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Open Source @Github

Biomni: A General-Purpose Biomedical AI Agent

https://github.com/snap-stanford/Biomni
117•GavCo•4h ago•25 comments

MCP-B: A Protocol for AI Browser Automation

https://mcp-b.ai/
30•bustodisgusto•1h ago•8 comments

Tree Borrows

https://plf.inf.ethz.ch/research/pldi25-tree-borrows.html
387•zdw•9h ago•60 comments

Show HN: FlopperZiro – A DIY open-source Flipper Zero clone

https://github.com/lraton/FlopperZiro
156•iraton•6h ago•42 comments

Show HN: MCP server for searching and downloading documents from Anna's Archive

https://github.com/iosifache/annas-mcp
37•iosifache•2h ago•21 comments

Jank Programming Language

https://jank-lang.org/
186•akkad33•3d ago•38 comments

A Typology of Canadianisms

https://dchp.arts.ubc.ca/how-to-use
26•gnabgib•1h ago•5 comments

Multi-Region Row Level Security in CockroachDB

https://www.cockroachlabs.com/blog/fine-grained-access-control-row-level-security/
14•rusticwizard•2h ago•0 comments

A fast 3D collision detection algorithm

https://cairno.substack.com/p/improvements-to-the-separating-axis
168•OlympicMarmoto•9h ago•23 comments

HyAB k-means for color quantization

https://30fps.net/pages/hyab-kmeans/
18•ibobev•2h ago•6 comments

Configuring Split Horizon DNS with Pi-Hole and Tailscale

https://www.bentasker.co.uk/posts/blog/general/configuring-pihole-to-serve-different-records-to-different-clients.html
65•gm678•6h ago•17 comments

Understand CPU Branch Instructions Better

https://chrisfeilbach.com/2025/07/05/understand-cpu-branch-instructions-better/
20•mfiguiere•3d ago•3 comments

Linda Yaccarino is leaving X

https://www.nytimes.com/2025/07/09/technology/linda-yaccarino-x-steps-down.html
347•donohoe•9h ago•514 comments

Archaeologists unveil 3,500-year-old city in Peru

https://www.bbc.co.uk/news/articles/c07dmx38kyeo
113•neversaydie•2d ago•28 comments

White Noise – secure and private messenger

https://www.whitenoise.chat/
19•onhacker•2h ago•3 comments

Would You Like an IDOR With That? Leaking 64m McDonald's Job Applications

https://ian.sh/mcdonalds
33•samwcurry•4h ago•18 comments

Making Explainable Minesweeper

https://sublevelgames.github.io/blogs/2025-07-06-making-explainable-minesweeper/
13•greentec•3d ago•8 comments

Ruby 3.4 frozen string literals: What Rails developers need to know

https://www.prateekcodes.dev/ruby-34-frozen-string-literals-rails-upgrade-guide/
193•thomas_witt•3d ago•99 comments

The most otherworldly, mysterious forms of lightning on Earth

https://www.nationalgeographic.com/science/article/lightning-sprites-transient-luminous-events-thunderstorms
47•Anon84•3d ago•14 comments

Most RESTful APIs aren't really RESTful

https://florian-kraemer.net//software-architecture/2025/07/07/Most-RESTful-APIs-are-not-really-RESTful.html
273•BerislavLopac•16h ago•442 comments

Bootstrapping a side project into a profitable seven-figure business

https://projectionlab.com/blog/we-reached-1m-arr-with-zero-funding
783•jonkuipers•2d ago•208 comments

An ambitious vision of a city built from lava

https://www.cnn.com/2025/07/03/style/lava-material-architecture-venice-biennale
3•dabinat•2d ago•0 comments

QRS: Epsilon Wrangling

https://www.tbray.org/ongoing/When/202x/2025/07/07/Epsilon-Wrangling
10•zdw•3h ago•0 comments

Nuclear Waste Reprocessing Gains Momentum in the U.S.

https://spectrum.ieee.org/nuclear-waste-reprocessing-transmutation
83•rbanffy•8h ago•72 comments

Phrase origin: Why do we "call" functions?

https://quuxplusone.github.io/blog/2025/04/04/etymology-of-call/
242•todsacerdoti•19h ago•168 comments

Memory-Level Parallelism: Apple M2 vs. Apple M4

https://lemire.me/blog/2025/07/09/memory-level-parallelism-apple-m2-vs-apple-m4/
24•zdw•2h ago•3 comments

Evolution Mail Users Easily Trackable

https://www.grepular.com/Evolution_Mail_Users_Easily_Trackable
95•mike-cardwell•6h ago•53 comments

