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OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
624•klaussilveira•12h ago•182 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
926•xnx•18h ago•548 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
32•helloplanets•4d ago•24 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
109•matheusalmeida•1d ago•27 comments

Jeffrey Snover: "Welcome to the Room"

https://www.jsnover.com/blog/2026/02/01/welcome-to-the-room/
9•kaonwarb•3d ago•7 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
40•videotopia•4d ago•1 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
219•isitcontent•13h ago•25 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
210•dmpetrov•13h ago•103 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
322•vecti•15h ago•143 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
370•ostacke•18h ago•94 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
358•aktau•19h ago•181 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
477•todsacerdoti•20h ago•232 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
272•eljojo•15h ago•160 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
402•lstoll•19h ago•271 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
85•quibono•4d ago•20 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
14•jesperordrup•2h ago•6 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
25•romes•4d ago•3 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
56•kmm•5d ago•3 comments

Start all of your commands with a comma

https://rhodesmill.org/brandon/2009/commands-with-comma/
3•theblazehen•2d ago•0 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
12•bikenaga•3d ago•2 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
244•i5heu•15h ago•188 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
52•gfortaine•10h ago•21 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
140•vmatsiiako•17h ago•63 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
280•surprisetalk•3d ago•37 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1058•cdrnsf•22h ago•433 comments

Why I Joined OpenAI

https://www.brendangregg.com/blog/2026-02-07/why-i-joined-openai.html
132•SerCe•8h ago•117 comments

Show HN: R3forth, a ColorForth-inspired language with a tiny VM

https://github.com/phreda4/r3
70•phreda4•12h ago•14 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
28•gmays•7h ago•11 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
176•limoce•3d ago•96 comments

FORTH? Really!?

https://rescrv.net/w/2026/02/06/associative
63•rescrv•20h ago•22 comments
Open in hackernews

Show HN: GeneGuessr – a daily biology web puzzle

https://geneguessr.brinedew.bio/
88•brinedew•1mo ago
I made a web game inspired by Geoguessr and Wordle, where you get shown a 3D model of a random human protein each day, and you have to triangulate its gene name using similarity clues.

My background is in wet lab molecular biology and I intend this game to be engaging mostly to other biologists. But if you're outside the field, I'm interested to know if you can still solve it with browser use LLMs, and if you learned something interesting doing so. Let me know what you think.

I made it with Claude over the last 2 months. My coding experience is limited to basic python data analysis and figure making. I've seen people online asking, "Now that we have coding AI, why isn't there a deluge of awesome AI-generated apps made by non-coders?" - if this sounds like you, check out Geneguessr to understand what a web app by a non-coder looks like.

I might write more about the process if there's a demand, but what really unlocked the project for Claude was Linear MCP, where it could put each individual issue on a shared Kanban board. This, and Playwright MCP for testing on live site, were the two workhorses that got me through this. For bugs Claude couldn't one-shot, Linear was great for consolidating issue information so that I could dump it into ChatGPT Codex - it would usually think for like half an hour, output very confusing explanations, but the bug was gone.

Game is free, no log-in required, sorry if you run into any mobile bugs - didn't test it much there.

https://geneguessr.brinedew.bio/

Comments

miladyincontrol•1mo ago
For a moment thought this was gonna be some ethnoguessr clone
lovegrenoble•1mo ago
Dayly, that means one puzzle per day? And how many of them in total?
brinedew•1mo ago
You can play more than once in the practice mode. It turns on after you complete the daily puzzle.

There's almost 20k entries in my human gene database. You can choose any of them as your guess, but the "gene of the day" is chosen from a subset that has decent 3D structure coverage (meaning, not falling back to alphafold2 for visualization).

lovegrenoble•1mo ago
Thank you
bgbntty2•1mo ago
Very interesting game!

How can I enable practice mode? I just see "Practice Mode OFF" on the right, but nothing to click on. Does practice mode have infinite hints and guesses? That would be nice for people like me who know very little about proteins.

brinedew•1mo ago
After you finish the game, the "game over" screen will show you the "practice" button to try again with a different protein.

