Usually, at some point in time, cells cannot replicate correctly due to telomere shrinking.
Are jellyfishes not subject to any of this?
https://www.newscientist.com/article/2335495-immortal-jellyf...
> Transcripts associated with telomere organization and maintenance, DNA integration, repair, and damage response were among those that showed high expression in the cyst relative to medusa and polyp.
According to this theory, the reason the epigenome accumulates damage is because while the dna strand is static through the life of the organism, and therefore has all sorts of error correction mechanisms, the epigenome changes on a per-cell level as the organism grows according to hormonal signals and so on. That's how a nerve cell and a muscle cell can have the same dna strand but act almost as if they are from totally different species. Therefore it has to be flexible and can't be error checked in the same robust way. So aging is a consequence of multicellular life cycles.
decimalenough•6h ago
https://www.asiaone.com/singapore/pe-2023-it-consultant-says...
IncreasePosts•5h ago