The reason for the plague was disastrous health and cleanliness standards.
* https://en.wikipedia.org/wiki/Renaissance
* https://en.wikipedia.org/wiki/Italian_Renaissance
it was not the first in history:
* https://en.wikipedia.org/wiki/Renaissance_of_the_12th_centur...
There's a certain 'critical mass' of people and thinkers, as well as decent enough communications (roads, letters) to allow for collaboration, needed to achieve a flowering/growth of knowledge, and that was cut off by (amongst other things) the Black Death:
* https://en.wikipedia.org/wiki/Crisis_of_the_late_Middle_Ages
stevenjgarner•58m ago
[1] https://www.nature.com/articles/s43247-025-02964-0
[2] https://news.ycombinator.com/item?id=46151324