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Liquid Glass Is Cracked, and Usability Suffers in iOS 26

https://www.nngroup.com/articles/liquid-glass/
107•uxjw•27m ago•61 comments

Show HN: Semantic search over the National Gallery of Art

https://nga.demo.mixedbread.com/
27•breadislove•1h ago•15 comments

I built physical album cards with NFC tags to teach my son music discovery

https://fulghum.io/album-cards
28•jordanf•1h ago•29 comments

How to save the world with ZFS and 12 USB sticks: 4th anniversary video (2011)

https://constantin.glez.de/posts/2011-01-24-how-to-save-the-world-with-zfs-and-12-usb-sticks-4th-...
12•mariuz•52m ago•0 comments

Lánczos Interpolation Explained (2022)

https://mazzo.li/posts/lanczos.html
46•tobr•5d ago•1 comments

Show HN: A Digital Twin of my coffee roaster that runs in the browser

https://autoroaster.com/
37•jvkoch•4d ago•8 comments

Does our “need for speed” make our wi-fi suck?

https://orb.net/blog/does-speed-make-wifi-suck
53•jamies•3h ago•58 comments

Show HN: I invented a new generative model and got accepted to ICLR

https://discrete-distribution-networks.github.io/
462•diyer22•13h ago•56 comments

Ryanair flight landed at Manchester airport with six minutes of fuel left

https://www.theguardian.com/business/2025/oct/10/ryanair-flight-landed-at-manchester-airport-with...
430•mazokum•6h ago•345 comments

OpenGL: Mesh shaders in the current year

https://www.supergoodcode.com/mesh-shaders-in-the-current-year/
105•pjmlp•10h ago•80 comments

Notes on switching to Helix from Vim

https://jvns.ca/blog/2025/10/10/notes-on-switching-to-helix-from-vim/
237•chmaynard•7h ago•137 comments

NanoMi: Source-available transmission electron microscope

https://nanomi.org/
53•pillars•2d ago•8 comments

Love C, hate C: Web framework memory problems

https://alew.is/lava.html
71•OneLessThing•18h ago•80 comments

Dimensions of everyday objects

https://www.dimensions.com/
8•kaniksu•4d ago•2 comments

Igalia, Servo, and the Sovereign Tech Fund

https://www.igalia.com/2025/10/09/Igalia,-Servo,-and-the-Sovereign-Tech-Fund.html
335•robin_reala•9h ago•55 comments

Toyota aims to launch the ' first' all-solid-state EV batteries

https://electrek.co/2025/10/08/toyota-aims-to-launch-worlds-first-all-solid-state-ev-batteries/
61•thelastgallon•3h ago•44 comments

Multi-Core by Default

https://www.rfleury.com/p/multi-core-by-default
80•kruuuder•14h ago•43 comments

My approach to building large technical projects (2023)

https://mitchellh.com/writing/building-large-technical-projects
310•mad2021•18h ago•44 comments

Ask HN: What's the best hackable smart TV?

190•xrd•4d ago•140 comments

A story about bypassing air Canada's in-flight network restrictions

https://ramsayleung.github.io/en/post/2025/a_story_about_bypassing_air_canadas_in-flight_network_...
162•samray•14h ago•127 comments

After nine years of grinding, Replit found its market. Can it keep it?

https://techcrunch.com/2025/10/02/after-nine-years-of-grinding-replit-finally-found-its-market-ca...
71•toomanyrichies•4d ago•57 comments

Show HN: Gitcasso – Syntax Highlighting and Draft Recovery for GitHub Comments

https://github.com/diffplug/gitcasso
23•etwigg•6h ago•4 comments

Ohno Type School: A (2020)

https://ohnotype.co/blog/ohno-type-school-a
166•tobr•4d ago•60 comments

All-natural geoengineering with Frank Herbert's Dune

https://www.governance.fyi/p/all-natural-geoengineering-with-frank
65•toomuchtodo•7h ago•17 comments

Datastar: Lightweight hypermedia framework for building interactive web apps

https://data-star.dev/
192•freetonik•13h ago•200 comments

Weave (YC W25) is hiring a founding AI engineer

https://www.ycombinator.com/companies/weave-3/jobs/SqFnIFE-founding-ai-engineer
1•adchurch•10h ago

Google Safe Browsing incident

https://www.statichost.eu/blog/google-safe-browsing/
173•ericselin•8h ago•134 comments

Google, Meta and Microsoft to stop showing political ads in the EU

https://www.politico.eu/article/eu-political-ad-rules-google-meta-microsoft-big-tech-kick-in/
165•martinohansen•3h ago•118 comments

