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FracturedJson

https://github.com/j-brooke/FracturedJson/wiki
77•PretzelFisch•1h ago•13 comments

10 years of personal finances in plain text files

https://sgoel.dev/posts/10-years-of-personal-finances-in-plain-text-files/
142•wrxd•2h ago•45 comments

39th Chaos Communication Congress Videos

https://media.ccc.de/b/congress/2025
40•Jommi•49m ago•3 comments

Standard Ebooks: Public Domain Day 2026 in Literature

https://standardebooks.org/blog/public-domain-day-2026
170•WithinReason•5h ago•28 comments

One Number I Trust: Plain-Text Accounting for a Multi-Currency Household

https://lalitm.com/post/one-number-i-trust/
53•ayi•3h ago•20 comments

Show HN: Dealta – A game-theoretic decentralized trading protocol

https://github.com/orgs/Dealta-Foundation/repositories
9•kalenvale•1h ago•0 comments

HPV vaccination reduces oncogenic HPV16/18 prevalence from 16% to <1% in Denmark

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.27.2400820
146•stared•3h ago•68 comments

Why users cannot create Issues directly

https://github.com/ghostty-org/ghostty/issues/3558
482•xpe•12h ago•177 comments

OfferGridAI – side-by-side comparison of real estate offers from PDFs

https://offergridai.com
5•beechwood•37m ago•5 comments

Happy Public Domain Day 2026

https://publicdomainreview.org/blog/2026/01/public-domain-day-2026/
340•apetresc•12h ago•63 comments

Matz 2/2: The trajectory of Ruby's growth, Open-Source Software today etc.

https://en.kaigaiiju.ch/episodes/matz2
60•kibitan•6d ago•28 comments

A website to destroy all websites

https://henry.codes/writing/a-website-to-destroy-all-websites/
611•g0xA52A2A•17h ago•315 comments

Can I throw a C++ exception from a structured exception?

https://devblogs.microsoft.com/oldnewthing/20170728-00/?p=96706
19•birdculture•4d ago•4 comments

FreeBSD: Home NAS, part 1 – configuring ZFS mirror (RAID1)

https://rtfm.co.ua/en/freebsd-home-nas-part-1-configuring-zfs-mirror-raid1/
77•todsacerdoti•7h ago•7 comments

What You Need to Know Before Touching a Video File

https://gist.github.com/arch1t3cht/b5b9552633567fa7658deee5aec60453/
10•qbow883•5d ago•1 comments

Windows 11 surges among PC gamers on Steam as Linux stalls

https://www.windowscentral.com/gaming/pc-gaming/windows-11-surges-among-pc-gamers-on-steam-as-lin...
12•pjmlp•22m ago•8 comments

Round the tree, yes, but not round the squirrel

https://www.futilitycloset.com/2026/01/02/round-and-round/
46•beardyw•5h ago•38 comments

Joseph Campbell Meets George Lucas – Part I (2015)

https://www.starwars.com/news/mythic-discovery-within-the-inner-reaches-of-outer-space-joseph-cam...
24•indigodaddy•23h ago•4 comments

Cameras and Lenses (2020)

https://ciechanow.ski/cameras-and-lenses/
460•sebg•20h ago•53 comments

Show HN: I built a clipboard tool to strip/keep specific formatting like Italics

https://custompaste.com
10•EvaWorld9•1h ago•7 comments

Can Bundler be as fast as uv?

https://tenderlovemaking.com/2025/12/29/can-bundler-be-as-fast-as-uv/
285•ibobev•16h ago•89 comments

Contact the ISS

https://www.ariss.org/contact-the-iss.html
61•logikblok•5d ago•20 comments

A small collection of text-only websites

https://shkspr.mobi/blog/2025/12/a-small-collection-of-text-only-websites/
9•danielfalbo•3h ago•3 comments

Going immutable on macOS, using Nix-Darwin

https://carette.xyz/posts/going_immutable_macos/
83•weird_trousers•5h ago•47 comments

Linux is good now

https://www.pcgamer.com/software/linux/im-brave-enough-to-say-it-linux-is-good-now-and-if-you-wan...
889•Vinnl•17h ago•704 comments

