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OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
632•klaussilveira•13h ago•187 comments

Start all of your commands with a comma

https://rhodesmill.org/brandon/2009/commands-with-comma/
20•theblazehen•2d ago•2 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
930•xnx•18h ago•548 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
34•helloplanets•4d ago•26 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
110•matheusalmeida•1d ago•28 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
43•videotopia•4d ago•1 comments

Jeffrey Snover: "Welcome to the Room"

https://www.jsnover.com/blog/2026/02/01/welcome-to-the-room/
10•kaonwarb•3d ago•10 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
222•isitcontent•13h ago•25 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
213•dmpetrov•13h ago•103 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
323•vecti•15h ago•142 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
372•ostacke•19h ago•94 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
359•aktau•19h ago•181 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
478•todsacerdoti•21h ago•234 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
275•eljojo•15h ago•164 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
404•lstoll•19h ago•273 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
85•quibono•4d ago•21 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
25•romes•4d ago•3 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
56•kmm•5d ago•3 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
16•jesperordrup•3h ago•9 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
245•i5heu•16h ago•189 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
13•bikenaga•3d ago•2 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
54•gfortaine•10h ago•22 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
141•vmatsiiako•18h ago•64 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
281•surprisetalk•3d ago•37 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1060•cdrnsf•22h ago•436 comments

Why I Joined OpenAI

https://www.brendangregg.com/blog/2026-02-07/why-i-joined-openai.html
133•SerCe•9h ago•119 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
177•limoce•3d ago•96 comments

Show HN: R3forth, a ColorForth-inspired language with a tiny VM

https://github.com/phreda4/r3
70•phreda4•12h ago•14 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
28•gmays•8h ago•11 comments

FORTH? Really!?

https://rescrv.net/w/2026/02/06/associative
63•rescrv•20h ago•23 comments
Open in hackernews

AI-Designed Antivenoms: New Proteins to Block Deadly Snake Toxins

https://plentyofroom.beehiiv.com/p/antivenoms-with-ai-designed-proteins
103•Lol_arco•9mo ago

Comments

rsedgwick•9mo ago
I almost forgot there were ML models besides LLMs! [RFdiffusion](https://www.bakerlab.org/2023/07/11/diffusion-model-for-prot...), used for the protein discovery, is a model somewhat related to diffusion-based image generation. So much of the attention right now is about what LLMs can do with their coding, agentic, and research capabilities as they get more and more powerful and self-improving. It's fun to be reminded that ground-breaking things still can come from "your dad's neural networks."

Also... just because I was checking through the results of the paper to see if it was actually an interesting result: "The SHRT binder provided complete protection (100%) to mice . . . . The LNG binder exhibited comparable efficacy, completely neutralizing α‐cobratoxin but not the non-target ScNtx"

Lol_arco•9mo ago
Yeah David Baker and co. are using a lot of diffusion models for their research! And yeah some of these mice results are very good, and hopefully they translate to a good degree to humans
speed_spread•9mo ago
Now do spiders.
johnisgood•9mo ago
And ticks.
cinntaile•9mo ago
That's not quite the same. Ticks can spread bacteria, viruses and pathogens. Venom consists of proteins. I assume this impacts development.

Tick vaccines for different diseases such as lyme disease are in development though. For TBE they already exist.

johnisgood•9mo ago
Anything that effectively deters or kills them without being dangerous to humans would work for me (and is convenient enough).
clathratevnp•9mo ago
Gene drive perhaps?
johnisgood•9mo ago
Can you elaborate on that? Thanks!
jfengel•9mo ago
Spider bites are far less deadly. Worldwide, yearly deaths from spider bites number in the dozens, not tens of thousands.

Spiders target small prey and it's hard for their venom to kill something as big as a person. It's certainly unpleasant and can cause significant damage even when it doesn't kill, but snakes are responsible for far more deaths.

lupusreal•9mo ago
Scorpions would be a much better candidate than spiders. They kill fewer people globally than snakes, but still thousands a year.
ReptileMan•9mo ago
This means they also are amazing at designing venoms. Biological and chemical warfare in the ai age have the potential to be really fun and amusing
fancyfredbot•9mo ago
As opposed to before the AI age when biological and chemical warfare were a friendly affair?
squigz•9mo ago
I'm not a chemical warfare expert, but I feel like we're probably not limited by our own ability to come up with new ideas in that regard. I imagine we already have plenty of horrible options.
AIPedant•9mo ago
The "over 100,000 deaths" seems like a slight exaggeration, this paper bounds the estimate at 40,000-80,000: https://www.nature.com/articles/s41467-022-33627-9 Wikipedia's "Epidemiology of snakebites" had similar estimates.

