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Stanford scientists found a way to regrow cartilage and stop arthritis

https://www.sciencedaily.com/releases/2026/01/260120000333.htm
107•saikatsg•2h ago

Comments

blakesterz•1h ago
Of course, why are the good ones always in mice?

  A study led by Stanford Medicine researchers has found that an injection blocking a protein linked to aging can reverse the natural loss of knee cartilage in older mice.
agumonkey•1h ago
I guess we should pay scientist to look into the human-to-mice transformation problem
random3•1h ago
This :))) or the other way around
seydor•1h ago
We live in the Matrix, and Mice are the overlords.
trebligdivad•1h ago
It's all that wheel running, terrible on the knees.
irishcoffee•1h ago
Douglas Adams continues to be ahead of his time.
abdullahkhalids•1h ago
If only a small percentage of studies make it past the mice stage to be tested on humans, it means that a lot more studies have been done on mice than humans. Hence, we know more about mouse biology than human biology. So over time, it must get easier and easier to generate positive results in mice, which are uncorrelated with the success in humans.
spwa4•57m ago
It's worse than that. People get to interfere in mice. You can stunt their growth, give them transparent skin, grow more or less limbs, cut into them ... you can't experiment at all on humans.

Especially when it comes to pregnancies we know more about a lot of animals than about humans. Why? Well pregnancies is how you multiply meat in animals, which is what farmers are interested in (and pay for). Which ironically also means animal pregnancies can be treated in case of trouble much more effectively.

Why pregnancies? Pregnancy changes a LOT of chemical processes in the body and so quite a bit of "normal" medical knowledge doesn't apply to pregnant women. Which has caused the medical establishment to declare anything that isn't explicitly tested on pregnant women as a no-go zone. So even problems and medications that we do know about, doctors won't apply them to pregnant women.

tima101•1h ago
https://www.science.org/doi/10.1126/science.adx6649

A small molecule inhibitor of 15-hydroxy prostaglandin dehydrogenase causes cartilage regeneration. I hope they fast-track it to human trials.

fraserharris•1h ago
"Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration" - Helen Blau, Baxter Laboratory for Stem Cell Biology & the Donald E. and Delia B. Baxter Foundation Professorship
mobilejdral•1h ago
ERa activation promotes PGE2 resulting in decreased 15-PGDH.

So this is one of those standard poor estrogen signaling downstream things and simply improving the estrogen signaling and you get improved cartilage. Anyone can do this today along with getting all of the other positive effects. Those with EDS who have say variants on their TNXA/B have poor production ability to start and so we do everything we can to improve their cartilage production as they can only make so much which include doing stuff like this.

llmslave•1h ago
basically every growth process in the body can be induced by chemicals. and so now people are starting to take some of these chemicals. we will see how it turns out
jleyank•1h ago
As long as regrowth can be controlled. Otherwise we call it cancer. Would be amazing to get a treatment for osteoarthritis.
deburo•1h ago
You should check out Michael Levin. Cancerous cells do not grow organ-like structures. Normal cells communicate with other cells as a network to control growth.
da02•37m ago
I had good results with hyaluronic acid for knee osteoarthritis. Sometimes they sell it as Type II Collagen. "Source Naturals Hyaluronic Joint Complex" was the best for my relatives/friends' knee problems. I take it a few times a month (with resveratrol) for smooth skin. I have been taking it since 2008 without any negative result.
arjie•43m ago
Fusion Power

Cartilage Regrowth

Room Temperature Semiconductors

Quantum Computing

    def generate(topic, year):
       return f"Scientists have made a major breakthrough in {topic}"
The only subjects that are more Year Of The Linux Desktop than Linux itself.
legohead•29m ago
Battery tech
KellyCriterion•20m ago
Blockchain & DeFi!

Bingo!

:-D

bramhaag•28m ago
Don't forget about Alzheimer's disease
razingeden•10m ago
[delayed]
carlmr•4m ago
>Year Of The Linux Desktop

After Win11 Microsoft really did all they could to get us there this year.

inglor_cz•38m ago
The discovery of gerozymes is interesting. Maybe aging is pre-programmed after all, to make space for new generations.
clickety_clack•35m ago
Would this work for rheumatoid arthritis? I don’t know anything about it myself so it could be a completely different thing, but someone I know has it and it is awful. Would be great to see a treatment coming through.
surfsvammel•33m ago
My dream is to be able to run again. Please. Let me run a 10k at least once more in my life. To feel that stillness and freedom and calm that sets in when the brain start going to hibernation after about 7km.

That would be quiet something to feel that again.

pegasus•19m ago
Hope you see your dream realized. But know that that stillness is achievable through other activities as well. Most directly and deeply, through a meditation practice which is geared towards reaching those deep meditation states (called Jhanas in the Pali canon). My favorite guide on that particular path is Leigh Brasington.
levl289•23m ago
I’ve had my shoulders “cleaned up” arthroscopically, and the pain is still a major preventer of movement. I would love to stay on the mats longer with something that doesn’t harken to medieval times. So excited at this prospect.

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Stanford scientists found a way to regrow cartilage and stop arthritis

https://www.sciencedaily.com/releases/2026/01/260120000333.htm
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