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Al Lowe on model trains, funny deaths and working with Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
38•thelok•2h ago•3 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
101•AlexeyBrin•6h ago•18 comments

First Proof

https://arxiv.org/abs/2602.05192
51•samasblack•3h ago•38 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
789•klaussilveira•20h ago•243 comments

Stories from 25 Years of Software Development

https://susam.net/twenty-five-years-of-computing.html
39•vinhnx•3h ago•5 comments

Reinforcement Learning from Human Feedback

https://rlhfbook.com/
63•onurkanbkrc•5h ago•5 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
1040•xnx•1d ago•587 comments

Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
462•theblazehen•2d ago•165 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
509•nar001•4h ago•235 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
183•jesperordrup•10h ago•65 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
63•1vuio0pswjnm7•7h ago•59 comments

Coding agents have replaced every framework I used

https://blog.alaindichiappari.dev/p/software-engineering-is-back
186•alainrk•5h ago•280 comments

Software factories and the agentic moment

https://factory.strongdm.ai/
49•mellosouls•3h ago•51 comments

A Fresh Look at IBM 3270 Information Display System

https://www.rs-online.com/designspark/a-fresh-look-at-ibm-3270-information-display-system
27•rbanffy•4d ago•5 comments

What Is Stoicism?

https://stoacentral.com/guides/what-is-stoicism
17•0xmattf•2h ago•7 comments

72M Points of Interest

https://tech.marksblogg.com/overture-places-pois.html
19•marklit•5d ago•0 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
108•videotopia•4d ago•27 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
58•speckx•4d ago•62 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
268•isitcontent•20h ago•34 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
197•limoce•4d ago•107 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
281•dmpetrov•21h ago•150 comments

British drivers over 70 to face eye tests every three years

https://www.bbc.com/news/articles/c205nxy0p31o
169•bookofjoe•2h ago•152 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
152•matheusalmeida•2d ago•47 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
549•todsacerdoti•1d ago•266 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
422•ostacke•1d ago•110 comments

Ga68, a GNU Algol 68 Compiler

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
39•matt_d•4d ago•14 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
365•vecti•23h ago•167 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
465•lstoll•1d ago•305 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
341•eljojo•23h ago•210 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
66•helloplanets•4d ago•70 comments
Open in hackernews

'Off switch' discovery could help clear our brains of a common parasite

https://www.sciencealert.com/off-switch-discovery-could-help-clear-our-brains-of-a-common-parasite
49•amichail•1mo ago
https://journals.asm.org/doi/10.1128/msphere.00438-25

Comments

Aurornis•1mo ago
The "off switch" is a protein within the parasite that they turned off with genetic modifications. They didn't actually find a treatment that could be used on wild parasites.

> Gaji and his team might have found a lead, though: in a new study, they have shown that switching off just a single protein inside the microscopic parasite can kill it.

> The protein, TgAP2X-7, appears to be essential to the parasite's ability to invade a host, form plaques, and self-replicate. To prove this, the team genetically modified some parasites so that their TgAP2X-7 proteins function normally unless auxin (a plant hormone that regulates growth) is added, in which case the proteins would quickly degrade.

So it could be helpful research for something, but there are a lot of proteins within parasites that are necessary for growth and survival. Turning any number of proteins off could end the parasite's ability to do something, but that's not helpful unless you also have a mechanism to induce that change without harming the host.

chasil•1mo ago
Toxoplasma Gondii is noted for causing behavioral differences in infected hosts.

https://en.wikipedia.org/wiki/Toxoplasma_gondii#Behavioral_d...

andrekandre•1mo ago
after reading the whole wiki on that thing.... kind of terrifying...

was thinking of getting a cat but maybe not anymore...

adastra22•1mo ago
Just keep your cat indoors.

FWIW the health impacts of a rodent infestation are probably worse than the cat parasite thing. Best defense against mice/rats is a feline friend.

esperent•1mo ago
> Just keep your cat indoors.

Maybe if you have a big house, but I keep seeing people keep cats or dogs in small houses or even apartments and it feels so sad, it's a kind of animal abuse. If you can't give your pet a good life you should not get a pet.

aspect0545•1mo ago
What if it’s a small apartment, but the life is a significant albeit marginal improvement over life in a shelter? Would it make a difference if it were a shelter where animals are killed after a certain period without being adopted?

Please note that I’m on purpose phrasing this to be a bit contrarian. Not trying to rattle any cages (no pun intended), just found myself initially agreeing with you and then not being sure anymore.

adastra22•1mo ago
I grew up with many cats, all outdoor. I have since known many cats that are kept indoor only. The indoor pets lead happier, less stressful lives. We tend to forget that it is a jungle out there, and even domestic animals have territorial fights and pecking orders. Indoor only cats live comparatively peaceful and stress free lives.
Jach•1mo ago
Zoo keepers sometimes experiment with giving their tigers or other big cats larger enclosures, but that can increase their stress because now they have a bigger territory to patrol.
adastra22•1mo ago
Cats love boxes for a reason :)

Growing up my cat would get antsy and stressed if she hadn’t gone outside in a day. I can see how people can mistake this for needing space, but it wasn’t relaxing for her. She had to go out to remark her territory, and seek out any stray cats encroaching on her space. Noticeably very stressful for her! In the end when she couldn’t retainer her territory anymore, she went in fast decline.

DerArzt•1mo ago
If you're in the new world (the Americas) house cats are an invasive species that, when let to roam outside, harm the native small animal population. Cats shouldn't be left outside to roam free in this situation.
adastra22•1mo ago
Small animals that carry lethal diseases.
Wobbles42•1mo ago
Best defense against rats and mice is a ferret friend. Their odor is far more effective at deterring rodents than felines are.
adastra22•1mo ago
Unfortunately illegal to own where I live :(
richardatlarge•1mo ago
And see here :)

https://usop.substack.com/

BobbyTables2•1mo ago
They did tests on human foreskin…

I have some questions about the goals…

pointlessone•1mo ago
Toxoplasma Gondii.

Damn clickbait… it took title, 5 paragraphs, and an ad break before they even mentioned what the parasite is.

pipes•1mo ago
Click bait title.