The illegible nature of software development talent

https://surfingcomplexity.blog/2025/10/08/the-illegible-nature-of-software-development-talent/
92•hackthemack•4h ago•90 comments

It's OpenAI's world, we're just living in it

https://stratechery.com/2025/its-openais-world-were-just-living-in-it/
91•feross•5h ago•178 comments
Open in hackernews

Show HN: Modeling the human body in Rust so I can cmd+click through it

https://github.com/lantos1618/open_human_ontology
40•lleong1618•4h ago
I started this trying to understand two things: why my Asian friends turn red after drinking, and why several friends all seemed to have migraine clusters.

I was reading medical papers and textbooks, but kept getting lost jumping between topics. I thought: what if I could just Cmd+Click through this like code? What if "ALDH2 gene" was actually clickable, and took me to the variant, the phenotype, the population frequencies?

So I started modeling human biology in Rust with my Ralph agent (Claude in a loop, ty ghuntley). Turns out the type system is perfect for this. Every biological entity is strongly-typed with relationships enforced at compile time.

After 1 day of agent coding: - 277 Rust files, ~95k lines of code - 1,561 tests passing - 13 complete organ systems - Genetics with ancestry-specific variants - Clinical pathology models

Try it:

git clone https://github.com/lantos1618/open_human_ontology cd open_human_ontology cargo run --example ide_navigation_demo

Then open `examples/ide_navigation_demo.rs` and Cmd+Click through:

Understanding Asian flush:

AsianGeneticVariantsCatalog::get_metabolic_variants()

// Click through to:

// → ALDH2 gene on chromosome 12q24.12

// → rs671 variant (Glu504Lys)

// → 40% frequency in Japanese population

// → Alcohol flush reaction

// → 10x esophageal cancer risk with alcohol

// → Acetaldehyde metabolism pathway

Understanding migraines: Migraine { subtype: WithAura, triggers: [Stress, LackOfSleep, HormonalChanges], genetic_variants: ["rs2075968", "rs1835740"], ... }

// Click through to:

// → 17 migraine trigger types

// → 12 aura symptom types

// → Genetic risk factors

// → Why clusters happen (HormonalChanges → Menstruation)

Now I can actually navigate the connections instead of flipping through PDFs. Heart → CoronaryArtery → Plaque. VisualCortex → 200M neurons → NeuralConnection pathways. It's like Wikipedia but type-checked and with jump-to-definition.

This isn't production medical software - it's a learning tool. But it's way more useful than textbooks for understanding how biological systems connect.

The agent keeps expanding it. Sometimes it OOMs but that's part of the fun.

Tech: Rust, nalgebra, serde, rayon, proptest

I am not a dr or medical professional this is for my education you can commit to it if you want to or review and open some PR's if you find wrong information or want to add references.

Comments

pacoWebConsult•3h ago
Any grounding in medical truth/ is anything sourced to legitimate references or is this entirely pulled from the model's general training of human anatomy?
lovecg•3h ago
100k lines in one day of “coding”? I think you already know the answer.
lleong1618•3h ago
exactly, i mean can attach a research agent to each file or commit to validate and confirm the values, which would just give validity to internet information I guess.
lleong1618•3h ago
I am pulling from the model and was thinking of attaching a research agent on per file to validate each file and adding sourced validated information.

it seems sound to get structure but on real values and source grounding is needed to be validated.

just a poc

sixo•3h ago
the absurd things people come up with to meet their own needs are usually good indicators of products and services which want to exist
lleong1618•3h ago
Yeah ahaha, I mean I just needed 2 pieces of information and got carried away. But would be awesome to have a runnable human emulation.
dietr1ch•3h ago
True, but to me it seems the product is halfway there with org-roam/logseq/obsidian and that Rust code is the wrong way to start building it.

I'd try generating markdown to be rendered in logseq by teaching the AI how to link and whatnot in my AGENT.md (or whatever people call their project-local instruction/context file).

From outside, I'd not trust hallucinated stuff, but it'd be neat to start a project where knowledgeable humans did oversee all the proposed changes.

sixo•3h ago
well yeah this is not itself the product, this is a demonstration of the need

Obsidian/etc really isn't it either, though; clearly OP wants to be able to do calculations with this stuff. They want both the knowledge graph AND an executable code environment. (I imagine Emacs can do both.)

But think more broadly. Imagine just

```

import <established knowledge>.anatomy

import <established knowledge>.high_energy_physics

import <established knowledge>.microeconomics

...

