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Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
258•theblazehen•2d ago•86 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
26•AlexeyBrin•1h ago•3 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
706•klaussilveira•15h ago•206 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
969•xnx•21h ago•558 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
69•jesperordrup•6h ago•31 comments

Reinforcement Learning from Human Feedback

https://arxiv.org/abs/2504.12501
7•onurkanbkrc•48m ago•0 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
135•matheusalmeida•2d ago•35 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
45•speckx•4d ago•36 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
68•videotopia•4d ago•7 comments

Welcome to the Room – A lesson in leadership by Satya Nadella

https://www.jsnover.com/blog/2026/02/01/welcome-to-the-room/
39•kaonwarb•3d ago•30 comments

Ga68, a GNU Algol 68 Compiler

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
13•matt_d•3d ago•2 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
45•helloplanets•4d ago•46 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
240•isitcontent•16h ago•26 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
238•dmpetrov•16h ago•127 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
340•vecti•18h ago•149 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
506•todsacerdoti•23h ago•248 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
389•ostacke•22h ago•98 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
304•eljojo•18h ago•188 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
361•aktau•22h ago•186 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
428•lstoll•22h ago•284 comments

Cross-Region MSK Replication: K2K vs. MirrorMaker2

https://medium.com/lensesio/cross-region-msk-replication-a-comprehensive-performance-comparison-o...
3•andmarios•4d ago•1 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
71•kmm•5d ago•10 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
24•bikenaga•3d ago•11 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
96•quibono•4d ago•22 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
26•1vuio0pswjnm7•2h ago•16 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
271•i5heu•18h ago•219 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
34•romes•4d ago•3 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1079•cdrnsf•1d ago•462 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
64•gfortaine•13h ago•30 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
306•surprisetalk•3d ago•44 comments
Open in hackernews

Clinical trial: novel nutritional formula treats gut microbial overgrowth

https://medicalxpress.com/news/2025-04-clinical-trial-nutritional-formula-effectively.html
66•wglb•9mo ago

Comments

wglb•9mo ago
Journal pre-proof (pdf) https://www.cghjournal.org/article/S1542-3565(25)00241-1/pdf
canadiantim•9mo ago
Quite amazing success rate for just two weeks of treatment when the alternative is doing multiple rounds of antibiotics for months/years and not even getting that level of success.
kavalg•9mo ago
Indeed. I am just a bit concerned that the subjects were to return to their "normal" diet after the experiment, which probably was the reason to get this condition in the first place. In a next study it would be interesting to look closer into the functioning of related organs, such as liver and gallbladder (vesica fellea). E.g. did subjects have any biliary sand issues. Correlation with potable water used by the subjects would also be interesting, especially things like mineral composition, pH, organic contaminants (e.g. microplastics) as well as microbial content.
ecuaflo•9mo ago
That’s assuming it’s not typically some immunocompromising event as small as a period of stress that allows for the colonization.
kavalg•9mo ago
Yes, that is a major factor too as well as antibiotics or the combination of the two.
pazimzadeh•9mo ago
Here are the ingredients: https://mbiota.com/cdn/shop/files/OriginalFlavor-Nutrition.p...

Study design:

Eligible subjects underwent 1 week of screening, 2 weeks of exclusive oral PED, and 2 weeks of follow-up after returning to their regular diet (Supplemental Figure 1). The primary endpoint was the change in stool microbiome after PED and regular food reintroduction. Secondary endpoints included tolerance, LBT normalization rate, stool form changes, symptomatic response, and adverse events. The PED (mBiota Elemental, Good LFE, Santa Monica, USA) was provided in 300-calorie packets, adjusted eucalorically to each participant’s caloric needs (Supplemental Figure 2).

Additional packets were provided for hunger, with daily consumption documented. Water intake was unrestricted, but other foods were prohibited during the diet phase. After completing the diet, participants transitioned to bland foods (e.g., rice, potatoes, eggs, chicken, beef) for 2–3 days before resuming their regular diet.

kavalg•9mo ago
It looks it contains mostly amino acids and vitamins, usually found in other fitness supplements. Is there any "secret sauce" that I am missing?
Aurornis•9mo ago
It’s amino acids, fats, and sugar in a ratio that mirrors the elements of a standard diet.

