frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

New protein therapy shows promise as antidote for carbon monoxide poisoning

https://www.medschool.umaryland.edu/news/2025/new-protein-therapy-shows-promise-as-first-ever-antidote-for-carbon-monoxide-poisoning.html
118•breve•3h ago•27 comments

NSF and Nvidia award Ai2 $152M to support building an open AI ecosystem

https://allenai.org/blog/nsf-nvidia
77•_delirium•2h ago•33 comments

Statement Regarding Misleading Media Reports

https://www.kodak.com/en/company/blog-post/statement-regarding-misleading-media-reports/
25•whicks•38m ago•4 comments

Why LLMs Can't Build Software

https://zed.dev/blog/why-llms-cant-build-software
97•srid•2h ago•43 comments

Launch HN: Cyberdesk (YC S25) – Automate Windows legacy desktop apps

9•mahmoud-almadi•22m ago•1 comments

Is chain-of-thought AI reasoning a mirage?

https://www.seangoedecke.com/real-reasoning/
26•ingve•1h ago•16 comments

What's the strongest AI model you can train on a laptop in five minutes?

https://www.seangoedecke.com/model-on-a-mbp/
287•ingve•2d ago•103 comments

Arch shares its wiki strategy with Debian

https://lwn.net/SubscriberLink/1032604/73596e0c3ed1945a/
234•lemper•6h ago•82 comments

Jujutsu and Radicle

https://radicle.xyz/2025/08/14/jujutsu-with-radicle
31•vinnyhaps•1h ago•6 comments

Org-social is a decentralized social network that runs on an Org Mode

https://github.com/tanrax/org-social
117•todsacerdoti•4h ago•21 comments

Brilliant illustrations bring this 1976 Soviet edition of 'The Hobbit' to life (2015)

https://mashable.com/archive/soviet-hobbit
125•us-merul•3d ago•43 comments

Blood Oxygen Monitoring Returning to Apple Watch in the US

https://www.apple.com/newsroom/2025/08/an-update-on-blood-oxygen-for-apple-watch-in-the-us/
32•thm•2h ago•5 comments

Passion over Profits

https://dillonshook.com/passion-over-profits/
33•dillonshook•2h ago•22 comments

Mbodi AI (YC X25) Is Hiring a Founding Research Engineer (Robotics)

https://www.ycombinator.com/companies/mbodi-ai/jobs/ftTsxcl-founding-research-engineer
1•chitianhao•3h ago

SIMD Binary Heap Operations

http://0x80.pl/notesen/2025-01-18-simd-heap.html
20•ryandotsmith•2d ago•2 comments

Meta accessed women's health data from Flo app without consent, says court

https://www.malwarebytes.com/blog/news/2025/08/meta-accessed-womens-health-data-from-flo-app-without-consent-says-court
218•amarcheschi•4h ago•125 comments

Ask HN: How do you tune your personality to get better at interviews?

13•tombert•32m ago•18 comments

Linux Address Space Isolation Revived After Lowering 70% Performance Hit to 13%

https://www.phoronix.com/news/Linux-ASI-Lower-Overhead
102•teleforce•3h ago•25 comments

Show HN: Zig-DbC – A design by contract library for Zig

3•habedi0•2d ago•0 comments

Funding Open Source like public infrastructure

https://dri.es/funding-open-source-like-public-infrastructure
169•pabs3•12h ago•81 comments

A new poverty line shifted the World Bank's poverty data. What changed and why?

https://ourworldindata.org/new-international-poverty-line-3-dollars-per-day
34•alphabetatango•3d ago•23 comments

Zenobia Pay – A mission to build an alternative to high-fee card networks

https://zenobiapay.com/blog/open-source-payments
201•pranay01•13h ago•213 comments

Meta's flirty AI chatbot invited a retiree to New York

https://www.reuters.com/investigates/special-report/meta-ai-chatbot-death/
32•edent•54m ago•14 comments

Great Myths #16: The Conflict Thesis

https://historyforatheists.com/2025/08/the-great-myths-16-the-conflict-between-science-and-religion/
7•stone-on-stone•2d ago•1 comments

Show HN: Yet another memory system for LLMs

https://github.com/trvon/yams
128•blackmanta•12h ago•33 comments

PYX: The next step in Python packaging

https://astral.sh/blog/introducing-pyx
698•the_mitsuhiko•21h ago•424 comments

"None of These Books Are Obscene": Judge Strikes Down Much of FL's Book Ban Bill

https://bookriot.com/penguin-random-house-florida-lawsuit/
192•healsdata•2h ago•180 comments

OCaml as my primary language

https://xvw.lol/en/articles/why-ocaml.html
352•nukifw•21h ago•251 comments

What Medieval People Got Right About Learning (2019)

https://www.scotthyoung.com/blog/2019/06/07/apprenticeships/
130•ripe•15h ago•77 comments

Kodak says it might have to cease operations

https://www.cnn.com/2025/08/12/business/kodak-survival-warning
299•mastry•2d ago•204 comments
Open in hackernews

New protein therapy shows promise as antidote for carbon monoxide poisoning

https://www.medschool.umaryland.edu/news/2025/new-protein-therapy-shows-promise-as-first-ever-antidote-for-carbon-monoxide-poisoning.html
118•breve•3h ago

