"Metagenomics technology uses cutting-edge genomic sequencing, which can identify all bacteria, fungi or parasites present in a sample by comparing them against a database of millions of pathogens.
[if you] do a separate test for each and every one and if you've got an infection with something that's unexpected, rare or not previously known, you won't find it."
Leptospirosis is known to be both prevalent in tropical areas and to be difficult to positively culture and identify.
Don't doctors always ask about international travel when you present with an unknown illness? The exact timeline is difficult to infer from the article but that seems like pretty important detail to overlook.
Metagenomics are particularly good in cases like this where tissue samples are small. These spirochete are too small for light microscopy - probably why the lab missed them.
dtech•4h ago
ars•4h ago
From my understanding it's much less common to get antibiotics in the UK vs US.
OJFord•3h ago
Maybe they tried something broad spectrum here, and what was necessary (and required the sequencing to know what it actually was) was something more targeted.
MattPalmer1086•9m ago
I've had 4 infections this year, including an ear infection, fingernail, chest (that caused pneumonia on my son) and one that caused my left eye to swell up.
I received no antibiotics for any of them, just a suggestion that if they didn't go away they might prescribe some. They all got better without them (except my son, who ended up in emergency and was given two different ones which cleared up his infection rapidly).
In the past though I'm pretty sure I would have been prescribed them immediately.
ajb•4h ago
tekla•4h ago
You know how everyone complains about antibiotic resistance? Yeah, they're not going to give some random antibiotic if they have no idea what something might be.
londons_explore•3h ago
Modern medical ethics requires you always prioritise the individual over society, which means one should always give antibiotics if the benefits outweigh the downsides for this specific patient, even if that means you might cause antibiotic resistance for everyone else in the future.
tekla•3h ago
You don't get to complain about antibiotic resistance if at the first sign of an issue you demand a bathing in random antibiotics, especially if you don't even know if you have a bacterial infection in the first place
Hnrobert42•3h ago
londons_explore•3h ago
Antibiotic resistance could just as easily first happen in the sewers and other places where there is a lowish concentration of antibiotics.
TaurenHunter•2h ago
londons_explore•48m ago
The prisoner would undoubtedly have a better life if not imprisoned. But society does better if they are imprisoned.
tialaramex•3h ago
You're assuming (and indeed US medicine seems to assume this everywhere) that since there don't usually seem to be major negative side effects from antibiotics they're harmless. However we are now confident they're not - lots of interesting things live inside us and whether or not they can cope with antibiotics varies, we're an ecosystem and so this intervention is a massive change to that ecosystem, and while it will usually be justifiable if we know there's an infection if we don't know that's now a gamble.
BobbyTables2•2h ago
jghn•3h ago
like_any_other•3h ago
typingonmyphone•3h ago
nsagent•3h ago
If not for getting sick recently I'd probably still be dealing with whatever gut infection I had that the doctors essentially ignored.
Aurornis•2h ago
There are non-absorbable antibiotics designed to target intestinal bacterial overgrowth. It’s hit or miss, though.
Unfortunately for many people, taking antibiotics can have the opposite effect where it creates or worsens gut problems. It’s not an easy or reliable solution.
2Gkashmiri•2h ago
.dressed chicken .peanuts .soyabean oil .cumin
And we used to use these food "daily".
The allergy eruptions, digestive issues went from 100 to 5 starting next day.
This is such a small thing to check but it has saved us as a lot of trouble.
jchw•1h ago
I've personally had quite some experiences navigating health issues, health anxiety, the medical system, etc. Nothing terribly interesting, but, still. I'm actually in middle of scheduling tests to see if I might, in fact, have an autoimmune condition. If they do find evidence of that, then it will have taken me around 6 years to figure it out from my very first symptoms. Thanks to modern medical science, I have little reason to sweat over it, though. (Of course, I'm still hoping for a negative, but at least in the case of a positive I can have the relief of knowing what the hell was wrong with me all this time.)
soulofmischief•1h ago
Now I have to go through the entire process again to rule out everything else before getting a fibromyalgia diagnosis.
Anyway antibiotics have unrelatedly literally saved my life on several occasions now and I am glad that in a few emergencies I was able to access them on the street without needing to navigate the healthcare system. Antibiotics are too tightly controlled for humans and not enough for animals.
That said, I have had to take them enough that I've definitely experienced negative gut effects a couple of times. Now I reach for probiotics after a regimen.
TZubiri•1h ago
sushid•30m ago