It’s not a supplement. It has to replace your diet completely for 2 weeks, no exceptions.

By consuming amino acids instead of proteins (which are composed of amino acids) and omitting fiber it starves skips straight to absorption and starves the bacterial overgrowth.

It’s an old concept. The unique part of this one is that it supposedly tastes okay.

kavalg•9mo ago
Yeah, the taste matters if you are going to eat it for 2 weeks :). You will probably still hate it after the first week, but it is just one week of misery instead of two. I did some fasting in the past, leaving only water, tea (no sugar) and peeled apples in my diet. Had to do it for 2 weeks, but only made it to the 11th day. The issue with that one was the low calories, which doesn't correspond well with active work (I did not plan properly to take the second week off). Nevertheless, it helped solve the colitis issue, with which I'd been struggling for a few months. An interesting observation was that up to say day 4 or 5 you actually have more energy and sleep less. But after that it was a bit of a struggle to retain the same levels of energy and be productive at work.
Etheryte•9mo ago
The secret sauce, so to say, is that it's not a supplement, it's all you eat for the duration of the treatment. As someone who was on a liquid only diet for six weeks following a surgery, I can't imagine this being anything short of absolutely miserable.
Aurornis•9mo ago
This is an elemental diet, which is not new. An elemental diet uses amino acids, fats, sugars, and vitamins to provide the elements of a human diet (hence the name) without whole or partial proteins, fiber, and other things that gut bacteria like to eat. The bacterial overgrowth subsides because you’re not giving it the food it wants. This means you can’t eat anything other than this diet mix for 2 weeks, no exceptions.

The only novel part about this branded one is that it’s palatable. That’s actually a big advantage because a plain elemental diet tastes so bad that it’s hard to tolerate.

You can search for DIY elemental diet recipes and there are several sources for the amino acid blends they use. People report some success, if they can tolerate the taste.

geden•9mo ago
Presumably fasting would achieve the same result?
0xEF•9mo ago
Maybe, but nobody can package and sell you fasting.
Etheryte•9mo ago
Novo Nordisk sure is trying.
bitmasher9•9mo ago
Quick, someone make an online course about fasting and sell it for $49.99.
failrate•9mo ago
In my personal experience with SIBO, fasting can mitigate symptoms but does not resolve the SIBO.
Aurornis•9mo ago
It requires two continuous weeks. Fasting that long would be devastating.
rikkert•9mo ago
I actually followed this specific elemental diet for two weeks to treat my hydrogen SIBO, unfortunately without success. I would not recommend this to anybody unless it's absolutely your last chance. I was constantly hungry, cold and lethargic. The shakes taste /terrible/ so I wouldn't really call it palatable. I shiver just thinking about it. I'm sure it works for some people, and I'm happy for them.
NotGMan•9mo ago
~350$ per week if you want to buy it.

Pretty sure carnivore or some other no-fiber low carb would be a bit cheaper :)

pingou•9mo ago
Don't forget 425 euros to ship to Europe.
rikkert•9mo ago
Yeah, that's really a dick move.
eth0up•9mo ago
If anyone is willing, please help me understand, not why, but how someone can subsist on a diet with zero fiber. I know folks who can sit down to a plate of nothing more than white rice and meat without petrifying their backside. If I tried to do the same, I'd be using solvents and chipping hammers every morning. Have I missed something? Is this a 99% absorption rate diet? Where does it go?
sixplusone•9mo ago
Fiber is not necessary, and can be the cause of constipation. Your body has ways of managing, and individuals who don't eat fiber have more motility:

https://pmc.ncbi.nlm.nih.gov/articles/PMC3435786/

"Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms"

eth0up•9mo ago
Fascinating. I intend to do some research on this, but if you're aware of any methods or protocols to retrain the system for increased motility in absence of fiber, drop a link. I'm pretty sure that an abrupt change would not work well for one adapted to fiber and observe such every time the situation arises. Probiotics and physical activity don't affect this for me.

Edit: I see that the report did pretty much exactly what I say doesn't work. This is confusing when considered through my own experience. Definitely interesting though.

jinpa_zangpo•9mo ago
I wonder if a water only fast would also work.