frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Tiny C Compiler

https://bellard.org/tcc/
84•guerrilla•2h ago•35 comments

SectorC: A C Compiler in 512 bytes

https://xorvoid.com/sectorc.html
170•valyala•6h ago•30 comments

You Are Here

https://brooker.co.za/blog/2026/02/07/you-are-here.html
52•mltvc•2h ago•65 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
105•surprisetalk•6h ago•102 comments

Brookhaven Lab's RHIC concludes 25-year run with final collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
40•gnufx•5h ago•43 comments

The F Word

http://muratbuffalo.blogspot.com/2026/02/friction.html
91•zdw•3d ago•44 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
125•mellosouls•9h ago•262 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
874•klaussilveira•1d ago•268 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
164•AlexeyBrin•12h ago•29 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
122•vinhnx•9h ago•15 comments

FDA intends to take action against non-FDA-approved GLP-1 drugs

https://www.fda.gov/news-events/press-announcements/fda-intends-take-action-against-non-fda-appro...
51•randycupertino•1h ago•49 comments

First Proof

https://arxiv.org/abs/2602.05192
89•samasblack•8h ago•61 comments

Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
78•thelok•8h ago•16 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
258•jesperordrup•16h ago•84 comments

Show HN: A luma dependent chroma compression algorithm (image compression)

https://www.bitsnbites.eu/a-spatial-domain-variable-block-size-luma-dependent-chroma-compression-...
25•mbitsnbites•3d ago•1 comments

Show HN: Browser based state machine simulator and visualizer

https://svylabs.github.io/smac-viz/
7•sridhar87•4d ago•3 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
544•theblazehen•3d ago•199 comments

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

https://github.com/Momciloo/fun-with-clip-path
45•momciloo•6h ago•9 comments

I write games in C (yes, C) (2016)

https://jonathanwhiting.com/writing/blog/games_in_c/
158•valyala•6h ago•140 comments

Selection rather than prediction

https://voratiq.com/blog/selection-rather-than-prediction/
22•languid-photic•4d ago•5 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
228•1vuio0pswjnm7•13h ago•368 comments

Microsoft account bugs locked me out of Notepad – Are thin clients ruining PCs?

https://www.windowscentral.com/microsoft/windows-11/windows-locked-me-out-of-notepad-is-the-thin-...
68•josephcsible•4h ago•91 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
105•onurkanbkrc•11h ago•5 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
132•videotopia•4d ago•43 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
291•alainrk•11h ago•466 comments

72M Points of Interest

https://tech.marksblogg.com/overture-places-pois.html
46•marklit•5d ago•6 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
54•rbanffy•4d ago•15 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
673•nar001•10h ago•291 comments

Show HN: Kappal – CLI to Run Docker Compose YML on Kubernetes for Local Dev

https://github.com/sandys/kappal
44•sandGorgon•2d ago•17 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
114•speckx•4d ago•164 comments
Open in hackernews

Reducing Huntington’s-related repeat expansions in patient cells and in mice

https://www.nature.com/articles/s41588-025-02172-8
25•bookofjoe•8mo ago

Comments

loa_in_•8mo ago
This century truly is amazing to witness as incurable diseases slowly become reasonably within reach to tackle. A huge step from widely established symptom treatment into reaching right to the source/root cause.
chevman•8mo ago
What is the timeline/next steps to make this a usable therapy in humans?

Not familiar with state of the art techniques in this realm currently.

throwawayObvs27•8mo ago
I think lots of people would support a world in which it was illegal for Huntington's carriers to reproduce (or two people with recessive Huntington's alleles, whichever). That rule would stop an unimaginable amount of human suffering. But unfortunately that highly acceptable idea (I think) sits within a wider category that is extremely controversial, unpopular and dangerous.

People cannot be trusted to just outlaw Huntington's on its own, because the next politician will take power and outlaw some ethnic group they hate, arguing that there is precedence. Which is really annoying.

atiedebee•8mo ago
That is extremely unethical. Going off Wikipedia, most people with Huntington's start presenting symptoms from 30 to 50 years of age. Those are 30 years that they can live a normal fulfilling life. Prohibiting people from having kids because their children may or may not live a shorter life is, as you pointed out, a slippery slope.
throwawayObvs27•8mo ago
Have you seen a patient presenting with Huntington's? I wouldn't wish that suffering on my worst enemy.

The chance is 50% for every child of a person with Huntington's. Is it ethical to deliberately have children knowing that they have a 50% chance of of their lifespan being cut in half, then dying in unimaginable pain guaranteed? There is always a risk for birth defects, but this one is a _choice_. Some people knowingly choose this fate for their children instead of adopting - that feels so wrong to me.

Even ignoring the humanitarian side, think of the societal cost. Every patient needs expensive round-the-clock care in the later stages, families and friends watch their loved ones deteriorate. If I was born knowing I had an early expiration date with that fate, I'd certainly need therapy. It's completely preventable.