Comments

DonHopkins•3h ago
>New Protein Therapy Shows Promise as Antidote for Carbon Monoxide Poisoning

So Shatner was right all along: not only is Promise Margarine good for lowering your cholesterol level, but it can also treat carbon monoxide poisoning! And it tastes like butter, promise.

https://www.youtube.com/watch?v=n3wf717fKFE

majkinetor•2h ago
I don't see a relation of any kind and I hate commercials maybe more than anybody else, but it's always a good time for a funny one with Shatner :)
DonHopkins•52m ago
Sheez, I can't believe I have to explain that Shatner shows Promise as antidote for high cholesterol too.
narrator•2h ago
Methylene blue works great, is very cheap, and it's been around for over a century. I guess I shouldn't be a hater. This seems to improve the effectiveness of existing treatments. However, shame they don't mention methylene blue though in the article.
majkinetor•2h ago
God forbid we have alternatives that work in minutes
lagniappe•28m ago
Given that MB is commonly supported by those with right leaning politics, it won't be reported on for risk of appearing to support the "wrong" party.
Traubenfuchs•18m ago
Awful.

Reminds me how ivermectin was approached during the covid pandemic. No, it did not help against covid, but it did prevent people with strongyloidiasis receiving corticosteroids for covid from almost certain death.

Instead of ridiculing the people taking it, trying to prevent them taking it and strengthening conspiracy theories, from a public trust and health perspective, people should have been advised in how to safely take it, if they really wanted to.

From those perspective you sometimes have to work with idiots, not try to fight them. Same with the vaccinations: "hey, this vaccine might prevent you from a disease that could kill you, especially if you are fat, old and male -you SHOULD take it, but you don't have to" we got an absolutely diabolical "you will leave your job and won't be allowed to leave the house if you don't get vaccinated" laws.

jrajav•11m ago
"hey, speeding down the highway 35mph over the limit could kill you, especially if you are fat and old. you SHOULD drive under the speed limit, but you don't have to."

No, the point is that it could kill other people. Speed all you want when you're on your own private roads.

Laws are generally meant to ensure public safety and the ability for us to live and cooperate together with mutual trust. They usually do end up restricting your personal freedoms to that end. Deal with it.

tekno45•7m ago
health officials shouldn't have to work around the fucking president pulling conspiracies out their ass.
EvanAnderson•2h ago
Methylene blue has a fun/shocking side-effect.
canadiantim•2h ago
it turns you red?
schmidtleonard•2h ago
Is that the one that turns your organs blue?
yard2010•1h ago
It turns you into a meth head.
zoklet-enjoyer•1h ago
Turns your pee blue
DonHopkins•48m ago
It's an easy way to blue yourself.

https://www.youtube.com/watch?v=9GYtgFdXCGE

Traubenfuchs•16m ago
It can be beautiful.

https://www.reddit.com/r/medlabprofessionals/comments/16lep3...

gus_massa•1h ago
IANAMD I made a quick search and the evidence of methylene blue as a carbon monoxide antidote looks controversial.

IIUC part of the effect is oxidizing/reducing the iron atom in the hemoglobin, and that changes how strong is the bound with the O2, CO, NO. But my chemistry is not enough to give a good guess of the results.

Herodotus38•21m ago
Hello, I would be interested if you could give evidence that methylene blue "works great" for carbon monoxide poisoning in humans.

It is not the standard of care in any guidelines I can find from any country. There is a paper from 2018 out of china showing some benefit in a rat model: https://onlinelibrary.wiley.com/doi/10.1111/bcpt.12940

bananapub•1h ago
not very on topic, but for those who missed one of the more surreal reddit threads in history:

- [MA] Post-it notes left in apartment [0]

- and the update from OP a while later [1]

[0]: https://www.reddit.com/r/legaladvice/comments/34l7vo/ma_post...

[1]: https://www.reddit.com/r/AskReddit/comments/49zfvb/what_is_t...

gus_massa•1h ago
It looks like he found a note in his room and see some strange thing in the window, and someone somehow says it's CO but it may be that the OP has unrelated hallucinations. Is this a symptom of CO poisoning? I think you only get sleepy, faint and die.
maxbond•52m ago
Chronic exposure can lead to memory loss, yes. You're describing the symptoms of acute exposure.
hinkley•38m ago
CO exposure is accumulative. If you’re around an intense source of it you’re toast. But with a small point source or decent ventilation it kills you slower.

And your body produces new blood cells every day, so minor sources like wood smoke or burning a candle don’t dose you enough to be a problem, unless perhaps your day job is as an athlete.

dtgriscom•59m ago
How is this administered? Seems like a crucial detail to omit.
DonHopkins•51m ago
You can spread it on bread, melt it over pancakes, rub it all over corn on the cob, put it in baked potatoes, etc, promise!
elric•32m ago
> This has the potential to become a rapid, intravenous antidote for carbon monoxide

So intravenously, presumably.

searine•29m ago
This research was funded by multiple NIH grants, a Department of Defense grant, and the Martin Family Foundation.