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Start all of your commands with a comma

https://rhodesmill.org/brandon/2009/commands-with-comma/
58•theblazehen•2d ago•11 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
637•klaussilveira•13h ago•188 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
935•xnx•18h ago•549 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
35•helloplanets•4d ago•31 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
113•matheusalmeida•1d ago•28 comments

Jeffrey Snover: "Welcome to the Room"

https://www.jsnover.com/blog/2026/02/01/welcome-to-the-room/
13•kaonwarb•3d ago•12 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
45•videotopia•4d ago•1 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
222•isitcontent•13h ago•25 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
214•dmpetrov•13h ago•106 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
324•vecti•15h ago•142 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
374•ostacke•19h ago•94 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
479•todsacerdoti•21h ago•237 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
359•aktau•19h ago•181 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
279•eljojo•16h ago•166 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
407•lstoll•19h ago•273 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
17•jesperordrup•3h ago•10 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
85•quibono•4d ago•21 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
58•kmm•5d ago•4 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
27•romes•4d ago•3 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
245•i5heu•16h ago•193 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
14•bikenaga•3d ago•2 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
54•gfortaine•11h ago•22 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
143•vmatsiiako•18h ago•65 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1061•cdrnsf•22h ago•438 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
179•limoce•3d ago•96 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
284•surprisetalk•3d ago•38 comments

Why I Joined OpenAI

https://www.brendangregg.com/blog/2026-02-07/why-i-joined-openai.html
137•SerCe•9h ago•125 comments

Show HN: R3forth, a ColorForth-inspired language with a tiny VM

https://github.com/phreda4/r3
70•phreda4•12h ago•14 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
29•gmays•8h ago•11 comments

FORTH? Really!?

https://rescrv.net/w/2026/02/06/associative
63•rescrv•21h ago•23 comments
Open in hackernews

Comparing benefits of every-third-day vs. daily low-dose aspirin therapy (2001)

https://pubmed.ncbi.nlm.nih.gov/11190906/
34•walterbell•1mo ago

Comments

dzdt•1mo ago
Is there a good heuristic now for which things on nih.gov.or cdc.gov are real science?
illini1•1mo ago
This is a paper published from 2001 with no bearing on the current political climate.
Dwedit•1mo ago
The concern is whether the file is unaltered from its original 2001 release.
walterbell•1mo ago
Source PDF with identical summary text: https://journals.sagepub.com/doi/epdf/10.1177/10760296010070...
walterbell•1mo ago
This could mitigate side effects (stomach ulcers, bleeding) while retaining most of the benefits.
abrookewood•1mo ago
So in one case you get triple the daily dose (325 mg vs 81mg) every three days. I'm not sure how that would mitigate side effects?
walterbell•1mo ago
From the summary, only small difference between 81mg daily vs 81mg every 3 days, i.e 87% benefit at 33% averaged dosage.

  325mg every third day: 86% inhibition
  81mg per day:          85% inhibition
  81mg every third day:  74% inhibition
chr15m•1mo ago
Some research suggests the stomach bleed risk comes from the platelet inhibition itself, which would mean you can't have the good effect without the bad.
chr15m•1mo ago
Hang on, the 2015 study suggests otherwise.

Daily dose suppressed PGE2 while 3-daily dose didn't.

> Since PGE2 is involved in gastric healing, we understand that this new approach could be safer and as efficient as the standard daily therapy on a long-term basis.

sathomasga•1mo ago
Follow up in 2015 with essentially the same conclusions:

"Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2 Synthesis"

https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.6...

chr15m•1mo ago
Thanks for sharing this!
polishdude20•1mo ago
What's the benefit of taking aspirin regularly anyways?
DougN7•1mo ago
It’s supposed to help reduce clotting, and thus help a bit to prevent a heart attack, at least that’s what I understood from my heart doctor. Generally you’d take the 81mg “baby aspirins” for this, not a full adult dose.
Keyframe•1mo ago
or in this case one fizzy tablet every three days? Are tehre people doing this long term? Doesn't sound all that compatible with colon.
DougN7•1mo ago
After a heart procedure my doctor told me to take the 81mg daily for the rest of my life. It’s been about 20 years now, with no side effects that I know of.
OptionOfT•1mo ago
I got prescribed 30 days of low-dose aspirin after my hip replacement to prevent clotting. 81mg. At least I didn't have side effects, the other anti-inflammatory made my brain foggy.
hn_throw2025•1mo ago
I would recommend asking your medical practitioner about enteric-coated forms.

I am nearly nine months into NSAID gastritis from only a week of daily 75mg soluble Aspirin.

I have had more painful acute illnesses in the past, but the grind of a long-term illness is new to me and it has been absolutely terrible.