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Reducing Huntington’s-related repeat expansions in patient cells and in mice

https://www.nature.com/articles/s41588-025-02172-8
25•bookofjoe•3d ago

Comments

loa_in_•1d ago
This century truly is amazing to witness as incurable diseases slowly become reasonably within reach to tackle. A huge step from widely established symptom treatment into reaching right to the source/root cause.
chevman•1d ago
What is the timeline/next steps to make this a usable therapy in humans?

Not familiar with state of the art techniques in this realm currently.

throwawayObvs27•11h ago
I think lots of people would support a world in which it was illegal for Huntington's carriers to reproduce (or two people with recessive Huntington's alleles, whichever). That rule would stop an unimaginable amount of human suffering. But unfortunately that highly acceptable idea (I think) sits within a wider category that is extremely controversial, unpopular and dangerous.

People cannot be trusted to just outlaw Huntington's on its own, because the next politician will take power and outlaw some ethnic group they hate, arguing that there is precedence. Which is really annoying.

atiedebee•9h ago
That is extremely unethical. Going off Wikipedia, most people with Huntington's start presenting symptoms from 30 to 50 years of age. Those are 30 years that they can live a normal fulfilling life. Prohibiting people from having kids because their children may or may not live a shorter life is, as you pointed out, a slippery slope.

Photos taken inside musical instruments

https://www.dpreview.com/photography/5400934096/probe-lenses-and-focus-stacking-the-secrets-to-incredible-photos-taken-inside-instruments
477•worik•9h ago•24 comments

Valkey Turns One: Community fork of Redis

https://www.gomomento.com/blog/valkey-turns-one-how-the-community-fork-left-redis-in-the-dust/
115•cebert•7h ago•29 comments

Surprisingly fast AI-generated kernels we didn't mean to publish yet

https://crfm.stanford.edu/2025/05/28/fast-kernels.html
240•mfiguiere•9h ago•60 comments

Mary Meeker's first Trends report since 2019, focused on AI

https://www.bondcap.com/reports/tai
121•kjhughes•9h ago•41 comments

Reverse engineering of Linear's sync engine

https://github.com/wzhudev/reverse-linear-sync-engine
65•flashblaze•2d ago•6 comments

Beating Google's kernelCTF PoW using AVX512

https://anemato.de/blog/kctf-vdf
270•anematode•13h ago•82 comments

The ‘white-collar bloodbath’ is all part of the AI hype machine

https://www.cnn.com/2025/05/30/business/anthropic-amodei-ai-jobs-nightcap
345•lwo32k•16h ago•576 comments

Show HN: MCP Defender – OSS AI Firewall for Protecting MCP in Cursor/Claude etc.

https://mcpdefender.com
15•gsundeep•1d ago•7 comments

Show HN: Icepi Zero – The FPGA Raspberry Pi Zero Equivalent

https://github.com/cheyao/icepi-zero
123•Cyao•2d ago•25 comments

How large should your sample size be?

https://vickiboykis.com/2015/08/04/how-large-should-your-sample-size-be/
13•sebg•2d ago•3 comments

Microsandbox: Virtual Machines that feel and perform like containers

https://github.com/microsandbox/microsandbox
282•makeboss•16h ago•127 comments

Revenge of the Chickenized Reverse-Centaurs

https://pluralistic.net/2022/04/17/revenge-of-the-chickenized-reverse-centaurs/
75•GreenWatermelon•2d ago•21 comments

Systems Correctness Practices at Amazon Web Services

https://cacm.acm.org/practice/systems-correctness-practices-at-amazon-web-services/
317•tanelpoder•16h ago•111 comments

Java Virtual Threads Ate My Memory: A Web Crawler's Tale of Speed vs. Memory

https://dariobalinzo.medium.com/virtual-threads-ate-my-memory-a-web-crawlers-tale-of-speed-vs-memory-a92fc75085f6
46•dariobalinzo•1d ago•16 comments

Every 5x5 Nonogram

https://pixelogic.app/every-5x5-nonogram
37•eieio•5h ago•12 comments

Ray Tracing in J

https://idle.nprescott.com/2020/ray-tracing-in-j.html
55•todsacerdoti•2d ago•8 comments

Silicon Valley finally has a big electronics retailer again: Micro Center opens

https://www.microcenter.com/site/mc-news/article/micro-center-santa-clara-photos.aspx
193•modeless•7h ago•105 comments

Anthropic launches a voice mode for Claude

https://techcrunch.com/2025/05/27/anthropic-launches-a-voice-mode-for-claude/
70•kordlessagain•2d ago•19 comments

The Darwin Gödel Machine: AI that improves itself by rewriting its own code

https://sakana.ai/dgm/
158•birriel•17h ago•166 comments

Show HN: Circle Crop Image

https://circlecropimage.io/
9•artiomyak•3d ago•6 comments

How to run cron jobs in Postgres without extra infrastructure

https://wasp.sh/blog/2025/05/28/how-to-run-cron-jobs-in-postgress-without-extra-infrastructure
58•Liriel•2d ago•20 comments

StackAI (YC W23) Is Looking for SWR and Tailwind Wizards

https://www.ycombinator.com/companies/stackai/jobs/C1rOopy-frontend-engineer
1•baceituno•8h ago

Jerry Lewis's “The Day the Clown Cried” discovered in Sweden after 53 years

https://www.thenationalnews.com/arts-culture/film-tv/2025/05/29/jerry-lewis-day-the-clown-cried-discovered/
147•danso•9h ago•68 comments

Show HN: Smart Silence – Remind your iPhone to stay quiet in quiet places

https://testflight.apple.com/join/47CJ31VK
28•ebagsnave•2d ago•11 comments

Adam Riess and the Hubble tension

https://www.theatlantic.com/science/archive/2025/05/adam-riess-hubble-tension/682980/
79•samizdis•14h ago•67 comments

Copy Excel to Markdown Table (and vice versa)

https://thisdavej.com/copy-table-in-excel-and-paste-as-a-markdown-table/
78•thisdavej•1d ago•14 comments

Show HN: Leap – Full-stack AI developer agent that deploys to AWS

https://leap.new
11•machekb•14h ago•1 comments

De Bruijn notation, and why it's useful

https://blueberrywren.dev/blog/debruijn-explanation/
124•blueberry87•13h ago•34 comments

A Smiling Public Man

https://salmagundi.skidmore.edu/articles/1407-a-smiling-public-man
39•crescit_eundo•12h ago•2 comments

Show HN: W++ – A Python-style scripting language for .NET with NuGet support

https://github.com/sinisterMage/WPlusPlus
89•sinisterMage•14h ago•49 comments