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Biomolecular shifts occur in our 40s and 60s (2024)

https://med.stanford.edu/news/all-news/2024/08/massive-biomolecular-shifts-occur-in-our-40s-and-60s--stanford-m.html
117•fzliu•3h ago•37 comments

XSLT

https://github.com/pacocoursey/xslt
78•_kush•2h ago•35 comments

Show HN: Sick of emailing yourself stuff? me too

https://github.com/sirbread/sink
17•sirbread•1h ago•24 comments

AlphaGenome: AI for better understanding the genome

https://deepmind.google/discover/blog/alphagenome-ai-for-better-understanding-the-genome/
435•i_love_limes•17h ago•141 comments

A lumberjack created more than 200 sculptures in Wisconsin's Northwoods

https://www.smithsonianmag.com/travel/when-a-lumberjacks-imagination-ran-wild-he-created-more-than-200-sculptures-in-wisconsins-northwoods-180986840/
49•noleary•5h ago•19 comments

Launch HN: Issen (YC F24) – Personal AI language tutor

253•mariano54•16h ago•222 comments

Sailing the fjords like the Vikings yields unexpected insights

https://arstechnica.com/science/2025/06/this-archaeologist-built-a-replica-boat-to-sail-like-the-vikings/
32•pseudolus•3d ago•4 comments

Alternative Layout System

https://alternativelayoutsystem.com/scripts/#same-sizer
212•smartmic•11h ago•27 comments

Kea 3.0, our first LTS version

https://www.isc.org/blogs/kea-3-0/
82•conductor•10h ago•26 comments

Denmark to tackle deepfakes by giving people copyright to their own features

https://www.theguardian.com/technology/2025/jun/27/deepfakes-denmark-copyright-law-artificial-intelligence
35•tfourb•2h ago•19 comments

How much slower is random access, really?

https://samestep.com/blog/random-access/
70•sestep•3d ago•30 comments

Bogong moths use a stellar compass for long-distance navigation at night

https://www.nature.com/articles/s41586-025-09135-3
15•Anon84•3d ago•0 comments

New EU rules on digital accessibility to come into force

https://www.rte.ie/news/technology/2025/0627/1520552-digital-accessibility/
8•austinallegro•31m ago•0 comments

Collections: Nitpicking Gladiator's Iconic Opening Battle, Part I

https://acoup.blog/2025/06/06/collections-nitpicking-gladiators-iconic-opening-battle-part-i/
35•diodorus•3d ago•11 comments

Show HN: Magnitude – Open-source AI browser automation framework

https://github.com/magnitudedev/magnitude
90•anerli•12h ago•33 comments

The time is right for a DOM templating API

https://justinfagnani.com/2025/06/26/the-time-is-right-for-a-dom-templating-api/
131•mdhb•11h ago•91 comments

Apple Research unearthed forgotten AI technique and using it to generate images

https://9to5mac.com/2025/06/23/apple-ai-image-model-research-tarflow-starflow/
96•celias•3d ago•32 comments

Snow - Classic Macintosh emulator

https://snowemu.com/
233•ColinWright•22h ago•79 comments

VA Tech scientists are building a better fog harp

https://arstechnica.com/science/2025/06/these-va-tech-scientists-are-building-a-better-fog-harp/
4•PaulHoule•3d ago•1 comments

Uv and Ray: Pain-Free Python Dependencies in Clusters

https://www.anyscale.com/blog/uv-ray-pain-free-python-dependencies-in-clusters
8•robertnishihara•1h ago•0 comments

Typr – TUI typing test with a word selection algorithm inspired by keybr

https://github.com/Sakura-sx/typr
69•Sakura-sx•3d ago•32 comments

Judge rejects Meta's claim that torrenting is “irrelevant” in AI copyright case

https://arstechnica.com/tech-policy/2025/06/judge-rejects-metas-claim-that-torrenting-is-irrelevant-in-ai-copyright-case/
38•Bluestein•4h ago•16 comments

