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Tiny C Compiler

https://bellard.org/tcc/
137•guerrilla•4h ago•60 comments

Show HN: LocalGPT – A local-first AI assistant in Rust with persistent memory

https://github.com/localgpt-app/localgpt
17•yi_wang•1h ago•3 comments

SectorC: A C Compiler in 512 bytes

https://xorvoid.com/sectorc.html
220•valyala•9h ago•41 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
127•surprisetalk•8h ago•135 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
154•mellosouls•11h ago•312 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
893•klaussilveira•1d ago•272 comments

Brookhaven Lab's RHIC concludes 25-year run with final collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
49•gnufx•7h ago•51 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
145•vinhnx•12h ago•16 comments

Show HN: Craftplan – Elixir-based micro-ERP for small-scale manufacturers

https://puemos.github.io/craftplan/
13•deofoo•4d ago•1 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
170•AlexeyBrin•14h ago•30 comments

FDA intends to take action against non-FDA-approved GLP-1 drugs

https://www.fda.gov/news-events/press-announcements/fda-intends-take-action-against-non-fda-appro...
82•randycupertino•4h ago•154 comments

First Proof

https://arxiv.org/abs/2602.05192
110•samasblack•11h ago•69 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
278•jesperordrup•19h ago•90 comments

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

https://github.com/Momciloo/fun-with-clip-path
61•momciloo•8h ago•11 comments

Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
91•thelok•10h ago•20 comments

Show HN: A luma dependent chroma compression algorithm (image compression)

https://www.bitsnbites.eu/a-spatial-domain-variable-block-size-luma-dependent-chroma-compression-...
31•mbitsnbites•3d ago•2 comments

The F Word

http://muratbuffalo.blogspot.com/2026/02/friction.html
103•zdw•3d ago•52 comments

IBM Beam Spring: The Ultimate Retro Keyboard

https://www.rs-online.com/designspark/ibm-beam-spring-the-ultimate-retro-keyboard
3•rbanffy•4d ago•0 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
558•theblazehen•3d ago•206 comments

Eigen: Building a Workspace

https://reindernijhoff.net/2025/10/eigen-building-a-workspace/
8•todsacerdoti•4d ago•2 comments

Selection rather than prediction

https://voratiq.com/blog/selection-rather-than-prediction/
28•languid-photic•4d ago•9 comments

Microsoft account bugs locked me out of Notepad – Are thin clients ruining PCs?

https://www.windowscentral.com/microsoft/windows-11/windows-locked-me-out-of-notepad-is-the-thin-...
106•josephcsible•6h ago•127 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
263•1vuio0pswjnm7•15h ago•434 comments

I write games in C (yes, C) (2016)

https://jonathanwhiting.com/writing/blog/games_in_c/
175•valyala•8h ago•166 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
114•onurkanbkrc•13h ago•5 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
141•videotopia•4d ago•47 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
133•speckx•4d ago•209 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
222•limoce•4d ago•124 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
297•isitcontent•1d ago•39 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
578•todsacerdoti•1d ago•279 comments
Open in hackernews

The three thousand year journey of colchicine

https://www.worksinprogress.news/p/the-three-thousand-year-journey-of
36•quadrin•2mo ago

Comments

CheeseFromLidl•2mo ago
I opened the article expecting to read about its use in plant breeding: colchicine is renowned there for inducing polyploidy. Never knew it has a history in medicine.

https://en.wikipedia.org/wiki/Polyploidy

34679•2mo ago
Same here. I have a bottle in my freezer for that purpose.
kubafu•2mo ago
Never heard of it, please tell me more about using it in plant breeding!
mapmeld•2mo ago
Humans have two copies of each chromosome. Plants in nature can have many more, and some can be induced to duplicate their chromosomes which sometimes gives them larger seeds and resilience to environmental conditions. Similar to hybrid crops but somehow containing the full genomes of both parents. Bread wheat is hexapoloid (containing sub-genomes from three varieties of wheat) and quinoa is tetraploid (containing two different species). There have been projects for ~100 years to make polyploid rice with heavier grain-weight, but they haven't been able to reproduce.
kubafu•2mo ago
Super interesting, thanks!
siamese_puff•2mo ago
After seeing multiple doctors in the USA (where I no longer live thankfully) for a chronic mouth ulcer problem an allergist prescribed me colchicine which seemed to cure them. These ulcers lasted over 15 years and colchicine seemed to be the only thing to eradicate them.

Insurance wouldn’t cover the cost and colchicine cost me $500 a month for a bottle. In the UK I can pay 10 pounds. Crazy drug and crazy price for something 3000 years old

readthenotes1•2mo ago
Someone has to pay for the regulatory studies. Someone has to pay for purity. Someone has to pay for marketing, legal, and other corporate overhead.

My understanding is that for drugs with FDA approval, almost all that cost burden has historically been borne by customers in the USA.

Oh, and profit. Ditto

vad1d3v•2mo ago
colchicine is a life safer for me with gouty went rough on of me! 3000 years of poison!! I'd have never imagine that.