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Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
235•theblazehen•2d ago•72 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
12•AlexeyBrin•1h ago•0 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
696•klaussilveira•15h ago•206 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
963•xnx•21h ago•558 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
133•matheusalmeida•2d ago•35 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
56•jesperordrup•5h ago•25 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
67•videotopia•4d ago•6 comments

ga68, the GNU Algol 68 Compiler – FOSDEM 2026 [video]

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
12•matt_d•3d ago•2 comments

Jeffrey Snover: "Welcome to the Room"

https://www.jsnover.com/blog/2026/02/01/welcome-to-the-room/
38•kaonwarb•3d ago•28 comments

UK infants ill after drinking contaminated baby formula of Nestle and Danone

https://www.bbc.com/news/articles/c931rxnwn3lo
14•__natty__•3h ago•0 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
36•speckx•3d ago•24 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
236•isitcontent•15h ago•26 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
234•dmpetrov•16h ago•126 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
336•vecti•17h ago•147 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
503•todsacerdoti•23h ago•246 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
387•ostacke•21h ago•97 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
300•eljojo•18h ago•186 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
361•aktau•22h ago•186 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
427•lstoll•22h ago•283 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
69•kmm•5d ago•10 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
96•quibono•4d ago•22 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
21•1vuio0pswjnm7•2h ago•9 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
22•bikenaga•3d ago•11 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
266•i5heu•18h ago•217 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
33•romes•4d ago•3 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
64•gfortaine•13h ago•29 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1078•cdrnsf•1d ago•461 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
300•surprisetalk•3d ago•44 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
39•gmays•10h ago•13 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
154•vmatsiiako•20h ago•72 comments
Open in hackernews

Reducing Huntington’s-related repeat expansions in patient cells and in mice

https://www.nature.com/articles/s41588-025-02172-8
25•bookofjoe•8mo ago

Comments

loa_in_•8mo ago
This century truly is amazing to witness as incurable diseases slowly become reasonably within reach to tackle. A huge step from widely established symptom treatment into reaching right to the source/root cause.
chevman•8mo ago
What is the timeline/next steps to make this a usable therapy in humans?

Not familiar with state of the art techniques in this realm currently.

throwawayObvs27•8mo ago
I think lots of people would support a world in which it was illegal for Huntington's carriers to reproduce (or two people with recessive Huntington's alleles, whichever). That rule would stop an unimaginable amount of human suffering. But unfortunately that highly acceptable idea (I think) sits within a wider category that is extremely controversial, unpopular and dangerous.

People cannot be trusted to just outlaw Huntington's on its own, because the next politician will take power and outlaw some ethnic group they hate, arguing that there is precedence. Which is really annoying.

atiedebee•8mo ago
That is extremely unethical. Going off Wikipedia, most people with Huntington's start presenting symptoms from 30 to 50 years of age. Those are 30 years that they can live a normal fulfilling life. Prohibiting people from having kids because their children may or may not live a shorter life is, as you pointed out, a slippery slope.
throwawayObvs27•8mo ago
Have you seen a patient presenting with Huntington's? I wouldn't wish that suffering on my worst enemy.

The chance is 50% for every child of a person with Huntington's. Is it ethical to deliberately have children knowing that they have a 50% chance of of their lifespan being cut in half, then dying in unimaginable pain guaranteed? There is always a risk for birth defects, but this one is a _choice_. Some people knowingly choose this fate for their children instead of adopting - that feels so wrong to me.

Even ignoring the humanitarian side, think of the societal cost. Every patient needs expensive round-the-clock care in the later stages, families and friends watch their loved ones deteriorate. If I was born knowing I had an early expiration date with that fate, I'd certainly need therapy. It's completely preventable.