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Open Source @Github

Biomni: A General-Purpose Biomedical AI Agent

https://github.com/snap-stanford/Biomni
55•GavCo•2h ago•12 comments

Tree Borrows

https://plf.inf.ethz.ch/research/pldi25-tree-borrows.html
344•zdw•6h ago•49 comments

Show HN: FlopperZiro – A DIY open-source Flipper Zero clone

https://github.com/lraton/FlopperZiro
114•iraton•3h ago•29 comments

Jank Programming Language

https://jank-lang.org/
129•akkad33•3d ago•21 comments

A fast 3D collision detection algorithm

https://cairno.substack.com/p/improvements-to-the-separating-axis
142•OlympicMarmoto•7h ago•20 comments

Desktop Publishing Tools That Didn't Make It (2022)

https://tedium.co/2022/10/12/forgotten-desktop-publishing-tools-history/
33•rbanffy•3h ago•19 comments

Configuring Split Horizon DNS with Pi-Hole and Tailscale

https://www.bentasker.co.uk/posts/blog/general/configuring-pihole-to-serve-different-records-to-different-clients.html
37•gm678•4h ago•8 comments

Nuclear Waste Reprocessing Gains Momentum in the U.S.

https://spectrum.ieee.org/nuclear-waste-reprocessing-transmutation
60•rbanffy•5h ago•24 comments

Evolution Mail Users Easily Trackable

https://www.grepular.com/Evolution_Mail_Users_Easily_Trackable
80•mike-cardwell•3h ago•44 comments

Archaeologists unveil 3,500-year-old city in Peru

https://www.bbc.co.uk/news/articles/c07dmx38kyeo
87•neversaydie•2d ago•22 comments

Google fails to dismiss wiretapping claims on SJ, settles with app users

24•1vuio0pswjnm7•2h ago•1 comments

Ruby 3.4 frozen string literals: What Rails developers need to know

https://www.prateekcodes.dev/ruby-34-frozen-string-literals-rails-upgrade-guide/
183•thomas_witt•3d ago•89 comments

Why LLMs Can't Write Q/Kdb+: Writing Code Right-to-Left

https://medium.com/@gabiteodoru/why-llms-cant-write-q-kdb-writing-code-right-to-left-ea6df68af443
164•gabiteodoru•1d ago•107 comments

US Court nullifies FTC requirement for click-to-cancel

https://arstechnica.com/tech-policy/2025/07/us-court-cancels-ftc-rule-that-would-have-made-canceling-subscriptions-easier/
516•gausswho•22h ago•479 comments

The most otherworldly, mysterious forms of lightning on Earth

https://www.nationalgeographic.com/science/article/lightning-sprites-transient-luminous-events-thunderstorms
26•Anon84•3d ago•7 comments

I Ported SAP to a 1976 CPU. It Wasn't That Slow

https://github.com/oisee/zvdb-z80/blob/master/ZVDB-Z80-ABAP.md
113•weinzierl•2d ago•48 comments

Most RESTful APIs aren't really RESTful

https://florian-kraemer.net//software-architecture/2025/07/07/Most-RESTful-APIs-are-not-really-RESTful.html
257•BerislavLopac•14h ago•408 comments

Bootstrapping a side project into a profitable seven-figure business

https://projectionlab.com/blog/we-reached-1m-arr-with-zero-funding
758•jonkuipers•1d ago•201 comments

Let Kids Be Loud

https://www.afterbabel.com/p/let-kids-be-loud
80•trevin•2h ago•86 comments

Phrase origin: Why do we "call" functions?

https://quuxplusone.github.io/blog/2025/04/04/etymology-of-call/
218•todsacerdoti•17h ago•154 comments

7-Zip for Windows can now use more than 64 CPU threads for compression

https://www.7-zip.org/history.txt
236•doener•2d ago•159 comments

TaIrTe₄ photodetectors show promise for sensitive room-temperature THz sensing

https://phys.org/news/2025-07-tairte-photodetectors-highly-sensitive-room.html
11•wglb•3d ago•6 comments

Helm local code execution via a malicious chart

https://github.com/helm/helm/security/advisories/GHSA-557j-xg8c-q2mm
153•irke882•15h ago•73 comments

RapidRAW: A non-destructive and GPU-accelerated RAW image editor

https://github.com/CyberTimon/RapidRAW
241•l8rlump•18h ago•102 comments

The Architecture Behind Lovable and Bolt

https://www.beam.cloud/blog/agentic-apps
46•Mernit•5h ago•20 comments

QRS: Epsilon Wrangling

https://www.tbray.org/ongoing/When/202x/2025/07/07/Epsilon-Wrangling
6•zdw•35m ago•0 comments