Marmot – A distributed SQLite server with MySQL wire compatible interface

https://github.com/maxpert/marmot
129•zX41ZdbW•11h ago•27 comments

BYD Sells 4.6M Vehicles in 2025, Meets Revised Sales Goal

https://www.bloomberg.com/news/articles/2026-01-01/byd-sells-4-6-million-vehicles-in-2025-meets-r...
293•toomuchtodo•22h ago•455 comments

Show HN: Enroll, a tool to reverse-engineer servers into Ansible config mgmt

https://enroll.sh
199•_mig5•1d ago•38 comments

Show HN: OpenWorkers – Self-hosted Cloudflare workers in Rust

https://openworkers.com/introducing-openworkers
464•max_lt•22h ago•143 comments

Bluetooth Headphone Jacking: A Key to Your Phone [video]

https://media.ccc.de/v/39c3-bluetooth-headphone-jacking-a-key-to-your-phone
517•AndrewDucker•1d ago•187 comments
Open in hackernews

HPV vaccination reduces oncogenic HPV16/18 prevalence from 16% to <1% in Denmark

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.27.2400820
144•stared•3h ago

Comments

kasperni•2h ago
It has really been a great success in Denmark.

In the 1960s, more than 900 people were diagnosed with cervical cancer each year, corresponding to more than 40 cases per 100,000 Danes.

Today, that number is below 10 per 100,000 nationwide – and among women aged 20 to 29, only 3 out of 100,000 are affected. This is below the WHO’s threshold for elimination of the disease.

garbawarb•2h ago
> Infection with HPV types covered by the vaccine (HPV16/18) has been almost eliminated. Before vaccination, the prevalence of HPV16/18 was between 15–17%, which has decreased in vaccinated women to < 1% by 2021. However, about one-third of women still had HPV infection with non-vaccine high-risk HPV types, and new infections with these types were more frequent in vaccinated than in unvaccinated women.

I wonder if we'll those non-vaccine strains will eventually become the most prevalent.

perlgeek•1h ago
Sounds like in countries like Denmark, they are already on their way to becoming the most prevalent.

Hope we'll develop vaccines against those too.

IndrekR•25m ago
In my EU country Gardasil 9 is the most common HPV vaccine nowadays. This protects against 9 most common strains. I would assume the same is true in other countries. We have gone from HPV 16/18 -> +6/11 -> +31/33/45/52/58 protection with 2/4/9-valent vaccines.

Ref: https://en.wikipedia.org/wiki/HPV_vaccine

Traubenfuchs•1h ago
Everyone already knows!

HPV vaccination leads to massive reduction in nasopharyngeal, penile and rectal cancer in men.

The focus of messaging around HPV vaccination on ovarian cancer, female fertility and the age limitations for recommendations / free vaccination in some places are nothing short of a massive public health failure and almost scandal.

Just truthfully tell the boys their dicks might fall off and see how all of them quicklky flock to the vaccine.

jorvi•1h ago
> Just truthfully tell the boys their dicks might fall off and see how all of them quicklky flock to the vaccine.

Every male above the age of 26 is locked out of the vaccine unless you pay out of pocket, which will be €300-€500 (or even higher).

It's led to this really weird situation, where HPV vaccination for men is now recommended up to 40s but only covered up to 26yr old, and that recommendation upgrade happened relatively recently. Which means there's a whole generation of men who are told they should get the vaccine, who would have had covered access to the vaccine in the past, but are now expected to go out of pocket.

tecleandor•40m ago
Yep, I paid for mine. male/43/Spain. Almost €400. Two shots of the nonavalent vaccine, ~€190 each.

For younger people it's three shots (second after two months, third after 6 months of the first one), now for older (over 30s or 40s, I can't remember exactly) it's recommended to get two shots (second after six months).

coreyh14444•1h ago
Just a quick point as an American living in Denmark, one of the reasons government programs like this work so well is everything is delivered digitally. We have "e-boks" https://en.digst.dk/systems/digital-post/about-the-national-... official government facilitated inboxes so when they need to notify you of vaccinations or whatever else, it arrives to your inbox. And basically 100% of residents use these systems.
tokai•50m ago
I fail to see how e-boks makes this work. Younger people check their e-boks less frequently than average, so sending a physical letter to their address would work just as well if not better.

What makes it work is the public registers.

silvestrov•2m ago
e-boks sends a text message to the phone, so I see it much faster than a paper mail.

e-boks is like gmail (and others) in that it keeps your old mail. So you can easily find old stuff, a great improvement on paper mail.

