on one hand they claim chronic or recurring inflammation is THE big health problem, and if we could it under control everything we'd be much healthier.
on the other hand there are messages like inflammation is good for your body because it keeps it working and e.g. the reason vegetables are so healthy is because they are basically indigestible and therefore cause mild inflammation, ergo good.
so what is it now? or are there different kinds of inflammation?
> are there different kinds of inflammation?
> on the other hand there are messages like inflammation is good for your body because it keeps it working
There's no contradiction here. The first one is chronic, it's long term.
The second one is acute, it's short term, to heal or to deal with invaders.
Also, as the comment below mine points out, even this split is a massive simplification. There's many different types of inflammation, some good, some required for survival, and some which can do damage over time if they never get shut off.
I mean, we name viruses & bacterias by their category/shape/etc, so shouldn't we do something similar to inflammation? eg. blue, vege-inflammation, red inflammation, pink-diamond-shaped inflammation inflammation-from-burn, etc?
> The study used a panel of 19 cytokines—small immune-signaling proteins—to assess inflammation patterns. While these markers aligned with aging in the Italian and Singaporean datasets, they did not replicate among the Tsimane and Orang Asli, whose immune systems were shaped by persistent infections and distinct environmental exposures.
[...]
> The authors call for a reevaluation of how aging and inflammation are measured across populations and emphasize the need for standardized, context-aware tools. "Factors like environment, lifestyle—such as high physical activity or a very low-fat diet—and infection may all influence how the immune system ages," said Cohen. "Understanding how these elements interact could help develop more effective global health strategies."
Not sure how you think your fictitious categories would help or present any new ideas. The study already does what you call for, but using science instead of imagination.
Same kind of thing
i.e. I don't understand what you're saying.
One day, you eat wheat that was contaminated with something, call it thing X. It causes a reaction. Yet the reaction now targets wheat and thing X, and so wheat is now troublesome.
Unsure on the validity of this.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10230051/#:~:text=G...
I am cheating as I don't want to do a lot of writing to summarize so I just had chatGPT summarize for me:
Mechanisms Beyond Weight Loss Direct Action on Immune Cells:
GLP-1 receptors are found on several immune cells (like macrophages, T cells, and dendritic cells).
Activation of these receptors can suppress pro-inflammatory cytokines (like TNF-α, IL-6) and enhance anti-inflammatory ones (like IL-10).
Reduction in Systemic Inflammation:
Studies show reduced levels of C-reactive protein (CRP) and interleukins in patients taking GLP-1s, even when controlling for weight loss.
In diabetic patients, GLP-1s can reduce oxidative stress and endothelial inflammation, improving cardiovascular outcomes.
Improved Gut Barrier Function:
GLP-1s may reduce gut permeability ("leaky gut"), which helps prevent the translocation of inflammatory endotoxins (like LPS) into circulation.
Neuroinflammation:
In animal models, GLP-1s cross the blood-brain barrier and have shown protective effects against neuroinflammation, relevant in diseases like Alzheimer’s and Parkinson’s.
adrianN•7mo ago
amelius•7mo ago
k__•7mo ago
elcritch•7mo ago
Ideally you need to stop inflammatory signals at the source, but we understand very few of those.
cryzinger•7mo ago