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OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
438•klaussilveira•6h ago•100 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
785•xnx•11h ago•475 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
150•isitcontent•6h ago•15 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
15•matheusalmeida•1d ago•0 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
137•dmpetrov•6h ago•60 comments

A century of hair samples proves leaded gas ban worked

https://arstechnica.com/science/2026/02/a-century-of-hair-samples-proves-leaded-gas-ban-worked/
77•jnord•3d ago•5 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
44•quibono•4d ago•3 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
254•vecti•8h ago•120 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
316•aktau•12h ago•155 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
181•eljojo•9h ago•124 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
315•ostacke•12h ago•85 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
398•todsacerdoti•14h ago•218 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
325•lstoll•12h ago•235 comments

Make Trust Irrelevant: A Gamer's Take on Agentic AI Safety

https://github.com/Deso-PK/make-trust-irrelevant
5•DesoPK•54m ago•2 comments

Show HN: R3forth, a ColorForth-inspired language with a tiny VM

https://github.com/phreda4/r3
48•phreda4•5h ago•8 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
15•kmm•4d ago•1 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
109•vmatsiiako•11h ago•34 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
188•i5heu•9h ago•131 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
145•limoce•3d ago•79 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
239•surprisetalk•3d ago•31 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
982•cdrnsf•15h ago•417 comments

I'm going to cure my girlfriend's brain tumor

https://andrewjrod.substack.com/p/im-going-to-cure-my-girlfriends-brain
53•ray__•3h ago•13 comments

FORTH? Really!?

https://rescrv.net/w/2026/02/06/associative
41•rescrv•14h ago•17 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
19•gfortaine•4h ago•2 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
4•gmays•1h ago•0 comments

Evaluating and mitigating the growing risk of LLM-discovered 0-days

https://red.anthropic.com/2026/zero-days/
36•lebovic•1d ago•11 comments

Show HN: Smooth CLI – Token-efficient browser for AI agents

https://docs.smooth.sh/cli/overview
77•antves•1d ago•57 comments

Why I Joined OpenAI

https://www.brendangregg.com/blog/2026-02-07/why-i-joined-openai.html
59•SerCe•2h ago•47 comments

The Oklahoma Architect Who Turned Kitsch into Art

https://www.bloomberg.com/news/features/2026-01-31/oklahoma-architect-bruce-goff-s-wild-home-desi...
19•MarlonPro•3d ago•4 comments

Show HN: Slack CLI for Agents

https://github.com/stablyai/agent-slack
40•nwparker•1d ago•10 comments
Open in hackernews

New species of methane-producing archaea discovered in the human gut

https://phys.org/news/2025-04-microbiologists-species-methane-archaea-human.html
68•PaulHoule•9mo ago

Comments

vincekerrazzi•9mo ago
I love seeing this kind of thing posted but it’s not surprising in the slightest. We’re forever discovering brew bacteria in our guts that are apparently unique. When I had my gut bacteria tested a full 20% of what I had hadn’t been named yet, and some possibly hadn’t been seen before.
rbanffy•9mo ago
I find it shocking and disturbing that we know so little about our own biology we are still discovering such things.

It’s like doctors didn’t have centuries to examine human bodies to learn from them.

PaulHoule•9mo ago
It is not just the human body. Mysterious bacteria that people don't know how to cultivate in isolation are everywhere. Part of the story is that many bacteria don't really live alone but they depend on a plant or an animal or even other bacteria such as one species of large rod bacteria that has a different species of little rod bacteria that live on it, biofilms, etc.
rbanffy•9mo ago
> It is not just the human body.

I know, but I would expect doctors would, by know, not be so frequently surprised by things lurking in their own bodies.

Not that long ago a never before observed structure every human always had was discovered: https://www.science.org/content/article/scientists-say-they-...

pfdietz•9mo ago
One disturbing recent discovery is that a strain of E. coli produces a genotoxin, colibactin, that could be the cause of the doubling in colon cancer among those under age 55 in the last 20 years.

https://www.opb.org/article/2025/05/01/gut-bacteria-may-play...

m3047•9mo ago
How many people took Zantac (ranitidine) the highly spammed H2 blocker? https://www.nfcr.org/blog/3-common-heartburn-drugs-are-assoc...

Doctors don't ask about this. People still take Prilosec, and it's acknowledged that it causes cancer. You get what you give: confirmation bias.

Edit: The essential problem is that ranitidine isn't shelf-stable. This could explain some problems with other theraputics which we won't name to avoid downvoting / politics.

pfdietz•9mo ago
> and it's acknowledged that it causes cancer.

This is not acknowledged as demonstrated, the studies are contradictory and observational.

m3047•9mo ago
It is acknowledged that nitrosamines cause cancer. It is acknowledged that ranitidine breaks down on the shelf to nitrosamines: this wasn't discovered by the FDA or another government agency, it was discovered by a mail-order, compounding pharmacy which also tests ingredients. Their discovery led to ranitidine being recalled.