I don't even check my physical mailbox once a week.

Denmark is one of the very most digital countries. Physical mail is very much on the way out. We no longer has mailboxes to send mail, you have to go to a shop to send letters, which now cost at last $6 per letter due to the low amount of mail sent.

It is only a matter of less than 10 years before letters will be fully gone.

closewith•34m ago
Okay, well Ireland has similar vaccination rates, broader childhood vaccination coverage, and no central medical records at all, so while e-boks may assist administration, it's certainly not necessary.
nextos•1h ago
Lots of viruses are really oncogenic. The real success here is the ability of Denmark to track effectiveness. It sounds crazy but most countries do not have electronic health record capability to measure the effect of many interventions at population scale. Once good EHRs are rolled out, we will be able to double down on effective interventions, like this one, and vice versa.
spiderfarmer•1h ago
Sadly, no matter how good the data is, some societies will value opinions of uninformed celebrities above facts and reason, leading to a resurgence of preventable diseases.
jacquesm•1h ago
These celebrities should serve some jailtime. Quackery is criminal, it kills people.
alecco•1h ago
Agreed. But we should also stop enabling celebrities when they push popular agendas even if they are correct. For example, climate change.
shevy-java•31m ago
Celebrities in general are quite dubous. See a certain actor suddenly promoting Palantir spysniffing on mankind. I decided that guy won't get a dime from me for the rest of my life - when actors suddenly become lobbyists for Evil, they need to not get any money from regular people really.
im3w1l•1h ago
Idk the Danish approach of opennnes seems to be working for them. They acknowledge it isn't fully effective. They acknowledge that there may be a small risk of side effects. And they tell people it's worth it and to go take it.

"Since HPV vaccination was implemented in the Danish childhood vaccination programme in 2009, we have received 2,320 reports of suspected adverse reactions from HPV vaccines up to and including 2016. 1,023 of the reported adverse reactions have been categorised as serious. In the same period, 1,724,916 vaccine doses were sold. The reports related to HPV vaccination that we have classified as serious include reports of the condition Postural Orthostatic Tachycardi Syndrome (POTS), fainting, neurological symptoms and a number of diffuse symptoms, such as long-term headache, fatigue and stomach ache."

"The risk of cervical changes at an early stage was reduced by 73% among women born in 1993 and 1994, who had been vaccinated with the HPV vaccine compared with those who had not been vaccinated."

"The Danish Health Authority recommends that all girls are vaccinated against HPV at the age of 12. The Danish Health Authori- ty still estimates that the benefits of vaccination by far outweigh any possible adverse reactions from the vaccine."

https://laegemiddelstyrelsen.dk/en/sideeffects/side-effects-...

tokai•53m ago
Its not like it wasn't without issues. You had the documentary from a state funded tv station that uncritically let people claim all kind of issues after getting the vaccine. It drastically lowered the uptake of the vaccine.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6288961/

jacquesm•40m ago
> They acknowledge it isn't fully effective. They acknowledge that there may be a small risk of side effects. And they tell people it's worth it and to go take it.

Those are basic bits of knowledge that apply to most vaccinations.

The problem is that the quacks diminish the positive effects, exaggerate the negatives and engage in a campaign of fear mongering that costs some people (and in some cases lots of people, see COVID) their lives. They are not only clueless, they are malicious.

From Gwyneth Paltrow, JFK Jr, all the way to Donald Trump and a whole raft of others the damage is immense. I have a close family member who now is fully convinced of the healing power of crystals and there isn't a thing you can do to reason with people that have fallen into a trap like that.

shevy-java•32m ago
The numbers are quite solid. People who don't want to accept the numbers, need to come up with an explanation why the data can not be trusted. With regard to oncogenic HPV, I think the data is very convincing. To me it was a lot more convincing than the SARS covid datapoints (e. g. the media constantly shifted; I noticed this with regard to Sweden, which had a bad early data due to barely any protection of the elderly, but lateron it still had better data than e. g. Austria which went into lockdown - so Austria had worse data points than Sweden overall. Japan or Taiwan had excellent data points, so the respective governments were much better than either Sweden or Austria. The most incompetent politicans acted in Austria during that time, replacing facts with promo and propaganda. The data points, though, were always solid. I remember I compared this about weekly and it was interesting to me when Austria suddenly surpassed Sweden negatively; the media here in Austria critisized Sweden early on, but once Sweden outperformed Austria in a better, more positive manner, suddenly the media no longer reported that. Private media simply can not be trusted.)
shevy-java•35m ago
"Lots of viruses are really oncogenic."

