frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Open in hackernews

Show HN: Evidex – AI Clinical Search (RAG over PubMed/OpenAlex and SOAP Notes)

https://www.getevidex.com
24•amber_raza•4h ago
Hi HN,

I’m a solo dev building a clinical search engine to help my wife (a resident physician) and her colleagues.

The Problem: Current tools (UpToDate/OpenEvidence) are expensive, slow, or increasingly heavy with pharma ads.

The Solution: I built Evidex to be a clean, privacy-first alternative. Search Demo (GIF): https://imgur.com/a/zoUvINt

Technical Architecture (Search-Based RAG): Instead of using a traditional pre-indexed vector database (like Pinecone) which can serve stale data, I implemented a Real-time RAG pattern:

Orchestrator: A Node.js backend performs "Smart Routing" (regex/keyword analysis) on the query to decide which external APIs to hit (PubMed, Europe PMC, OpenAlex, or ClinicalTrials.gov).

Retrieval: It executes parallel fetches to these APIs at runtime to grab the top ~15 abstracts.

Local Data: Clinical guidelines are stored locally in SQLite and retrieved via full-text search (FTS) ensuring exact matches on medical terminology.

Inference: I’m using Gemini 2.5 Flash to process the concatenated abstracts. The massive context window allows me to feed it distinct search results and force strict citation mapping without latency bottlenecks.

Workflow Tools (The "Integration"): I also built a "reasoning layer" to handle complex patient histories (Case Mode) and draft documentation (SOAP Notes). Case Mode Demo (GIF): https://imgur.com/a/h01Zgkx Note Gen Demo (GIF): https://imgur.com/a/DI1S2Y0

Why no Vector DB? In medicine, "freshness" is critical. If a new trial drops today, a pre-indexed vector store might miss it. My real-time approach ensures the answer includes papers published today.

Business Model: The clinical search is free. I plan to monetize by selling billing automation tools to hospital admins later.

Feedback Request: I’d love feedback on the retrieval latency (fetching live APIs is slower than vector lookups) and the accuracy of the synthesized answers.

Comments

neil_naveen•1h ago
FYI, You are using Clerk in development mode
amber_raza•1h ago
Oof, good catch! I must have left the test keys active in the deployment config.

Swapping them to production keys right now. Thanks for the heads up!

bflesch•54m ago
Somehow "clerk" is on my ublock origin blocklist and therefore the whole website is not loading. I didn't add "clerk" to the blocklist so it must've been added by one of the blocklists that ublock origin is subscribed to, so there must be a good reason why "clerk" is on that blocklist.

When building a product for medical audience which might care a lot about privacy maybe don't use components which are shady enough that they end up on blocklists.

Edit:

> Why no Vector DB? In medicine, "freshness" is critical. If a new trial drops today, a pre-indexed vector store might miss it. My real-time approach ensures the answer includes papers published today.

This is total rubbish - did you talk to a single medical practitioner when building this? Nobody will do new treatments on their patients if a new paper was "published" (whatever that means, just being added to some search index). These people require trusted source, experimental treatment is only done for private clients who have tried all other options.

amber_raza•21m ago
Thanks for the feedback—this is helpful.

1. Re: Clerk/uBlock: You were spot on. The default Clerk domain often gets flagged by strict blocklists. I just updated the DNS records to serve auth from a first-party subdomain (clerk.getevidex.com) to resolve this. It should be working now.

2. Re: Freshness & 'Rubbish': You are absolutely right that standard of care doesn't (and shouldn't) change overnight based on one new paper.

However, the decision to ditch the Vector DB for Live Search wasn't about pushing 'experimental treatments'—it was about Safety and Engineering constraints:

Retractions & Safety Alerts: A stale vector index is a safety risk. If a major paper is retracted or a drug gets a black-box warning today, a live API call to PubMed/EuropePMC reflects that immediately. A vector store is only as good as its last re-index.

The 'Long Tail': Vectorizing the entire PubMed corpus (35M+ citations) is expensive and hard to keep in sync. By using the search APIs directly, we get the full breadth of the database (including older, obscure case reports for rare diseases) without maintaining a massive, potentially stale index.

