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We Mourn Our Craft

https://nolanlawson.com/2026/02/07/we-mourn-our-craft/
80•ColinWright•1h ago•43 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
21•surprisetalk•1h ago•19 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
121•AlexeyBrin•7h ago•24 comments

U.S. Jobs Disappear at Fastest January Pace Since Great Recession

https://www.forbes.com/sites/mikestunson/2026/02/05/us-jobs-disappear-at-fastest-january-pace-sin...
105•alephnerd•2h ago•56 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
58•vinhnx•4h ago•7 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
824•klaussilveira•21h ago•248 comments

Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
54•thelok•3h ago•6 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
105•1vuio0pswjnm7•8h ago•123 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
1058•xnx•1d ago•608 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
76•onurkanbkrc•6h ago•5 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
479•theblazehen•2d ago•175 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
205•jesperordrup•11h ago•69 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
549•nar001•6h ago•253 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
217•alainrk•6h ago•335 comments

Selection Rather Than Prediction

https://voratiq.com/blog/selection-rather-than-prediction/
8•languid-photic•3d ago•1 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
35•rbanffy•4d ago•7 comments

72M Points of Interest

https://tech.marksblogg.com/overture-places-pois.html
28•marklit•5d ago•2 comments

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

https://github.com/Momciloo/fun-with-clip-path
4•momciloo•1h ago•0 comments

I Write Games in C (yes, C)

https://jonathanwhiting.com/writing/blog/games_in_c/
4•valyala•1h ago•1 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
113•videotopia•4d ago•30 comments

SectorC: A C Compiler in 512 bytes

https://xorvoid.com/sectorc.html
4•valyala•1h ago•0 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
73•speckx•4d ago•74 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
68•mellosouls•4h ago•73 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
273•isitcontent•22h ago•38 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
199•limoce•4d ago•111 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
285•dmpetrov•22h ago•153 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
155•matheusalmeida•2d ago•48 comments

Show HN: Kappal – CLI to Run Docker Compose YML on Kubernetes for Local Dev

https://github.com/sandys/kappal
21•sandGorgon•2d ago•11 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
555•todsacerdoti•1d ago•268 comments

Ga68, a GNU Algol 68 Compiler

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
43•matt_d•4d ago•18 comments
Open in hackernews

Efficient mRNA delivery to resting T cells to reverse HIV latency

https://www.nature.com/articles/s41467-025-60001-2
110•matthewmacleod•8mo ago

Comments

Jalad•8mo ago
Also discussed here https://news.ycombinator.com/item?id=44202664
Zigurd•8mo ago
MRNA therapies have such high potential, there really ought to be much more public education and outreach to prevent people falling down the quackery rabbit hole. I don't just say that to pile on to the quacks. It's so detrimental and costs so many lives that it's probably a target for influence by adversary nation actors.
therein•8mo ago
[flagged]
foota•8mo ago
Unsubstantiated skepticism is unhealthy.
briangriffinfan•8mo ago
One requires a better reason than simply because they were told that their skepticism is unsubstantiated.
the_real_cher•8mo ago
Lobotomy's were viewed to have so much high potential back in the day that they won the Nobel prize.

In true scientific fashion both sides would ideally just stick with the facts.

hobs•8mo ago
There's no "both sides" in science.
more_corn•8mo ago
I mean, there is the side that is backed by evidence and the one that is not. That’s two sides. I just don’t feel inclined to listen to the side that is not.
the_real_cher•8mo ago
I guess the side that give the Nobel prize to lobotomies wasnt backed by evidence?

Or were they backed by evidence?

And then stronger more compelling evidence came out later against?

Thats kind of how science works, its a process of discovery not a set in stone right/wrong.

Things arent as reductionist as you claim, it does people good when they open their world up to that fact.

sheepdestroyer•8mo ago
Not only in science. Even (or especially) in impartial journalism or public debate, there's no valid reason why any unfounded (thus illegitimate) opinions should get as much consideration as sound and researched arguments.
dpe82•8mo ago
If we hadn't had a pandemic in which lots of people lost their collective minds and an irresponsible political machine that took advantage of that, mRNA would be pretty universally hailed as the miracle it is.

That aside, yes. Education is important. Sadly at least in the US some of the people who lost their minds are now in charge of such education.

chasil•8mo ago
This article asserts that white blood cells are the target, but we also know that (within the brain) astrocytes and [iirc] microglia can bear latent infection.

Is such a carrier capable of addressing latent reservoirs inside the blood-brain barrier? Can it cross the barrier, pervade the cerebrospinal fluid, then penetrate all infected cells?

White blood cells are a fantastic achievement, but far from the whole story.

joemazerino•8mo ago
Part of the pushback was the use of censorship apparatus during COVID. Science is supposed to be open to dispute, and silencing opposing opinions only adds to the conspiracy fuel.
sroussey•8mo ago
I wonder if this can be used for other latent viruses that embed in cells like herpes and chickenpox/shingles.
XorNot•8mo ago
That would be interesting because both of those have links to various late-life neurological conditions aa well.
stephen_g•8mo ago
Yeah, latent EBV would be great too since it seems to be one of the main causes of MS.

I believe this is already being researched with mRNA now, it would be amazing if it works out and we could treat all of these.

amy214•8mo ago
Not just those but there are various other lesser known latent viruses such as JC virus and BK virus. Most of us are infected with these viruses latently. For most of us, they do nothing (that we know of!) for life. For the immunosuppressed (eg AIDS, organ transplants), because there is no immune system to keep these viruses "latent", they do actually reactivate and cause problems. For viruses which operate by embedding themselves in the DNA itself, such that for some time the virus may only exist as information encoded in some nucleotides and not a physical virus, to cure that would be a powerful achievement