I wouldn't say so at all. Poor eyesight carries on smartly. Baldness. I enjoy both.
But an old story about the controller code for a surface-to-air missile comes to mind.
Someone looking at the memory allocator spots an obvious resource leak: "This code is going to crash."
The reply was that, while the point was theoretically valid, it was irrelevant, since the system itself would detonate long before resource exhaustion became an issue.
So too prostate cancer back in the day: war, famine and plague were keeping the lifespan well below the threshold of every man's time bomb.
A better method would be to confine the program to monozygotic twin pairs of young women with spotless genetic heritage, and inseminate one twin with frozen sperm and the other with current sperm. The "current sperm" child (CS) could be closely monitored, and the "frozen sperm" (FS) child fitted with an explosive chastity device which, in the event that CS is found to have developmental issues, are remotely-detonated to ensure the tainted line does not persist.
Simple-as.
Do you have any source for this? As someone born in the summer to a farming family with poor eyesight, I find it hard to believe that happened because I wasn't exposed to enough sun as an infant or child.
I've worn glasses since I was 2.
I just so happen to have Hyperopia with astigmatism, neither of which came from a lack of outdoor exposure. (If anything, I needed less time outside).
That's a bit of the issue I have with such a broad generalization. It's true that for some, a lack of time outdoors damaged their eyesight, it's not universally true that all or perhaps even most poor eyesight is a result of staying indoors.
I strongly suspect it's more a matter of "won't kill you". Nearsightedness is far more common than farsightedness, and it's only in the last two hundred or so years that there's been any major benefit in seeing fine details at distance. The fuzzy shapes afforded by 20/80 vision are plenty enough to hunt a mammoth.
Having 20-20 vision is nice for avoiding lions and tigers, but it's a luxury spec, because movement acuity doesn't decrease linearly with nearsightedness, and movement acuity (plus traveling in groups, as prehistoric humans were wont to do) can take care of business decently-enough on its own - so I wouldn't call it "evolutionary-pressure"-nice.
> It’s odd for there to be such an easily-removable design flaw in the human body; evolution tends to remove them.
What's up with those things?!
I couldn't find the source just now (in the 30 seconds I searched for it), but I always thought it was an interesting idea.
The answer to every "why hasn't evolution done x" question is selection pressure.
An enlarged prostate is something that people get in their 60s and later. Most people are done with reproduction long before that event. There is simply very little and very low selection pressure.
It's pretty much the reason why most humans have peak health into their 40s.
Don't expect evolution to "fix" anything for humans that doesn't commonly impact 20yos.
"It’s odd for there to be such an easily-removable design flaw in the human body; evolution tends to remove them. Since it strikes at advanced ages, BPH doesn’t make a big impact on a man’s ability to pass on his genes. But being the leading cause of male infertility sure does. Their explanation is that evolution hasn’t had much time to work on the problem; in animals the spermatic vein is horizontal, and doesn’t have or need one-way valves. It’s our standing upright that yields the problem; in evolutionary terms that’s a recent development."
What is the problem with baldness other than having a cheap excuse for not being successful in life? I actually enjoy looking a bit like Larry Fink.
Hides long list of ethical problems with the concept
And I don’t see any problems with late-life reproduction, assuming we can make it reliable and healthy. If anything, some countries desperately need it.
Evolution is really slow on average, but locally it moves quite quickly and probably explains the large variation between members of a species.
Add strong selective pressure to that high local speed and you can change a good part of the genotype within a couple of generations. See: animal husbandry. You can breed a new race of dog within 5-10 generations.
Ethics aside we could probably breed people who can sniff out Alzheimer's in less than 250 years.
Our current late reproduction style will very likely influence future generations health at older ages.
Men are (within reason) considered handsome in media even in old age. Wrinkles and gray hair can be seen as sexy (again, within reason), but only in men.
Women are discarded or relegated to sexless granny roles (except maybe for comedic purposes, where sexuality is the butt of a joke). Actresses are replaced by younger women because they are not sexy enough even when their male equivalents aren't (looking at you, Top Gun: Maverick).
