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OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
576•klaussilveira•10h ago•167 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
889•xnx•16h ago•540 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
91•matheusalmeida•1d ago•20 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
18•helloplanets•4d ago•10 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
21•videotopia•4d ago•0 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
197•isitcontent•11h ago•24 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
199•dmpetrov•11h ago•91 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
307•vecti•13h ago•136 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
352•aktau•17h ago•175 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
350•ostacke•17h ago•91 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
453•todsacerdoti•18h ago•228 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
20•romes•4d ago•2 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
79•quibono•4d ago•18 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
52•kmm•4d ago•3 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
253•eljojo•13h ago•153 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
388•lstoll•17h ago•263 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
5•bikenaga•3d ago•1 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
231•i5heu•13h ago•175 comments

Zlob.h 100% POSIX and glibc compatible globbing lib that is faste and better

https://github.com/dmtrKovalenko/zlob
12•neogoose•3h ago•7 comments

Show HN: R3forth, a ColorForth-inspired language with a tiny VM

https://github.com/phreda4/r3
68•phreda4•10h ago•12 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
24•gmays•6h ago•6 comments

Why I Joined OpenAI

https://www.brendangregg.com/blog/2026-02-07/why-i-joined-openai.html
116•SerCe•7h ago•94 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
135•vmatsiiako•16h ago•59 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
43•gfortaine•8h ago•13 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
268•surprisetalk•3d ago•36 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
168•limoce•3d ago•87 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1039•cdrnsf•20h ago•431 comments

FORTH? Really!?

https://rescrv.net/w/2026/02/06/associative
60•rescrv•18h ago•22 comments

Show HN: ARM64 Android Dev Kit

https://github.com/denuoweb/ARM64-ADK
14•denuoweb•1d ago•2 comments

Show HN: Smooth CLI – Token-efficient browser for AI agents

https://docs.smooth.sh/cli/overview
88•antves•1d ago•63 comments
Open in hackernews

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

https://www.nature.com/articles/s42255-025-01297-8
97•bookofjoe•8mo ago

Comments

zajio1am•8mo ago
(In mice)
myst•8mo ago
(So far)
r2_pilot•8mo ago
(also observed to be lethal in cases)
mbil•8mo ago
This 2012 study in humans says

> Since this was also a noninterventional study, two possibilities for interpretation of the findings were either that a high cysteine somehow promotes obesity or that obesity influences cysteine turnover, thereby raising plasma tCys.

https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2011.93

nkmnz•8mo ago
In genetically modified mice.
jdnier•8mo ago
An overview of other studies investigating cysteine and glycine sources and effects (from 2023; video or transcript):

https://nutritionfacts.org/hnta-video/how-to-get-less-cystei...

profstasiak•8mo ago
so... basically limit proteins especially from meat?
jostmey•8mo ago
This should only act as a clue into driving weight loss. Depleting of cysteine is severe. It would be depriving a team from writing html and discovery the code runs faster… very drastic imposition
LPisGood•8mo ago
Cysteine is also an irreplaceable building block of vital proteins required to sustain life. It’s unclear if there is any potential benefit of applying these findings to the problem of human weight loss or fitness.
kens•8mo ago
Cysteine is not an essential amino acid. Humans can synthesize it from methionine.
bell-cot•8mo ago
Wikipedia's disclaimers on that: "Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available."
nkmnz•8mo ago
These mice were GMO’d to be incapable of synthesising cysteine.
gus_massa•8mo ago
I agree, for example Pepsin[1] that is the protein inside the stomach that split proteins has Cysteine [2]

> Pepsin forms three between the sulfur atoms of cysteine residues in the peptide chain which hold important roles in the folding of the protein and stabilizing the two domains

[1] https://en.wikipedia.org/wiki/Pepsin

[2] https://biology.kenyon.edu/BMB/jsmol2021/Cat_Marko/index.htm...

User23•8mo ago
I would make a stronger statement and say that this belongs squarely on the effect and not the cause side.

I could be wrong, but I doubt it. Amino acid depletion sounds way more likely to be due to some kind of disruption in homeostasis rather than dietary intake.

readthenotes1•8mo ago
"Systemic cysteine depletion in mice causes lethal weight loss"

I didn't read much after that

dr_kiszonka•8mo ago
Maybe you should have.
bilsbie•8mo ago
Is this the same as homocysteine?
poirot2•8mo ago
Funny because cysteinuria doesn’t do this (pee out cysteine)
RS-232•8mo ago
Cysteine protease inhibitors could be used to reduce free cysteine available to cells. Some natural sources of those are papaya, kiwi, pineapple, fig, apples, and rice.
meew0•8mo ago
Cysteine proteases are named after their reaction mechanism, which involves a key cysteine residue within the enzyme. It doesn't have anything to do with the amino acids in the cleaved proteins.
riknos314•8mo ago
The phrasing of the title and paper steer the interpretation towards reducing cysteine as a method for increasing weight loss, however I think that the much more interesting takeaway is this:

> Notably, restoration of up to 75% cystine levels in the diet of Cth−/− CysF mice that were undergoing weight loss was sufficient to completely rescue the body weight

This might indicate that cysteine depletion could be one mechanism present in some wasting diseases, and that strategic supplementation of cysteine may be beneficial in reducing excessive weight loss in such diseases. I would be quite interested to see future research in this area.

biomcgary•8mo ago
Cysteine plays a key role in redox metabolism and removing reactive oxygen species (ROS). During brown fat burning, high flux of electrons increases the NADH/NAD⁺ and FADH₂/FAD ratios — shifting redox state toward a more reduced environment, which is exactly what you would need if deprived of cysteine.
drob518•8mo ago
So, does taking NAC make me fat? If I stop taking NAC, will it help me lose weight?
nkmnz•8mo ago
According to the article, you’ll lose so much weight that you need euthanasia if you stop taking NAC - but only if you’re also a mice that also happens to be genetically modified to not produce any Cysteine biologically. Oh, and you shouldn’t eat anything containing cysteine naturally.
drob518•8mo ago
Gotcha. So basically I’m going to be fat no matter what, you’re saying.
derbOac•8mo ago
Another linked article suggests that NAC administration if anything causes weight loss, and has a lot of opposite effects as cysteine. I don't think they're interchangeable.
drob518•8mo ago
Interesting. I missed that.
burnt-resistor•8mo ago
If only there were NAC that doesn't stink opening the bottle.
dave333•8mo ago
It's difficult to reduce cysteine by diet since it occurs in a wide variety of foods plus reducing it may be harmful as it is used in beneficial ways as well. So more research needed.