```

into a notebook-like environment, with good intellisense and completions. But not quite as a programming language—somewhere between that and a wiki.

sixo•3h ago
Similar: for years I've been lugging around the idea of making a game like Civilization but where all of the different theories of history can be turned on/off as modules. Maybe going back to prehistory:

- did fire lead to cooking lead to big brains lead to tools lead to agriculture?

- or was it ice ages ending that lead to agriculture?

- or did oxygen levels change leading to more efficient brains?

- or were we Born to Run?

- or did women's hips change shapes to allow bigger brains?

- or perhaps 2001: A Space Odyssey occurred as written

- or Ancient Aliens...

Repeat for every other highly-debated period of history.

Somehow having all of these in the same modular system feels like it would metabolize them in a way that reading a bunch of separate theories can't really do. Same for OP's anatomy.

pagekicker•34m ago
like this idea. Add "tech trees": path dependence can be arbitrary. What if we kept going with vacuum tubes/no transistors?
rfl890•3h ago
How do we know this is accurate and not some big hallucination? Is the data sourced anywhere? Has anyone with a relevant background even skimmed through the code? It seems like a great idea in theory, but this execution is worrying.
lleong1618•3h ago
Yes, It's very much a "I wonder if this would work" and kinda did. to be taken in some what of a regard would be attaching a research agent on each commit.

I did spot checks on random files with research agents and it seems to be ok for a claude code loop.

I'm not a Dr'

Please! is anyone a DR

rfl890•3h ago
I mean, it is a pretty cool idea, but trusting an LLM to correctly implement an entire human body in software is a recipe for disaster. There's bound to be tons of hallucinations and errors.
lleong1618•3h ago
absolutely agree but for the purposes of working out what ALDH2 deficiency is and clicking through it was successful

should absolutely have a research agent or eyes on for hallucinations and errors

JumpCrisscross•3h ago
> for the purposes of working out what ALDH2 deficiency is and clicking through it was successful

Does your code model acetaldehyde metabolism?

The exercise is an interesting proof of concept for a click-through model of a biological system. But it's also a warning for trusting LLMs for understanding.

lleong1618•2h ago
no it didn't do click through for this metabolism at first but it read your comment and then added it I guess. "examples/acetaldehyde_metabolism.rs" its about to push this in a moment
JumpCrisscross•2h ago
> its about to push this in a moment

The point is acetaldehyde metabolism is at the heart of your question: Why do some people flush red with alcohol.

Reading the first reference on Wikipedia's article about alcohol flushing [1][2] would have generated, I believe, more understanding about the biochemistry involved. (And the fact that ALDH2 deficiency simply exacerbates something we all do--acetaldehyde is a big part of what causes hangovers.)

What that would not have done is demonstrate (a) a genuinely interesting way to "step through" a physical system and (b) the ease with which a biochemist might be able to do so. As a hack and a project and a mode of communicating a model, I love this. Where I'm objecting is in pitching it per se as a mode for understanding a phenomenon, in this case, "what ALDH2 deficiency is."

[1] https://en.wikipedia.org/wiki/Alcohol_flush_reaction#cite_no...

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC2659709/

jll29•3h ago
I wasn't sure what to expect, so I opened a random bit of the code.

                Some(Ancestry::Ashkenazi) => Self {
                    ancestry,
                    lactose_restricted: false,
                    alcohol_restriction_level: AlcoholRestrictionLevel::Moderate,
                    vitamin_d_supplementation_iu: 800.0,
                    recommended_foods: vec![
                        "Fish".to_string(),
                        "Whole grains".to_string(),
                        "Vegetables".to_string(),
                        "Olive oil".to_string(),
                        "Nuts".to_string(),
                    ],
                    foods_to_limit: vec![
                        "High-fat dairy".to_string(),
                        "Processed meats".to_string(),
                    ],
Now this seems to mix a couple of things in the same module: I would suggest to separate out dietary views from a model of the human body and its genetic heritage.

Scientific views may change over time based on new results, and even body properties like blood pressure or BMI are not constant per person but bound to vary; so perhaps a Body should be modeled as a view or snapshot of a set of time series?

I would like to encourage you to take a scientist's view: if you had not just one (your own) but two models, how would you evaluate which is "better" - in other words the evaluation question. You could set a particular task and perhaps finding out something works better with your model than with a full-text index of the textbook you used and a simple Lucene search interface?