Hmm. Compared to what measurement? Most viruses are actually not oncogenic.

From cancer causes, oncogenic viruses are thought to be responsible for about 12% of human cancers worldwide:

https://www.mdpi.com/2079-7737/14/7/797

From what I remember, most viruses are not oncogenic in nature, so I am unsure whether the statement made is correct.

closewith•27m ago
EHRs are definitely not necessary for health surveillance and many countries perform equally or better without centralised records.

I'm a proponent of EHRs, but the key value is at patient-level, not population level where other approaches perform equally well.

afarah1•46m ago
A comment with an article citing published medical literature on risks associated with this type of vaccine was flagged and hidden. Why? I don't know the author nor am I a medical doctor to understand the topic at depth, so it's a genuine question. Was it misleading? If so, how? That's what the comment was asking, actually, if there were counter-points to the text, which was favorable to live vaccines (e.g. shingles) but critical of those developed with other methods. Is there no merit to that? I genuinely don't know, and since it seems impossible to discuss the topic, it's hard to say.
wpietri•14m ago
I sometimes vouch for incorrectly flagged posts. You got me curious, so I took a look. What I found was a blog from an anonymous conspiracist vaccine opponent claiming to be a doctor. He's a decent writer but in my estimation a loon.

So I'm fine with it being flagged and decline to vouch for it.

stared•42m ago
I would like to add:

- HPVs are extremely common: 80% of men and 90% of women will have at least one strain in their lives. Unless you plan to remain completely celibate, you are likely to contract a strain.

- Sooner is better, but vaccination can be done at any age. Guidelines often lag behind, but vaccination makes sense even if you are currently HPV-positive. While it won't clear an existing infection, it protects against different strains and reinfection (typically body removed HPV in 1-2 years). See: https://pubmed.ncbi.nlm.nih.gov/38137661/

- HPV16 is responsible for a large number of throat cancers (around 50% in smokers and 80% in non-smokers!). This affects both men and women. Vaccinating men is important for their own safety and to reduce transmission to their partners.

shevy-java•37m ago
> Unless you plan to remain completely celibate

You can get HPV without sex too.

https://www.cdc.gov/sti/about/about-genital-hpv-infection.ht...

"HPV is most commonly spread during vaginal or anal sex. It also spreads through close skin-to-skin touching during sex"

This focuses on sex, but any virus that can be found on skin, also has a chance to be transmitted without sex just as well. Admittedly the chance here for HPV infection is much higher with regard to sex, but not non-zero otherwise. The HeLa cells also contain a HPV virus in the genome, though this was probably transmitted via sex:

"The cells are characterized to contain human papillomavirus 18 (HPV-18)"

HPV-18. I think HPV-18 may in general be more prevalent than HPV-16.

formerly_proven•6m ago
> - Sooner is better, but vaccination can be done at any age. Guidelines often lag behind, but vaccination makes sense even if you are currently HPV-positive.

However, the vaccination is expensive (~1k) and it is difficult to find doctors who will do non-recommended vaccinations for self-payers.

YCMV

elric•2m ago
> However, the vaccination is expensive (~1k)

Depends entirely on where you are and what your healthcare situation is. Mine cost me ~100eur.

elric•2m ago
I, a male, got vaccinated with the Gardasil 9 shortly before turning 40. Convincing my doctor to prescribe it wasn't terribly difficult, I told them a few things about my sexual history and explained some of my sexual plans, and that was that.

I wish more people would get vaccinated.

shevy-java•40m ago
The data is IMO quite convincing. Harald zur Hausen pointed this out decades ago already; this is another data point that adds to the theory which back then he proposed was fairly new (not that viruses cause cancer, that is much older knowledge, but specifically the role of some HPV strains; Harald died about 2 years ago).
wewewedxfgdf•22m ago
Do the conspiracy theorists believe it or not?
esafak•13m ago
At what age can you start getting vaccinated?
gizmo686•4m ago
I don't know about Denmark, but the US CDC indicates that you can get the HPV vaccine starting at 9; with a recommendation do get it at 11 or 12.

https://www.cdc.gov/vaccines/vpd/hpv/hcp/recommendations.htm...