I'm not saying there aren't exceptions in particular movies that deal with this topic; I'm talking about the general trend.
Women are different. It ranges — alot, and is more about EQ and scarcity. If you have a moderate baseline level of physical attractiveness, moderately fit (Jon two miles let’s say), not an asshole, and not living with mom, a 40-60 year old guy is a hot commodity.
I think we are already post evolutionary, or control it ourselves. Not a big issue either IMO, it's totally ok that this is happening.
The ethical problems were fun to read about! But would be significantly less fun to live through.
Just kill all offspring if one of the parents die of some unwanted cause.
Allows people to still get kids in the optimal age, yet applying old-age selection pressure.
Modern medicine has messed with this. We weren’t meant to “old”.
Finasteride or dutasteride. They control BPH perfectly, while also treating male pattern baldness. Combine with daily tadalafil to offset any chance of the dubious sexual side effects, while also reducing gynecomastia (it's also an aromatase inhibitor!). Make sure to have regular 5ari-aware PSA screenings to make sure high grade cancers are caught and you are golden.
fin/dut + tad are my favorite medications to keep men fresh for many more years than intended by nature.
Have your children before you start though, as dut will probably make you sterile eventually.
I've personally had very little luck with official channels there. Most won't prescribe anything for hair loss, several dermatologists said to just get used to it, one would prescribe fin pills, i.e. systemic - which did eventually give me pain in the breast tissues (so I ceased using it), but not topical, citing that it's too new on the market. I was unable to find anyone who would or even could look at serum DHT. I eventually settled on just paying one of these apparently legal telemedicine vendors 20 bucks per topical fin prescription.
You already decided to take one hormonal disruptor, so why not go all the way? Find a private andrologist that prescribes you fin/dut + an aromatase inhibitor. Daily tadalafil also acts as aromatase inhibitor by the way. Should be enough to offset the estrogen increase from finasteride. It's worth a try.
I personally don't really believe in topical min/fin/dut: You are probably just getting the same effects and side effects you'd get from a lower oral dose.
The studies on topical finasteride support this. You just believe it's not in your blood and thus there is no nocebo effect to give you ED but it very much is.
I believe people with self diagnosed PFS have a mix of mental illness and (sometimes) non diagnosed physical illness.
I'd like to see a self diagnosed PFS sufferer not get an erection, pumped up on 150 mg sildenafil + 10g L-Citrullin.
> Is Tad addressing this hazard in your view?
Let me address your question from a different angle: Being on an sufficient amount of daily tadalafil would certainly reduce the chance of you believing you got PFS, because it would guarantee you a working erection in any situation.
Good luck :)
I do not know about Finasterid in detail, but the small-printing for Taladafil says clearly its _not_ for daily use.
https://www.hims.com/blog/daily-cialis-costs-benefits
https://investor.lilly.com/news-releases/news-release-detail...
It's superior to taking it on an as-needed basis because it has positive long term effects on your cardiovascular and penile tissue.
Apart from that: I do not expect the skeletal pain after D2 to be less when dropping it daily? :-D
EDIT: Or i'm mixing up Sindenafil and Taladafil? Im not a medic :-D
That being said, the article does state that its proposed treatment doesn't last forever, though I couldn't find any numbers on how long it is expected to last.
Tadalafil (Cialis) does not seem to do the same, however other potential side effects involving sight and hearing are listed.
I’ll ask my doctor if such a swap would be advisable.
Interesting. I wonder how many how many other issues we could screen for using such simple, low cost tools. Some scales can already detect reduced blood flow in the feet (which can be a sign of all sorts of nastiness).
Once per day, when peeing, do it differently. 1. Release the stream during the in-breath. 2. Stop and hold the stream on the outbreath. 3. If not yet bored or tired go back to 1. Else - finish peeing normally. That's it.
And note that for most people, a week to few weeks of the exercise give stronger orgasms and ability to delay the ejaculation.
I've experienced all those benefits when I started walking two times a day, 8-10 thousands of steps a day continuously for several weeks. I haven't performed any other exercises.