Why LLMs Can't Write Q/Kdb+: Writing Code Right-to-Left

https://medium.com/@gabiteodoru/why-llms-cant-write-q-kdb-writing-code-right-to-left-ea6df68af443
170•gabiteodoru•1d ago•117 comments

7-Zip for Windows can now use more than 64 CPU threads for compression

https://www.7-zip.org/history.txt
249•doener•2d ago•170 comments

I Ported SAP to a 1976 CPU. It Wasn't That Slow

https://github.com/oisee/zvdb-z80/blob/master/ZVDB-Z80-ABAP.md
125•weinzierl•2d ago•56 comments
Open in hackernews

Using MPC for Anonymous and Private DNA Analysis

https://vishakh.blog/2025/07/08/using-mpc-for-anonymous-and-private-dna-analysis/
34•vishakh82•12h ago

Comments

odyssey7•10h ago
What makes Monadic DNA monadic?
vishakh82•9h ago
Think monad as in philosophy, less monad as in a programming burrito.

Our intention is to let each user be a self-contained, enclosed (through encryption) unit where they get insights tailored to their unique genome. At the same time, we want to aggregate data (securely and with consent) from all users to power medical and research findings.

It sort of also works in the programming monad sense as the data is always enclosed and encrypted and never "directly" operated on.

goopypoop•9h ago
"Anonymized" ≠ anonymous

What is the contract with "some legalese" for?

Couldn't it be as simple as "pay, spit, receive unique physical token"? A disgusting vending machine, even

vishakh82•9h ago
You're right about "anonymized" and "anonymous". We do point out avenues to reach anonymity.

The legalese is for informed consent since biological materials are involved, handling liability and pointing out that the exercise itself was experimental and an early step towards productionzation.

The physical token could be a UX nightmare and it could get expensive at scale. Using a more developed app which accept revocable public keys from the user might be more workable.

phoronixrly•9h ago
So... It's just uploading your DNA to S3 but with extra steps this time? Before selling it off with the rest of the company assets later.
vishakh82•9h ago
Not at all. "S3" is only in the loop because that's what labs generally use. In production, when we have ongoing scale, we will not use S3 or anything like it to transfer data between labs and our infra, even if it means using sneakernet!

The whole point of our project is to keep people's data always under encryption so that nobody can sell the data even if they wanted to. Using MPC (and FHE) we ensure that nobody can decrypt your data without your permission.

You can also delete your data any time without needing any third party's permission using the latest versions of the libraries we use.

We are building all this go get away from the closed, exploitative model that 23andMe built. The way we are building our infra, our company could go out of business tomorrow and you'll still be able to use the protocol and have access to your data and insights.

Also, fun fact, genetic data from newborns is retained by the state in many industrialized countries. We need to get that data away from "trust me, bro" infrastructure to securing it using MPC and FHE.

mbeavitt•4h ago
Ok but the lab has access to the unencrypted data? You haven't removed the requirement that the user needs to trust the lab with their raw genome markers. This entire operation hinges on the lab's trustworthiness, does it not?
Real_S•3h ago
Excellent point.

We are developing a solution that will allow cryptography for DNA molecules, allowing DNA to be secure in any lab. It fits well with Monadic's front end.

https://www.geneinfosec.com/

vishakh82•3h ago
We address this point in the article. On the default path with existing rules and regulations some degree of trust in labs will always be required.

At-home sequencing could be a game changer.

The other reply also mentions molecular cryptography which could provide really strong anonymity and privacy guarantees. We hope to do a PoC accordingly some time in the neat future.

wackget•8h ago
Wow, Media Player Classic has come a long way. I knew it could play most types of videos but this is next-level compatibility.
smilevideo•6h ago
For those who just read the comments, this is a joke. The MPC in the article refers to "multi-party compute".
khqc•4h ago
I'm pretty sure it's model predictive control
krunck•6h ago
It's great to see privacy-focused service using FHE.

I'd love to see the results of an external audit of the systems that touch personal DNA information.

vishakh82•5h ago
Unfortunately, credible external audits are really expensive.

Our project is bootstrapped so we won't be able to afford a 100k audit for a while.

Real_S•5h ago
We did an external audit of these systems and published on it a few years ago:

https://www.frontiersin.org/journals/bioengineering-and-biot...

A publication from this year highlights the ongoing challenges:

https://ieeexplore.ieee.org/abstract/document/10930454/

vishakh82•5h ago
Your links seem to relate to regular plaintext sequencing, storage and analysis.

We are building under full encryption.