Kyoto University team develops pain reliever comparable to morphine

https://www.japantimes.co.jp/news/2025/08/05/japan/japan-new-painkiller-comparable-to-morphine/

79•nogajun•6mo ago

Comments

petesergeant•6mo ago

Marginally more info, along with the title of the paper, but the doi is broken: https://medicalxpress.com/news/2025-08-discovery-analgesic-p...

There's also the alternative Journavx: https://en.wikipedia.org/wiki/Suzetrigine

pogue•6mo ago

I can't find the study about this compound, Discovery and development of an oral analgesic targeting the α2B adrenoceptor, anywhere. I'd like to read more about the clinical pharmacology in detail.

petesergeant•6mo ago

If you didn't already find it, this has now shown up: https://www.pnas.org/doi/10.1073/pnas.2500006122

pogue•5mo ago

Thank you!

burnt-resistor•6mo ago

A new class of selective α2B-adrenoceptor antagonist.

kelseyfrog•6mo ago

How is it different from Imiloxan?

erickhill•6mo ago

Why is this written in such a way to only target cancer patients?

bitwize•6mo ago

The class of patients most likely to require opioids over long periods of time?

delusional•6mo ago

And a class disproportionately insensitive to long term negative side effects.

briangriffinfan•6mo ago

I have GOT to find a way to describe more things like this.

lmm•6mo ago

Probably that's where the funding is available.

raylad•6mo ago

It works by causing a release of noadrenalin.

Prediction: It will end up being used by the military and/or fighters to provide instantaneous muscle strength coupled with pain relief from overexertion.

FirmwareBurner•6mo ago

Star Craft marine stim packs let's gooooo

binary132•6mo ago

My exact first thought

harvie•6mo ago

Isn't that just gonna keep the patients in constant fight-or-flight mode? Perhaps developing PTSD or something over time...

miningape•6mo ago

Sounds like a secondary concern to me /s

mvdtnz•6mo ago

It's only constant if you constantly administer it

buran77•6mo ago

With soldiers it makes sense to use it explicitly to enforce the "fight" mode as needed. This can range from "occasionally in emergencies" to "all the time".

But militaries have famously not cared about the long term health and well being of their forces past their active use. So any consequence of "long term fight mode" past victory day are just the cost of doing business.

xeonmc•6mo ago

"Your injuries were not service related."

phatskat•6mo ago

“Victory day” lol, I think the only one I’ve been alive for so far was “Mission Accomplished”

cluckindan•6mo ago

Sounds like it comes with an increased risk of stroke and cardiological issues, psychomotor agitation, anxiety, aggression, possibly even psychosis. Humans have noradrenaline regulation for a reason.

elric•6mo ago

Does the article not consider those to be serious side effects then? What is considered serious?

cluckindan•6mo ago

In this case, I believe ”serious side effects” is referring to opioid addiction and physical dependency.

tsol•6mo ago

We'll have to see. There are a lot of natural and experimental painkillers that aren't used either because of side effects or more often because they just don't work consistently. It just so happens that so far the opioids are the only ones that can handle extreme pain. It's a hard problem to solve

tsoukase•6mo ago

It is hard to beat morphine and its derivatives (eg fentanyl). In strict medical settings they are excellent analgetics and anxiolytics, safe with minor side effects. The only problem is when things go wary after the initial use (dependence etc).

M95D•6mo ago

What about tolerance? Will it need increasing doses to be effective?

We Mourn Our Craft

Speed up responses with fast mode

Hoot: Scheme on WebAssembly

U.S. Jobs Disappear at Fastest January Pace Since Great Recession

Stories from 25 Years of Software Development

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

Al Lowe on model trains, funny deaths and working with Disney

The AI boom is causing shortages everywhere else

The Waymo World Model

Reinforcement Learning from Human Feedback

Start all of your commands with a comma (2009)

Vocal Guide – belt sing without killing yourself

France's homegrown open source online office suite

Coding agents have replaced every framework I used

Selection Rather Than Prediction

A Fresh Look at IBM 3270 Information Display System

72M Points of Interest

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

I Write Games in C (yes, C)

Unseen Footage of Atari Battlezone Arcade Cabinet Production

SectorC: A C Compiler in 512 bytes

Where did all the starships go?

Software factories and the agentic moment

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

Learning from context is harder than we thought

Monty: A minimal, secure Python interpreter written in Rust for use by AI

Making geo joins faster with H3 indexes

Show HN: Kappal – CLI to Run Docker Compose YML on Kubernetes for Local Dev

Hackers (1995) Animated Experience

Ga68, a GNU Algol 68 Compiler