If you're interested to learn more about proteins, I suggest asking an in-browser LLM like Claude Chrome to play and explain its guesses at your preferred level of familiarity. https://claude.com/chrome

noduerme•1mo ago
Huh. Is this kind of manifold something that a group of humans can now identify on sight and associate with a part of a DNA sequence? That's pretty spectacular. I have a friend who worked for years on AlphaFold, but wasn't aware that people had gotten to this level of confidence in visually identifying proteins.
brinedew•1mo ago
My dream is forming a team of Tetlock-style superbiologists who can identify gene names on sight like Rainbolt, beat prediction markets on shorting biotech stocks, and smell out pre-cancerous cells like it's the final round of amongus.
noduerme•1mo ago
Hahahaa ... I kinda love this, along with humans who can sit at a piano and play a song they've only heard once, or cook a complicated dish they only tasted once. That seems like the great Turing test... zero-shot humans.

But seriously, there probably are a few people who can see genes from proteins like that, faster than a whole datacenter of GPUs. Putting together such a brain trust could be invaluable.

wigglewoggle•1mo ago
I went straight to cd-4 and was crushed to find out I didn't get it in one guess
oreilles•1mo ago
Clicking the leftmost menu icon raise the following error:

    Geneguessr encountered a problem:
    runtime-error
    SyntaxError: redeclaration of const NAVIGATION_START
brinedew•1mo ago
That's the frontpage link, fixed it, thank you.
RestartKernel•1mo ago
This seems super well-done, albeit completely impossible for laymen. Great work, I'd love to see someone with the necessary knowledge play this.
boldlybold•1mo ago
Great work! I really like the interface here, I think you put a lot of taste into the way this all came together. It's quite hard (appropriately so!) I would love to see a experienced structural biologist go at this.
brinedew•1mo ago
Thank you. I started the development with the interface first, basically making a mockup of how the finished game should look like, and then prodding LLMs with a stick to make a backend that would support this interface without crashing.

Making a nice-looking web GUI without knowing relevant vocabulary was a very clunky process in comparison to code pipelines, basically just pasting screenshots into the chat window and asking LLMs to "line up stuff properly", which they still couldn't manage to do in places.

andrewrn•1mo ago
This is a super cool game, nicely done.
ithkuil•1mo ago
Missed opportunity to call it:

GeneGuesserIt

jfarlow•1mo ago
This is a challenge, even for someone who has professionally used the breadth of proteins. I really like the test. I'm actually kind of surprised at my own pulling on knowledge to make a guess - it's an orthogonal way to think about the question than is usually posed.

I wonder if there's a way to ease the difficulty by filling in 'correct' features of the guesses: if your guess is a 'transmembrane' then it reveals that as a property. On the other hand, I don't think the annotations are clean enough - and are often designed for 'at all' rather than 'primary' features. For one of the examples, once I noticed it was an adhesion protein, it would have been interesting to sift through classes or cell types as opposed to just continuing to shoot in the dark based on the structure alone.

I presume you're showing even the 'low confidence' portions of the predicted structure? Please do.

You could also show the primary amino acid sequence too - there's a weird familiarity with those given how often the structures themselves have historically not been so accessible. BLASTING each of the guesses would be another interesting thing to see.

brinedew•1mo ago
I'm glad you enjoyed it.

> I wonder if there's a way to ease the difficulty by filling in 'correct' features of the guesses

Rather than allowing players to guess individual features, I opted for the "highlight" system where all hidden features that match your guessed protein's features get auto-revealed. This way, if you suspect a transmembrane protein, you can just guess a known transmembrane protein and see which features auto-reveal.

> it would have been interesting to sift through classes or cell types

You're welcome to suggest databases with good coverage over the proteome that I could use for these.

> I presume you're showing even the 'low confidence' portions of the predicted structure?

Yes, any residues in the files I fetch get rendered. I rank by coverage before fetching.

> You could also show the primary amino acid sequence too

I'll consider it.

pks016•1mo ago
Cool game. Harder for me. I have background in most of the undergrad and some grad molecular biology. Still, the hints didn't help much. The most useful hints were on function of the gene and cellular components. Also, I have been out of touch with gene names from the last few years. I tried searching using a gene's function but didn't work as much. At the end I got 81% close but far from the answer.

You could start with popular gene names.