This is all covered cursorily even by Wikipedia - https://en.wikipedia.org/wiki/AlphaFold#AlphaFold_2_(2020).
And I do love the optimism.
But then you must admit this reads like a B-movie intro:
Then AI companies showed up in 2020 and said "we got this" and
solved it in an afternoon. ... We're playing God with molecules
and it's working.The text looks pretty reasonable overall, I didn't notice any completely outrageous statements at a quick glance. Though I don't like the "folding is reproducible" statement as that is a huge oversimplification. Proteins do misfold, and there is an entire apparatus in the cells to handle those cases and clean them up.
How many H100s do you need to simulate one human cell? Probably more than the universe can power.
On a sidenote, what is this new style of writing using small sentences where each sentence is supposed to be a punchline?
"And most of those sequences? They don't fold into anything useful. They're junk. They aggregate into clumps. They get degraded by cellular quality control. Only a TINY fraction of possible sequences fold into stable, functional proteins."
atomlib•1h ago