The goal isn't to be 'bleeding edge'—it's to be 'currently accurate'.

adit_ya1•44m ago
Out of curiosity, what's the prioritization of evidence (RTC Metanalysis > RTC > observational ) etc, and what's the end user benefit over a tool like OpenEvidence? You mention that other tools are expensive, slow, or increasingly heavy with pharma ads, but OpenEvidence for now seems to be pretty similiar with offerings, speed, and responses. What's your pitch as to why one should prefer this?
amber_raza•12m ago
Great questions.

1. Prioritization: I instruct the model to prioritize evidence in this hierarchy: Meta-Analyses & Systematic Reviews > RCTs > Observational Studies > Case Reports. It explicitly deprioritizes non-human studies unless specified.

2. Why not OpenEvidence? OE is excellent! But we made two architectural choices to solve different problems:

'Long Tail' Coverage: OE relies on a pre-indexed vector store, which often creates a blind spot for niche/rare diseases where papers aren't in the 'Top 1% of Journals.' Because Evidex queries live APIs, we catch the obscure case reports that static indexes often prune out.

Workflow: OE is a 'Consultant' (Q&A). Evidex is a 'Resident' (Grunt work). The 'Case Mode' is built to take messy patient histories and draft the actual documentation (SOAP Notes/Appeals) you have to write after finding the answer.

eoravkin•32m ago
Out of curiosity, did you actually see any pharma ads on OpenEvidence?
amber_raza•11m ago
Great question. I haven't seen banner ads on OpenEvidence yet, but the 'hidden tax' of free tools is often Publisher Bias.

Users have noted that some current tools heavily overweight citations from 'Partner Journals' (like NEJM/JAMA) because they index the full text, effectively burying better papers from non-partner journals in the vector retrieval.

My goal is strictly Neutral Retrieval. By hitting the PubMed/OpenAlex APIs live, Evidex treats a niche pediatric journal with the same relevance weight as a major publisher, ensuring the 'Long Tail' of evidence isn't drowned out by business partnerships.

dataviz1000•19m ago
I'm working on building an AI agent that creates queries over a time-series database focused on financial data. For example, it can quantify Federal Reserve reports and generate a table showing how SPY reacted 30 minutes after, at EoD, at the next day’s open, and at the next day’s EoD. It will plan the database query and then query the data from a materialized view. It is magic!

How would biomedical researchers use tons of time-series data? A better question is: what questions are biomedical researchers asking with time-series data? I'm a lot more interested in generalized querying over time-series data than just financial data. What would be a great proof of concept?

amber_raza•8m ago
That sounds like a fascinating project.

To answer your question: In the biomedical world, the 'Time-Series' equivalent is Patient Telemetry (Continuous Glucose Monitors, ICU Vitals, Wearables).

The Question Researchers Ask: 'Can we predict sepsis/stroke 4 hours before it happens based on the velocity of change in Heart Rate + BP?'

Right now, Evidex is focused on the Unstructured Text (Literature/Guidelines) rather than the structured time-series data, but the 'Holy Grail' of medical AI is eventually combining them: Using the Literature to interpret the Live Vitals in real-time.

Google is dead. Where do we go now?

https://www.circusscientist.com/2025/12/29/google-is-dead-where-do-we-go-now/
228•tomjuggler•1h ago•171 comments

Static Allocation with Zig

https://nickmonad.blog/2025/static-allocation-with-zig-kv/
138•todsacerdoti•6h ago•74 comments

Left Behind: Futurist Fetishists, Prepping and the Abandonment of Earth (2019)

https://www.boundary2.org/2019/08/sarah-t-roberts-and-mel-hogan-left-behind-futurist-fetishists-p...
21•naves•2h ago•8 comments

Flame Graphs vs. Tree Maps vs. Sunburst (2017)

https://www.brendangregg.com/blog/2017-02-06/flamegraphs-vs-treemaps-vs-sunburst.html
62•gudzpoz•2d ago•12 comments

The Future of Software Development Is Software Developers

https://codemanship.wordpress.com/2025/11/25/the-future-of-software-development-is-software-devel...
57•cdrnsf•2h ago•27 comments

