back to how it was in the 20s and 30s in the United Sates... Said noone ever. I wish I had a time machine for these people.
slowmovintarget•10mo ago
I'm not saying we should have a plutocracy, I think we've achieved one. It needs breaking up.
FuriouslyAdrift•10mo ago
I'm a huge fan of how Switzerland does it. We USED to be that pre-Great Depression / New Deal.
moffkalast•10mo ago
in mice
fnord77•10mo ago
so how long until clinical deployment?
bookofjoe•10mo ago
I don't know if I did the right thing when I stopped posting research articles here involving mice rather than humans. All I know is that I got tired of always seeing

>in mice

as the top comment.

tqi•10mo ago
(I have not taken a biology class since high school so please bear with me if this is a stupid question)

For this treatment to work in people, does the targeting peptide have to be tailored specifically for the individual receiving the treatment, or is mostly universal?