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Tiny C Compiler

https://bellard.org/tcc/
102•guerrilla•3h ago•44 comments

SectorC: A C Compiler in 512 bytes

https://xorvoid.com/sectorc.html
186•valyala•7h ago•34 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
110•surprisetalk•7h ago•116 comments

Brookhaven Lab's RHIC concludes 25-year run with final collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
43•gnufx•6h ago•45 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
130•mellosouls•10h ago•280 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
880•klaussilveira•1d ago•269 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
129•vinhnx•10h ago•15 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
166•AlexeyBrin•12h ago•29 comments

The F Word

http://muratbuffalo.blogspot.com/2026/02/friction.html
97•zdw•3d ago•46 comments

FDA intends to take action against non-FDA-approved GLP-1 drugs

https://www.fda.gov/news-events/press-announcements/fda-intends-take-action-against-non-fda-appro...
60•randycupertino•2h ago•90 comments

First Proof

https://arxiv.org/abs/2602.05192
96•samasblack•9h ago•63 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
265•jesperordrup•17h ago•86 comments

I write games in C (yes, C) (2016)

https://jonathanwhiting.com/writing/blog/games_in_c/
167•valyala•7h ago•148 comments

Eigen: Building a Workspace

https://reindernijhoff.net/2025/10/eigen-building-a-workspace/
4•todsacerdoti•4d ago•1 comments

Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
85•thelok•9h ago•18 comments

The silent death of Good Code

https://amit.prasad.me/blog/rip-good-code
48•amitprasad•1h ago•45 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
549•theblazehen•3d ago•203 comments

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

https://github.com/Momciloo/fun-with-clip-path
49•momciloo•7h ago•9 comments

Show HN: A luma dependent chroma compression algorithm (image compression)

https://www.bitsnbites.eu/a-spatial-domain-variable-block-size-luma-dependent-chroma-compression-...
26•mbitsnbites•3d ago•2 comments

Selection rather than prediction

https://voratiq.com/blog/selection-rather-than-prediction/
24•languid-photic•4d ago•6 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
246•1vuio0pswjnm7•13h ago•388 comments

Microsoft account bugs locked me out of Notepad – Are thin clients ruining PCs?

https://www.windowscentral.com/microsoft/windows-11/windows-locked-me-out-of-notepad-is-the-thin-...
80•josephcsible•5h ago•107 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
108•onurkanbkrc•12h ago•5 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
137•videotopia•4d ago•44 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
57•rbanffy•4d ago•17 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
215•limoce•4d ago•123 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
303•alainrk•12h ago•482 comments

72M Points of Interest

https://tech.marksblogg.com/overture-places-pois.html
48•marklit•5d ago•9 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
121•speckx•4d ago•185 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
294•isitcontent•1d ago•39 comments
Open in hackernews

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

https://www.nature.com/articles/s42255-025-01297-8
97•bookofjoe•8mo ago

Comments

zajio1am•8mo ago
(In mice)
myst•8mo ago
(So far)
r2_pilot•8mo ago
(also observed to be lethal in cases)
mbil•8mo ago
This 2012 study in humans says

> Since this was also a noninterventional study, two possibilities for interpretation of the findings were either that a high cysteine somehow promotes obesity or that obesity influences cysteine turnover, thereby raising plasma tCys.

https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2011.93

nkmnz•8mo ago
In genetically modified mice.
jdnier•8mo ago
An overview of other studies investigating cysteine and glycine sources and effects (from 2023; video or transcript):

https://nutritionfacts.org/hnta-video/how-to-get-less-cystei...

profstasiak•8mo ago
so... basically limit proteins especially from meat?
jostmey•8mo ago
This should only act as a clue into driving weight loss. Depleting of cysteine is severe. It would be depriving a team from writing html and discovery the code runs faster… very drastic imposition
LPisGood•8mo ago
Cysteine is also an irreplaceable building block of vital proteins required to sustain life. It’s unclear if there is any potential benefit of applying these findings to the problem of human weight loss or fitness.
kens•8mo ago
Cysteine is not an essential amino acid. Humans can synthesize it from methionine.
bell-cot•8mo ago
Wikipedia's disclaimers on that: "Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available."
nkmnz•8mo ago
These mice were GMO’d to be incapable of synthesising cysteine.
gus_massa•8mo ago
I agree, for example Pepsin[1] that is the protein inside the stomach that split proteins has Cysteine [2]

> Pepsin forms three between the sulfur atoms of cysteine residues in the peptide chain which hold important roles in the folding of the protein and stabilizing the two domains

[1] https://en.wikipedia.org/wiki/Pepsin

[2] https://biology.kenyon.edu/BMB/jsmol2021/Cat_Marko/index.htm...

User23•8mo ago
I would make a stronger statement and say that this belongs squarely on the effect and not the cause side.

I could be wrong, but I doubt it. Amino acid depletion sounds way more likely to be due to some kind of disruption in homeostasis rather than dietary intake.

readthenotes1•8mo ago
"Systemic cysteine depletion in mice causes lethal weight loss"

I didn't read much after that

dr_kiszonka•8mo ago
Maybe you should have.
bilsbie•8mo ago
Is this the same as homocysteine?
poirot2•8mo ago
Funny because cysteinuria doesn’t do this (pee out cysteine)
RS-232•8mo ago
Cysteine protease inhibitors could be used to reduce free cysteine available to cells. Some natural sources of those are papaya, kiwi, pineapple, fig, apples, and rice.
meew0•8mo ago
Cysteine proteases are named after their reaction mechanism, which involves a key cysteine residue within the enzyme. It doesn't have anything to do with the amino acids in the cleaved proteins.
riknos314•8mo ago
The phrasing of the title and paper steer the interpretation towards reducing cysteine as a method for increasing weight loss, however I think that the much more interesting takeaway is this:

> Notably, restoration of up to 75% cystine levels in the diet of Cth−/− CysF mice that were undergoing weight loss was sufficient to completely rescue the body weight

This might indicate that cysteine depletion could be one mechanism present in some wasting diseases, and that strategic supplementation of cysteine may be beneficial in reducing excessive weight loss in such diseases. I would be quite interested to see future research in this area.

biomcgary•8mo ago
Cysteine plays a key role in redox metabolism and removing reactive oxygen species (ROS). During brown fat burning, high flux of electrons increases the NADH/NAD⁺ and FADH₂/FAD ratios — shifting redox state toward a more reduced environment, which is exactly what you would need if deprived of cysteine.
drob518•8mo ago
So, does taking NAC make me fat? If I stop taking NAC, will it help me lose weight?
nkmnz•8mo ago
According to the article, you’ll lose so much weight that you need euthanasia if you stop taking NAC - but only if you’re also a mice that also happens to be genetically modified to not produce any Cysteine biologically. Oh, and you shouldn’t eat anything containing cysteine naturally.
drob518•8mo ago
Gotcha. So basically I’m going to be fat no matter what, you’re saying.
derbOac•8mo ago
Another linked article suggests that NAC administration if anything causes weight loss, and has a lot of opposite effects as cysteine. I don't think they're interchangeable.
drob518•8mo ago
Interesting. I missed that.
burnt-resistor•8mo ago
If only there were NAC that doesn't stink opening the bottle.
dave333•8mo ago
It's difficult to reduce cysteine by diet since it occurs in a wide variety of foods plus reducing it may be harmful as it is used in beneficial ways as well. So more research needed.