List of domains censored by German ISPs

https://cuiiliste.de/domains
201•elcapitan•3h ago•77 comments

Which Humans?

https://osf.io/preprints/psyarxiv/5b26t_v1
20•surprisetalk•2h ago•9 comments

All Delisted Steam Games

https://delistedgames.com/all-delisted-steam-games/
117•Bondi_Blue•2h ago•38 comments

Show HN: Aroma: Every TCP Proxy Is Detectable with RTT Fingerprinting

https://github.com/Sakura-sx/Aroma
37•Sakura-sx•4d ago•23 comments

High-performance C++ hash table using grouped SIMD metadata scanning

https://github.com/Cranot/grouped-simd-hashtable
31•rurban•5d ago•11 comments

USPS Announces Changes to the Postmark Date System

https://nstp.org/article/usps-announces-changes-postmark-date-system
3•rbanffy•21m ago•0 comments

GOG is getting acquired by its original co-founder

https://www.gog.com/blog/gog-is-getting-acquired-by-its-original-co-founder-what-it-means-for-you/
453•haunter•5h ago•258 comments

Libgodc: Write Go Programs for Sega Dreamcast

https://github.com/drpaneas/libgodc
175•drpaneas•8h ago•41 comments

Kidnapped by Deutsche Bahn

https://www.theocharis.dev/blog/kidnapped-by-deutsche-bahn/
847•JeremyTheo•9h ago•790 comments

Static Allocation for Compilers

https://matklad.github.io/2025/12/23/static-allocation-compilers.html
13•enz•5d ago•4 comments

Linux DAW: Help Linux musicians to quickly and easily find the tools they need

https://linuxdaw.org/
145•prmoustache•9h ago•74 comments

The production bug that made me care about undefined behavior

https://gaultier.github.io/blog/the_production_bug_that_made_me_care_about_undefined_behavior.html
69•birdculture•3h ago•45 comments

Show HN: Evidex – AI Clinical Search (RAG over PubMed/OpenAlex and SOAP Notes)

https://www.getevidex.com
24•amber_raza•4h ago•10 comments

Nvidia takes $5B stake in Intel under September agreement

https://www.reuters.com/legal/transactional/nvidia-takes-5-billion-stake-intel-under-september-ag...
150•taubek•4h ago•57 comments

Show HN: Z80-μLM, a 'Conversational AI' That Fits in 40KB

https://github.com/HarryR/z80ai
457•quesomaster9000•16h ago•101 comments

You can't design software you don't work on

https://www.seangoedecke.com/you-cant-design-software-you-dont-work-on/
205•saikatsg•14h ago•71 comments

Meta's ads tools started switching out top-performing ads with AI-generated ones

https://www.businessinsider.com/meta-ai-generating-bizarre-ads-advantage-plus-2025-10
92•zdw•2h ago•56 comments

Why is calling my asm function from Rust slower than calling it from C?

https://ohadravid.github.io/posts/2025-12-rav1d-faster-asm/
86•gavide•2d ago•27 comments

Karpathy on Programming: "I've never felt this much behind"

https://twitter.com/karpathy/status/2004607146781278521
193•rishabhaiover•3d ago•141 comments

What an unprocessed photo looks like

https://maurycyz.com/misc/raw_photo/
2264•zdw•23h ago•365 comments

AI Is Forcing Us to Write Good Code

https://bits.logic.inc/p/ai-is-forcing-us-to-write-good-code
16•sgk284•2h ago•5 comments

Binance's Trust Wallet extension hacked; users lose $7M

https://www.web3isgoinggreat.com/?id=trust-wallet-hack
40•ilamont•2h ago•4 comments

Feynman's Hughes Lectures: 950 pages of notes

https://thehugheslectures.info/the-lectures/
154•gnubison•11h ago•35 comments

Show HN: See what readers who loved your favorite book/author also loved to read

https://shepherd.com/bboy/2025
103•bwb•10h ago•24 comments

Show HN: Vibe coding a bookshelf with Claude Code

https://balajmarius.com/writings/vibe-coding-a-bookshelf-with-claude-code/
245•balajmarius•8h ago•184 comments