A Review of Aerospike Nozzles: Current Trends in Aerospace Applications

https://www.mdpi.com/2226-4310/12/6/519
76•PaulHoule•15h ago•41 comments

SigNoz (YC W21, Open Source Datadog) Is Hiring DevRel Engineers (Remote)(US)

https://www.ycombinator.com/companies/signoz/jobs/cPaxcxt-devrel-engineer-remote-us-time-zones
1•pranay01•12h ago

Introducing Gemma 3n

https://developers.googleblog.com/en/introducing-gemma-3n-developer-guide/
337•bundie•14h ago•145 comments

Show HN: I built an AI dataset generator

https://github.com/metabase/dataset-generator
135•matthewhefferon•16h ago•27 comments

Dickinson's Dresses on the Moon

https://www.theparisreview.org/blog/2025/06/20/dickinsons-dresses-on-the-moon/
17•Bluestein•3d ago•0 comments

Matrix v1.15

https://matrix.org/blog/2025/06/26/matrix-v1.15-release/
169•todsacerdoti•11h ago•61 comments

Fault Tolerant Llama training

https://pytorch.org/blog/fault-tolerant-llama-training-with-2000-synthetic-failures-every-15-seconds-and-no-checkpoints-on-crusoe-l40s/
45•Mougatine•3d ago•7 comments

'Peak flower power era': The story of first ever Glastonbury Festival in 1970

https://www.bbc.com/culture/article/20250620-the-story-of-the-first-ever-glastonbury-festival-in-1970
12•keepamovin•3d ago•1 comments
Open in hackernews

Some thoughts on my first YC Demo Day

https://billchambers.me/articles/yc-demo-day-spring-25/
33•kaycebasques•3h ago

Comments

mkagenius•3h ago
Why is this top post on hn within one minute of posting?
TZubiri•3h ago
Maybe karma affects post visibility?
mkagenius•3h ago
No, then he would keep posting whatever every day
sillyfluke•3h ago
I'm guessing the speed with which it received its initial few votes.

It's a threadbare article with little or no meat on the bone. So it is a little strange.

mkagenius•3h ago
It had literally two votes. Anyway looks like I shouldn't have brought this issue up, getting downvoted
sillyfluke•3h ago
Yeah, you're supposed to email hn instead of posting if you think it's an issue.

I've seen 3 point new posts up near the top before so I assumed that's what it was. 2 points top of the page is pretty aggressive tho, it might have been a near instant upvote by someone who was interested in the topic.

ge96•3h ago
Carl Weathers
Brajeshwar•2h ago
I don’t know how or why, but I have seen this happen many times. Many of my submissions appear at the front within minutes of receiving 2-3 votes. I have no affiliation with YC, nor are my submissions.
chickenzzzzu•3h ago
Sounds more like a cattle auction than a place where partnerships are formed to deliver meaningful value to consumers.
echelon•3h ago
This is market efficiency. That's the very definition of delivering meaningful value.

The more efficient the capital allocation is, the greater the benefit to the whole market.

The only weirdness is that these are companies led by founders with "personalities". That's a weird variable to correct for.

chickenzzzzu•2h ago
How much more efficient is it to allocate capital to a group individuals who have been educated at institutions that produce an increasingly rigid type of thinker, who are all making the same hype driven products?
orsorna•3h ago
If you aren't already connected beforehand these rituals are a waste of time.
chickenzzzzu•2h ago
Painfully true!
soared•3h ago
https://billchambers.me/about/

This page on mobile made me laugh.

But otherwise, makes sense - get rid off all the flash and this is what demo days/etc are about

ecb_penguin•2h ago
I didn't realize how poorly YC startups were managed until I joined one.

It's mostly a ponzi scheme, where unprofitable companies pass their books off to non-technical investors that love hype.

> 1 slide. 1 minute pitches. 1 speaker.

