From what I’ve gathered the actual splicing is partly automated today and relatively straightforward if somewhat tedious. The big variable is the context. New construction should have relatively few variables.

With repair, everything goes out the window. I just talked to him last night and he was out on a cable cut repair all night Friday. Middle of a snowstorm, maps were not accurate, repair site was very difficult to work in.

https://en.wikipedia.org/wiki/Helicase

The wild thing is that it doesn't have a 'gas tank' of ATP to drive the reaction, it goes this fast while being fueled one molecule at a time from the environment.

Where does the ATP come from?

Buckle up my mechanical engineer friend - https://www.youtube.com/watch?v=OT5AXGS1aL8

I've watched that video a hundred times and it still gives me chills haha.