Are you planning to connect your model to any kind of visualization? Should be useful.

rafram•2h ago
Hah. Ashkenazis marked as not being lactose-intolerant? Interesting stuff.
ShrimpHawk•2h ago
The entire project is AI coded. Thought of this level was not put into developing it.
csunoser•3h ago
Maybe this is the future. But I dread looking at perfectly formatted yet sterile readme with too many emojis for comfort.
moron4hire•3h ago
It's one emoji
csunoser•2h ago
I mean, literally not true. There are 7. The problem is that most of the emojis there don't do anything for the content.

Emojis are not the core problem. Mindlessly letting claude do the work and then farm karma on HN is.

moron4hire•2h ago
Your reply mentioned "perfectly formatted yet sterile", which could just be someone paying more than 10 minutes of attention to the damn thing, and the emoji. The way you made it sound, it was full of smileys and trees and rocket ships. It's one check mark emoji used in a list of 5 items and at the end of 2 headers. You didn't say anything about Claude.
csunoser•1h ago
It seems like you think the author wrote this by hand and paid a great deal attention.

What do you think is the chance that claude code wrote the readme?

koakuma-chan•3h ago
I think it's time to learn to stop publishing clearly fully AI generated "projects." Anyone can pull up CC and type "model the human body in Rust," or whatever.
nomilk•2h ago
That was my first impression too, but not my conclusion. A project of this scale would take years if not for AI assistance, and OP is absolutely not trying to pass this off as a medical tool developed by professionals, but as a fun learning tool and interesting application of type systems and agents to solve a problem.
lleong1618•2h ago
nomilk gets it.

This is 100% a hack and fun learning tool. It is an experiment to see if modeling biological processes with rust (leveraging specifically its strong type system)

and to see what agents can do. In fact the agent is listening to this thread and taking feed back and changing the repo.

tehlike•2h ago
This is hackernews, this is the place for people to hack stuff, and share.
lleong1618•2h ago
Yes this is 100% a hack.
lleong1618•2h ago
maybe putting - Ai as a tag might help? but this is 100% a hack and experiment for fun. Test out what agents can do and can we model bio with rust.
jvanderbot•2h ago
The old "Look what I built" thread has really bifurcated into "here's what I painstakingly crafted and maybe some lessons learned" and "look what I asked AI to make and it worked".

The latter feels a bit less hacker. Akin to saying "I got someone on fiver to mod this game look how cool it is". Sure, ideas are something, but as AI gets better this is less hacker and more just "Tool worked".

lleong1618•2h ago
Ai will replace more of what we are doing, but I had fun with this so I thought I would share
moron4hire•2h ago
The AI bubble will pop, nobody will be able to afford AI code completion without VC money subsidizing companies like Anthropic, and it will all go the way of UML tools: A thing one old guy the company in short sleeved, plaid shirts, cargo khakis, and a George Lucas haircut keeps insisting is the future 20 years later.
koakuma-chan•2h ago
I think this is an outdated view. People are already running local models for code completion, and it will not be much longer until you can run code agents locally as well.
jstrieb•3h ago
This project reminds me of Matt Might's work (predating LLMs) on using techniques from Precision Medicine to help his son, who had a rare disease.

https://www.youtube.com/watch?v=Rt3XyeFHvt4 (poorly transcribed here: https://www.janestreet.com/tech-talks/algorithm-for-precisio...)

If I recall correctly, he used miniKanren along with formalized, structured data extracted from medical research. Unfortunately, his son has since passed away.

lleong1618•2h ago
This is an incredible story, heart goes out to him. He has done some amazing work from this information.

There's nothing that is not actionable, you can always do science.

dleeftink•2h ago
If you're looking for a 'click-through' experience, the JKU vis lab has long provided some awesome tools and visuals (ca. 2009) for interacting with the human genome[0][1].

[0]: https://jku-vds-lab.at/tools/

[1]: https://jku-vds-lab.at/publications/2009_bioinformatics_cale...

lleong1618•2h ago
amazing and its open source thanks fro bring this up.
dleeftink•2h ago
Some sophisticated tools coming out of that lab, I wish we could we could put more effort towards developing tools similar to their embedding explorer[0].

[0]: https://youtu.be/yBCe8SqGwK8

stronglikedan•2h ago
I have an Asian friend that gets flushed when drinking, but I didn't know it was an Asian thing. TIL
overtone1000•2h ago
I wonder how much it would cost to pay a domain expert to review 95k lines of code. As a domain expert who codes for fun and loves rust, I can only say the answer is, "A lot."
HeavyStorm•2h ago
Clickable? Like a... Hyperlink?

After the "this meeting could have been an email", we get the "code could have been html"