This is why YC has such poor results. They're more interested in "1 slide" vs actual financials.

> Vertical AI was all over the place. Cursor for X was also prevalent.

No thought leadership at all.

HPMOR•2h ago
YC is very similar to a university. There is a small group of companies that create the reputation on which everybody lives. The results are extremely exponentially distributed. So yes, it makes sense you joining some arbitrary YC startup was a bad experience. The average performance of a YC company is __phenomenal__, the median performance is poor.
ecb_penguin•2h ago
> YC is very similar to a university

No it's not. It's not even remotely comparable.

> There is a small group of companies that create the reputation on which everybody lives

Also called luck. YC investors cannot articulate what made them successful, or else they'd have better results.

Universities have decades of sustained output. They are not comparable.

> you joining some arbitrary YC startup was a bad experience

I am at a YC unicorn. We are one of YC's most successful startups.

> The average performance of a YC company is __phenomenal__

It absolutely is not. It doesn't even beat the SP500. The __vast__ majority of YC companies are unprofitable failures.

You could flip a coin and beat YC.

HPMOR•2h ago
You're wrong. YC's returns far exceed the returns of the S&P 500. This is why LP's throw money at YC's funds. And secondly, I've been through YC. It is very apparent after many many group office hours, which startups are likely to be in the 6% unicorn group and which are not. You are correct the vast majority of YC companies are failures. However this does not preclude that the *mean* of YC outcomes is very very good. If Bill Gates were in a room with me and my friends the MEAN net worth would be tens of billions of dollars, the median would be less than a $100k.
ecb_penguin•2h ago
> You're wrong

You thought YC was comparable to a university

> This is why LP's throw money at YC's funds

Yeah, we know hedge funds that throw money at things usually beat the SP500.

> It is very apparent after many many group office hours, which startups are likely to be in the 6% unicorn group and which are not

Group office hours and not actual revenue. Proving my point!

> However this does not preclude that the mean of YC outcomes is very very good

It absolutely does, lmao.

> If Bill Gates were in a room with me and my friends the MEAN net worth would be tens of billions of dollars, the median would be less than a $100k.

Yes, one person being successful, the rest failures would skew the results! Way to prove the point I'm making, lmao.

jasonfrost•1h ago
You agreed with his rephrasing of his original assertion
sillyfluke•37m ago
> There is a small group of companies that create the reputation on which everybody lives

>> Also called luck.

Startup skill is a necessary but not sufficient condition for success. You also need luck. I doubt YC would claim otherwise.

Let's say each startup is a planet. Whoever gets hit with the most asteriods wins. Every conscious right decision and technical prowess that constitutes skill increases the size of the planet. The bigger the planet the more likely that more asteriods hit it. But space is a hig place, the largest planet is not guarenteed to have the most asteriod hits. A smaller planet could actually win. So it is with luck.

>YC investors cannot articulate what made them successful, or else they'd have better results.

Again, I doubt YC would contest this. But the power law so far has allowed them to be successful without having to guess correctly who in their pool would become the unicorn.

>You could flip a coin and beat YC

Where are you flipping this coin exactly? Are you flipping a coin in a pool containing all the startups in the world? If that's the case I'd like to see you take that bet. But if you flip a coin on Demo day, I'm sure you can beat some YC partners who additionally invest in a personal capacity.

pyb•2h ago
"2 on 20" Am I understanding correctly? If every YC startup is shooting for a 20 million USD valuation, that's amazing. Even if not all will make it.
HPMOR•2h ago
Nobody ever pays too much or too little for a startup. Because either you __really__ make it, or you don't. It is statistically more likely for your YC startup to be worth more than $1 billion, than it is to be acquired in a cash deal for $80mm. It is because of this fact that $2/22mm is not unreasonable. However, most of the hot companies during the batch will fetch $3-4mm/30-40mm valuation. The average raise during demo day is close to ~$3mm, the median <$800k.