frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Open in hackernews

Why there are no cracked biotechnologists?

https://partialagonism.substack.com/p/why-there-are-no-cracked-biotechnologists
9•Jun8•2h ago

Comments

Nevermark•1h ago
The corresponding 10x biologists might appear when a simple "programmable" friendly cell platform for bio invention is created.

Think of reducing an existing cell to its minimalist possible survivable form. Then painstakingly recomplicating it. By refactoring and augmenting the DNA, proteins, epigenetics, behavior, and structure, into a modular, regular as possible, optimized to be extensible, form.

A bio OS kernel.

Then go to town. Imagine cells that can self-CRISPR. Cells that can spin off differentiated cells, then trigger their death, for temporary purposes. Communication standards between cells. Standards for cells to group and ungroup.

As apposed to today. Where anything amibitous is like trying to replace a plane's liquid fuel engine with a nuclear reactor assembled from parts taken from passengers, mid-flight, in low visibility and turbulence, with the help of too many first class martinis.

Evolution is the OG of low-effort expediency-first technical debt factories. "That random edit didn't destroy one model, in one test case, in one context? Replicate it!"

Now we must clean up that wet mess, so we can 10x.

Zebra-Llama: Towards Efficient Hybrid Models

https://arxiv.org/abs/2505.17272
55•mirrir•3h ago•26 comments

GrapheneOS is the only Android OS providing full security patches

https://grapheneos.social/@GrapheneOS/115647408229616018
391•akyuu•9h ago•152 comments

Tiny Core Linux: a 23 MB Linux distro with graphical desktop

http://www.tinycorelinux.net/
320•LorenDB•9h ago•155 comments

OMSCS Open Courseware

https://sites.gatech.edu/omscsopencourseware/
100•kerim-ca•4h ago•35 comments

Coffee linked to slower biological ageing among those with severe mental illness

https://www.kcl.ac.uk/news/coffee-linked-to-slower-biological-ageing-among-those-with-severe-ment...
49•bookofjoe•1h ago•30 comments

Z-Image: Powerful and highly efficient image generation model with 6B parameters

https://github.com/Tongyi-MAI/Z-Image
205•doener•6d ago•73 comments

HTML as an Accessible Format for Papers

https://info.arxiv.org/about/accessible_HTML.html
187•el3ctron•8h ago•96 comments

The past was not that cute

https://juliawise.net/the-past-was-not-that-cute/
22•mhb•1h ago•16 comments

United States Antarctic Program Field Manual (2024) [pdf]

https://www.usap.gov/usapgov/travelAndDeployment/documents/Continental-Field-Manual-2024.pdf
4•SheinhardtWigCo•1h ago•0 comments

Show HN: Tascli, a command line based (human) task and record manager

https://github.com/Aperocky/tascli
16•Aperocky•2h ago•4 comments

Screenshots from developers: 2002 vs. 2015 (2015)

https://anders.unix.se/2015/12/10/screenshots-from-developers--2002-vs.-2015/
8•turrini•1h ago•0 comments

Mathematics Without Numbers (1959)

https://www.jstor.org/stable/20026529?seq=1
11•measurablefunc•4d ago•1 comments

Wave of (Open Street Map) Vandalism in South Korea

https://www.openstreetmap.org/user/KennyDap/diary/407844
27•shortrounddev2•52m ago•2 comments

Autism's confusing cousins

https://www.psychiatrymargins.com/p/autisms-confusing-cousins
204•Anon84•12h ago•212 comments

Abstract Interpretation in the Toy Optimizer

https://bernsteinbear.com/blog/toy-abstract-interpretation/
28•ChadNauseam•2d ago•5 comments

Touching the Elephant – TPUs

https://considerthebulldog.com/tte-tpu/
144•giuliomagnifico•10h ago•43 comments

Catala – Law to Code

https://catala-lang.org
3•Grognak•1h ago•0 comments

Finding Gene Cernan's Missing Moon Camera

https://www.spacecamera.co/articles/2020/3/3/gene-cernans-missing-lunar-surface-camera
55•theodorespeaks•3d ago•5 comments

Infisical (YC W23) Is Hiring Engineers to Build the Modern OSS Security Stack

https://www.ycombinator.com/companies/infisical/jobs/2pwGcK9-senior-full-stack-engineer-us-canada
1•vmatsiiako•6h ago

The unexpected effectiveness of one-shot decompilation with Claude

https://blog.chrislewis.au/the-unexpected-effectiveness-of-one-shot-decompilation-with-claude/
164•knackers•1w ago•86 comments

Self-hosting my photos with Immich

https://michael.stapelberg.ch/posts/2025-11-29-self-hosting-photos-with-immich/
609•birdculture•6d ago•341 comments

Term-keys – Lossless keyboard input for Emacs

https://github.com/CyberShadow/term-keys
10•harryday•6d ago•2 comments

A compact camera built using an optical mouse

https://petapixel.com/2025/11/13/this-guy-built-a-compact-camera-using-an-optical-mouse/
227•PaulHoule•3d ago•45 comments

Copy-Item is 27% slower than File Explorer

https://til.andrew-quinn.me/posts/copy-item-is-27-percent-slower-than-file-explorer-drag-and-drop...
29•hiAndrewQuinn•1h ago•19 comments

Kids who ran away to 1960s San Francisco

https://www.fieldnotes.nautilus.quest/p/the-kids-who-ran-away-to-1960s-san
122•zackoverflow•4d ago•18 comments

Linux Instal Fest Belgrade

https://dmz.rs/lif2025_en
141•ubavic•13h ago•19 comments

Germany votes to bring in voluntary military service programme for 18-year-olds

https://www.bbc.com/news/articles/ckg9drg8pg1o
8•petermcneeley•4h ago•1 comments

Nook Browser

https://browsewithnook.com
94•ray__•19h ago•78 comments

Mapping Amazing: Bee Maps

https://maphappenings.com/2025/11/06/bee-maps/
52•altilunium•6d ago•29 comments

How the 'hypnagogic state' of drowsiness could enhance your creativity

https://theconversation.com/how-the-hypnagogic-state-of-drowsiness-could-enhance-your-creativity-...
13•zeristor•1h ago•3 comments