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2025: The Year in LLMs

https://simonwillison.net/2025/Dec/31/the-year-in-llms/
67•simonw•1h ago•32 comments

Nerd: The first programming language not built for humans

https://www.nerd-lang.org/about
21•gnanagurusrgs•39m ago•37 comments

Scientists unlock brain's natural clean-up system for new treatments for stroke

https://www.monash.edu/pharm/about/news/news-listing/latest/scientists-unlock-brains-natural-clea...
56•PaulHoule•3h ago•6 comments

Warren Buffett steps down as Berkshire Hathaway CEO after six decades

https://www.latimes.com/business/story/2025-12-31/warren-buffett-steps-down-as-berkshire-hathaway...
355•ValentineC•4h ago•216 comments

I canceled my book deal

https://austinhenley.com/blog/canceledbookdeal.html
326•azhenley•7h ago•216 comments

The Delete Act

https://privacy.ca.gov/drop/about-drop-and-the-delete-act/
98•weaksauce•1h ago•49 comments

Show HN: BusterMQ, Thread-per-core NATS server in Zig with io_uring

https://bustermq.sh/
12•jbaptiste•1h ago•1 comments

GoGoGrandparent (YC S16) Is Hiring Tech Leads

https://www.ycombinator.com/companies/gogograndparent/jobs/w2jGKM7-gogograndparent-yc-s16-is-hiri...
1•davidchl•52m ago

All-optical synthesis chip for large-scale intelligent semantic vision

https://www.science.org/doi/10.1126/science.adv7434
54•QueensGambit•5h ago•9 comments

Demystifying DVDs

https://hiddenpalace.org/News/One_Bad_Ass_Hedgehog_-_Shadow_the_Hedgehog#Demystifying_DVDs
101•boltzmann-brain•2d ago•8 comments

Observed Agent Sandbox Bypasses

https://voratiq.com/blog/yolo-in-the-sandbox/
24•m-hodges•3d ago•13 comments

My role as a founder-CTO: year 8

https://miguelcarranza.es/cto-year-8
94•ridruejo•5d ago•87 comments

Ÿnsect, a French insect farming startup, has been been placed into liquidation

https://techcrunch.com/2025/12/26/how-reality-crushed-ynsect-the-french-startup-that-had-raised-o...
63•fcpguru•5d ago•66 comments

PyPI in 2025: A Year in Review

https://blog.pypi.org/posts/2025-12-31-pypi-2025-in-review/
43•miketheman•6h ago•8 comments

Scaffolding to Superhuman: How Curriculum Learning Solved 2048 and Tetris

https://kywch.github.io/blog/2025/12/curriculum-learning-2048-tetris/
117•a1k0n•10h ago•27 comments

Akin's Laws of Spacecraft Design (2011) [pdf]

https://www.ece.uvic.ca/~elec399/201409/Akin%27s%20Laws%20of%20Spacecraft%20Design.pdf
264•tosh•15h ago•79 comments

When square pixels aren't square

https://alexwlchan.net/2025/square-pixels/
109•PaulHoule•12h ago•52 comments

Show HN: Use Claude Code to Query 600 GB Indexes over Hacker News, ArXiv, etc.

https://exopriors.com/scry
300•Xyra•18h ago•112 comments

The most famous transcendental numbers

https://sprott.physics.wisc.edu/pickover/trans.html
140•vismit2000•13h ago•83 comments

Microtonal Spiral Piano

https://shih1.github.io/spiral/
71•phoenix_ashes•5d ago•13 comments

Show HN: Frockly – A visual editor for understanding complex Excel formulas

37•jack_ruru•6d ago•9 comments

Stewart Cheifet, creator of The Computer Chronicles, has died

https://obits.goldsteinsfuneral.com/stewart-cheifet
194•spankibalt•8h ago•59 comments

How AI labs are solving the power problem

https://newsletter.semianalysis.com/p/how-ai-labs-are-solving-the-power
120•Symmetry•12h ago•197 comments

The compiler is your best friend

https://blog.daniel-beskin.com/2025-12-22-the-compiler-is-your-best-friend-stop-lying-to-it
134•based2•10h ago•88 comments

On privacy and control

https://toidiu.com/blog/2025-12-25-privacy-and-control/
141•todsacerdoti•7h ago•76 comments

Nvidia GB10's Memory Subsystem, from the CPU Side

https://chipsandcheese.com/p/inside-nvidia-gb10s-memory-subsystem
68•ingve•13h ago•6 comments

Doom in Django: testing the limits of LiveView at 600.000 divs/segundo

https://en.andros.dev/blog/7b1b607b/doom-in-django-testing-the-limits-of-liveview-at-600000-divss...
168•andros•3d ago•48 comments

Kitchen optimizations

https://www.natemeyvis.com/kitchen-optimizations/
68•Theaetetus•1w ago•181 comments

The story of Squeak, a practical Smalltalk written in itself (1997) [pdf]

http://www.vpri.org/pdf/tr1997001_backto.pdf
104•fanf2•1w ago•27 comments

Toward a Grand Unified Theory of Snowflakes

https://www.quantamagazine.org/toward-a-grand-unified-theory-of-snowflakes-20191219/
10•tzury•1w ago•0 comments
Open in hackernews

Scientists unlock brain's natural clean-up system for new treatments for stroke

https://www.monash.edu/pharm/about/news/news-listing/latest/scientists-unlock-brains-natural-clean-up-system-to-develop-new-treatments-for-stroke-and-other-neurological-diseases
56•PaulHoule•3h ago

Comments

canadiantim•1h ago
Very interesting, especially in light of the Chinese study’s claiming to have success with a large subset of Alzheimer’s by adding a shunt to the cervical lymphatic nodes, which seems to be exactly what they’re doing here too.

For those who don’t want to wait and have someone they love who can benefit from this, simply massaging the lymph nodes in the neck 10 minutes a day also significantly increases flow through these lymph nodes and thereby increases drainage of lymph from the brain.

colordrops•53m ago
Hmm, I had a bunch removed due to thyroid cancer. I wonder if that reduced my brains ability to clean itself out.
monero-xmr•27m ago
It will turn out we just need to sit in a box for 15 minutes a day to pound us with magnets, sound waves, and hardcore vibrations to live to 125
hkt•18m ago
Don't forget near infrared lasers for some photobiomodulation!
yosito•4m ago
It would be really interesting if we find out that a simple 10 minute daily massage of the lymph nodes in the neck significantly prevents Alzheimer's.
lanakei•37m ago
Full article: https://www.monash.edu/news/articles/scientists-unlock-brain...