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Efficient mRNA delivery to resting T cells to reverse HIV latency

https://www.nature.com/articles/s41467-025-60001-2
73•matthewmacleod•3d ago

Comments

Jalad•7h ago
Also discussed here https://news.ycombinator.com/item?id=44202664
Zigurd•6h ago
MRNA therapies have such high potential, there really ought to be much more public education and outreach to prevent people falling down the quackery rabbit hole. I don't just say that to pile on to the quacks. It's so detrimental and costs so many lives that it's probably a target for influence by adversary nation actors.
the_real_cher•2h ago
Lobotomy's were viewed to have so much high potential back in the day that they won the Nobel prize.

In true scientific fashion both sides would ideally just stick with the facts.

hobs•51m ago
There's no "both sides" in science.
dpe82•2h ago
If we hadn't had a pandemic in which lots of people lost their collective minds and an irresponsible political machine that took advantage of that, mRNA would be pretty universally hailed as the miracle it is.

That aside, yes. Education is important. Sadly at least in the US some of the people who lost their minds are now in charge of such education.

chasil•2h ago
This article asserts that white blood cells are the target, but we also know that (within the brain) astrocytes and [iirc] microglia can bear latent infection.

Is such a carrier capable of addressing latent reservoirs inside the blood-brain barrier? Can it cross the barrier, pervade the cerebrospinal fluid, then penetrate all infected cells?

White blood cells are a fantastic achievement, but far from the whole story.

sroussey•4h ago
I wonder if this can be used for other latent viruses that embed in cells like herpes and chickenpox/shingles.
XorNot•2h ago
That would be interesting because both of those have links to various late-life neurological conditions aa well.
stephen_g•1h ago
Yeah, latent EBV would be great too since it seems to be one of the main causes of MS.

I believe this is already being researched with mRNA now, it would be amazing if it works out and we could treat all of these.

Poison everywhere: No output from your MCP server is safe

https://www.cyberark.com/resources/threat-research-blog/poison-everywhere-no-output-from-your-mcp-server-is-safe
67•Bogdanp•3h ago•34 comments

Why Android can't use CDC Ethernet (2023)

https://jordemort.dev/blog/why-android-cant-use-cdc-ethernet/
133•goodburb•4h ago•59 comments

Omnimax

https://computer.rip/2025-06-08-Omnimax.html
63•aberoham•4h ago•19 comments

Building supercomputers for autocrats probably isn't good for democracy

https://helentoner.substack.com/p/supercomputers-for-autocrats
74•rbanffy•4h ago•37 comments

Tracking Copilot vs. Codex vs. Cursor vs. Devin PR Performance

https://aavetis.github.io/ai-pr-watcher/
33•HiPHInch•3d ago•11 comments

Riding high in Germany on the world's oldest suspended railway

https://www.theguardian.com/travel/2025/jun/09/riding-high-in-germany-on-the-worlds-oldest-suspended-railway
13•pseudolus•1h ago•0 comments

Panjandrum: The 'giant firework' built to break Hitler's Atlantic Wall

https://www.bbc.com/future/article/20250603-the-giant-firework-built-to-break-hitlers-atlantic-wall
82•rmason•3d ago•62 comments

Administering immunotherapy in the morning seems to matter. Why?

https://www.owlposting.com/p/the-time-of-day-that-immunotherapy
115•abhishaike•9h ago•78 comments

The Wire That Transforms Much of Manhattan into One Big, Symbolic Home

https://www.atlasobscura.com/articles/eruv-manhattan-invisible-wire-jewish-symbolic-religious-home
32•rmason•5h ago•25 comments

OpenBSD IO Benchmarking: How Many Jobs Are Worth It?

https://rsadowski.de/posts/2025/fio_simple_benckmarking/
15•PaulHoule•2h ago•3 comments

Zig Devlog: Self-Hosted x86 Back End Is Now Default in Debug Mode

https://ziglang.org/devlog/2025/#2025-06-08
15•brson•3h ago•11 comments

Show HN: Let’s Bend – Open-Source Harmonica Bending Trainer

https://letsbend.de
78•egdels•9h ago•14 comments

I Used AI-Powered Calorie Counting Apps, and They Were Even Worse Than Expected

https://lifehacker.com/health/ai-powered-calorie-counting-apps-worse-than-expected
35•gnabgib•1h ago•14 comments

Gaussian integration is cool

https://rohangautam.github.io/blog/chebyshev_gauss/
138•beansbeansbeans•16h ago•29 comments

How Compiler Explorer Works in 2025

https://xania.org/202506/how-compiler-explorer-works
102•vitaut•4d ago•20 comments

Endangered classic Mac plastic color returns as 3D-printer filament

https://arstechnica.com/apple/2025/06/new-filament-lets-you-3d-print-parts-in-authentic-1980s-apple-computer-color/
44•CobaltFire•3d ago•4 comments

Ask HN: In 15 years, what will a gas station visit look like?

18•thomassmith65•2h ago•37 comments

Generating Pixels One by One

https://tunahansalih.github.io/blog/autoregressive-vision-generation-part-1/
18•cyruseption•3d ago•0 comments

Cheap yet ultrapure titanium might enable widespread use in industry (2024)

https://phys.org/news/2024-06-cheap-ultrapure-titanium-metal-enable.amp
67•westurner•4d ago•40 comments

How to get started with writing tech video essays

5•sonderotis•3d ago•2 comments

Binfmtc – binfmt_misc C scripting interface

https://www.netfort.gr.jp/~dancer/software/binfmtc.html.en
78•todsacerdoti•12h ago•19 comments

The last six months in LLMs, illustrated by pelicans on bicycles

https://simonwillison.net/2025/Jun/6/six-months-in-llms/
721•swyx•17h ago•186 comments

Joining Apple Computer (2018)

https://www.folklore.org/Joining_Apple_Computer.html
391•tosh•1d ago•113 comments

Efficient mRNA delivery to resting T cells to reverse HIV latency

https://www.nature.com/articles/s41467-025-60001-2
73•matthewmacleod•3d ago•15 comments

Launching the BeOS on Hitachi Flora Prius Systems (1999)

http://testou.free.fr/www.beatjapan.org/mirror/www.be.com/support/guides/hitachi_boot.html
39•doener•10h ago•13 comments

Self-Host and Tech Independence: The Joy of Building Your Own

https://www.ssp.sh/blog/self-host-self-independence/
414•articsputnik•1d ago•199 comments

<Blink> and <Marquee> (2020)

https://danq.me/2020/11/11/blink-and-marquee/
198•ghssds•21h ago•157 comments

Startup Equity 101

https://quarter--mile.com/Startup-Equity-101
100•surprisetalk•3d ago•51 comments

FAA to eliminate floppy disks used in air traffic control systems

https://www.tomshardware.com/pc-components/storage/the-faa-seeks-to-eliminate-floppy-disk-usage-in-air-traffic-control-systems
66•daledavies•18h ago•69 comments

Focus and Context and LLMs

https://taras.glek.net/posts/focus-and-context-and-llms/
70•tarasglek•16h ago•27 comments