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We Mourn Our Craft

https://nolanlawson.com/2026/02/07/we-mourn-our-craft/
119•ColinWright•1h ago•90 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
22•surprisetalk•1h ago•24 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
121•AlexeyBrin•7h ago•24 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
62•vinhnx•5h ago•7 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
828•klaussilveira•21h ago•249 comments

U.S. Jobs Disappear at Fastest January Pace Since Great Recession

https://www.forbes.com/sites/mikestunson/2026/02/05/us-jobs-disappear-at-fastest-january-pace-sin...
119•alephnerd•2h ago•79 comments

Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
55•thelok•3h ago•7 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
4•gnufx•39m ago•1 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
108•1vuio0pswjnm7•8h ago•138 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
1060•xnx•1d ago•611 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
76•onurkanbkrc•6h ago•5 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
484•theblazehen•2d ago•175 comments

I Write Games in C (yes, C)

https://jonathanwhiting.com/writing/blog/games_in_c/
9•valyala•2h ago•1 comments

SectorC: A C Compiler in 512 bytes

https://xorvoid.com/sectorc.html
9•valyala•2h ago•0 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
210•jesperordrup•12h ago•70 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
559•nar001•6h ago•256 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
222•alainrk•6h ago•343 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
37•rbanffy•4d ago•7 comments

Selection Rather Than Prediction

https://voratiq.com/blog/selection-rather-than-prediction/
8•languid-photic•3d ago•1 comments

History and Timeline of the Proco Rat Pedal (2021)

https://web.archive.org/web/20211030011207/https://thejhsshow.com/articles/history-and-timeline-o...
19•brudgers•5d ago•4 comments

72M Points of Interest

https://tech.marksblogg.com/overture-places-pois.html
29•marklit•5d ago•2 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
114•videotopia•4d ago•31 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
76•speckx•4d ago•75 comments

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

https://github.com/Momciloo/fun-with-clip-path
6•momciloo•2h ago•0 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
273•isitcontent•22h ago•38 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
201•limoce•4d ago•111 comments

Show HN: Kappal – CLI to Run Docker Compose YML on Kubernetes for Local Dev

https://github.com/sandys/kappal
22•sandGorgon•2d ago•11 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
286•dmpetrov•22h ago•153 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
155•matheusalmeida•2d ago•48 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
71•mellosouls•4h ago•75 comments
Open in hackernews

Scientists use bacteria to turn plastic waste into paracetamol

https://www.theguardian.com/science/2025/jun/23/scientists-use-e-coli-bacteria-to-turn-plastic-waste-into-paracetamol-painkiller
52•bdev12345•7mo ago

Comments

doitLP•7mo ago
Paracetamol also known as Tylenol, Panadol and plain old acetaminophen
frogulis•7mo ago
Can't speak for the UK, but in Australia at least, "paracetamol" is the most commonly used non-brand name.
asplake•7mo ago
UK too.

Edit:

> Paracetamol is the Australian Approved Name and British Approved Name as well as the international nonproprietary name used by the WHO and in many other countries; acetaminophen is the United States Adopted Name and Japanese Accepted Name and also the name generally used in Canada, Venezuela, Colombia, and Iran. Both paracetamol and acetaminophen are contractions of chemical names for the compound.

Source: Wikipedia

cyberge99•7mo ago
Good to know the USA has something in common with IRAN. Perhaps start building from there.
ioma8•7mo ago
Paralen in Czech republic.
lawlessone•7mo ago
Could they put it in an mRNA vaccine so my body can break down plastic?
Arubis•7mo ago
The plastic in your body might be _less_ toxic than paracetamol.
lawlessone•7mo ago
Probably true , but my body can already remove the paracetamol
Arubis•7mo ago
That’d actually be a neat balance to figure out. Would the increased short-term liver toxicity be better over the long run than having bloodborne microplastics persist?
xattt•7mo ago
> … can already remove the paracetamol

In amounts less than 4 grams every 24 hours.

oharapj•7mo ago
Depending on how quickly the body would convert the plastic in this highly unrealistic hypothetical, that might work out just fine
colechristensen•7mo ago
The major part of this discovery was about something that e. coli already did on its own before genetic modification, so no not particularly. They might be able to engineer a symbiotic bacterium to live in your blood (there's a lot of doubt here), or more likely and less risky engineer a bacterium that consumed microplastics to live in your gut delivered as a probiotic or as a "vaccine" that you ate that would infect your existing microbiome.

And not an mRNA vaccine, those are kind of too simple and are mainly there to annoy the immune system. You would either use a virus to inject new genes into bacteria or insert plasmids into bacteria in a lab which would later be consumed.

aduwah•7mo ago
Geordie apocalypse is becoming reality

https://youtu.be/ctQXDpXTNZc?si=r52UCpxSN3fgjZfq

tux3•7mo ago
So, taking a non-expert look at the actual study, it looks like they first depolimerize PET into some acyl hydroxamate as a preparatory step.

Then it seems the big finding here is that this Lossen rearrangement, a regular non-biological chemical step, doesn't kill E. Coli. They derive PABA from that step.

And the E. Coli hasn't done anything yet, but since it's still alive, the cute trick is to turn PABA into APAP (acetaminophen). We already knew how to do that, but I suppose it demonstrates the point

Now what I don't get is what was wrong with running the Lossen step separately, and only feeding the output to the bacteria.

This article makes it sound like a miracle way to turn plastic into small molecules. They found that one of the step won't kill E. Coli. But it seems like all the steps were already possible before.

d4mi3n•7mo ago
I know nothing about this, but it seems like the kind of distinction that might make something easier/cheaper in practice. As in, do everything in a vat rather than needing to filter and pipe things around in a chemical facility.
6d6b73•7mo ago
Oh so now we can just ingest the bacteria and be pain free because of all the micro plastics in our body. Wonder what has more side effects?
melagonster•7mo ago
If blood contain enough bacteria, we have more problem should worry.
casey2•7mo ago
I wish there were 10 stories on how reducing plastic production would help clean up the waste problem for every innovation theater story like this