As for prilosec: the cancer risk is acknowledged in the packaging.

pfdietz•9mo ago
I wasn't talking about ranitidine, so I don't know why you brought that up.

I don't see anything about cancer in the product information for Prilosec.

https://www.amazon.com/Prilosec-OTC-Heartburn-Medicine-Versi...

Perhaps you mean in California, where everything + dog has a cancer warning by law?

m3047•9mo ago
Squeeze this lemon till the juice come out: https://www.verywellhealth.com/does-omeprazole-cause-cancer-...

ddg:prilosec cancer

Buy some. Read the packaging. Fuck Amazon.

pfdietz•9mo ago
I have a package of generic omeprazole right in front of me. There is no cancer warning.
m3047•9mo ago
Fix it, so somebody doesn't have to die like you.
pfdietz•9mo ago
Your effort to fabricate evidence having failed, we see you didn't actually need evidence to reach your conclusion anyway.
m3047•9mo ago
Hey. I brought up ranitidine because it is specifically associated with nitrosamines, and nitrosamines cause colon cancer. No redirect: colon cancer. You take issue with prilosec being admitted to this debate, then that would be because ion pump moderators cause stomach cancer. My bad: stomach cancer irrelevant to you.

You can't see ranitidine when it farts in your face: nitrosamines cause colon cancer. Why is that not relevant? Why is that not potentially more relevant than foo foo microbes? (By the way, I eat sour cream or yogurt when I eat meat or take e.g. glucosamine. YMMV.)

olau•9mo ago
Biology is so complex that extremely little is known about details. Grab a college textbook on introduction to zoology, and prepare to be blown away.
parasti•9mo ago
Why do you find it shocking and disturbing? If you go to the doctor, the average process of diagnosis and treatment is much like printf debugging - just sprinkle some based on instinct and run it again. We're surrounded by technological advancement that is making us feel like we're far in the future, but there's still so much we don't know.
DougN7•9mo ago
How many of those centuries would they have been able to inspect, catalog, and widely distribute their findings about stuff as small as bacteria? The tools we have now are quite new, and still insufficient even now. Maybe in another 100 years we’ll have it all mapped out.
thegrim33•9mo ago
I had an interesting experience recently where I was sick with a virus for an entire month, ending up in multiple urgent cares followed by the ER for 24 hours.

They took blood from me seemingly every 10 minutes and ran every test they could and in the end couldn't figure out what it was. The doctors (in a very major hospital in a very major city) didn't even seem surprised, they just shrugged and said I had some unknown virus that they didn't have a test for. The way they acted it seemed like a regular occurrence. Just some mystery virus.

It was just so shocking for me that there could be some virus out there that had me horribly sick for an entire month, much sicker than covid or the flu ever made me, and there's not even a test for it, it's just spreading out there doing its thing. Makes me wonder how little we really know.

rbanffy•9mo ago
I’m not surprised you got sick from something that wasn’t identified before you got better. These things happen all the time.

I would imagine it was a known (or new) virus that would be identified if we had the time and resources. With so much money in pharmaceutical applications I am surprised there is still unsequenced DNA.

BobbyTables2•9mo ago
Try getting one of three experienced specialists to even test for the #2 most common ailment in their field…

Would be easier to catch oiled seals while blindfolded, in the rain.

mmooss•9mo ago
Archaea are not bacteria; that's why this discovery is so significant.
kayo_20211030•9mo ago
> The discovery of Methanobrevibacter intestini and GRAZ-2 opens up a new chapter in archaea research as well as new perspectives for personalized microbiome medicine in the future.

It advances research, but personalized microbiome research seems a stretch goal. At least, it doesn't sound like it's likely to happen soon.

leephillips•9mo ago
You can blame the dog if you want to. I’m blaming Methanobrevibacter intestini sp. nov. (strain WWM1085).
wonderwonder•9mo ago
we are not even individuals, we are just walking cities of cells. We are Chimera.
ChuckMcM•9mo ago
This is perhaps what amazes me the most. We're each a Borg, we are a collective that has adapted the biological distinctiveness of bacteria that we've assimilated into a collective that "thinks." Pretty wild. That we gather in groups and act collectively just adds another layer of recursion to life.
wonderwonder•9mo ago
It does make one reconsider the brain as the center of consciousness. Can we really upload our mind if the mind is actually the entirety of our collective being.
partomniscient•9mo ago
Marvin Minsky wrote about this in the 1980's:

https://en.wikipedia.org/wiki/Society_of_Mind

johnea•9mo ago
The original source article:

https://microbiologysociety.org/news/press-releases/new-spec...

Which also works without javascript or cookies, unlike phys.org