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CRISPR-like tools that finally can edit mitochondria DNA

https://www.nature.com/articles/d41586-025-03307-x
105•ck2•5h ago

Comments

Miaourt•3h ago
A nice soul have a non-paywalled version to share ?
byrantech•3h ago
https://www.nature.com/articles/d41586-025-03307-x.pdf

this should work?

Miaourt•3h ago
Maybe I'm just stupid, but I'm seeing the typical "fade-out" at the bottom of the article, followed by a subscription-wall, suggesting more of the content is behind this gate. Tho, maybe the "Making the edit" infographic is really the bottom of the article...
bil7•3h ago
the only current archive on archive.is also has that. Watch this space for a complete archive, hopefully:

https://archive.is/https://www.nature.com/articles/d41586-02...

varispeed•3h ago
Imagine the future - vibe coding own DNA.

"Hey ChatGPT, I need third ear. Make it grow in two months."

Iolaum•2h ago
Now we "just" need a CRISPR-MCP server :p
mountainriver•2h ago
On the public internet
CSMastermind•2h ago
I've been reading a lot about biochemistry lately and it's actually insane how complicated all of life is. The idea that we can edit genes at all is a miracle and I think most software engineers significantly underestimate how hard it would be to make meaningful changes to our bodies through gene editing.
lanfeust6•2h ago
Recently have been reading the Gene by Mukherjee. I'm amazed at what had been accomplished in the mid 20th Century. A lot of what still seems crazy now was done already albeit in small scale.
fragmede•2h ago
Growing new appendages is clearly much more involved, but a Youtuber was able to give themselves lactose tolerance for a couple of months (they were lactose intolerant before). Assuming it wasn't faked for views, and that we are what we eat, that suggests other modifications to gut bateria aren't inconceivably far off.
throwup238•1h ago
Considering that there aren’t any mammals that can regrow appendages, chances are adding an appendage would be impossible with gene editing because it would require editing both the mother and offspring to support novel embryonic development.
seanhunter•30m ago
My understanding is that lactose tolerance is a particularly interesting case because lactose tolerance is in fact the mutation and lactose intolerance is the "default". It's just that for historical reasons lactose tolerance obviously conferred an advantage in Europe in particular which is why the mutation persisted. That's why around 40% of the global population are lactose tolerant and intolerance is the global norm.

https://en.wikipedia.org/wiki/Lactase_persistence

toasterlovin•1h ago
Unfortunately biology only does spaghetti code.
BartjeD•1h ago
We just haven't found God's IDE yet
rabf•1h ago
Maybe this: https://teselagen.com/

Nice list here: https://github.com/davidliwei/awesome-CRISPR

testdelacc1•1h ago
I read a book about the immune system and it’s actually insane how much tech debt there is in there. We have several systems, each one built a hundred million years after the previous one. Each one targets the kind of threats that were prevalent then but are still there because they haven’t completely disappeared. So much complexity, and systems can go haywire so easily - autoimmune diseases, allergic reactions and so on.

And yet, like a startup that found product market fit with a garbage tech stack, this pile of jenga spaghetti is still going strong. Complexity doesn’t matter, people dying because they looked at a peanut doesn’t matter - ultimately this spaghetti works well enough to get humans to where we are today.

sillywabbit•31m ago
Most of the biotech stuff comes from bacteria and bacteriophages. It's their world. We just live in it.
thwarted•1h ago
This reminded me of the 1995 The Outer Limits episode "The New Breed".
tracker1•1h ago
I don't like to be alarmist, but some of this is a little scary, IMO. Small changes in a society can have massive impacts over generations. If you look at what happened to experiments with feeding house cats an altered diet in just a few generations. People are already eating a lot of things that wouldn't even be considered food a couple centuries ago, and maybe still shouldn't be.

We have a lot of increasing hormone production issues in western society already, I'm not sure that fiddling with things further is a real solution here without risking a lot of damage to society as a whole.

lazyfanatic42•1h ago
The amount of change that has happened just because of The Internet, and the speed of those changes is already too fast for us to cope with. We haven't even properly coped with that single change as a society and things are just accelerating...
guluarte•1h ago
"Hey you #$#@ remove the ear from my anus"
peder•1h ago
And then when it gets it wrong and you ask why it grew a nose instead of an ear: "You're absolutely right! I can fix this!"
echelon•49m ago
You mean cancer.

Or a wicked disease state like Huntington's that causes your DNA to slip.

Simple failures with catostrophic outcomes are much more likely than rewiring and restarting all of the developmental program across huge cell and tissue populations.

It would be more likely to grow transplant tissue exogenously. It's far safer than using the body as a test tube.

These gene editing techniques are used to fix simple (typically one cause) genetic diseases. Not reengineer live organisms "in flight".

koeng•32m ago
We've known TALENs work for years. For example - https://pmc.ncbi.nlm.nih.gov/articles/PMC4817924/ - from 2015

I worked on a project many years ago to do RNA import into yeast mitochondria (and then hopefully reverse transcribe there). Didn't work, and a lot of the info on RNA import into the mitochondria is... suspect.

Mitochondria engineering is just actually tough. 30 years and no new protocols for getting DNA in there :(

How bad can a $2.97 ADC be?

https://excamera.substack.com/p/how-bad-can-a-297-adc-be
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CRISPR-like tools that finally can edit mitochondria DNA

https://www.nature.com/articles/d41586-025-03307-x
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