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We Mourn Our Craft

https://nolanlawson.com/2026/02/07/we-mourn-our-craft/
76•ColinWright•1h ago•42 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
21•surprisetalk•1h ago•19 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
121•AlexeyBrin•7h ago•24 comments

U.S. Jobs Disappear at Fastest January Pace Since Great Recession

https://www.forbes.com/sites/mikestunson/2026/02/05/us-jobs-disappear-at-fastest-january-pace-sin...
104•alephnerd•2h ago•56 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
58•vinhnx•4h ago•7 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
824•klaussilveira•21h ago•248 comments

Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
54•thelok•3h ago•6 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
105•1vuio0pswjnm7•8h ago•122 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
1058•xnx•1d ago•608 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
76•onurkanbkrc•6h ago•5 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
478•theblazehen•2d ago•175 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
205•jesperordrup•11h ago•69 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
547•nar001•5h ago•253 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
216•alainrk•6h ago•335 comments

Selection Rather Than Prediction

https://voratiq.com/blog/selection-rather-than-prediction/
8•languid-photic•3d ago•1 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
35•rbanffy•4d ago•7 comments

72M Points of Interest

https://tech.marksblogg.com/overture-places-pois.html
28•marklit•5d ago•2 comments

Show HN: I saw this cool navigation reveal, so I made a simple HTML+CSS version

https://github.com/Momciloo/fun-with-clip-path
3•momciloo•1h ago•0 comments

I Write Games in C (yes, C)

https://jonathanwhiting.com/writing/blog/games_in_c/
4•valyala•1h ago•1 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
113•videotopia•4d ago•30 comments

SectorC: A C Compiler in 512 bytes

https://xorvoid.com/sectorc.html
4•valyala•1h ago•0 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
73•speckx•4d ago•74 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
68•mellosouls•4h ago•73 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
273•isitcontent•22h ago•38 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
199•limoce•4d ago•111 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
285•dmpetrov•22h ago•153 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
155•matheusalmeida•2d ago•48 comments

Show HN: Kappal – CLI to Run Docker Compose YML on Kubernetes for Local Dev

https://github.com/sandys/kappal
21•sandGorgon•2d ago•11 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
555•todsacerdoti•1d ago•268 comments

Ga68, a GNU Algol 68 Compiler

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
43•matt_d•4d ago•18 comments
Open in hackernews

The three thousand year journey of colchicine

https://www.worksinprogress.news/p/the-three-thousand-year-journey-of
36•quadrin•2mo ago

Comments

CheeseFromLidl•2mo ago
I opened the article expecting to read about its use in plant breeding: colchicine is renowned there for inducing polyploidy. Never knew it has a history in medicine.

https://en.wikipedia.org/wiki/Polyploidy

34679•2mo ago
Same here. I have a bottle in my freezer for that purpose.
kubafu•2mo ago
Never heard of it, please tell me more about using it in plant breeding!
mapmeld•2mo ago
Humans have two copies of each chromosome. Plants in nature can have many more, and some can be induced to duplicate their chromosomes which sometimes gives them larger seeds and resilience to environmental conditions. Similar to hybrid crops but somehow containing the full genomes of both parents. Bread wheat is hexapoloid (containing sub-genomes from three varieties of wheat) and quinoa is tetraploid (containing two different species). There have been projects for ~100 years to make polyploid rice with heavier grain-weight, but they haven't been able to reproduce.
kubafu•2mo ago
Super interesting, thanks!
siamese_puff•2mo ago
After seeing multiple doctors in the USA (where I no longer live thankfully) for a chronic mouth ulcer problem an allergist prescribed me colchicine which seemed to cure them. These ulcers lasted over 15 years and colchicine seemed to be the only thing to eradicate them.

Insurance wouldn’t cover the cost and colchicine cost me $500 a month for a bottle. In the UK I can pay 10 pounds. Crazy drug and crazy price for something 3000 years old

readthenotes1•2mo ago
Someone has to pay for the regulatory studies. Someone has to pay for purity. Someone has to pay for marketing, legal, and other corporate overhead.

My understanding is that for drugs with FDA approval, almost all that cost burden has historically been borne by customers in the USA.

Oh, and profit. Ditto

vad1d3v•2mo ago
colchicine is a life safer for me with gouty went rough on of me! 3000 years of poison!! I'd have never imagine that.