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Synthetic Biology for Space Exploration

https://www.nature.com/articles/s41526-025-00488-7
8•PaulHoule•2d ago

Comments

PaulHoule•1h ago
As I see it, the real question for space colonization is "How small of a population can be 100% self-sufficient in manufacturing?" and the smaller that number is the more likely it can be successful. If N=1, the odds are great, if N=10,000,000 it will not succeed.

The basic problem is that you can't export anything from Mars to Earth that makes Mars colonization profitable from a Terrestrial perspective -- so at any time the flow of resources could be cut off, see the Asimov classic story

https://en.wikipedia.org/wiki/The_Martian_Way

The Muskian model that we're just going to send millions of people canned food makes no sense at all.

Eric Drexler's molecular assembler program has foundered but we need something functionally equivalent, living things pull off basically the same trick, maximizing what we can do with them is an obvious path to "advanced manufacturing" together with flow chemistry, 3-d printing and other methods.

Infinite Pixels

https://meyerweb.com/eric/thoughts/2025/08/07/infinite-pixels/
151•OuterVale•2h ago•36 comments

How to Sell if Your User is not the Buyer

https://writings.founderlabs.io/p/how-to-sell-if-your-user-is-not-the
26•mooreds•54m ago•12 comments

AWS Restored My Account: The Human Who Made the Difference

https://www.seuros.com/blog/aws-restored-account-plot-twist/
26•mhuot•42m ago•7 comments

Building Bluesky Comments for My Blog

https://natalie.sh/posts/bluesky-comments/
6•g0xA52A2A•7m ago•0 comments

Laptop Support and Usability (LSU): July 2025 Report from the FreeBSD Foundation

https://github.com/FreeBSDFoundation/proj-laptop/blob/main/monthly-updates/2025-07.md
38•grahamjperrin•2h ago•18 comments

Windows XP Professional

https://win32.run/
130•pentagrama•2h ago•84 comments

Monte Carlo Crash Course: Quasi-Monte Carlo

https://thenumb.at/QMC/
36•zote•3d ago•3 comments

New AI Coding Teammate: Gemini CLI GitHub Actions

https://blog.google/technology/developers/introducing-gemini-cli-github-actions/
152•michael-sumner•6h ago•64 comments

Arm Desktop: x86 Emulation

https://marcin.juszkiewicz.com.pl/2025/07/22/arm-desktop-emulation/
40•PaulHoule•3h ago•11 comments

We replaced passwords with something worse

https://blog.danielh.cc/blog/passwords
647•max__dev•13h ago•528 comments

Sweatshop Data Is Over

https://www.mechanize.work/blog/sweatshop-data-is-over/
18•whoami_nr•2h ago•9 comments

Google confirms it has been hacked

https://www.forbes.com/sites/daveywinder/2025/08/07/google-confirms-it-has-been-hacked---user-data-stolen/
20•hidden_sheepman•12m ago•5 comments

Global Trade Dynamics

https://alhadaqa.github.io/globaltradedynamics/
19•gmays•1h ago•2 comments

GoGoGrandparent (YC S16) Is Hiring Back End and Full-Stack Engineers

1•davidchl•4h ago

An LLM does not need to understand MCP

https://hackteam.io/blog/your-llm-does-not-care-about-mcp/
69•gethackteam•3h ago•80 comments

The Whispering Earring (Scott Alexander)

https://croissanthology.com/earring
65•ZeljkoS•5h ago•26 comments

Claude Code IDE integration for Emacs

https://github.com/manzaltu/claude-code-ide.el
714•kgwgk•1d ago•236 comments

Cracking the Vault: How we found zero-day flaws in HashiCorp Vault

https://cyata.ai/blog/cracking-the-vault-how-we-found-zero-day-flaws-in-authentication-identity-and-authorization-in-hashicorp-vault/
174•nihsy•9h ago•71 comments

Leonardo Chiariglione: “I closed MPEG on 2 June 2020”

https://leonardo.chiariglione.org/
182•eggspurt•5h ago•152 comments

Hopfield Networks Is All You Need (2020)

https://arxiv.org/abs/2008.02217
7•liamdgray•2d ago•1 comments

SUSE Donates USD 11,500 to the Perl and Raku Foundation

https://www.perl.com/article/suse-donates-to-tprf/
7•oalders•1h ago•0 comments

Budget Car Buyers Want Automakers to K.I.S.S

https://www.thedrive.com/news/budget-car-buyers-want-automakers-to-k-i-s-s
8•PaulHoule•31m ago•1 comments

PastVu: Historical Photographs on Current Maps

https://pastvu.com/?_nojs=1
31•lapetitejort•2d ago•3 comments

Let's stop pretending that managers and executives care about productivity

https://www.baldurbjarnason.com/2025/disingenuous-discourse/
25•speckx•1h ago•3 comments

More shell tricks: first class lists and jq

https://alurm.github.io/blog/2025-08-07-first-class-lists-in-shells.html
3•alurm•1h ago•0 comments

Debounce

https://developer.mozilla.org/en-US/docs/Glossary/Debounce
114•aanthonymax•2d ago•61 comments

Project Hyperion: Interstellar ship design competition

https://www.projecthyperion.org
333•codeulike•19h ago•259 comments

Maybe we should do an updated Super Cars

https://spillhistorie.no/2025/07/31/maybe-we-should-do-an-updated-version/
17•Kolorabi•3h ago•3 comments

Baltimore Assessments Accidentally Subsidize Blight–and How We Can Fix It

https://progressandpoverty.substack.com/p/how-baltimore-assessments-accidentally
53•surprisetalk•3h ago•61 comments

Show HN: Aura – Like robots.txt, but for AI actions

https://github.com/osmandkitay/aura
26•OsmanDKitay•1d ago•21 comments