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France's homegrown open source online office suite

https://github.com/suitenumerique
216•nar001•2h ago•115 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
377•theblazehen•2d ago•134 comments

British drivers over 70 to face eye tests every three years

https://www.bbc.com/news/articles/c205nxy0p31o
6•bookofjoe•8m ago•1 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
65•AlexeyBrin•3h ago•12 comments

Reinforcement Learning from Human Feedback

https://arxiv.org/abs/2504.12501
41•onurkanbkrc•3h ago•2 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
749•klaussilveira•18h ago•234 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
1004•xnx•23h ago•570 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
109•alainrk•2h ago•125 comments

Show HN: One-click AI employee with its own cloud desktop

https://cloudbot-ai.com
9•fainir•1h ago•4 comments

First Proof

https://arxiv.org/abs/2602.05192
12•samasblack•38m ago•6 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
8•vinhnx•1h ago•1 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
134•jesperordrup•8h ago•55 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
91•videotopia•4d ago•21 comments

Ga68, a GNU Algol 68 Compiler

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
30•matt_d•4d ago•6 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
148•matheusalmeida•2d ago•40 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
254•isitcontent•18h ago•27 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
267•dmpetrov•18h ago•142 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
7•rbanffy•3d ago•0 comments

Show HN: Kappal – CLI to Run Docker Compose YML on Kubernetes for Local Dev

https://github.com/sandys/kappal
10•sandGorgon•2d ago•2 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
531•todsacerdoti•1d ago•258 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
409•ostacke•1d ago•105 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
353•vecti•20h ago•159 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
322•eljojo•21h ago•198 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
55•helloplanets•4d ago•54 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
450•lstoll•1d ago•296 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
365•aktau•1d ago•190 comments

Cross-Region MSK Replication: K2K vs. MirrorMaker2

https://medium.com/lensesio/cross-region-msk-replication-a-comprehensive-performance-comparison-o...
6•andmarios•4d ago•1 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
293•i5heu•21h ago•246 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
103•quibono•5d ago•30 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
53•gmays•13h ago•22 comments
Open in hackernews

Reducing Huntington’s-related repeat expansions in patient cells and in mice

https://www.nature.com/articles/s41588-025-02172-8
25•bookofjoe•8mo ago

Comments

loa_in_•8mo ago
This century truly is amazing to witness as incurable diseases slowly become reasonably within reach to tackle. A huge step from widely established symptom treatment into reaching right to the source/root cause.
chevman•8mo ago
What is the timeline/next steps to make this a usable therapy in humans?

Not familiar with state of the art techniques in this realm currently.

throwawayObvs27•8mo ago
I think lots of people would support a world in which it was illegal for Huntington's carriers to reproduce (or two people with recessive Huntington's alleles, whichever). That rule would stop an unimaginable amount of human suffering. But unfortunately that highly acceptable idea (I think) sits within a wider category that is extremely controversial, unpopular and dangerous.

People cannot be trusted to just outlaw Huntington's on its own, because the next politician will take power and outlaw some ethnic group they hate, arguing that there is precedence. Which is really annoying.

atiedebee•8mo ago
That is extremely unethical. Going off Wikipedia, most people with Huntington's start presenting symptoms from 30 to 50 years of age. Those are 30 years that they can live a normal fulfilling life. Prohibiting people from having kids because their children may or may not live a shorter life is, as you pointed out, a slippery slope.
throwawayObvs27•8mo ago
Have you seen a patient presenting with Huntington's? I wouldn't wish that suffering on my worst enemy.

The chance is 50% for every child of a person with Huntington's. Is it ethical to deliberately have children knowing that they have a 50% chance of of their lifespan being cut in half, then dying in unimaginable pain guaranteed? There is always a risk for birth defects, but this one is a _choice_. Some people knowingly choose this fate for their children instead of adopting - that feels so wrong to me.

Even ignoring the humanitarian side, think of the societal cost. Every patient needs expensive round-the-clock care in the later stages, families and friends watch their loved ones deteriorate. If I was born knowing I had an early expiration date with that fate, I'd certainly need therapy. It's completely preventable.