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Reversing memory loss via gut-brain communication

https://med.stanford.edu/news/all-news/2026/03/gut-brain-cognitive-decline.html
75•mustaphah•2h ago

Comments

fnord77•1h ago
... in mice. So if any of this held in humans, I think you'd see reversal of old-age memory problems in people treated with antibiotics that kill Parabacteroides goldsteinii.

As far as I know, no such effect has been observed.

And this article claims inflamation from that strain, the NIH claims otherwise: "Parabacteroides goldsteinii is a next-generation probiotic gut bacterium with significant anti-inflammatory and metabolic benefits, often reduced in obese or diseased states. "

vidarh•1h ago
It's possible the specifics are different but that the overall idea still could work for humans. It seems worth at least exploring.
maxall4•1h ago
I smell bad data. This sounds too good to be true and most studies of this kind have turned out to be false a few years down the line.

Edit: one of many examples: https://www.science.org/content/article/journal-retracts-inf...

theusus•1h ago
Mice mice mice. Tell me when you test on humans
inanutshellus•53m ago
Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while.

Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:

  * "My butt made me crave candy."[1]
  * "Gee, I'm not bipolar anymore thanks to my husband's butt juice infusion."[2]
Crazy, right?

   [1] https://www.psychologytoday.com/us/blog/the-behavioral-microbiome/202404/hacking-an-individuals-personality-through-their-gut-contents

   [2] https://www.abc.net.au/news/2025-07-28/faecal-microbiota-transplant-credited-with-curing-bipolar/105541522
hbcondo714•36m ago
I would recommend the site https://gutbrainaxistherapeutics.com for learning more about Microbiota Transplant Therapy (MTT) and its opportunities, especially for Autism and Pitt-Hopkins Syndrome.
1shooner•36m ago
This seems to be a recent anti-science meme to dismiss studies that use mouse models. I'm sure there is an interesting line of discussion about the strengths and limits of those models, but that's probably a complex, nuanced thread to pull, not something you blow off with a hand-waving internet comment.
inanutshellus•27m ago
To some degree the other posts are just pointing out the misleading "assumed protagonist" of the title (which doesn't mention mice) but I was surprised to see that the majority of posts boiled down to "eek! mice!"
seethishat•13m ago
IMO people should eat more fiber. A lot more fiber. It cleans the gut, the liver, absorbs cholesterol, slows insulin response and makes you feel full longer. The microbes in our guts need it to function.

Rather than jumping from one fad diet to another, just eat what you like and be sure to get a lot of fiber each day.

mustaphah•13m ago
Yeah, it's a mouse study, but there are literally tons of human studies backing the whole gut-brain connection. There are even a bunch of books on it [1][2].

What's really cool is that the paper used low-dose capsaicin (just 5 μg/kg injected), and it completely restored hippocampal FOS activity and memory in older mice. Basically, that's the same stuff you get in cayenne pepper supplements - pretty easy to get your hands on.

[1] https://www.goodreads.com/book/show/28837738-the-mind-gut-co...

[2] https://www.goodreads.com/book/show/35210457-the-psychobioti...

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Reversing memory loss via gut-brain communication

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