A Emoji Reverse Polish Notation Calculator Written in COBOL

https://github.com/ghuntley/cobol-emoji-rpn-calculator
28•ghuntley•3d ago•5 comments

Is the doc bot docs, or not?

https://www.robinsloan.com/lab/what-are-we-even-doing-here/
182•tobr•13h ago•106 comments

X Chief Says She Is Leaving the Social Media Platform

https://www.nytimes.com/2025/07/09/technology/linda-yaccarino-x-steps-down.html
295•donohoe•6h ago•429 comments

ESIM Security

https://security-explorations.com/esim-security.html
119•todsacerdoti•12h ago•44 comments
Open in hackernews

Using MPC for Anonymous and Private DNA Analysis

https://vishakh.blog/2025/07/08/using-mpc-for-anonymous-and-private-dna-analysis/
33•vishakh82•9h ago

Comments

odyssey7•8h ago
What makes Monadic DNA monadic?
vishakh82•7h ago
Think monad as in philosophy, less monad as in a programming burrito.

Our intention is to let each user be a self-contained, enclosed (through encryption) unit where they get insights tailored to their unique genome. At the same time, we want to aggregate data (securely and with consent) from all users to power medical and research findings.

It sort of also works in the programming monad sense as the data is always enclosed and encrypted and never "directly" operated on.

goopypoop•7h ago
"Anonymized" ≠ anonymous

What is the contract with "some legalese" for?

Couldn't it be as simple as "pay, spit, receive unique physical token"? A disgusting vending machine, even

vishakh82•6h ago
You're right about "anonymized" and "anonymous". We do point out avenues to reach anonymity.

The legalese is for informed consent since biological materials are involved, handling liability and pointing out that the exercise itself was experimental and an early step towards productionzation.

The physical token could be a UX nightmare and it could get expensive at scale. Using a more developed app which accept revocable public keys from the user might be more workable.

phoronixrly•6h ago
So... It's just uploading your DNA to S3 but with extra steps this time? Before selling it off with the rest of the company assets later.
vishakh82•6h ago
Not at all. "S3" is only in the loop because that's what labs generally use. In production, when we have ongoing scale, we will not use S3 or anything like it to transfer data between labs and our infra, even if it means using sneakernet!

The whole point of our project is to keep people's data always under encryption so that nobody can sell the data even if they wanted to. Using MPC (and FHE) we ensure that nobody can decrypt your data without your permission.

You can also delete your data any time without needing any third party's permission using the latest versions of the libraries we use.

We are building all this go get away from the closed, exploitative model that 23andMe built. The way we are building our infra, our company could go out of business tomorrow and you'll still be able to use the protocol and have access to your data and insights.

Also, fun fact, genetic data from newborns is retained by the state in many industrialized countries. We need to get that data away from "trust me, bro" infrastructure to securing it using MPC and FHE.

mbeavitt•1h ago
Ok but the lab has access to the unencrypted data? You haven't removed the requirement that the user needs to trust the lab with their raw genome markers. This entire operation hinges on the lab's trustworthiness, does it not?
Real_S•1h ago
Excellent point.

We are developing a solution that will allow cryptography for DNA molecules, allowing DNA to be secure in any lab. It fits well with Monadic's front end.

https://www.geneinfosec.com/

vishakh82•41m ago
We address this point in the article. On the default path with existing rules and regulations some degree of trust in labs will always be required.

At-home sequencing could be a game changer.

The other reply also mentions molecular cryptography which could provide really strong anonymity and privacy guarantees. We hope to do a PoC accordingly some time in the neat future.

wackget•5h ago
Wow, Media Player Classic has come a long way. I knew it could play most types of videos but this is next-level compatibility.
smilevideo•3h ago
For those who just read the comments, this is a joke. The MPC in the article refers to "multi-party compute".
khqc•1h ago
I'm pretty sure it's model predictive control
krunck•4h ago
It's great to see privacy-focused service using FHE.

I'd love to see the results of an external audit of the systems that touch personal DNA information.

vishakh82•3h ago
Unfortunately, credible external audits are really expensive.

Our project is bootstrapped so we won't be able to afford a 100k audit for a while.

Real_S•3h ago
We did an external audit of these systems and published on it a few years ago:

https://www.frontiersin.org/journals/bioengineering-and-biot...

A publication from this year highlights the ongoing challenges:

https://ieeexplore.ieee.org/abstract/document/10930454/

vishakh82•2h ago
Your links seem to relate to regular plaintext sequencing, storage and analysis.

We are building under full encryption.