But it's really boring and you need to do it every day. I do it only because I need to walk a dog.
One such prescription would be to do deep work early in the day then walk after and walk again 2 hours before bed. Another would be split the deep work with a 1 hour walk and do the 2nd walk after the 2nd block.
It may be more fulfilling with lots of interesting ideas rattling around. YMMV
Even when I'm not working, I like taking long walks to think about family, friends, video games, etc.
Its a great way to get into your head without the distraction of a phone or feed or forced message.
- I started carrying a camera
- I started using the Merlin Bird ID app
Photography has made me realize how much I was previously ignoring. There’s so much to see, and even when walking the same route over and over, there’s an astounding amount of change over time. Often little things.
The Bird ID app made me realize just how many unique birds were making up the sounds I was hearing. As I learned to distinguish between them, I found myself fascinated in a way that I’d never been before.
Walks became almost meditative over time, and the sights and sounds a kind of salve for my often tired brain.
I often feel like I can think more clearly when walking as well, and thought processes kind of just sort themselves out as I go.
I highly recommend making walks more than just a way to move your body. They can be much more, and getting the benefits of movement almost feels like a happy side effect.
I do a lot of daydreaming when I walk, too (to my wife and daughter's impatience!).
I'm lucky enough to have a pedestrian path to do my long walks (so no cars or even bikes to contend with, bikes have a dedicated parallel path), so I listen to a podcast while walking around 1 hour/day.
The problem is really prudeness in society, especially the American one (the main market for many industries). It's holding back things like sex tech.
The startup company is Vivifi Medical[1] and they have clinical trials underway with ten men in a Central American country (El Salvador?). They claim that BPH reverses in a few months after their procedure. Their procedure uses a minimally invasive tool of their own invention to snip the vertical blood vessels that are backflowing from age and gravity, and splice them into some existing horizontal blood vessels. On their board of advisors is Dr. Billy Cohn[2], the wildly innovative heart surgeon who is famous for shopping for his medical device components at Home Depot. Dr. Cohn is on the team building the BiVACOR Total Artificial Heart. Vivifi presented their estimated timeline to FDA approval, with proposed general availability in 2028. My personal BPH will be at the head of the line for this procedure.
As far as a startup, their TAM is about 500 million men. I had the Urolift procedure for BPH three years ago, and it cost about $15K on the Medicare benefits statement, though Urolift's clips amounted to only a few thousand dollars. Similarly, Vivifi's charges for this procedure are only a few thousand dollars per procedure, but it holds the promise of being a final solution. Currently Urolift is much less disruptive than TURP, which needs a couple of days in the hospital and almost always leads to retrograde ejaculation (into the bladder).
it seemed to work for me, took it for few months, 10y+ ago. "Lasted" 8-9 years.. - until recently..
Except that you make work your prostate everyday, multiple times, since your adolescence, whereas a woman doesn't breastfeed everyday since adolescence.
Although the rest of the world benefitted from this research, it was the US that paid for it and did it. I am sad that we are now entering a 'transactional democracy' (you only get as much democracy as you can afford) but then again, that's where the rest of the world has been since WW2. Anecdotal data has driven 'old wives tale medicine' for millenia. I am hoping though that big data, the internet, AI, and the judicious use of Bayes' theorem can distill real knowledge from the vast sea of misinformation that surrounds us.
marvel_boy•6h ago
cs02rm0•5h ago
I wonder how many potential answers to such problems are out there, known to a few but not acted on by the masses.
cactusplant7374•2h ago
Multiple surgeries is not sustainable. Too much uncertainty.
kevin_thibedeau•1h ago
It seems highly failure prone. If you don't block the flow are you going to stroke out?
gavinray•5h ago
One of the primary causes of BPH is from androgens, specifically the conversion of testosterone -> dihydrotestoerone via the 5-ar enzyme.
The prostate is an androgen-sensitive tissue, and DHT causes enlargement.
It's not guaranteed to fix it, but it's one option.
amelius•2h ago
ekianjo•5h ago
fredsmith219•3h ago