That's still a lot of people! But I was skeptical of 100,000, especially without a source.

Lol_arco•9mo ago
Yes you're right! It's very hard to estimate how many people die from snake bite, for a thousand reasons (under reporting, incomplete snake databases, etc). This meta analysis indeed puts the numbers above 100.000 https://pmc.ncbi.nlm.nih.gov/articles/PMC11020954/ but I get where you're coming from! The uncertainty in these data is huge.
rvz•9mo ago
> So, I love snakes: I think they are the coolest animals out there

No they are not. Said almost no-one.

These creatures contribute almost nothing to society and even if they're used to get rid of pests, there are other animals that do it better without being an extreme danger to humans or they can be safely caught and released.

But instead, these creatures just want to bite, spit or strangle you if they feel like it and in some cases really just want to kill you (because they think you will kill them first).

You cannot reason with these creatures with full of venom in their fangs even if the situation was an accident.

squigz•9mo ago
> These creatures contribute almost nothing to society

Animals have to contribute to society to be useful to the ecology of our planet?

> You cannot reason with these creatures with full of venom in their fangs even if the situation was an accident.

You can't really reason with any creature other than a human, and that's often spotty too!

theF00l•9mo ago
That is interesting and I think it's a popular opinion. I think in line with the Epic of Gilgamesh or the Old Testament.

But allow me present another opinion.

Snakes don't do things they don't have to do. They don't kill for no reason (cf humans, cats). They do what they have to do, without much emotion or fanfare. They shed their skin and don't carry extra weight. In other cultures, a snake is a symbol of wisdom, rebirth and healing (eg the rod of Asclepius).

Outside the symbolic arguments, I think snake venom does have some research use (eg blood thinners) and some would argue snakes are mechanically cool.

Just another perspecive ofc, and I respect yours.

In the end, snakes want to survive in a competitive world.

lupusreal•9mo ago
Snakes are cuties and almost all of them are completely harmless. A great many of them have very sweet and gentle personalities.
kopos•9mo ago
We were talking to the reptile caretaker at the Abu Dhabi zoo and we learnt that

- snakes are actually cuties. And more like babies. They do not have strong fight or flight ability like mammals. If they get hurt, they go into a corner and just give up

- they're extremely misunderstood beings. When a snake is hissing, it is because it it actually very very frightened.

- their eye sight is very very bad. They detect mostly by that body heat. And they've a very hard time detecting friends vaa foes. A ball python actually curls into a ball when tensed up. The caretaker had to pet the snake to help it relax.

- most of that snakes are non venomous.

liamwire•9mo ago
I am incredibly afraid of snakes, and living in Australia that’s not an unfounded fear. Yet even I recognise this is an abhorrent and arrogant take. Nature does not need to serve us to earn its existence.
aurizon•9mo ago
Now, how to prevent the attempts of big pharma to patent these to make tens of thousand of Indians/Africans pay big $$. These AI modelers are reputedly not validly a human creation = patent/copyright. These protein constructs might have a long room temp shelf life = needed in most Indian/African bite victims.
philipkglass•9mo ago
These will probably be ignored rather than patented/monopolized by Big Pharma. A few million treatable cases per year globally, concentrated in low-income countries, is a small market to chase. Medical needs in low-income countries need to be addressed by governments or nonprofits rather than for-profit companies.

EDIT: replaced "100,000 treatable cases" with "a few million treatable cases" per https://pmc.ncbi.nlm.nih.gov/articles/PMC11020954/ referenced by Lol_arco.

aurizon•9mo ago
One hopes a storable and long lasting product will be able to save many of those 100,000 deaths(??), but you are correct - it might not offer enough $$ to USA pharma?
Lol_arco•9mo ago
Yeah there isn't enough money in it for big pharma. Maybe some other form of funding, but this is the reason why all these tropical diseases are neglected.