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Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
233•theblazehen•2d ago•68 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
695•klaussilveira•15h ago•206 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
7•AlexeyBrin•1h ago•0 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
962•xnx•20h ago•555 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
130•matheusalmeida•2d ago•35 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
67•videotopia•4d ago•6 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
54•jesperordrup•5h ago•25 comments

ga68, the GNU Algol 68 Compiler – FOSDEM 2026 [video]

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
11•matt_d•3d ago•2 comments

Jeffrey Snover: "Welcome to the Room"

https://www.jsnover.com/blog/2026/02/01/welcome-to-the-room/
37•kaonwarb•3d ago•27 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
236•isitcontent•15h ago•26 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
234•dmpetrov•16h ago•125 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
33•speckx•3d ago•21 comments

UK infants ill after drinking contaminated baby formula of Nestle and Danone

https://www.bbc.com/news/articles/c931rxnwn3lo
12•__natty__•3h ago•0 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
335•vecti•17h ago•147 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
502•todsacerdoti•23h ago•244 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
386•ostacke•21h ago•97 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
300•eljojo•18h ago•186 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
361•aktau•22h ago•185 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
425•lstoll•21h ago•282 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
68•kmm•5d ago•10 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
96•quibono•4d ago•22 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
21•bikenaga•3d ago•11 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
19•1vuio0pswjnm7•1h ago•5 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
265•i5heu•18h ago•217 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
33•romes•4d ago•3 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
64•gfortaine•13h ago•28 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1077•cdrnsf•1d ago•460 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
39•gmays•10h ago•13 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
298•surprisetalk•3d ago•44 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
154•vmatsiiako•20h ago•72 comments
Open in hackernews

The three thousand year journey of colchicine

https://www.worksinprogress.news/p/the-three-thousand-year-journey-of
36•quadrin•2mo ago

Comments

CheeseFromLidl•2mo ago
I opened the article expecting to read about its use in plant breeding: colchicine is renowned there for inducing polyploidy. Never knew it has a history in medicine.

https://en.wikipedia.org/wiki/Polyploidy

34679•2mo ago
Same here. I have a bottle in my freezer for that purpose.
kubafu•2mo ago
Never heard of it, please tell me more about using it in plant breeding!
mapmeld•2mo ago
Humans have two copies of each chromosome. Plants in nature can have many more, and some can be induced to duplicate their chromosomes which sometimes gives them larger seeds and resilience to environmental conditions. Similar to hybrid crops but somehow containing the full genomes of both parents. Bread wheat is hexapoloid (containing sub-genomes from three varieties of wheat) and quinoa is tetraploid (containing two different species). There have been projects for ~100 years to make polyploid rice with heavier grain-weight, but they haven't been able to reproduce.
kubafu•2mo ago
Super interesting, thanks!
siamese_puff•2mo ago
After seeing multiple doctors in the USA (where I no longer live thankfully) for a chronic mouth ulcer problem an allergist prescribed me colchicine which seemed to cure them. These ulcers lasted over 15 years and colchicine seemed to be the only thing to eradicate them.

Insurance wouldn’t cover the cost and colchicine cost me $500 a month for a bottle. In the UK I can pay 10 pounds. Crazy drug and crazy price for something 3000 years old

readthenotes1•2mo ago
Someone has to pay for the regulatory studies. Someone has to pay for purity. Someone has to pay for marketing, legal, and other corporate overhead.

My understanding is that for drugs with FDA approval, almost all that cost burden has historically been borne by customers in the USA.

Oh, and profit. Ditto

vad1d3v•2mo ago
colchicine is a life safer for me with gouty went rough on of me! 3000 years of poison!! I'd have never imagine that.